Hypercapnia promotes maladaptive airway and vascular remodeling in mice In this Research Letter, Masahiko Shigemura & team show CO2 can remodel lungs and worsen COPD with partial reversibility through lowered CO2: www.jci.org/articles/vie...

A Research Letter by Joshua T. Schiffer & team: Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...

New insights into lipid redistribution! Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease: www.jci.org/articles/vie... The figure shows MASH liver has elevated S100A8+ macrophages.

What is the missing link between initiating and progression mutations in acute myeloid leukemia? Timothy J. Ley & team reveal Gab2 can accelerate AML development in mice and its overexpression may facilitate signaling mutations in AML and other cancers. www.jci.org/articles/vie...

Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms. www.jci.org/articles/vie...

Chronic kidney disease currently affects 850 million people @mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie...

Spinal & bulbar muscular atrophy is a degenerative disorder of the neuromuscular system with no cure ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955

Pleased to see the official release of our research letter in @jci.org ! In my first-ever corresponding author publication, we leveraged a publicly available scRNA-seq dataset and asked how prostate cancer cells systemically reprogram the cells of the bone marrow. www.jci.org/articles/vie...

Why do TLR7 and TLR9 have opposing effects (protective or proinflammatory) in systemic lupus erythematosus? Here, Mark J. Shlomchik & team swapped specific intracellular receptor regions in lupus-prone mice, discovering divergent TIR signaling domains. www.jci.org/articles/vie...

How can we enhance muscle insulin sensitivity in low-active individuals? Rasmus Kjøbsted & team find intermittent ischemia-reperfusion with knee-extensions improves insulin sensitivity via increased blood flow and reduced muscle decanoyl-L-carnitine. www.jci.org/articles/vie...

Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone. www.jci.org/articles/vie...

Osteoarthritis is the most common joint disease, but there are no approved disease-modifying treatments. Martin K. Lotz & team now discover histamine H1 receptor inverse agonists improve structure and pain in an #osteoarthritis mouse model: www.jci.org/articles/vie...

Our work on #sleep and #ALS is out now. JCI - Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis www.jci.org/articles/vie...

Previously shared: Systemic shock can lead to vascular dysfunction and organ failure. This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA. www.jci.org/articles/vie...

From earlier this week: Some macrophages have their toe in multiple inflammatory diseases… Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice: www.jci.org/articles/vie...

Alveolar macrophage-fibroblast crosstalk includes a feedforward arginase 1/IL-6 circuit implicated in pulmonary fibrosis: www.jci.org/articles/vie... G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...

TET3-overexpressing macrophages are a unifying pathogenic feature with therapeutic potential in chronic inflammatory diseases: www.jci.org/articles/vie... Shojiro Haji & Yoshihiro Ogawa comment on Beibei Liu et al.: www.jci.org/articles/vie...

Commentary: Neutrophils take center stage in VEXAS syndrome pathogenesis www.jci.org/articles/vie... Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...

Could subtle changes in #sleep patterns indicate #ALS long before symptoms manifest? In presymptomatic carriers and early patients, #EEG revealed early & brain-wide loss of microarchitectural oscillations, linked to memory and cognitive decline (@jci.org). doi.org/10.1172/JCI1...

Revisiting renin-angiotensin-aldosterone system in aging: translational insights from bench to bedside and back In this Review Caglar Cosarderelioglu & Peter M. Abadir discuss RAAS as a driver of age-related disease & a modifiable player in aging: www.jci.org/articles/vie...

Long COVID can occur after SARS-CoV2 infection Gisela Gabernet @ggabernet.bsky.social et al. describe a multi-omics recovery factor that predicts long COVID in the IMPACC cohort & reveals LC biomarkers & potential treatment targets www.jci.org/articles/vie...

A new mechanism helps explain idiopathic pulmonary fibrosis Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue. www.jci.org/articles/vie...

As part of the JCI’s ongoing Review Series: Clinical Innovation and Scientific Progress in GLP-1 Medicine, Mark E Cooper & Daniël H. van Raalte present: GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity: www.jci.org/articles/vie...

VEXAS syndrome is a severe, adult-onset autoinflammatory condition characterized by vacuoles in blood-forming and immune cells. Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...

Some macrophages have their toe in multiple inflammatory diseases… Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice. www.jci.org/articles/vie...

Identification of a new, autosomal dominant form of familial partial lipodystrophy from Abhimanyu Garg and team. This disease is caused by a recurrent variant in ACAA2, which encodes an enzyme in mitochondrial fatty acid oxidation. www.jci.org/articles/vie...

Solute carrier (SLC) transporters are implicated in many human diseases. In @jclinicalinvest, we show that efavirenz potentiates metal transporter SLC39A8 via a cryptic allosteric pocket—revealing new potential for therapeutic targeting. www.jci.org/articles/vie...

Elizabeth Wellberg @lwellberg.bsky.social & colleagues present a Review in the JCI series on Clinical innovation and Scientific Progress in GLP-1 Medicine: GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research: www.jci.org/articles/vie...

Mark Shlomchik and and his team have solved a 20-year #lupus mystery! In a new @jci.org paper, they show that TLR7 & TLR9 receptors signal differently, overturning textbook assumptions & explaining their opposite effects on #autoimmune disease. lnkd.in/extqYBYR

Rothenberg & team discover allergen-specific mRNA-lipid nanoparticle therapy modulates immune responses, reducing allergy symptoms while enhancing protection in mice: www.jci.org/articles/vie... @jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social

GLP-1 drugs have intrinsic potent anti-inflammatory action beyond their metabolic beneficial impact on glucose regulation and weight loss www.jci.org/articles/vie...

Many clinical studies have shown reduced cancer risk in people with diabetes of obesity taking GLP-1 family of drugs. A new JCI piece makes the case these drugs should be studied to reduce cancer in people without metabolic disease jci.org/articles/vie...

Will GLP-1 medicines modify the rates and/or outcomes of one or more #cancers A review on the biology, limitations of the data and the road ahead from @lwellberg.bsky.social and colleagues in JCI www.jci.org/articles/vie...

The interaction of GLP-1 medicines with the immune system is complex, enabled by direct and indirect actions, including neural inter organ communication. These studies have been led @SinaiHealth by CK Wong. His latest perspective here in the JCI www.jci.org/articles/vie...

A new review series on key aspects of GLP-1 biology from the JCI. First up, Cooper, van Raalte and the kidney www.jci.org/articles/vie...

Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today. For now just enjoy that gorgeous image taken by my student Fatma Awadalla!

This editorial on Gold Standard Science by @emmcnally.bsky.social, @sarahcjack.bsky.social, Corinne Williams, & Oliver Eickelberg urges the NIH to work hand-in-hand with journals in their future plans to enhance rigor and reproducibility. 🧵1/12 #skytorial www.jci.org/articles/vie...

Anti-inflammatory actions of glucagon-like peptide 1 medicines beyond metabolic benefits Chi Kin Wong & Daniel J. Drucker provide a Review for JCI’s Series on Clinical Innovation and Scientific Progress in GLP-1 Medicine: www.jci.org/articles/vie...

Systemic shock can lead to vascular dysfunction and organ failure. This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...

ICYMI: Protection against the fungus among us after mold spore inhalation… @fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs and neutrophils in the lung is necessary for antifungal activity. www.jci.org/articles/vie...

🚨Thrilled to share our latest paper: 🧬New evidence for Menkes disease: Elesclomol-copper (ES-Cu) therapy improved neurodevelopment in 2 children diagnosed shortly after birth 💊Promising step for this otherwise fatal disorder

This paper made it to the top of our readership list: SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...

IFN-γ signaling stimulates intestinal crypt hyperplasia in celiac disease: www.jci.org/articles/vie... Alexa R. Weingarden comments on Jorunn Stamnaes et al. (www.jci.org/articles/vie...)

Little progress has been made in the treatment of anaplastic thyroid cancer James A. Fagin & team now find mice with aggressive ATC respond to the inhibitor combination dabrafenib/trametinib by affecting cancer cell MHCII expression & increasing T-cell infiltration. www.jci.org/articles/vie...

Proud to highlight the contribution of Sandra Jurado & María Royo to a new study with @quintanalab.bsky.social, exploring alterations in the excitation/inhibition balance in the external globus pallidus (GPe) linked to mitochondrial-disease-induced epilepsy 👇

In recognition of #BreastCancerAwarenessMonth, we’re highlighting our recent publications: insight.jci.org/articles/vie... www.jci.org/articles/vie... www.jci.org/articles/vie...

A new paradigm for ion channel regulation! @geoffrey-pitt.bsky.social & team reveal FGF13 regulates cardiac sodium channels (no binding required) by affecting membrane cholesterol: www.jci.org/articles/vie...

Here the authors propose that inhibition of the serine threonine kinase FAM20C in adipocytes may serve as a potential therapy for #T2D by restoring adipocyte health www.jci.org/articles/vie...

A healing holdup for skin infections Richard L. Gallo & team find Staphylococcus aureus inhibits the expression of lipid synthesis genes in skin cells, delaying wound healing and impairing barrier formation. www.jci.org/articles/vie...

A team of researchers led by Dr Albert Quintana has identified the mechanism behind a potentially fatal type of epilepsy, a symptom of #mitochondrialdiseases Read the article: cutt.ly/2r7yUBrl 🧵