BARI is celebrating Yin Shen’s new Nature Comms study! It shows how the brain cleverly compensates when enhancers are deleted on one SIN3A allele by boosting the other, precise dosage control that could matter a lot for healthy brain aging. www.nature.com/articles/s41...

BARI is celebrating Guo Huang’s new PNAS study! It shows how TOX3 supercharges Atoh1 to keep cerebellar progenitors thriving during development and plays a big role in medulloblastoma too. Elegant work on brain growth and disease!

BARI’s celebrating Peggy Cawthon’s new Age and Ageing study! It shows advanced imaging features from CT scans capture skeletal muscle details that strongly tie to physical performance in older men, helping us fight sarcopenia and keep mobility high with aging. bit.ly/3OqwN3u

BARI’s cheering for Saul Villeda! His research just got spotlighted in The Washington Post! It shows exercise strengthens the blood-brain barrier in Alzheimer's models, leading to better memory and learning. Read it here: www.washingtonpost.com/wellness/202...

BARI's celebrating Dr. Andrei Goga's new Cell Reports study! It shows MYC-driven liver tumors depend on breaking down alanine for energy and survival, and targeting this pathway (with a drug or genetics) really slows them down. Meaningful step forward for age-related cancer research.

BARI’s been busy! If you’re into aging research, swing by our Updated News page for the newest publications and discoveries from our labs. Super proud of our members and would love for you to check it out and join the conversation. geroscience.ucsf.edu/updated-news

Check out BARI’s Kelsey Collins excellent review in JOR. It reveals how fat is a key driver of osteoarthritis through metabolic and immune signals, linking directly to age-related joint decline. This could transform how we approach healthy aging and pain management. Fantastic work Kelsey!

Cheers for BARI's Martin Kampmann on his new JBC paper! It uncovers how DNAJC7 fights polyQ aggregation in Huntington's-like diseases and tweaks polyG, connected to aging, where protein clumping drives neurodegeneration. Read more here: www.jbc.org/article/S002...

Big congrats to BARI's Dr. Brian Feeley on his JAMA Internal Medicine article! It breaks down how most shoulder MRI "issues" are just normal aging wear-and-tear, even in pain-free folks—super relevant to aging biology for smarter care and avoiding extra surgeries. jamanetwork.com/journals/jam...

Big cheers for BARI's Dr. Diane Barber on her Acta Physiologica review about lysosome pH in health & disease! It connects the dots on how pH shifts affect lysosomal roles: super relevant to aging, where off-balance pH worsens neurodegeneration and protein buildup. Exciting therapeutic angles!

BARI's Peggy Cawthon at the ICFSR conference on healthy longevity & aging biomarkers: Hosted by Nature Aging's Sébastien Thuault, with Luigi Ferrucci, David Furman, & Dan Belsky.

Big cheers for BARI member Isha Jain on her new Cell paper! It reveals how vitamins B2 and B3 can treat NAXD disease, saving metabolism, shielding the brain, and stretching lifespan over 40x in models. Ties right into aging biology, where boosting NAD could slow down age-related breakdowns.

BARI is celebrating today! Kelsey Collins just won the 2026 NEXT Award for her research on the surprising role of fat in osteoarthritis and joint pain. Turning personal inspiration into real mechanistic discoveries – this is why we do what we do. Congratulations, Kelsey! bit.ly/4sCUdBd

BARI’s Dengke Ma shows non-visual light tweaks genes & improves adaptability in worms in a bacteria-dependent, wavelength-sensitive pathway. Enhances olfactory memory & potential for aging sensory research. Check it out: elifesciences.org/articles/108...

Isha Jain at BARI just published this in Cell Metabolism: Living high up makes blood sugar drop because red blood cells soak up glucose in low oxygen. Hypoxia can even treat diabetes in mice! #metabolism www.sciencedirect.com/science/arti...

BARI’s Andrew Yang breaks down how immune cells in the brain fuel neurodegeneration and what we can target to stop it. From microglial states to complement and inflammasomes, this review maps therapies that could help aging brains stay sharp longer. go.nature.com/4096fGg #aging #neuroscience

New out in Cell! Bari’s Saul Villeda shows how a liver factor from exercise (GPLD1) rejuvenates brain barriers, clears AD gunk, and boosts memory in old mice. By hitting specific vessel proteins, it mimics workout perks. Promising for fighting dementia! #aging #neuroscience

BARI’s Michelle Arkin explores how tiny glues can calm overactive proteins in the pathways that control cell growth, key for cancer and growth disorders. As we age, these signals can mess up, so this might lead to ways to protect our brains and bodies from decline. #aging #cancer

BARI’s Aimee Kao explores APP’s lysosomal breakdown: pH-sensitive, mutation-boosted (faster with Arctic/Dutch variants), and sAPP amps up tau proteolysis by CTSG. Links APP & tau in neurodegeneration. Big implications for AD research. #geroscience pmc.ncbi.nlm.nih.gov/articles/PMC...

BARI’s Sara LaHue breaks down neurologic issues tied to pregnancy and menopause in her latest review in Continuum. From preeclampsia-related stroke to menopause’s effects on cognition and MS, a great overview of key windows in women’s brain aging. Check it out: continuum.aan.com/doi/10.1212/...

BARI’s Andrew Yang unpacks how hypertension quietly injures the brain via AngII long before pressure rises. Early hits to endothelial cells, oligodendrocyte precursors, and inhibitor neurons, all independent of blood pressure. Strong implications for better dementia prevention strategies.

John Newman at BARI looks at ICU delirium and epigenetic clocks: Feasible from serum, with Elastic Net acceleration linked to lower severity scores (day 8 and at discharge). A noteworthy finding on biological aging in acute illness. academic.oup.com/biomedgeront...

BARI spotlight: Dr. Martin Kampmann leads Cell study using CRISPR in iPSC neurons to decode tau handling, spotting ways to block toxic buildup in age-related diseases like Alzheimer’s. Read the article here: www.cell.com/cell/fulltex...

This Nature study shows how aging slows protein cleanup in the brain, leading microglia to fill up with old synaptic proteins. Andrew Yang (BARI) contributed key methods to reveal it. Interesting for neurodegeneration research: pubmed.ncbi.nlm.nih.gov/41565824/ #neuroscience #brainaging

Big congrats to BARI’s Tien Peng on his latest review! Diving into how fibroblasts steer stem cell plasticity & metaplasia in fibrosis, super relevant for lung aging & disease. Read it here: pubmed.ncbi.nlm.nih.gov/40839781/

Key review by BARI member Jean Nakamura: Low-does radiotherapy for nonmalignant issues has low carcinogenic risk, particularly in older populations where these ailments hit hardest. Age, dose, & genetics matter too, read more here: www.sciencedirect.com/science/arti...

Insightful review by BARI member Aimee Kao & team connects development and aging through lysosomal dysfunction and neuronal vulnerability. They highlight how proteostatic stress in high-stress life stages can lead to lysosomal clearance disorders. www.sciencedirect.com/science/arti... #Neuroscience

Check out BARI member Su Guo’s @naturecomms paper where they uncover PCM1’s role in regulating daughter cell fate via centrosome-endosome interplay. www.nature.com/articles/s41... #neuroscience

Fascinating perspectives on aging science in Nature Aging! BARI’s Dena Dubal offers insights on real-world translation, plus input from two of our advisory board members Vera Gorbunova & George Kuchel. Inspiring read: www.nature.com/articles/s43... #Aging #Science

Neil Risch and his BARI team have a paper out in AJHG: Predicted loss-of-function variants linked to serious diseases often don’t show up as expected in big biobanks. Why? Residual activity from the variant allele keeps some function going (leaky penetrance).

UCSF has a cool article on BARI member Hao Li’s work. They found gene-regulating proteins that drop with age, slowing repair. Boosting them made old fibroblasts act young again and increasing EZH2 in mice rejuvenated livers. Read more here: www.ucsf.edu/news/2026/01...

Congrats to BARI’s Tamara Alliston on her latest paper in Osteoarthritis and Cartilage! They show loss of MMP13 in bone cells is protective against cartilage damage in injured jaw joints (TMJ), similar to effects seen in knees: www.oarsijournal.com/article/S106...

What a whirlwind at #JPM2026! Grateful for the inspiring chats, new ideas, and connections that make this field so exciting. From BARI in SF: thanks for coming, safe travels home, and let’s keep pushing geroscience forward together! #agingresearch

Aging mice are precious (and expensive!) – so why not get max data from each? BARI member Hanna Martens & team share a JoVE protocol for multi-organ collection. Over 15 organs from a single mouse. Smart & ethical: app.jove.com/t/69128/mult... #agingscience

What if lowering triglycerides could help you survive low oxygen and age better? New EMBO Reports from BARI member Dengke Ma & team explores this conserved mechanism: from arctic ground squirrel brain cells to C. elegans, reducing lipid biosynthesis protects mitochondria and extends life.

Well done to Tien Peng and team – exciting new paper out in Cell Stem Cell! The study shows how certain senescent fibroblasts drive metabolic reprogramming in lung adenocarcinoma and demonstrates that targeting them with an HSP90 inhibitor shrinks tumors.

Wishing you all a brilliant 2026 from everyone at BARI! May the new year bring discoveries that change the world by advancing aging research. See how we’re building on the past to make a great future in 2026 and beyond: www.nature.com/articles/d42... #2026 #Geroscience

In case you missed it: Diana Laird and her lab dropped this awesome Science paper. A deep dive comparing human and mouse ovaries over time, spotlighting conserved aging features to enhance our translational understanding. A major win for reproductive health! www.science.org/doi/epdf/10....

In case you missed it: BARI’s John Greenland and lab found frailty in lung transplant recipients links to shorter telomeres and anemia – but not epigenetic age or inflammation. Not all aging hallmarks hit equally! Read the interesting details here: www.amjtransplant.org/action/showP...

Big congrats to BARI’s Xian Piao and her lab for their awesome paper in Neuron! They found that microglial ADGRG1 turns on MYC to make microglia more protective and better at clearing amyloid to keep neurons healthier in Alzheimer's models. Huge win for AD research! #Alzheimers #Neuroscience

BARI congratulates fellow UCSF aging scientist Lauren Hunt for winning the 2025 Terrie Fox Wetle Rising Star Award from AFAR! Using big data to make hospice & palliative care for dementia patients – such important work. BARI is cheering you on! #AgingResearch www.afar.org/news/afar-pl...

Huge congrats to Jarin Tusnim, postdoc in the Piao Lab at BARI, for her Cure Alzheimer's Fund grant! Jarin is exploring how ADGRG1 helps microglia stop tau from spreading, which could lead to boosting brain protection for new AD therapies. Great work Jarin! #Alzheimers #CureAlz bit.ly/4j79J4Q

Exciting research from BARI member Ken Nakamura! Their study out in @ScienceAdvances shows for the first time in vivo, a better understanding of how mitochondrial dysfunction can lead to α-synuclein accumulation and neurodegeneration in Parkinson’s Disease. Check out the story here: bit.ly/4aWt4n4

So proud of our research teams at BARI - @ucsanfrancisco.bsky.social now #2 globally in this year’s Nature Index for Aging! Excited to keep challenging what’s possible for healthier aging. Check out the full list: www.nature.com/nature-index... #BARI #UCSF #Geroscience

Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1... Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.

Nancy Allen and Tien Peng's study reveals that age-dependent NF-kB activation in tissue fibroblasts contributes to #inflammaging by remodeling immune architecture and promoting exhausted T cell populations. bit.ly/4qlIR4k

Kate Cavanaugh and Orion Weiner's research out now on @biorxivpreprint.bsky.social identifies a mechanical defect in embryos from aged mothers that impairs implantation. These findings could enhance embryo selection in Assisted #Reproductive Technologies. bit.ly/47tY7V8

In our October issue: Ferritin light chain 1 (FTL1), an iron-associated protein, is a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice @VilledaLab @ucsfaging.bsky.social @UCSF www.nature.com/articles/s43...

Sara LaHue, @geriscidoc.bsky.social, and others published in @geroscience.bsky.social an interdisciplinary effort to identify longitudinal transcriptomic changes in adults with #delirium hospitalized with #COVID-19. bit.ly/4o8wMO7

It's wonderful to see the number of outstanding applicants increase each year for our graduate student fellowships in collaboration with the UCSF Hillblom Center for the Biology of Aging. Congrats to this year's recipients! #GeroSky #SciSky