From earlier this week: A MRSA strain emerged ~2009 in Brooklyn, NY that is now a major cause of skin infections in the US. Bo Shopsin & team discover a prophage-encoded methyltransferase that increases virulence by promoting biofilm formation in a mouse infection model: buff.ly/g0i2DGm

NR2F1 and mTORC1 provide the bridge between melanoma dormancy and therapeutic resistance: buff.ly/3q89Dgt Narsimha Mamidi, Swadesh K. Das, and Paul B. Fisher comment on Tiago et al. (buff.ly/vR5bwGt)

An open letter to the NIH: Value and costs in publishing Here we share our response to the NIH’s request for information on maximizing research funds by limiting allowable publishing costs: buff.ly/K6hbsA4 #AcademicPublishing #ScholarlyPublishing #OpenAccess @scholarlykitchen.bsky.social

Can a novel nanoparticle-based #vaccine replace the need for #allergy shots someday? Learn more about innovative research from experts at #CincinnatiChildrens and #PennMedicine. Study: www.jci.org/articles/vie... Blog summary: scienceblog.cincinnatichildrens.org/nanoparticle...

Listen to this👇 Shearer et al. reveal endocochlear potential contributes to hair cell degeneration in Tmprss3-null mice, providing a target for TMPRSS3-hearing loss: buff.ly/5zay7tr The image shows furosemide treatment promotes hair cell survival in Tmprss3-null mice.

Can we root out the seeds of metastasis? Huiping Liu & team identify a rare T cell subset that cluster circulating tumor cells to promote metastasis in breast cancer, then provide a proof-of-concept block using VLA-4 antibody in preclinical models: buff.ly/o5N4RMr

BRAF-mut melanoma tumors initially shrink with dual inhibitor treatment but then progress Andrew E. Aplin & team find the dormancy marker NR2F1 as highly expressed in drug-tolerant tumor cells, which show rapamycin sensitivity with BRAFi/MEKi in models: buff.ly/vR5bwGt

Classical type 1 dendritic cells have roles in immunoregulation, but their involvement in organ transplant was unclear. Two new papers report on cDCs in murine cardiac transplant models: buff.ly/3Q38dwL buff.ly/VECueEr

Huiping Liu, MD, PhD, and team reveal how tumor–immune cell clusters fuel #BreastCancer metastasis in a pair of new studies published in @natcomms.nature.com and @jclinical-invest.bsky.social.

Can we drive anti-tumor immunity in advanced prostate and ovarian cancers? Arul M. Chinnaiyan & team find pharmacologic degradation of CDK12/13 delays tumor growth and improves ICB response in several cancer models: buff.ly/SDFvlox

A MRSA strain emerged ~2009 in Brooklyn, NY that is now a major cause of skin infections in the US. Bo Shopsin & team discover a prophage-encoded methyltransferase that increases virulence by promoting biofilm formation in a mouse infection model: buff.ly/tbvVWoG

ICYMI: How diet affects atherosclerosis in obesity… @aweinstock.bsky.social & team show short-term caloric restriction resolves atherosclerosis inflammation in obese mice, but weight regain accelerates its adverse effects: buff.ly/ieqwQ3O

Take a peek: This issue’s cover features 3D imaging and single-cell genomics by David A. Long @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az

Loss of function of T-box 3 in the liver protects against MASLD: www.jci.org/articles/vie... This Commentary by Jacquelyn J. Maher highlights Mannino et al. www.jci.org/articles/vie...

Blocking extracellular glycine uptake mediated by GlyT1 mitigates protoporphyria @marcliesa.bsky.social provides a Commentary on Ducamp et al. (buff.ly/W67oexo) buff.ly/9TuVOy3

We are highlighting a new paper by @dianatavf.bsky.social published in @jclinical-invest.bsky.social. In this paper, they reveal how peripheral nerves shift towards inflammatory phenotypes in DPN. 🔬 Read the full study: utd.link/3df 📊 Explore the data: utd.link/3dg

MASH: the nexus of metabolism, inflammation and fibrosis This review by Gregory R Steinberg & colleagues is part of JCI’s ongoing series, Evolving Insights into MASLD and MASH Pathogenesis and Treatment with series editor @hepascott.bsky.social: buff.ly/BgLh6mn

Erythropoietic protoporphyria causes phototoxicity and can also involve the liver due to protoporphyrin IX accumulation in red blood cells. Mark D. Fleming & team find bitopertin reduces PPIX accumulation and mitigates liver disease in EPP models: buff.ly/9TuVOy3

So happy to see the final version of our paper out today @jclinical-invest.bsky.social 🤗

More on the gut-joint connection.

“The development of targeted therapeutics for #cysticfibrosis, recognized by this year’s #LaskerAward, represents the culmination of a decades-long partnership between academia, the NIH, patient advocates, and industry.” 🧪 #Lasker2025 jclinical-invest.bsky.social

Somatic mutations are surprisingly widespread in most tissues, and some may protect against disease. Hao Zhu & team now reveal TBX3 somatic mutations in the liver influence metabolic dysfunction-associated steatotic liver disease (#MASLD): buff.ly/Ob2JxYY

Microbial threads in the tapestry of rheumatoid arthritis In this Review, Jing Li & Kristine A. Kuhn discuss the bacterial microbiome’s role in RA pathogenesis and highlight microbiome-targeted interventions: buff.ly/Q1q10Ha

Thank you @jclinical-invest.bsky.social for inviting me to write a commentary about the original study published yesterday by Ducamp and colleagues, which shows a metabolic strategy to treat protoporphyrias. Commentary: www.jci.org/articles/vie.... Article: www.jci.org/articles/vie....

How diet influences atherosclerosis in obesity… @aweinstock.bsky.social & team show short-term caloric restriction resolves atherosclerosis inflammation in obese mice, but weight regain accelerates its adverse effects: buff.ly/ieqwQ3O

Professor Menna Clatworthy and colleagues at @sangerinstitute.bsky.social @ucl.ac.uk & @cam.ac.uk used innovative imaging to understand the significant role of lymphatic vessels in kidney transplant rejection. Now available in @jclinical-invest.bsky.social 👇

🚨 New paper in @jclinical-invest.bsky.social! Kidney lymphatics are a promising target in transplant rejection 🗺️ In rejection, lymphatics expand and adversely remodel ⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system www.jci.org/articles/vie... 1/4

The pathogenesis of hepatic steatosis in MASLD: A lipid droplet perspective A Viewpoint by Natalie Krahmer, Tobias C Walther, & Robert Farese, Jr: buff.ly/RJGg1ru

An in-depth look at lymphatic reorganization! This issue’s cover features 3D imaging and single-cell genomics by David A. Long, @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az

Current dogma posits IFN-γ and CD8+ T cells have anti-tumor roles. Now, Krupnick & team examine multiple lung adenocarcinoma models and discover IFN-γ derived from lung cancer cells can, in fact, promote tumor growth via CD8+ T cell chemokines: buff.ly/mEVwWHy

This research article on the regulation neuropathic pain and comorbid anxiodepression has cross-discipline implications Li et al. reveal a regulatory network in the anterior cingulate cortex involving retinoic acid signaling & the extracellular matrix: buff.ly/j3fNlzg

People with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares. In this research letter, Johann E. Gudjonsson & team show spesolimab treatment helps control the inflammation and prevent future flares: buff.ly/cYw1WJG

Excited to share my first-author publication! "Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome" was published on @jclinical-invest.bsky.social! #Genetics #Neonataldiabetes #Stemcells www.jci.org/articles/vie...

Patients with SCD transfused with blood stored >30 days have higher iron, cytokines, hemolysis, hypoxia and inflammation markers compared to recipients of RBCs stored <10 days. Metabolites in the bag impact in vivo metabolism (hypoxanthine —> urate). Kudos to Matt Karafin for this clinical trial

ICYMI: Flexing redundancy in limb-girdle muscular dystrophy R5 Ekaterina I. Mokhonova @emmcnally.bsky.social et al. discover transgenically expressed sarcospan restores membrane stability by swapping sarcoglycan homologs to preserve the DGC in dystrophic mice: buff.ly/zm5ZpLy

RBC units can be stored in the refrigerator for up to 42 days, but it’s unclear how extended storage affects recipients. @dalessandrolab.bsky.social & team compare short- and long-stored RBC transfusions in patients with sickle cell disease 👇 buff.ly/CWjcWGc

ICYMI: Mutations in the protein phosphatase 2A (PP2A) are linked to intellectual disability. Man Jiang & team now show impaired brain signaling and memory in mice lacking Pp2a that can be restored by blocking endocannabinoid degradation via MAGL inhibition. buff.ly/SZYXe2r

Could blocking FSH hormone prevent osteoporosis, obesity, and Alzheimer’s disease? In this issue, Mone Zaidi & team develop a humanized FSH-blocking antibody that reduces obesity and rescues memory & learning loss in preclinical models. See full report: buff.ly/c6XYm3p

Understanding the STING in autoimmunity! Anthony Shum & team investigate mouse models of the immune dysregulation disorder COPA syndrome and show STING activation in thymic epithelial cells has a role in shaping the T cell repertoire and promoting autoimmunity: buff.ly/l8QUW0D

Unraveling endocannabinoid signaling disruption in a preclinical model of neurodevelopmental disorders: buff.ly/SB85mt9 Nephi Stella provides a Commentary on Yirong Wang et al. (buff.ly/ey9g9Wc)

Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome #RareDisease #Genetics #morbidgene www.jci.org/articles/vie...

Lucy Shapiro was just awarded the 2025 Lasker~Koshland Special Achievement Award in Medical Science @laskerfdn.bsky.social! We spoke with Dr. Shapiro back in 2019: Conversations with Giants in Medicine @ushmaneill.bsky.social

When more isn’t better: The surprising superiority of glycoprotein-only Marburg vaccines: buff.ly/NK3Pmlf An Editor’s Note by @pemac.bsky.social @harvardmed.bsky.social on Subramani et al. (buff.ly/y6LTOo3)

In ALS, TDP43 mislocalizes to the cytoplasm. Sami J. Barmada (YPSA) & team now introduce a mechanism for nucleocytoplasmic transport defects in TDP43 proteinopathies, providing a framework for targeting nemo-like kinase in neurodegenerative diseases: buff.ly/29WnDns

Welsh, González, and Negulescu share #LaskerAward @laskerfdn.bsky.social Benjamin D. Singer & G.R. Scott Budinger provide a historical context for this year’s Lasker~DeBakey Award!

Doing more with less in vaccine protection against Marburg virus Bukreyev & team compare mRNA vaccines encoding MARV full length glycoprotein alone or as a virus-like particle, finding low-dose GP-only mRNA conferred 100% protection guinea pigs. buff.ly/y6LTOo3

The A20 protein is linked to Crohn’s disease and celiac disease. Averil Ma & team @ucsanfrancisco.bsky.social now describe spontaneous proximate enteritis in A20-knockin mice, revealing a binding motif that restrains IL-22 regulation in Th17 cells. buff.ly/9eriwht

A multi-omics recovery factor predicts long COVID in the IMPACC study @jclinical-invest.bsky.social @ggabernet.bsky.social @skleinstein.bsky.social @yalemedicine.bsky.social www.jci.org/articles/vie...

A recent manuscript published in @jclinical-invest.bsky.social led by Preeti Yadav from Mallar Bhattacharya's lab in collaboration with other BARI colleagues identifies an #immune-mesenchymal circuit that fuels fibrotic metabolism in #lung_fibrosis. bit.ly/4gmuiZM

Mutations in the protein phosphatase 2A (PP2A) are linked to intellectual disability. Man Jiang & team now show impaired brain signaling and memory in mice lacking Pp2a that can be restored by blocking endocannabinoid degradation via MAGL inhibition. buff.ly/ey9g9Wc