Following up with new results (see image) Found a case report of C3GN with positive antifactor H autoanantibody along with IgG4-RD failed rituximab and steroids but responded to cyclophosphamide and then rituximab maintenance pmc.ncbi.nlm.nih.gov/articles/PMC...

Woman, 71 yo, allopurinol user, U-Sed: Uric acid crystals. *First time I've seen crystals; How beautiful these crystals are! 😍 can't imagine how excited I am. Maybe only a few will understand 🤭 Happy New Year 2026! May there be more urinary sediments to explore #urinarysediment #urinarymicroscopy

A single-arm phase 2 trial of an investigational RNA therapeutic to complement factor B sefaxersen for treatment of IgA nephropathy doi.org/10.1016/j.kint.2025.11.017 #OpenAccess #MedSky #NephSky #IgAN

Happy to see our commentary with @jbrianbyrd.bsky.social suggesting that Angiotensin II should be part of the evaluation of primary hyperaldosteronism. @nu-nephrology.bsky.social @nufeinbergmed.bsky.social www.ahajournals.org/doi/10.1161/...

As we prepare to welcome a new editorial team to #ASNKidney360 in the new year, we thank inaugural Editor-in-Chief, Michael Allon, and Deputy Editors, Luis Juncos and Mark Perazella, for their invaluable work in creating ASN’s online-only open access journal.

New out today: Antiproteinuric Effect of Sparsentan in Patients with Genetic-Associated FSGS Enrolled in the DUPLEX Trial Genetic FSGS CAN be treated. journals.lww.com/cjasn/abstra...

It’s in #NOLA! #BigEasy #CrescentCity #CajunNephrology 💪🔥

1/n young adult gets transferred to our hospital for higher level of care. Had presented to a rural institution with weakness; found to have Hgb 7.5, serum Cr 2.6 mg/dL, hematuria. Prompted a positive p-ANCA. Nephrology is consulted on arrival

💬 Editor's Note: JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, speaks with insitro’s Chief eXploration Officer, Ajamete Kaykas, PhD, about using machine learning and wet lab research to accelerate new therapeutic development. ja.ma/44CAPL6

CASE REPORT: Hypokalemic Quadriparesis for Nephrologist A woman in her mid-20s presented to the ER with sudden-onset weakness in all limbs, unable to stand from sitting position. She'd had lower abdominal pain, vomiting & leg muscle pain for one week. What was causing this dramatic presentation? 🧵

12 Days of Lupus Scoring Findings Countdown! Day 5: Fibrous crescents: Fibrous (old/inactive) crescents indicate that at one point the patient had active disease in the form of cellular/fibrocellular crescents and are scored separately from global and segmental glomerulosclerosis.

Agree re CS and CNI for initial treatment, but perhaps RTX in addition to these? It is being tested in the UK, but don’t know the status of the trial. link.springer.com/article/10.1... In Denmark 1 g of RTX x 2 (biosimilar) comes to approx $2,500 US, so low cost for us

Important study validating what has become my standard practice for relapsing MCD-NS

Commentary Berger disease redux Richard J Glassock doi.org/10.1016/j.kint.2025.09.021 Original article: doi.org/10.1016/j.kint.2025.07.038 #MedSky #NephSky

A sample from the pathology teaching slide set on Anti-neutrophil Cytoplasmic Antibody Associated (ANCA) Vasculitis, jointly prepared by Arkana Laboratories and @goKDIGO. http://KDIGO.org/guidelines/gd/ #KDIGO #pathology #renal #kidneypath

𝗜𝗡𝗦𝗜𝗚𝗛𝗧 is out! 🌍 ✨ How ISN committees are driving the future how you can be part of it ✨ Kidney International Case Reports (KICR) journal launch ✨ Vote for the 2026 ISN Community Film Event until January 6, 2026 … and more ➡️ http://lite.spr.ly/6...

Excited about this @theisn.org initiative, especially under the leadership of @hswapnil.medsky.social as EIC. Nephrology needed this www.theisn.org/blog/2025/12...

1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:

#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Sternheimer-Malbin stain: RBC cast (bright field), WBC cast (oblique illumination), fibrinous cast (dark field), and renal tub epi cell cast (oblique). #OchsnerNephrology

#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Prescott-Brodie stain: RBC cast (bright field, 2 WBCs in cast), WBC cast (bright field, a few RBCs in it), lipid cast (dark field), and renal tub epi cell cast (oblique, many WBCs in blue around) #OchsnerNephrology

#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Sternheimer stain: WBC cast (bright field), broad RBC cast (bright), waxy cast (bright), and granular cast w/Ca Oxalate monohydrate crystals (oblique). #OchsnerNephrology #UrineMicroscopy

Heading back to #NOLA after a delightful and productive trip to KUMC. Had a chance to meet @alanyuneph.bsky.social and learn about some of his recent stellar work.

Now out @jclinicalinvest led by Christine_Behm with fantastic team of collaborators👇 We discover a corticomedullary gradient for Ca in kidney and show a critical role for claudin-2, with implications for kidney stone disease. @kumedcenter.bsky.social www.jci.org/articles/vie...

~15 years ago, Dr. Fred Coe put forward the “vas washdown” model for explaining kidney stone formation @alanyuneph.bsky.social & team now report on a new mouse model, showing kidney-specific Cldn-2 KO leads to medullary nephrocalcinosis—supporting the vas washdown model: doi.org/10.1172/JCI1...

A trial of pegcetacoplan, a C3 and C3b inhibitor, in patients with C3 glomerulopathy or primary immune-complex membranoproliferative glomerulonephritis showed that the drug significantly reduced proteinuria. Full VALIANT phase 3 trial results: nej.md/4pmT67G #MedSky #Nephrology

Podocyte specific exon skipping after disease onset improves kidney pathology and function in a mouse model of #Alport syndrome pmc.ncbi.nlm.nih.gov/articles/PMC...

Points acknowledged but the graph allows one to see the relative changes and the shape of things that came/to come. The losartan curve is our progress vs placebo, while the others show the progress against losartan. Overall one may expect an effect similar to losartan under single agent adoption

An aldosterone synthase (CYP11B2 enzyme)–specific 18F-labeled radioligand to help lateralize in PA www.nejm.org/doi/full/10.... very cool science and technology Any comments from the Aldo experts? @anandvaidya17.bsky.social #NephSky #EndoSky

Cholemic Nephropathy aka Cholemic Nephrosis aka Bile Acid/ Bile Cast Nephropathy ca. 2024 #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/

Sibeprenlimab: First @fda.gov approved therapy targeting B cells which produce the abnormal antibodies responsible for #IgAN, addressing the fundamental cause #Nephpearls #NephSky #VisualAbstract by @nephroseeker.medsky.social 👉🏼 www.fda.gov/drugs/news-e... 👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/

(1/2) The picture shows tissue submitted for routine immunofluorescence (fibrinogen stain is shown). Careful inspection confirms that this is an artery cross section which contains abnormal intraluminal tissue elements with numerous cleft-like spaces (see arrow). #TeachingPoints #kidneypath #renal

An announcement www.nephjc.com/news/2025/11... #NephJC @kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social

That was quick! The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA www.fda.gov/drugs/novel-... #NephSky #TopNephrology

even in their 2024 guidelines they downgrade the level of evidence for resistant hypertension. Yes, spiro causes hyperK but that is easily managed with diuretics, especially in CKD.

#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Sternheimer stain: WBC cast (bright field), broad RBC cast (bright), waxy cast (bright), and granular cast w/Ca Oxalate monohydrate crystals (oblique). #OchsnerNephrology #UrineMicroscopy

#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Prescott-Brodie stain: RBC cast (bright field, 2 WBCs in cast), WBC cast (bright field, a few RBCs in it), lipid cast (dark field), and renal tub epi cell cast (oblique, many WBCs in blue around) #OchsnerNephrology

#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Sternheimer-Malbin stain: RBC cast (bright field), WBC cast (oblique illumination), fibrinous cast (dark field), and renal tub epi cell cast (oblique). #OchsnerNephrology

Commentary Metabolic heavyweight: thick ascending limb or proximal tubule? Next round ✍️Kevin A Hurtado and Leslie S. Gewin doi.org/10.1016/j.kint.2025.08.010 Original article: doi.org/10.1016/j.kint.2025.07.021 #MedSky #NephSky @washunephrology.bsky.social #aki #acutekidneyinjury

1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:

#MassSpectrometry of Minimal Change Disease and Focal Segmental Glomerulosclerosis #MCD #FSGS #VisualAbstract by Sophia Ambruso https://www.kireports.org/article/S2468-0249(25)00618-7/fulltext

✨ Help spread the word about SCM26 #NKFClinicals! Share with a colleague or post on social—help us spread the word about the NKF Spring Clinical Meetings! Check it out and start sharing! ➡️ www.kidney.org/spring-clini...

After a fun and productive #KidneyWk, I’m right back in ✈️ mode again, this time heading to Santiago to share and learn more within the #UrinarySediment #UrineMicroscopy South American Lab/Pathol/Nephrol community 🇵🇪🇨🇱

I met a clever renal fellow at #KidneyWk who named his pets Ace and Arb. I’m inspired. I’ll name my next puppies Muddy and Waxy #UrinarySediment

Another active day for Ochsner Nephrology at #KidneyWk sharing original research work

Check out thr second part of a @coreimpodcast.bsky.social podcast episode on HRS www.coreimpodcast.com/2025/10/22/h...

Another ovation, for Reshma Kewalramani’s talk. #KidneyWk

After empa-kidney, it still wasn’t clear what to do for patients with CKD without diabetes or albuminuria. This meta-analysis suggests you use flozins. #kidneywk jamanetwork.com/journals/jam...

Mandatory #KidneyWk gathering with my fellow Channeleers from Channel Your Enthusiasm podcast 🎙️ www.rosebook.club @kidneyboy.bsky.social @amyaimei.bsky.social @annagaddy.bsky.social @jwaitz.bsky.social

#KidneyWk started with a nice dinner with my friend and LatinoAmerican Nephrology SoMe Icon 🇲🇽 Jonathan Chavez. And we had to do it with a proper high protein osmolar load 🥩 #NephBBQ

When a mentee Ochsner UQ Med Student Saleha Minhas is visited at a poster by 3 sodium rockstars (Sterns, Rodby and @kidneyboy.bsky.social) at #KidneyWk, that’s a highlight 🙌 @annagaddy.bsky.social