1/12 🛣️ Mapping nitrogen metabolism has lagged carbon due to substrate diversity. In @natmetabolism.nature.com, we introduce a platform to do this mapping at scale and identify mechanisms by which differentiation state dictates pyrimidine synthesis. 🧵👇 🔗 www.nature.com/articles/s42...

ONLINE NOW in @natmetabolism.nature.com: McBrayer Lab & first-author @milansavani.com have discovered cell maturity determines pyrimidine synthesis pathway preference using their new nitrogen metabolism profiling platform, organoid model. More ⬇️ cri.utsw.edu/cell-maturit... #relentlessdiscovery 🧪

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth https://www.biorxiv.org/content/10.1101/2025.09.15.676412v1

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice https://www.biorxiv.org/content/10.1101/2025.07.23.666448v1

Today's #MondayMotivation is courtesy CRI's McBrayer Lab: Congrats @milansavani.com for successfully defending your dissertation! Dr. Savani's family and lab mates joined to celebrate 🎉 Next steps: publishing his #research & finishing his M.D. #relentlessdiscovery 🧪