Here's a six-month time-lapse of me building the single objective light sheet fluorescence microscope at the UCSF Center for Advanced Light Microscopy! Also pictured is @nicostuurman.bsky.social and @kahsage.bsky.social. #snouty

One of the difficulties in developing code for microscopes is to get access to the equipment. So, wouldn't it be nice to have emulators? Turns out that AI is really good at converting documentation into an emulator: nicost.github.io/microscope-t...

I made teaching tools for training people on the SNOUTY. Here they are for other people! I recommend laminating them so you can draw on them with dry erase markers :)

@tanner-fadero.bsky.social told me there was a discussion about the unofficial name for #snouty V3. We have had Mr. Snouty and King Snouty, and there were people suggesting Emperor Snouty. I think it is time for a Lady or EMPRESS snouty. I have created Art to support this.

@tanner-fadero.bsky.social Fine. I remembered.

This was a quick sketch for the super kind postdoc Lisa Randolf who has kindly been providing me with samples to test on our microscope.

Congratulations to Takeshi Tsusaka on their recent publication on Reversible histone deacetylase activity www.nature.com/articles/s41.... Also, thank you to Takeshi for acknowledging our core facility, putting in hardware information about the microscope, and telling me about it all!!!!

Microscopes are Analog to Digital devices! I drew this for teaching purposes. #art #SciArt #artwork

The sticky note response to when someone tells you your age means “years more of experience” than them #art #comic

Live sketch time! Train commuters. #art #livesketch #sketch

Anyone in the SF Bay Area? Berkeley public library has a comic on this weekend! www.berkeleypubliclibrary.org/events/bpl-c...

Osmotic pressure!!! This is a drawing drom a few years ago insprired by @katrinavelle.bsky.social amoeba undergoing seome osmotic pressure! #art #sciart

Always 💖 Don't make me tap the sign

Slow-mo Calcium response! Here is a little neutrophil with a calcium sensor doing its best to respond to a chemoattractant! Work done by Evelyn Strickland inspired this! Check out her paper on self-extinguishing relay waves in neutrophil swarming www.sciencedirect.com/science/arti... #art #sciart

Decorated pumpkins at work! I had to go with a Vampire microscope because microscopes are light vampires. . . Bonus for anyone who noticed its deadly ultraviolet wings! . #sciart #acrylic #microscope #vampire

Magnification is not resolution! Resolution is the minimum distance required to distinguish between two objects. You need to take into account how light spreads and refraction. Magnification just makes things bigger. I drew this for a workshop I’m helping to teach! #art #artwork

#sciartseptember day 4: cursed There is nothing more cursed in this world then doing lab work on the weekend. #art #artwork #watercolormarkers #ink #cells #sketch #sketchbook #traditionalart

I’m behind on challenges because I guess it was Smaugust, for some reason I thought there was a Smaugtember with all the dragon images on my feed. Anyway it made me want to draw a dragon and I just like the idea of a giant powerful dragon performing delicate work. #art #sketch #sketchbook

PCR machines are the worst! Superstition is abound in the lab, so here is a bit of science humor with another little cartoon I drew on the train. #art #cartoon #sciart #watercolormarker #cells #ink

Morning commute 8/19/24 . #art #artwork #watercolormarkers #ink #commute #lifedrawing #sketch #sketchbook #traditionalart

Turns out I can’t help but draw microscopes on things. This ended up being an exercise in transposition to draw a microscope on this little marmal toy. I feels like a little puzzle that I will need to work on. #art #artwork #sciart

I found a new toy that you are supposed to draw on and wash off called a marmal (@lovemarmals) The first order of business was giving it a brain, which led to imagining what its nervous system would look like. It turned out a little bit like a supervillain. #art #artwork

Clown Fish! From the aquarium, done with acrylic inks! . #art #artwork #acrylicinc #ink #fish #aquarium

Watercolors at the beach park! . #art #artwork #watercolor #ink #beach #drawing #traditionalart

Beach supplies: sketchbook and watercolors . #art #artwork #watercolor #ink #beach

If you want to read more about the science for how Kirsten Meyer used optogenetics to study the effects of YAP proteins in stem cells, check out her paper here www.ncbi.nlm.nih.gov/pmc/articles...

Optogenetics! These little cells will have their proteins translocated by our spinning disk microscope and a blue light optoplate! I drew this to congratulate Kirsten Meyer whom I have had the opportunity to work with over the last few years! Now she is off to start her own lab at Yale! #art

Live drawings from the commute! Also thanks to the person who sat next to me on the train today and complimented my drawing ☺️ it’s always nice to hear! #art #artwork #livesketch

Compu-mancy: Harvesting computer parts from one computer to keep your computer of interest running! It is closely adjacent to scope-romancy, because the microscope is reliant on that computer. . #art #artwork #sciart #scienceart #markers #ink #sketch #sketchbook #microscope ##computer #drawing

Scope-romancy! The fine art of taking parts from one microscope to revive another microscope to keep it working! . #art #artwork #sciart #scienceart #markers #ink #sketch #sketchbook #microscope #drawing #illustration #traditionalart

If you were transfected with a protein that could make you glow. How annoying that would be for your sleep schedule? If it was MagLOV and you then discovered a magnet it would be glorious. Inspired by MagLOV protein:https://x.com/andrewgyork/status/1797408565742776348?s=46&t=2S117XXgyNbwHribuq4qcQ

I’m not touching you! In the objective world, the snouty is definitely the kid that is super close, but isn’t touching you. #art #artwork

This little cell can’t dodge ultra-fast volume imaging of the snouty light sheet even when it tries! . #art #artwork #sciart

Citing all the features of your microscope, no matter how small, makes your data more reproducible and makes everyone happy! . #art #artwork #sciart #scienceart

Cells perspective: Snouty single objective light sheet freeze frame! . #art #artwork #sciart

I have learned if you want to entertain a 7-year-old you just need to draw dragons. Incidentally , this makes you an awesome aunty! . #art #artwork

Mechanically characterizing cells!! #art #artwork #sciart

An Imaging Specialist Position is open at the CALM microscopy core at UCSF Mission Bay! Please share this post! and apply if you are interested! https://aprecruit.ucsf.edu/JPF05024

Live drawings from last week's commute! #art #artwork #livesketch

The RO(U)Ss are coming! Fluorescence and lasers create an ROS problem, but I bet there are some ROSs in the fire swamp as well…

Still doing live sketches of people when I’m not sure what else to draw. Here are some people from the last month!

It got better! Revisiting FRAP ( Fluorescence recovery after photobleaching) used to study the dynamic movement of proteins by bleaching a small portion of fluorescent proteins and observing how fast they recover!

You have to image to infinity and beyond!

Putting that light back where it is supposed to be! It’s always fun to do deconvolution with people that haven’t seen it before! #art #artwork #sciart

When people remember to cite the core facility and give details on the microscope they used! #art #artwork #sciart

If I were a Cell in a TIRF system, I would definitely dip one of my philopodia in and out of the evanescenct field. #art #artwork #sciart

Exemplar of seriousness! … well there was an attempt… . #art #artwork #sciart

Oh so serious! … well there was an attempt… . #art #artwork #sciart

Operation emergency contractile vacuole success! If only all epigenetic changes worked so well and could be planned… . #art #artwork #sciart