1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase www.science.org/doi/10.1126/...

True words!

Big and well deserved congratulations to @zhipengawang.bsky.social for his new Prostate Cancer Foundation Young Investigator Award! So well deserved! He is doing incredible work discovering new mechanisms of ketones in metabolism. And congrats to all the other PCF young investigator awardees! 🧪

Evidence that even when LLMs produce similar results to humans, they “rely on lexical associations and statistical priors rather than contextual reasoning or normative criteria. We term this divergence epistemia: the illusion of knowledge emerging when surface plausibility replaces verification”

Latest clinical data on HSD3B1 presented at ASTRO www.urotoday.com/conference-h...

"Rockets, computers and lifesaving medicines all come from decades of effort by scientists hunkered over pages of calculation or the laboratory bench. They required the same tireless, single-minded effort every elite athlete understands." 🧪 @adamfrank4.bsky.social www.nytimes.com/2025/10/03/o...

We are hiring and looking for exceptional faculty! If you are interested in the fundamental mechanisms of human biology, biochemistry, metabolism, or genetics, please look here! 🧪 jobs.sciencecareers.org/job/675109/f...

Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.

These pelicans out this morning are just magnificent and mesmerizing to watch

Reduced Screening May Have Led to Rise in Advanced Prostate Cancer Diagnoses www.nytimes.com/2025/09/02/s...

Congratulations @marinaparry.bsky.social! Wonderful work!

Enjoyed working with Masoud Bitaraf and Elena Castro on this review on prostate cancer germline variants with therapeutic implications for Trends in Molecular Medicine! 🧪 #UroSky #MedSky @cp-trendsmolecmed.bsky.social authors.elsevier.com/a/1lWYz5Eb1B...

Such an honor and so much fun to join the Cancer Clear and Simple @uwhealth.bsky.social Carbone Cancer Center Podcast to discuss liquid biopsies in cancer! cancer.wisc.edu/community-ou...

I consider myself fortunate for every day I can continue to do science

An Editor's Pick paper at J Biol Chem @asbmb.bsky.social! Don't forget to read the profile about the first author Xiuxiu Li at the end of our paper on HSD3B1 and breast cancer! Dr. Li recently moved from University of Miami to the University of Alabama! 🧪 www.sciencedirect.com/science/arti...

...a long way to go...

😣😩😭

Sage advice as always from @rjdlab.bsky.social 🧪

So impressed with the survival effects of excercise in this study in stage 2/3 colorectal cancer. Survival effects apparently independent of weight loss. How does it work? @nejm.org 🧪 www.nejm.org/doi/full/10....

I love coming across these majestic creatures! #pelicans

Congrats Zhenfei Li and his team on his story @pnas.org on fine structural design of 3βHSD1 inhibitors for prostate cancer therapy! His work builds on many years of work on HSD3B1 genetics and metabolism in prostate cancer! @pcf-science.bsky.social 🧪https://www.pnas.org/doi/10.1073/pnas.2422267122

Do you have a primary interest in fundamental mechanisms of human biology, biochemistry, metabolism, genetics, or medicinal and analytical chemistry and looking for a postdoctoral fellowship? 🧪 www.nature.com/naturecareer...

Congrats Xiuxiu Li on her story out JBC! HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer - Journal of Biological Chemistry @asbmb.bsky.social 🧪https://www.jbc.org/article/S0021-9258%2825%2902255-0/fulltext

So proud of @charles-dai.bsky.social who just landed a Damon Runyon Physician-Scientist Award! Charlie was previously an HHMI med fellow in our group. He truly has all the "right stuff" as he is becoming a leading investigator in breast and prostate cancers! 🧪 www.damonrunyon.org/news/entries...

Congratulations to Francesca Demichelis at U Trento on her and her team’s study just out in Cancer Discovery @theaacr.bsky.social aacrjournals.org/cancerdiscov...

Really amazing! 🧪 www.nejm.org/doi/full/10....

Big congratulations to Dipen Parekh - the next CEO of UHealth!!! news.miami.edu/stories/2025...

How do ketones impart their effects in physiology? Congrats to Zhipeng Wang on his story elucidating a new mechanism just out in @biorxivpreprint.bsky.social! In his exciting story, he shows that acetoacetate via another metabolite modifies mitochondrial cysteines! 🧪 www.biorxiv.org/content/10.1...

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

Really interesting story on bacterial metabolism and enzymes that may be involved in steroid metabolism - including from Karen Sfanos at Johns Hopkins. 🧪https://www.nature.com/articles/s41564-025-01979-9

Quite a brisk wind coming off the Atlantic this morning — enough to take flight apparently

Amazing to get our DSUI science group together for a potluck and to share some laughs! Oh - and check out the food and desserts!!! So grateful for this wonderful group of colleagues who all do great science!

Interesting paper on certain bile acids functioning as androgen receptor antagonists 🧪 www.cell.com/cell/abstrac...

1/3 Big congrats to Justin Hwang, Emmanuel Antonarakis, @charlesryanmd.bsky.social & team on a story looking at germline HSD3B1 (which is linked to prostate cancer mortality) vs. tumor findings in prostate cancer! A couple of things that I find interesting here!🧪 www.mdpi.com/2072-6694/17...

Delighted to have Chip Petricoin visiting us today to speak about discovery and use of proteomics in oncology! @georgemasonu.bsky.social

México! Que historia, que gente! Gracias por compartir ustedes país y una gran semana!

Radio Garden is a great app for listening to live music anywhere in the world. Right now my favorite station is in San Blas Atempa in Oxaca - sounds of a slow, timeless, perfect rhythm. radio.garden/listen/san-b...

Just a reminder that when you give (or take) abiraterone for prostate cancer, you get a bunch of complex steroidal metabolites with various activities. It is messy. Below is what occurs after a single dose. 🧪 www.jci.org/articles/vie...

The “hafseen” spread in our house for Persian New Year (which is the Spring equinox). I’m particularly happy with the small volumetric flask for the vinegar. That and the other items all begin with an S in Farsi.

1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social www.science.org/doi/10.1126/...

A spectacular full moon!

A great new general review on prostate cancer that is just out. Nicely covered by a leading edge and balanced group of physician-investigators for a very complex topic! 🧪 @jama.com jamanetwork.com/journals/jam...