A hit for base editing: Treatment of developmental epilepsy in a mouse model: doi.org/10.1172/JCI2... @ethangoldberg.bsky.social et al. provide a Commentary on Caeley M. Reever et al.: doi.org/10.1172/JCI1...

Autoantibody hotspots reveal the origin and impact of immunogenic XIST ribonucleoprotein complexes in autoimmune diseases @jci.org @howardychang.bsky.social @stanforduniversity.bsky.social www.jci.org/articles/vie...

Out now in @jci.org: chronic rhinosinusitis linked to toxin exposure (wildfire smoke, burn pits) shows >2× rise in sinus mast cells. Highlights mast cells as a fresh therapeutic target for veterans & civilians with no FDA‑approved options. #CRS #Veterans #Research buff.ly/cPneHmN

Might this strategy diagnose other mutationally quiet cancers? @srviswanathan.bsky.social & team detect the fusion-driven kidney cancer tRCC via epigenomic profiling in plasma with high accuracy, enabling non-invasive diagnosis and monitoring: doi.org/10.1172/JCI1...

Osimertinib is the standard therapy for metastatic lung adenocarcinoma with EGFR mutations ASCI member Jonathan M. Kurie & team show Osi-resistant cells secrete effector proteins that drive metastatic properties of drug-naive cells and via paracrine mechanisms: doi.org/10.1172/JCI1...

Offering a promising gene therapy for genetic causes of epilepsy. Caeley M. Reever & team present a gene therapy targeting a deadly mutation that causes epilepsy—SCN8A—which rescues seizures and disease symptoms in mice: doi.org/10.1172/JCI1...

Adding new information to our understanding of critical illness phenotypes Narges Alipanah-Lechner & team perform multi-omics analysis of patients with ARDS, revealing 4 molecular signatures associated with death, all characterized by mitochondrial dysfunction: doi.org/10.1172/JCI1...

A new contributor to cardiac allograft vasculopathy (CAV)… Emmanuel Zorn & team discover plasma cells in human cardiac allografts with vasculopathy target bilirubin, revealing local heme catabolism: doi.org/10.1172/JCI1...

In a cohort of 1000+ patients with breast cancer, Emilio Hirsch & team identify SH3BP5L as the most highly expressed guanine nucleotide exchange factor for RAB11A, and its inhibition lowers lung metastasis & cell spreading in triple negative breast cancer models: doi.org/10.1172/JCI1...

A new approach to photodynamics in vision that’s worth seeing Krzysztof Palczewski & team develop a method for visualizing retinoid distribution and movement in the retina of heathy and diseased mouse models: doi.org/10.1172/JCI1...

Proanthocyanidins are flavonoid antioxidants found in many fruits and vegetables. Here, Sanhong Liu & team report proanthocyanidins promote PD-L1 degradation via SYVN1 to enhance antitumor immunity in preclinical models of lung and colon cancer: doi.org/10.1172/JCI1...

Previously shared: Exploring the biology of metastatic hormone-sensitive prostate cancer: on the road to precision medicine In this Review, Alice Bernard-Tessier & @mishabeltran.bsky.social discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI2...

ICYMI: It’s about TIME (tumor immune microenvironment) for breast cancer Here, Carlos L. Arteaga & team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: doi.org/10.1172/JCI1...

Neurodegeneration biomarkers in Alzheimer’s disease: Axonal density index expands the “N” in the ATN framework: doi.org/10.1172/JCI2... Ryn Flaherty & Arjun V. Masurkar comment on Zhaoyuan Gong et al., highlighting a measure of neurodegeneration: doi.org/10.1172/JCI1...

Breaking Down to Rebuild: Lymphatic Ablation Enhances Osteoclast-Driven Regeneration: doi.org/10.1172/JCI1... Matthijs Luxen et al. comment on Neda Vishlaghi et al.: doi.org/10.1172/JCI2...

New research out in @jci.org finds that concomitant COX-1 & COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use ft. Kayla Barekat & Emanuela Ricciotti (@itmat.bsky.social) @FitzGerald__Lab www.jci.org/articles/vie...

Unraveling TIME: CD8+ T cell- and CXCL11-driven endocrine resistance in breast cancer: doi.org/10.1172/JCI2... Tim Kong & Cynthia X. Ma provide a Commentary on Fabiana Napolitano: doi.org/10.1172/JCI1...

The fingertip has notable regenerative capacity, yet the underlying mechanisms—especially the role of lymphatics—have been debated Benjamin Levi & team now find reducing lymphatic vessels in a mouse amputation model accelerates bone breakdown & enhances regeneration: doi.org/10.1172/JCI1...

Our circadian clock and cancer chronotherapy, a terrific @scripps.edu review, open-access, related to below! jci.org/articles/vie...

Could curbing inflammation prevent the progression of TP53-mutant clonal hematopoiesis to myeloid blood cancers? Yan Liu, @oawlab.bsky.social & team find mutant p53 in mice promotes clonal hematopoiesis through generating a chronic inflammatory microenvironment: doi.org/10.1172/JCI1...

Current methods for tracking cognitive decline in Alzheimer’s disease are invasive and expensive Zhaoyuan Gong & team now report on axonal density index as a biomarker detected by diffusion MRI for predicting dementia risk & monitoring AD progression: doi.org/10.1172/JCI1...

It’s about TIME (tumor immune microenvironment) for breast cancer Here, Carlos L. Arteaga & team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: doi.org/10.1172/JCI1...

Exploring the biology of metastatic hormone-sensitive prostate cancer: on the road to precision medicine In this Review, Alice Bernard-Tessier & @mishabeltran.bsky.social discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI2...

Congratulations to our Okoye, Estes, Axthelm, and Picker Lab teams with their contributors on their new publication which investigates the magnitude and activation of SIV-specific CD8+ T cells. Read more about SIV T Cell responses by visiting the below link. pubmed.ncbi.nlm.nih.gov/41609736/

Over 100 years ago, platelets were observed to interact with neutrophils in blood clots Eric Boilard & team now detail platelet-neutrophil interactions as more abundant in arthritic conditions, noting that neutrophils fail to migrate in the absence of platelets: doi.org/10.1172/JCI1...

Rhythms of risk: the intersection of clocks, cancer, and chronotherapy In this Review, Rebecca M. Mello et al. highlight the promise of integrating circadian biology into precision oncology: doi.org/10.1172/JCI1...

A rationale for combining KRAS/ERK inhibitors with standard-of-care chemotherapies in pancreatic cancer David M. Virshup & team report on the suppression of the master regulator of differentiation and chemosensitivity—GATA6 expression—in PC models: doi.org/10.1172/JCI1...

CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models Antonio Carlos Tallon-Cobos & team present a new ependymoma model and demonstrate a promising immunotherapeutic approach for this pediatric brain cancer: doi.org/10.1172/JCI1...

From earlier this week: Elevated tRNA halves in olfactory epithelial cells of schizophrenia patients In this Research Letter, Yohei Kirino & team find increased immunostimulatory tRNA halves in patient-derived cells that retain neural traits: doi.org/10.1172/JCI1...

ICYMI: This study marks the first description of a tumor suppressor role for FBXO11 in AML @alykarsan.bsky.social & team show depleted FBXO11 expression in AML promotes stem cell quiescence by attenuating mitochondrial metabolism through mislocalization of LONP1: doi.org/10.1172/JCI1...

#NSAID induced #Enteropathy: #Prostaglandin suppression plays only trivial role while enteropathic response to #NSAIDs might be amplified through #Dysbiosis of the #GutMicrobiome www.jci.org/articles/vie... @FitzGerald__Lab #TranslationalScience

Optimizing CAR affinity remains a matter of debate ASCI member Bert Vogelstein & team report that increasing binding affinity to a p53 R175H neoantigen improves anti-cancer activity for T cell-engaging bispecific antibodies yet decreases function for CAR T cells: doi.org/10.1172/JCI1...

There is a great need for diagnostics that distinguish pulmonary veno-occlusive disease as a subtype of group I pulmonary arterial hypertension. In this Research Letter, Akiko Hata & team report plasma GDF15 as a diagnostic and prognostic biomarker for PVOD: doi.org/10.1172/JCI1...

In this study, Qi Cao & team reveal a combinatorial therapeutic strategy for advanced prostate cancer. EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of m6A autoregulation pathway: doi.org/10.1172/JCI1...

A comprehensive quantitative proteomics data for primary human CD34+ MDS samples Madeline Niederkorn @MadelinePhD.bsky.social et al. suggest that suppression of the substrate receptor FBXO11causes inefficient NPM1 ubiquitylation, contributing to MDS pathogenesis: doi.org/10.1172/JCI1...

This study marks the first description of a tumor suppressor role for FBXO11 in AML @alykarsan.bsky.social & team show depleted FBXO11 expression in AML promotes stem cell quiescence by attenuating mitochondrial metabolism through mislocalization of LONP1: doi.org/10.1172/JCI1...

Elevated tRNA halves in olfactory epithelial cells of schizophrenia patients In this Research Letter, Yohei Kirino & team find increased immunostimulatory tRNA halves in patient-derived cells that retain neural traits: doi.org/10.1172/JCI1...

Previously shared: GLP-1 physiology and pharmacology along the gut-brain axis This Review by @lbeutler.bsky.social summarizes proposed gut-brain and central mechanisms through which GLP-1 and its synthetic analogs regulate food intake and bodyweight: doi.org/10.1172/JCI194744

Shared earlier this week: Signaling Architecture of the Glucagon-Like Peptide-1 Receptor In this Review, Gregory O Austin & Alejandra Tomas @tomaslab-imperial.bsky.social explore the spatiotemporal regulation of GLP-1R signaling: doi.org/10.1172/JCI1...

Check out some cool science images (with music by Shakira) from a @jci.org study. @tceliaterrassa.bsky.social et al. found that estrogen receptor signaling drives immune evasion and immunotherapy resistance in HR+ #BreastCancer. www.jci.org/articles/vie... #FluorescenceFriday 🧪

Helping alveolar macrophages live to fight another day during viral pneumonia: doi.org/10.1172/JCI2... Joseph P. Mizgerd & team provide a Commentary on Christina Malainou et al.: doi.org/10.1172/JCI1...

Our new research letter @JCI.org is out! “Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model.” Led by Dr. Karen Hoffmann, with Dr. Christian Zobel (BWKH) and myself as co-senior authors — a great NoVAP Lab collaboration! 🔗 doi.org/10.1172/JCI1...

Ksenia Matlawska-Wasowska @kseniam.bsky.social and team show T-cell leukemia exploits an inflammatory pathway to invade the brain's protective layers: doi.org/10.1172/JCI1... The image features GFP⁺ T-ALL leukemic infiltrates within whole-mount murine meningeal tissue.

Brincidofovir is a broad-spectrum antiviral that is currently FDA-approved for the treatment of smallpox Here, Stacey L. Piotrowski & team show brincidofovir inhibits Epstein-Barr virus and related gammaherpesvirus in human and nonhuman primate cells: doi.org/10.1172/JCI1...

Caught in the crossfire: cardiac complications of cancer therapy In this Review, Giulia Guerra et al. discuss the mechanisms and therapeutic strategies for cardiotoxicity caused by chemotherapy, targeted agents, and immune modulators: doi.org/10.1172/JCI1...

In this Research Letter, @geraldinen.bsky.social et al. use an advanced human lung-on-a-chip model to show that increased mechanical strain can make the lungs more vulnerable to harmful bacteria such as Pseudomonas aeruginosa: doi.org/10.1172/JCI1...

Signaling Architecture of the Glucagon-Like Peptide-1 Receptor In this Review, Gregory O Austin & Alejandra Tomas @tomaslab-imperial.bsky.social explore the spatiotemporal regulation of GLP-1R signaling: doi.org/10.1172/JCI1...

I learned and synthesized a lot writing this review for @jci.org and hope it helps others do the same.

…and don’t miss the Editorial by Jay Mizgerd an Elise Armstrong 😊 jci.me/201457/pdf

Our review on GLP-1R signal compartmentalization is now out in JCI, where we discuss current evidence for the existence of GLP-1R–cAMP–PKA signalosomes at different subcellular locations and the complexity of the GLP-1R spatiotemporal signaling architecture: www.jci.org/articles/vie...