bioRxiv Cancer Bio
@biorxiv-cancer.bsky.social
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Two-photon volumetric study of cleared, invasive ductal carcinoma breast tissue samples and associated axillary lymph nodes
https://www.biorxiv.org/content/10.1101/2025.11.07.687157v1
about 2 hours ago
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TriLeukeVax: A CD80/IL-15/IL-15Rα Expressing Autologous AML Cell Vaccine Elicits Robust Anti-Leukemic Cytolytic Activity
https://www.biorxiv.org/content/10.1101/2025.11.07.687000v1
about 2 hours ago
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Efficacy of Minnelide in a Next-Generation Dual-Recombinase Regulated Genetically Engineered Mouse Model of CIC::DUX4 Sarcoma
https://www.biorxiv.org/content/10.1101/2025.11.06.687065v1
1 day ago
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A Sequential Triple-Drug Strategy for Selective Targeting of p53-Mutant Cancers
https://www.biorxiv.org/content/10.1101/2025.11.06.687028v1
2 days ago
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2
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Hybrid Ornstein-Uhlenbeck-Branching Modeling of Pediatric Leukemia Evolution: A Computational Extension and Cohort-Level Application
https://www.biorxiv.org/content/10.1101/2025.11.07.686044v1
2 days ago
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Integrative single-cell and spatial mapping of oxidative stress response uncovers GCLC+ mesenchymal tumor cell state linked with favorable outcomes in triple negative breast cancer
https://www.biorxiv.org/content/10.1101/2025.11.06.686771v1
2 days ago
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2
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Taxonomy-free fecal microbiome profiles enable robust prediction of immunotherapy response and toxicity in melanoma
https://www.biorxiv.org/content/10.1101/2025.11.06.686285v1
2 days ago
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BAP1 modulates endoplasmic reticulum stress signaling and balances liver homeostasis and malignant progression
https://www.biorxiv.org/content/10.1101/2025.11.06.686752v1
2 days ago
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Explainable Machine Learning for Preoperative Relapse Prediction in Molecularly Stratified Endometrial Cancer: A Single-Center Finnish Cohort Study
https://www.biorxiv.org/content/10.1101/2025.11.06.686680v1
2 days ago
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High-Concordance Validation of Droplet Digital PCR and Next-Generation Sequencing for EGFR Mutation Detection Across Diverse Biospecimens in a Large-scale NSCLC Cohort Study
https://www.biorxiv.org/content/10.1101/2025.11.05.686693v1
2 days ago
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MEX3A control of mitochondrial fitness is essential for ovarian clear cell carcinoma tumorigenesis and liver metastasis
https://www.biorxiv.org/content/10.1101/2025.11.05.686880v1
2 days ago
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Machine Learning-Driven Discovery of Synergistic Protein Interactions Identifies ATL3 as a Putative Biomarker for Cancer Drug Response
https://www.biorxiv.org/content/10.1101/2025.11.05.686871v1
3 days ago
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Ambient mass spectrometry imaging enables spatial metabolomics of optimal cutting temperature compound (OCT)-embedded tumors
https://www.biorxiv.org/content/10.1101/2025.11.05.686836v1
3 days ago
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Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death
https://www.biorxiv.org/content/10.1101/2025.11.05.686813v1
3 days ago
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Integrated Proteomic and Epigenomic Analysis Reveals IGF2 as a Vulnerability in PRC2-Deficient Malignant Peripheral Nerve Sheath Tumors
https://www.biorxiv.org/content/10.1101/2025.11.05.686792v1
3 days ago
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1
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NOVEL SMALL-MOLECULE INHIBITORS OF THE PROTEIN KINASE DYRK: POTENTIAL THERAPEUTIC CANDIDATES IN CANCER
https://www.biorxiv.org/content/10.1101/2025.11.05.686653v1
3 days ago
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A Minimal Plasma Proteome-Based Biomarker Panel for Accurate Prostate Cancer Diagnosis
https://www.biorxiv.org/content/10.1101/2025.11.05.686712v1
3 days ago
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Synthesis and Preclinical Development of a Novel 68Ga/89Zr-Labelled α{nu}β6-Integrin Targeting Trimer
https://www.biorxiv.org/content/10.1101/2025.11.05.686720v1
3 days ago
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Spatial Conformation of Pancreatic Cancer Is Associated with Disease Recurrence after Curative-Intent Total Neoadjuvant Therapy
https://www.biorxiv.org/content/10.1101/2025.11.03.686383v1
3 days ago
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Phospho 394Y LCK flow-cytometry readout predicts dasatinib sensitivity in paediatric T-cell acute lymphoblastic leukaemia
https://www.biorxiv.org/content/10.1101/2025.11.04.684929v1
3 days ago
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Cascade-Targeting Nanoparticles for Reversing Chemoresistance in Osteosarcoma
https://www.biorxiv.org/content/10.1101/2025.11.04.686585v1
3 days ago
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A switch from histone methyltransferase-EZH2 to demethylase KDM6A activity marks reinitiation of proliferation of drug treated colorectal cancer cells
https://www.biorxiv.org/content/10.1101/2025.11.04.686665v1
3 days ago
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Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants
https://www.biorxiv.org/content/10.1101/2025.11.04.686643v1
3 days ago
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Cell-line specific role of Cathepsin B in triple-negative breast cancer growth, invasion and response to chemotherapy
https://www.biorxiv.org/content/10.1101/2025.11.04.686610v1
4 days ago
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Differential Wnt/β-Catenin Signaling via TCF7L2/LEF1 Binding Specificity Shapes Cellular and Tumor Phenotypes
https://www.biorxiv.org/content/10.1101/2025.11.04.686471v1
4 days ago
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Longitudinal investigation of prostate tumor spheroid proliferation with dynamic line-field optical coherence tomography
https://www.biorxiv.org/content/10.1101/2025.11.04.686594v1
4 days ago
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Identification and validation of liquid biopsy-based methylation biomarkers: a germ cell tumor subtype-specific study
https://www.biorxiv.org/content/10.1101/2025.11.04.686501v1
4 days ago
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Immune infiltration is linked to increased transcriptional activity and distinct metabolic profiles in chordomas
https://www.biorxiv.org/content/10.1101/2025.11.04.686078v1
4 days ago
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1
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Therapeutic Eradication of Cancer-associated Fibroblasts Inhibits in vivo progression of Pancreatic Cancer
https://www.biorxiv.org/content/10.1101/2025.11.04.686484v1
5 days ago
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TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma
https://www.biorxiv.org/content/10.1101/2025.11.03.686399v1
5 days ago
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Integrative transcriptomic analysis identifies miR-642a-5p as a regulator of POFUT1 expression in colon cancer
https://www.biorxiv.org/content/10.1101/2025.11.03.686298v1
5 days ago
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Mineralocorticoid and glucocorticoid receptor interaction drives TGFB1-induced triple-negative breast cancer progression to metastasis
https://www.biorxiv.org/content/10.1101/2025.11.03.686330v1
5 days ago
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1
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Agent-based simulations of lung tumour evolution suggest that ongoing cell competition drives realistic clonal expansions
https://www.biorxiv.org/content/10.1101/2025.11.04.686578v1
5 days ago
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1
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Design and Development of DNA Damage Chemical Inducers of Proximity (DD-CIP) for Targeted Cancer Therapy
https://www.biorxiv.org/content/10.1101/2025.11.03.686423v1
5 days ago
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AXL mediates mast cell survival and resistance to tyrosine kinase inhibitors in mastocytosis
https://www.biorxiv.org/content/10.1101/2025.11.03.686205v1
5 days ago
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1
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Cytoskeleton remodeling caused by keratin dysregulation triggers tumor aggressiveness via promoting genomic instability and cellular adaption
https://www.biorxiv.org/content/10.1101/2025.11.03.686269v1
5 days ago
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Suppression of Glucosylceramide Synthase Reverses Drug Resistance in Cancer Cells Harbor Homozygous p53 Mutants
https://www.biorxiv.org/content/10.1101/2025.11.02.686136v1
6 days ago
0
1
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IMMUNIA: A Multi-LLM Reasoning Agent for Immunoregulatory Surfaceome Discovery
https://www.biorxiv.org/content/10.1101/2025.11.02.686138v1
6 days ago
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The transcriptional regulatory circuit as a driver and therapeutic target in CML blast crisis
https://www.biorxiv.org/content/10.1101/2025.11.02.686161v1
6 days ago
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Lamin B1 Safeguards the B Cell Genome and Shapes Lymphoma Outcome
https://www.biorxiv.org/content/10.1101/2025.11.03.686246v1
6 days ago
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Longitudinal Imaging of the Premalignant Tumor Microenvironment Reveals Transient Myeloid States Predictive of Tumor Fate
https://www.biorxiv.org/content/10.1101/2025.11.02.686127v1
6 days ago
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Comprehensive Atlas of Cancer-Type-Specific Molecular Features from Comparative Analysis of TCGA Data
https://www.biorxiv.org/content/10.1101/2025.10.26.684620v1
6 days ago
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CD38hiCD19dim cells in lymph nodes predict favorable prognosis in patients with stage III melanoma receiving adjuvant PD-1-blockade
https://www.biorxiv.org/content/10.1101/2025.11.03.685725v1
6 days ago
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A functional map of CDK-drug interactions at single amino acid resolution
https://www.biorxiv.org/content/10.1101/2025.11.02.685764v1
6 days ago
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Macrophage-secreted Pyrimidine Metabolites Confer Chemotherapy Resistance in Acute Myeloid Leukemia (AML)
https://www.biorxiv.org/content/10.1101/2025.11.01.686055v1
6 days ago
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A novel 18F-labeled brain penetrant PET ligand for imaging poly(ADP-ribose) polymerase-1
https://www.biorxiv.org/content/10.1101/2025.11.01.686021v1
6 days ago
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Single recipient cell tracking of tellurium-labeled extracellular vesicle proteomes (TeLEV) identifies EV-driven immunomodulation
https://www.biorxiv.org/content/10.1101/2025.11.01.685872v1
6 days ago
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Contribution of Mesenchymal-like and Epithelial Cellular Subsets to Chemotherapy Resistance in Triple-Negative Breast Cancer
https://www.biorxiv.org/content/10.1101/2025.11.01.685128v1
6 days ago
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Scaffold-free 3D-Cell Co-Culture Model System for the Study of Metastatic Cancer Cell Behavior in the Brain TME
https://www.biorxiv.org/content/10.1101/2025.10.31.685975v1
6 days ago
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Empirical Evaluation of Single-Cell Foundation Models for Predicting Cancer Outcomes
https://www.biorxiv.org/content/10.1101/2025.10.31.685892v1
6 days ago
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