BARI’s Sara LaHue breaks down neurologic issues tied to pregnancy and menopause in her latest review in Continuum. From preeclampsia-related stroke to menopause’s effects on cognition and MS, a great overview of key windows in women’s brain aging. Check it out: continuum.aan.com/doi/10.1212/...

BARI’s Andrew Yang unpacks how hypertension quietly injures the brain via AngII long before pressure rises. Early hits to endothelial cells, oligodendrocyte precursors, and inhibitor neurons, all independent of blood pressure. Strong implications for better dementia prevention strategies.

John Newman at BARI looks at ICU delirium and epigenetic clocks: Feasible from serum, with Elastic Net acceleration linked to lower severity scores (day 8 and at discharge). A noteworthy finding on biological aging in acute illness. academic.oup.com/biomedgeront...

BARI spotlight: Dr. Martin Kampmann leads Cell study using CRISPR in iPSC neurons to decode tau handling, spotting ways to block toxic buildup in age-related diseases like Alzheimer’s. Read the article here: www.cell.com/cell/fulltex...

This Nature study shows how aging slows protein cleanup in the brain, leading microglia to fill up with old synaptic proteins. Andrew Yang (BARI) contributed key methods to reveal it. Interesting for neurodegeneration research: pubmed.ncbi.nlm.nih.gov/41565824/ #neuroscience #brainaging

Big congrats to BARI’s Tien Peng on his latest review! Diving into how fibroblasts steer stem cell plasticity & metaplasia in fibrosis, super relevant for lung aging & disease. Read it here: pubmed.ncbi.nlm.nih.gov/40839781/

Key review by BARI member Jean Nakamura: Low-does radiotherapy for nonmalignant issues has low carcinogenic risk, particularly in older populations where these ailments hit hardest. Age, dose, & genetics matter too, read more here: www.sciencedirect.com/science/arti...

Insightful review by BARI member Aimee Kao & team connects development and aging through lysosomal dysfunction and neuronal vulnerability. They highlight how proteostatic stress in high-stress life stages can lead to lysosomal clearance disorders. www.sciencedirect.com/science/arti... #Neuroscience

Check out BARI member Su Guo’s @naturecomms paper where they uncover PCM1’s role in regulating daughter cell fate via centrosome-endosome interplay. www.nature.com/articles/s41... #neuroscience

Fascinating perspectives on aging science in Nature Aging! BARI’s Dena Dubal offers insights on real-world translation, plus input from two of our advisory board members Vera Gorbunova & George Kuchel. Inspiring read: www.nature.com/articles/s43... #Aging #Science

Neil Risch and his BARI team have a paper out in AJHG: Predicted loss-of-function variants linked to serious diseases often don’t show up as expected in big biobanks. Why? Residual activity from the variant allele keeps some function going (leaky penetrance).

UCSF has a cool article on BARI member Hao Li’s work. They found gene-regulating proteins that drop with age, slowing repair. Boosting them made old fibroblasts act young again and increasing EZH2 in mice rejuvenated livers. Read more here: www.ucsf.edu/news/2026/01...

Congrats to BARI’s Tamara Alliston on her latest paper in Osteoarthritis and Cartilage! They show loss of MMP13 in bone cells is protective against cartilage damage in injured jaw joints (TMJ), similar to effects seen in knees: www.oarsijournal.com/article/S106...

What a whirlwind at #JPM2026! Grateful for the inspiring chats, new ideas, and connections that make this field so exciting. From BARI in SF: thanks for coming, safe travels home, and let’s keep pushing geroscience forward together! #agingresearch

Aging mice are precious (and expensive!) – so why not get max data from each? BARI member Hanna Martens & team share a JoVE protocol for multi-organ collection. Over 15 organs from a single mouse. Smart & ethical: app.jove.com/t/69128/mult... #agingscience

What if lowering triglycerides could help you survive low oxygen and age better? New EMBO Reports from BARI member Dengke Ma & team explores this conserved mechanism: from arctic ground squirrel brain cells to C. elegans, reducing lipid biosynthesis protects mitochondria and extends life.

Well done to Tien Peng and team – exciting new paper out in Cell Stem Cell! The study shows how certain senescent fibroblasts drive metabolic reprogramming in lung adenocarcinoma and demonstrates that targeting them with an HSP90 inhibitor shrinks tumors.

Wishing you all a brilliant 2026 from everyone at BARI! May the new year bring discoveries that change the world by advancing aging research. See how we’re building on the past to make a great future in 2026 and beyond: www.nature.com/articles/d42... #2026 #Geroscience

In case you missed it: Diana Laird and her lab dropped this awesome Science paper. A deep dive comparing human and mouse ovaries over time, spotlighting conserved aging features to enhance our translational understanding. A major win for reproductive health! www.science.org/doi/epdf/10....

In case you missed it: BARI’s John Greenland and lab found frailty in lung transplant recipients links to shorter telomeres and anemia – but not epigenetic age or inflammation. Not all aging hallmarks hit equally! Read the interesting details here: www.amjtransplant.org/action/showP...

Big congrats to BARI’s Xian Piao and her lab for their awesome paper in Neuron! They found that microglial ADGRG1 turns on MYC to make microglia more protective and better at clearing amyloid to keep neurons healthier in Alzheimer's models. Huge win for AD research! #Alzheimers #Neuroscience

BARI congratulates fellow UCSF aging scientist Lauren Hunt for winning the 2025 Terrie Fox Wetle Rising Star Award from AFAR! Using big data to make hospice & palliative care for dementia patients – such important work. BARI is cheering you on! #AgingResearch www.afar.org/news/afar-pl...

Huge congrats to Jarin Tusnim, postdoc in the Piao Lab at BARI, for her Cure Alzheimer's Fund grant! Jarin is exploring how ADGRG1 helps microglia stop tau from spreading, which could lead to boosting brain protection for new AD therapies. Great work Jarin! #Alzheimers #CureAlz bit.ly/4j79J4Q

Exciting research from BARI member Ken Nakamura! Their study out in @ScienceAdvances shows for the first time in vivo, a better understanding of how mitochondrial dysfunction can lead to α-synuclein accumulation and neurodegeneration in Parkinson’s Disease. Check out the story here: bit.ly/4aWt4n4

So proud of our research teams at BARI - @ucsanfrancisco.bsky.social now #2 globally in this year’s Nature Index for Aging! Excited to keep challenging what’s possible for healthier aging. Check out the full list: www.nature.com/nature-index... #BARI #UCSF #Geroscience

Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1... Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.

Nancy Allen and Tien Peng's study reveals that age-dependent NF-kB activation in tissue fibroblasts contributes to #inflammaging by remodeling immune architecture and promoting exhausted T cell populations. bit.ly/4qlIR4k

Kate Cavanaugh and Orion Weiner's research out now on @biorxivpreprint.bsky.social identifies a mechanical defect in embryos from aged mothers that impairs implantation. These findings could enhance embryo selection in Assisted #Reproductive Technologies. bit.ly/47tY7V8

In our October issue: Ferritin light chain 1 (FTL1), an iron-associated protein, is a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice @VilledaLab @ucsfaging.bsky.social @UCSF www.nature.com/articles/s43...

Sara LaHue, @geriscidoc.bsky.social, and others published in @geroscience.bsky.social an interdisciplinary effort to identify longitudinal transcriptomic changes in adults with #delirium hospitalized with #COVID-19. bit.ly/4o8wMO7

It's wonderful to see the number of outstanding applicants increase each year for our graduate student fellowships in collaboration with the UCSF Hillblom Center for the Biology of Aging. Congrats to this year's recipients! #GeroSky #SciSky

A recent manuscript published in @jclinical-invest.bsky.social led by Preeti Yadav from Mallar Bhattacharya's lab in collaboration with other BARI colleagues identifies an #immune-mesenchymal circuit that fuels fibrotic metabolism in #lung_fibrosis. bit.ly/4gmuiZM

Check out the recent publication by Ken Nakamura's Lab in @elife.bsky.social!

A new study, led by Kushal (Berkeley), Nicole&Victoria (UCSF) in full collaboration with @karthikshekhar.bsky.social, "Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma" sciencedirect.com/science/arti... #retina #MERFISH

A recent manuscript published in @nataging.nature.com by Laura Remesal Gomez and the Villeda Lab identifies ferritin light chain 1 (FTL1) as a pro-aging neuronal factor that impairs #cognition, and as a potential target for cognitive #rejuvenation. Link to manuscript here: bit.ly/4lG46dp #GeroSky

How do tumor cells co-opt neighboring #adipocytes to promote #tumorigenesis? @andreigoga.bsky.social and colleagues identify a direct tumor cell-adipocyte interaction that activates lipolysis in triple negative breast cancer models. #SciSky #GeroSky bit.ly/4mRZYYN @natureportfolio.nature.com

Our latest on cancer metabolism by star student Tonatiuh Montoya @ctbatucsf.bsky.social @ucsfcancer.bsky.social Liver cancers driven by the MYC oncogene are reliant on alanine metabolism. Alanine is the second most abundant amino acid and can partially substitute for glucose and glutamine. 🧪

Interesting work from Xianhua Piao, MD, PhD on the interplay between G-protein-coupled receptor, ADGRG1, and MYC activation to promote a protective microglial state in a 5xFAD mouse model. Manuscript here: bit.ly/3HhtmbP

Anudari Letian and the Goldberg Lab investigated how #neutrophils acquire #lipids from their environment and how this influences their functionality. Neutrophil-deficient mice showed protection against #atherosclerosis. Check on the article on bioRxiv here: bit.ly/3H9E3x5

We are thrilled to announce the awardees of our postdoctoral fellowships! Please join us in congratulating Ting Gong, @marioruizperez.bsky.social, Claire Huguenard, PhD, Hayden Holmlund, and Michaelangelo Gonzatti. 🎉

📣 We are thrilled to announce @denadubal.bsky.social is joining our Executive Committee! Dr. Dubal's research investigates the molecular mechanisms of #aging, #resilience, and #neurodegenerative_disease. #SciSky #GeroSky

Intriguing work by @rushika-perera.bsky.social identifies #PCSK9 as a driver of metastatic growth in #pancreatic ductal adenocarcinoma. Published in @nature.com. #SciSky go.nature.com/4ksf5Y1

A collaboration between Mallar Bhattacharya and Paul Wolters shows that in a mouse model of IPF, early AT2 cell transdifferentiation and senescence is driven by enhanced p53 activity in response to #DNA damage. Out now on @biorxivpreprint.bsky.social: bit.ly/4dJG6DN #GeroSky #SciSky

@nadavahituv.bsky.social and colleagues use a massively parallel jumping assay to assess the ability of retrotransposons to jump and identify nucleotide changes that have the potential to reactivate them in their latest manuscript published in @natcomms.nature.com. go.nature.com/4k7pqIK

Frailty in lung transplant patients is linked to anemia and telomere dysfunction. A study by John Greenland found that epigenetic aging correlated with chronological age, and not with frailty, highlighting the importance of telomere dysfunction and anemia in this patient population. bit.ly/4mvBgyi

Our morning concluded with a few more trainee talks and another keynote speaker, Dr. Beth Stevens. #microglial #CNS #inflammation #aging

Keynote speaker Dr. Vera Gorbunova kicked off the symposium followed by two of our trainees Mariko Foecke and Christoforos Meliadis. #ovary #bone #aging

Today is a special day! It's our second BARI symposium at the de Young Museum in the beautiful Golden Gate Park.

Could a reawakening of the silenced X chromosome in females help slow aging-induced cognitive decline? Check out the work by @denadubal.bsky.social along with colleagues Kaitlin Casaletto, Bérénice Benayoun, and Vijay Ramani in Science Advances: bit.ly/3FlN3hj #GeroSky #SciSky

Research from Isha Jain and colleagues published in @cellpress.bsky.social shows that HypoxyStat can prevent or reverse mitochondrial disease in a preclinical mouse model. The study suggests potential transformations in therapeutic strategy for treating other mitochondrial disorders. bit.ly/4kh0csc