Huge congrats to BARI’s Orion Weiner on this stunning Nature Cell Biology paper! Migrating cells don’t just have a front and back, they actively help each other across the whole cell.

BARI spotlight: Alexis Combes and team turned routine biopsy samples into rich maps of what’s happening in inflamed guts. Their work highlights cellular patterns linked to treatment success, offering new paths to help patients with ulcerative colitis get the right therapy sooner. #GutHealth #IBD

Big cheers for BARI’s Paul Wolter’s on this breakthrough! Telomere-stressed AT2 cells turn profibrotic early in lung fibrosis, p53 is the driver. Inhibiting it reverses damage, boosts healthy AT2 cells & halts fibrosis. Hopeful step toward better IPF therapies! academic.oup.com/ajrccm/artic...

Proud to highlight Christopher Hernandez’s review urging the field to target bone matrix quality for better fragility fracture prevention. Matrix mechanical properties matter as much as density, and they’re modifiable. A compelling case for new therapeutic strategies beyond current approaches.

BARI spotlight: Dena Dubal urges a shift in how we approach Alzheimer’s, recognizing women’s unique mix of vulnerability and resilience. Strong call for more research on female biology, sex-tailored care, and discoveries that help everyone age better. Important perspective! #Alzheimers #Womenshealth

Check this out from BARI’s Kevan Shokat: Chai-1 deep learning makes crystal-quality models of covalent K-Ras complexes fast, accurate, and works great with covalent restraints for tough targets. Super useful for speeding up drug discovery! #Kras #drugdiscovery

Big cheers for BARI’s Sarah Knox on this new iScience paper! Simple PBS rewetting restores damaged corneal stroma in autoimmune dry eye, fixing collagen, basement membrane & shifting keratocytes to reparative mode. Game-changer for dry eye! #opthalmology #dryeye www.cell.com/action/showP...

Big cheers for BARI’s Jayanta Debnath on this new Autophagy review! Membrane ATG8ylation helps cells secrete proteins, load EVs, and handle everything from metabolism to immune responses via clever non-degradative autophagy routes. Super interesting deep dive! pubmed.ncbi.nlm.nih.gov/42178909/

BARI’s celebrating Dengke Ma’s latest in Cell Reports! They uncovered how the ER guards itself against H2O2 with ERGU-1/TMEM161B, keeping protein folding smooth and supporting reproduction & stress responses. Outstanding discovery! pubmed.ncbi.nlm.nih.gov/42241275/

Congratulations to BARI/Hillblom fellows Lea Baskin Monk, who received the ARCS Scholarship, and Yujie (York) Zhang, who received the Fletcher Jones Fellowship!

BARI is celebrating Rushika Perera’s Molecular Cell study! They uncovered how pancreatic cancer cells use an autophagic capture complex to degrade ER-stalled MHC-I, reducing surface presentation. Links inefficient antigen loading and NFXL1 to immune escape. Beautiful work!

BARI is celebrating Andrew Yang’s Cell study! They developed genetic tracing to show brain protein clearance is regionally organized, with specialized border niches. Neuroinflammation and amyloid disrupt it differently, key for understanding neurodegeneration. Beautiful work!

Big cheers for BARI’s Katrina Abuabara on her new JAAD review! Atopic dermatitis is still diagnosed the old-fashioned way, history + exam + established criteria, but standardized tools make assessment clearer and care more consistent. Super practical guidance for clinicians!

BARI is celebrating Dengke Ma’s Nature Comms study! They found a simple way to trigger reversible suspended animation in worms using just crowded liquid conditions. Multi-omics, imaging, and genetics reveal how animals pause life and wake back up, fantastic work! #suspendedanimation

Check out Max Krummel’s new Nature Immunology study: Comparing mouse and human tumor microenvironments, they highlight key differences in how these immune ecosystems assemble, plus conserved gene programs that track with patient outcomes. Excellent work and a handy new resource!

BARI is celebrating Kevan Shokat’s new ACS Chem Biol study! They designed long-acting CFTR potentiators by tweaking the protein-membrane interface, longer lipophilic chains dramatically extend activity via enhanced membrane retention. Exciting for CF and membrane drug design!

BARI is celebrating Dr. Dean Sheppard’s latest in Thorax! It shows circulating CTHRC1 is elevated in IPF patients and strongly linked to disease severity and survival, a clear reflection of the pathological fibroblasts driving fibrosis. Important step forward for better patient care.

Big cheers for BARI’s Michelle Arkin on her new PNAS paper! Molecular glues fix a key regulatory interaction in Noonan syndrome, restoring balance to MAPK signaling. This has real potential for targeted therapies for RASopathies! www.pnas.org/doi/10.1073/...

BARI is celebrating our Director Leanne Jones, freshly inducted into the Academy of Geroscience! Her pioneering work in stem cells and tissue maintenance keeps pushing the frontiers of healthy aging research. What an honor for our leader and for BARI! www.prnewswire.com/news-release...

Nice work from BARI’s Martin Kampmann: In lab-grown neurons with an FTD-linked tau mutation, both the mutation and reducing tau led to shorter axons and changes in axon-related pathways.

Big congrats to BARI’s Todd Nystul and team on their new Aging Cell paper! As fruit fly ovaries age, the support cells that wrap and protect developing eggs start to fail, leading to poor egg packaging and built-up damage.

Congrats to BARI’s Dena Dubal: Klotho isn’t just a longevity factor, it protects cognition in Parkinson’s. Human data + mouse models show it rescues synaptic plasticity and lowers α-syn toxicity. Fantastic work! www.jneurosci.org/content/jneu...

BARI is celebrating Michelle Arkin’s election to the American Academy of Arts and Sciences 2026! This is a huge honor for her groundbreaking research and leadership. Fantastic recognition, congratulations Michelle! www.amacad.org/new-members-...

Check out Martin Kampmann’s latest in JBC! Using clever screens, they found DNAJC7 potently blocks polyQ aggregation (Huntington’s) and can also tame polyG aggregates when overexpressed.

Congrats to BARI’s Steh Shipman! His team’s new Nature Biotech paper takes retron recombineering to 15 different bacteria across multiple phyla, with impressively high editing efficiencies in many.

BARI’s celebrating Peggy Cawthon’s latest study. They track muscle mass, strength, power, and performance across the full adult lifespan and finds muscle loss tracks tightly with functional declines in key areas.

BARI Member Roarke Kamber Receives Prestigious W. M. Keck Award for Innovative Cancer Therapy Platform! Read more here: geroscience.ucsf.edu/news/bari-me...

Warm congrats to BARI’s Christopher Hernandez on his new mBio paper! It reveals that mechanical squeezing in sub-micrometer bone channels halts S. aureus growth and migration, bacteria can’t divide their way in and are likely pushed by fluid pressure.

BARI is celebrating Kevan Shokat’s latest in Biological Chemistry! Daraxonrasib acts like a GAP mimetic to restore GTPase activity in mutant Ras and teams up beautifully with K-Ras Switch-II pocket drugs. Strong synergy in cancer models. www.degruyterbrill.com/document/doi...

Huge congrats to BARI’s Jingjing Li on her beautiful new Nature paper! A detailed single-cell and spatial map of the human maternal-fetal interface across pregnancy reveals how cells talk, differentiate, and build this critical interface,

Congrats to BARI’s Tamara Alliston on her new paper! The Alzheimer’s risk gene APOE4 hits female bone hard, weakening the cells that keep bone strong and flexible, while effects in the brain are milder at the same age. A fascinating piece of the bone-brain puzzle in women’s aging!

BARI is celebrating Orion Weiner on his new review! It dives into how immune cells and tiny amoebas both build their own chemical signposts to team up from far away. Two very different cells solving the same puzzle in clever ways. cshperspectives.cshlp.org/content/earl...

Big cheers for BARI’s Nadav Ahituv on this new review! It dives into clever ways scientists can dial gene activity up or down, like a smart dimmer switch, to help treat genetic conditions without rewriting the DNA code. Promising for the future of medicine! www.annualreviews.org/content/jour...

Congrats to BARI’s Tien Peng on his new paper! It shows how aging fibroblasts in the lung starts a chain reaction of chronic inflammation and overactive immune cells, helping us understand why older folks are more at risk for serious lung issues. Hopeful step toward better aging!

BARI is celebrating John Vaughen’s new Neuron study! It shows developing glia phagocytose neuronal membranes, salvage the lipids in lysosomes, and turn them into CPE lipids needed for autophagy and synaptic ramification. Fantastic work! www.cell.com/neuron/fullt...

BARI is celebrating Yin Shen’s new Nature Comms study! It shows how the brain cleverly compensates when enhancers are deleted on one SIN3A allele by boosting the other, precise dosage control that could matter a lot for healthy brain aging. www.nature.com/articles/s41...

BARI is celebrating Guo Huang’s new PNAS study! It shows how TOX3 supercharges Atoh1 to keep cerebellar progenitors thriving during development and plays a big role in medulloblastoma too. Elegant work on brain growth and disease!

BARI’s celebrating Peggy Cawthon’s new Age and Ageing study! It shows advanced imaging features from CT scans capture skeletal muscle details that strongly tie to physical performance in older men, helping us fight sarcopenia and keep mobility high with aging. bit.ly/3OqwN3u

BARI’s cheering for Saul Villeda! His research just got spotlighted in The Washington Post! It shows exercise strengthens the blood-brain barrier in Alzheimer's models, leading to better memory and learning. Read it here: www.washingtonpost.com/wellness/202...

BARI's celebrating Dr. Andrei Goga's new Cell Reports study! It shows MYC-driven liver tumors depend on breaking down alanine for energy and survival, and targeting this pathway (with a drug or genetics) really slows them down. Meaningful step forward for age-related cancer research.

BARI’s been busy! If you’re into aging research, swing by our Updated News page for the newest publications and discoveries from our labs. Super proud of our members and would love for you to check it out and join the conversation. geroscience.ucsf.edu/updated-news

Check out BARI’s Kelsey Collins excellent review in JOR. It reveals how fat is a key driver of osteoarthritis through metabolic and immune signals, linking directly to age-related joint decline. This could transform how we approach healthy aging and pain management. Fantastic work Kelsey!

Cheers for BARI's Martin Kampmann on his new JBC paper! It uncovers how DNAJC7 fights polyQ aggregation in Huntington's-like diseases and tweaks polyG, connected to aging, where protein clumping drives neurodegeneration. Read more here: www.jbc.org/article/S002...

Big congrats to BARI's Dr. Brian Feeley on his JAMA Internal Medicine article! It breaks down how most shoulder MRI "issues" are just normal aging wear-and-tear, even in pain-free folks—super relevant to aging biology for smarter care and avoiding extra surgeries. jamanetwork.com/journals/jam...

Big cheers for BARI's Dr. Diane Barber on her Acta Physiologica review about lysosome pH in health & disease! It connects the dots on how pH shifts affect lysosomal roles: super relevant to aging, where off-balance pH worsens neurodegeneration and protein buildup. Exciting therapeutic angles!

BARI's Peggy Cawthon at the ICFSR conference on healthy longevity & aging biomarkers: Hosted by Nature Aging's Sébastien Thuault, with Luigi Ferrucci, David Furman, & Dan Belsky.

Big cheers for BARI member Isha Jain on her new Cell paper! It reveals how vitamins B2 and B3 can treat NAXD disease, saving metabolism, shielding the brain, and stretching lifespan over 40x in models. Ties right into aging biology, where boosting NAD could slow down age-related breakdowns.

BARI is celebrating today! Kelsey Collins just won the 2026 NEXT Award for her research on the surprising role of fat in osteoarthritis and joint pain. Turning personal inspiration into real mechanistic discoveries – this is why we do what we do. Congratulations, Kelsey! bit.ly/4sCUdBd

BARI’s Dengke Ma shows non-visual light tweaks genes & improves adaptability in worms in a bacteria-dependent, wavelength-sensitive pathway. Enhances olfactory memory & potential for aging sensory research. Check it out: elifesciences.org/articles/108...

Isha Jain at BARI just published this in Cell Metabolism: Living high up makes blood sugar drop because red blood cells soak up glucose in low oxygen. Hypoxia can even treat diabetes in mice! #metabolism www.sciencedirect.com/science/arti...