New paper from Dr. Wen Gu on the impact of L-2-hydroxyglutarate deficiency on neural stem cell function and neuronal differentiation. Interesting connection between an IEM and chronic oncogene activation. Thanks to Dr. Bushra Afroze and her patients for participating. www.jci.org/articles/vie...

I think the bucket was good luck. Go Blue!!!

Had a #GoBlue moment last week when Omer Yilmaz, Ph.D., came to speak about his #relentlessdiscovery for the CRI Speaker Series. Omer's ice bucket from @seanjmorrison.bsky.social Lab made the move from Ann Arbor to Dallas and is still being used two decades later! 🧪

Unfurl @casanovalab.bsky.social's whole 🧵👇 ... we're pumped to be adding another scientist passionate about #relentlessdiscovery to our roster. Onward! 🧪

Learn more about CRI's newest investigator @henrydebelly.bsky.social and his #relentlessdiscovery to define the molecular controls of membrane fluidity in order to influence immune and #cancer cell function. 👇 cri.utsw.edu/meet-dr-henr... 🧪

ONLINE now in @cellpress.bsky.social: A review by CRI's @haozhulab.bsky.social about their #relentlessdiscovery and how somatic mutations are becoming a key discovery engine for disease genetics. 🧪 Read more ⬇️ www.cell.com/cell/fulltex...

#RareDiseaseDay2026 #relentlessdiscovery 🧪

Great time in Boston, as always! Thanks for the invitation!

Become a CRI #postdoc & be part of CRI's #relentlessdiscovery 🧪 Apply at cri.utsw.edu/careers #jobs #opentowork #jobopenings #sciencejobs #HiringNow

My lab @cri-utsw.bsky.social is looking for a highly motivated postdoct interested in mechanobiology! We are building a highly collaborative and interdisciplinary team working on how mechanical forces shape immune and cancer cell behavior. Come do cool science with me! lnkd.in/gKEXWUGy

🚨NEW PI ALERT🚨 @henrydebelly.bsky.social is in the house, and look at that *fresh* new office. Clean slate for his next #relentlessdiscovery in CRI's Tissue Regeneration Program (TRP). Onward! Read more about his new lab 👉 cri.utsw.edu/faculty/henr... 🧪 @haozhulab.bsky.social

ICYMI, there's a new project CRI's @haozhulab.bsky.social will collaborate on: trying to create artificial livers. Read more ⬇️ #relentlessdiscovery #CRIcollaboration 🧪 www.utsouthwestern.edu/newsroom/art...

We can't wait to see you next week, @henrydebelly.bsky.social! #relentlessdiscovery

Today 1/9 at 4pm: UCSF Cancer Center Friday Seminar Series | Sean Morrison, PhD @seanjmorrison.bsky.social Founding Director, @cri-utsw.bsky.social presents "Immune regulation of melanoma metastasis" cancer.ucsf.edu/seminars Hosted by @rushika-perera.bsky.social @ucsanfrancisco.bsky.social

Millions of years ago, our ancestors lost the ability to make vitamin C. It’s long been unclear why. But Dallas researchers may have uncovered an explanation — and it involves parasitic infections.

Featured in @dallasnews.com: CRI's Agathocleous Lab talks about their recent #relentlessdiscovery: a potential benefit to vitamin c deficiency. 🧪 Read more ⬇️ www.dallasnews.com/news/2026/01...

That’s a wrap on the past 12 months, with even more #relentlessdiscovery to come in 2026. cri.utsw.edu/discoveries/ @seanjmorrison.bsky.social @rjdlab.bsky.social @haozhulab.bsky.social 🧪 #stemcells #regeneration #CancerResearch #metabolism #NYE2025 #NYE2026

ONLINE NOW in @pnas.org: Agathocleous Lab, collaborators discover why humans, some animals may need intermittent vitamin C deficiency: to survive parasite infections. 🧪 Read more ⬇️ cri.utsw.edu/loss-of-vita... #relentlessdiscovery

Just a nice lab happy hour before the holidays

Exciting news from the @rjdlab.bsky.social (with co-first author @zhengwu1.bsky.social)! We've uncovered a crucial new mechanism that controls the supply of purine nucleotides—a pathway essential for cancer growth.

Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!

ONLINE NOW in @science.org: @haozhulab.bsky.social discovers location matters for liver cancer's origins. 🧪 Read more ⬇️ cri.utsw.edu/zhu-lab-show... 🔖 @haozhulab.bsky.social's breakdown ➡️ x.com/Zhu_Lab/stat... #relentlessdiscovery

ONLINE NOW in @science.org: DeBerardinis Lab discovers protein regulating balance between purine nucleotide production pathways. 🧪 Read more ➡️ cri.utsw.edu/deberardinis... 🔖 full breakdown ⬇️

6 years ago, Lizz took a leap of faith by moving across the country to join our new and empty lab as a research tech. She then became our 1st grad student, playing a major role in shaping our research directions and lab culture. Today she defended her PhD, and I couldn’t be more proud.

Defended! 🍾 Introducing Elizabeth Maurais, Ph.D. 🎉 Congrats on your successful #dissertationdefense. Dr. Maurais was joined by her mentor @peterlylab.bsky.social & other Ly Lab mates. Next stop: #postdoc! 🧪

We moved the RJDLab potluck to Halloween this year. Thanks to Gaby Cano for organizing! (And decorating).

Happy Halloween 🎃 Scary: food in the lab (👋 Harrison) Sweet: problem-solving lab managers, like Jessica! 🎃🍬🤍🦇🕷️🕸️🐈‍⬛💀🧡🐦‍⬛🕯️🖤‍🍂🍁🪾🔮🧪 @rjdlab.bsky.social

ONLINE NOW: CRI's Ohlstein Lab presents new research that reevaluates whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila, in @pnas.org. Read more ⬇️ www.pnas.org/doi/10.1073/... #relentlessdiscovery 🧪

📍 #MotivationMonday: "Resilience isn’t something that you are born with – it is a set of skills you have to cultivate.” [email protected] Read more about pushing through adversity & #relentlessdiscovery with Sean & @rjdlab.bsky.social ⬇️ www.utsouthwestern.edu/ctplus/stori...

Interested in organellar metabolomics? Check out my talk tomorrow on how the Rapid Organellar IP technology has enabled discoveries in organellar biology over the past 10 years! Ty Tech Networks for the invite! @cri-utsw.bsky.social @rjdlab.bsky.social www.technologynetworks.com/proteomics/o...

Many thanks also to @cri-utsw.bsky.social for providing such an excellent environment for training and discovery.

Congrats to all Damon Runyon's SPARK Scholars, including our own scholar Imani Williams who is studying cancer metabolism. Thank you Damon Runyon Cancer Research Foundation @damonrunyon.org for supporting this great initiative. www.damonrunyon.org/news/entries...

Thrilled to announce the launch of my lab @cri-utsw.bsky.social at UTSW this January! We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.

We're growing! Our newest Investigator @henrydebelly.bsky.social will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henr... and 📌apply to research in his lab cri.utsw.edu/careers

One week left to apply!

Excited to present my research at the upcoming University of Utah Rising Stars Symposium and meet fellow scientists who love metabolism! @cri-utsw.bsky.social @rjdlab.bsky.social

Thank you @cri-utsw.bsky.social postdocs!

We have the best postdocs! We appreciate you being a critical part of our CRI team to help discover the treatments of tomorrow. #npaw2025 #npaw #relentlessdiscovery 🧪

🎉 JUST ANNOUNCED: @haozhulab.bsky.social named project co-leader for UTSW liver cancer SPORE. His project will study how to prevent hepatocellular carcinoma — which accounts for >85% of liver cancer cases across the nation. Read more ⬇️ cri.utsw.edu/zhu-named-co... #relentlessdiscovery 🧪

🔬 APPLY NOW: Seeking faculty scientists in #stemcells #TissueRegeneration #metabolism & #cancerbiology. You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛 #jobs #faculty #facultyjobs #ScienceJobs 🧪

Excited to join the @cri-utsw.bsky.social community to advance discoveries in genome instability. We are grateful to UTSW Pathology for 6 wonderful years. 🚨 We are also recruiting motivated postdocs to study how mitotic errors and aberrant nuclear structures drive cancer genome evolution—join us!

WELCOME to the Institute, @peterlylab.bsky.social! Dr. Ly studies how cells maintain genomic integrity and how dysregulation of these processes impacts human health. 🧪Learn more about his research 👉 cri.utsw.edu/faculty/pete... #relentlessdiscovery

👉New article in @newscientist.com features a #relentlessdiscovery 🧪 from CRI's Agathocleous Lab ⬇️

Thrilled and deeply honored to be named a 2025 Pew Biomedical Scholar! Huge congrats to my friend and colleague @cri-utsw.bsky.social Javi, who’s also joining the Pew family as a Pew-Stewart Scholar. CRI is on fire—let’s go make some bold, groundbreaking science happen! 🔥🧪✨

🎉 Huge congrats to Drs. Javier García-Bermudez and @hrshin.bsky.social for being named Pew-Stewart & Pew Scholars! Well-deserved recognition for two outstanding @cri-utsw.bsky.social scientists!

Congrats! 👏👏👏 Two CRI scientists named 2025 Pew-Stewart & Pew Scholars — Javier Garcia-Bermudez, Ph.D. & @hrshin.bsky.social — to advance cancer, biomedical research 🧪 Read more about their #relentlessdiscovery ⬇️ cri.utsw.edu/two-children... @pewtrusts.org

ONLINE NOW in @biologists.bsky.social "Disease Models & Mechanisms:" from CRI's @haozhulab.bsky.social about siRNAs for liver cancer prevention ⬇️ read more #relentlessdiscovery 🧪 journals.biologists.com/dmm/article/...

Big thanks to Jianguo Wu, Min Zhuang, @natcellbio.nature.com for a great News and Views on our work and that of Michael Skowyra, Tom Rapoport. www.nature.com/articles/s41...

1/New paper on peroxisome assembly, reporting the detailed mechanism of PEX39, a new peroxin involved in PTS2 protein transport. Fantastic work by ‪@walterwchen.bsky.social‬ and a dream team of collaborators, as explained below. www.nature.com/articles/s41...

🧵⬇️ @walterwchen.bsky.social #relentlessdiscovery 🧪