X-CODE: a dual RNA barcoding system for multi-platform clonal tracking and spatial phenotyping https://www.biorxiv.org/content/10.64898/2026.02.10.705126v1

CDK9 pharmacological inhibition with PRT2527 has antitumor activity in marginal zone lymphoma models and can improve the effects of BTK, PI3K, and BCL2 inhibitors https://www.biorxiv.org/content/10.64898/2026.02.10.705084v1

Integrated Cytotoxic and Safety Mechanism of IMV-M (TM), a MUC16 x DR5 Bispecific Antibody https://www.biorxiv.org/content/10.64898/2026.02.10.705083v1

MAPK ERK5 Is a Novel Regulator of MHC-I in Cancer Cells https://www.biorxiv.org/content/10.64898/2026.02.10.705047v1

Diet-induced macrophage-driven inflammation fuels pancreatic plasticity and aggressiveness https://www.biorxiv.org/content/10.64898/2026.02.10.703309v1

Oxidative Stress-Induced Immunogenic Cell Death Enhances Whole-Cell Vaccine Efficacy in a Syngeneic Pancreatic Cancer Model https://www.biorxiv.org/content/10.64898/2026.02.09.704828v1

NRF2 co-opts the SWI/SNF complex to drive liver cell plasticity https://www.biorxiv.org/content/10.64898/2026.02.09.704724v1

Network-based integration of gene expression and DNA methylation identifies prognostic biomarkers for early-stage pancreatic cancer https://www.biorxiv.org/content/10.64898/2026.02.09.704985v1

CAR-T Targeting of Mutant Calreticulin Establishes a Potentially Curative Stem Cell-Directed Therapy for Myeloproliferative Neoplasms https://www.biorxiv.org/content/10.64898/2026.02.09.704856v1

Nerve Injury-Induced Protein 2 Is Necessary for the Lysosome Membrane Integrity and Protects Cells from Ferroptosis https://www.biorxiv.org/content/10.64898/2026.02.09.704867v1

Obesity and Tumor Development Reprogram the Proteome and Metabolic Effects of Adipose- and Tumor-Derived Extracellular Vesicles https://www.biorxiv.org/content/10.64898/2026.02.08.704727v1

RaDRI: A computational model for radiosensitisation by DNA double strand break repair inhibitors https://www.biorxiv.org/content/10.64898/2026.02.08.704735v1

Lineage-restricted dependency on an oncofetal SNHG29-IGF2BP1 RNA axis in acute megakaryoblastic leukemia https://www.biorxiv.org/content/10.64898/2026.02.07.704501v1

Targeting one-carbon metabolic vulnerabilities of metastasis with therapeutic potential https://www.biorxiv.org/content/10.64898/2026.02.07.704548v1

Membrane-coupled conformational switching of VISTA regulates immune checkpoint signaling via CC' loop accessibility https://www.biorxiv.org/content/10.64898/2026.02.07.704574v1

Systemic hypoxia suppresses solid tumor growth https://www.biorxiv.org/content/10.64898/2026.02.09.704975v1

Targeting Myc activates a tissue-specific tumour resolution programme https://www.biorxiv.org/content/10.64898/2026.02.06.704498v1

The DNA damaging properties of the experimental G-quadruplex (G4) drug QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC https://www.biorxiv.org/content/10.64898/2026.02.06.704351v1

Evaluation and application of chemical decrosslinking in the context of histopathological spatial proteomics https://www.biorxiv.org/content/10.64898/2026.02.06.704439v1

Morphospatial profiling of cancer-associated fibroblasts reveals architectural subtypes of pancreatic ductal adenocarcinoma https://www.biorxiv.org/content/10.64898/2026.02.06.704414v1

Ex vivo drug testing in metastatic biopsies reveals patient-specific vulnerabilities to cancer targeting and immune activating drugs https://www.biorxiv.org/content/10.64898/2026.02.06.704037v1

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinomaprecursors https://www.biorxiv.org/content/10.64898/2026.02.06.704093v1

In situ vaccine effect of radiotherapy is associated with intratumoural ERV reactivation and RNA virus sensing https://www.biorxiv.org/content/10.64898/2026.02.06.704391v1

A genome-wide CRISPR screen reveals cancer-specific regulators of hyaluronan binding and cellular invasion https://www.biorxiv.org/content/10.64898/2026.02.06.704476v1

BAP1 Loss Induces Senescence and Enhances the Response to Radiation Therapy and Senolytics https://www.biorxiv.org/content/10.64898/2026.02.05.704104v1

A macrophage-derived noncanonical WNT niche drives immune exclusion in pancreatic cancer https://www.biorxiv.org/content/10.64898/2026.02.05.704114v1

Pharmacological induction of mitochondrial stress counteracts therapy resistance in glioblastoma stem-like cells https://www.biorxiv.org/content/10.64898/2026.02.05.704021v1

The ITCC-P4 PDX platform of pediatric cancers for preclinical testing https://www.biorxiv.org/content/10.64898/2026.02.04.703023v1

Proteomics and single-cell transcriptomics identify LRP1 as a diagnostic biomarker for atypical fibroxanthoma and pleomorphic dermal sarcoma. https://www.biorxiv.org/content/10.64898/2026.02.04.703892v1

Effects of Spin4 ablation in aging mice: body composition, bone density, and malignancy prevalence https://www.biorxiv.org/content/10.64898/2026.02.05.704000v1

Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination https://www.biorxiv.org/content/10.64898/2026.02.05.702638v1

Recurrent Escape from Osimertinib-Induced Senescence Promotes Genomic Instability Associated with Therapeutic Resistance https://www.biorxiv.org/content/10.64898/2026.02.07.704600v1

Accurate somatic variant detection from formalin fixed, paraffin embedded tissue (FFPE) derived WES and WGS by DeepOmicsFFPE-PLUS, a sequence context-based transformer https://www.biorxiv.org/content/10.64898/2026.02.05.702695v1

Engineered probiotics for tumor-targeted combination chemoimmunotherapy https://www.biorxiv.org/content/10.64898/2026.02.04.703875v1

In situ programming of intratumoural stem cell-like memory CD8+ T cells enables durable antitumour immunity in immunosuppressive tumours https://www.biorxiv.org/content/10.64898/2026.02.06.700840v1

Schlafen 11 (SLFN11) overexpression and nucleolar localization in response to bortezomib in multiple myeloma https://www.biorxiv.org/content/10.64898/2026.02.06.704297v1

MERTK inhibition cooperates with immunomodulatory cyclophosphamide to induce CXCL9⁺ monocyte-macrophage programming and durable anti-tumor immunity in triple negative breast cancer https://www.biorxiv.org/content/10.64898/2026.02.04.703648v1

Photodynamic priming with Vitamin D and ALA-based PDT induces intratumoral immune cell recruitment and signaling pathway activation in murine cutaneous squamous cell carcinoma https://www.biorxiv.org/content/10.64898/2026.02.04.703788v1

Aurora kinase A is a synthetic lethal target in FANCA-deficient cancers https://www.biorxiv.org/content/10.64898/2026.02.04.703705v1

Data-Driven Mechanistic Computational Modeling of Human Cell Cycle Phases for Defining Inhibitor Combinations in Silico https://www.biorxiv.org/content/10.64898/2026.02.04.703693v1

Discrete Transcriptional States Define Biphasic Immune Response and Dynamic CMS Transitions in Colorectal Cancer https://www.biorxiv.org/content/10.64898/2026.02.03.703597v1

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof-of-Concept Synthesis of Landscape-Level Regulation https://www.biorxiv.org/content/10.64898/2026.02.03.703596v1

Next generation protein-corrole bio-assemblies provide effective tumoricidal treatment in a metastatic triple-negative breast cancer model https://www.biorxiv.org/content/10.64898/2026.02.03.703292v1

LIMK Inhibition and Metformin Block Mitochondrial Transfer Overcoming Macrophage Driven Therapy Resistance in Acute Myeloid Leukaemia https://www.biorxiv.org/content/10.64898/2026.02.03.702377v1

JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast Cancer https://www.biorxiv.org/content/10.64898/2026.02.03.703506v1

Cellular mechanisms of acquired drug resistance against regorafenib in colon cancer cells. https://www.biorxiv.org/content/10.64898/2026.02.03.703469v1

Alkoxylated fisetin derivatives - the new potential drugs against head and neck cancers https://www.biorxiv.org/content/10.64898/2026.02.03.703451v1

Mutational signatures in cancer genomes alter protein sequence motifs in cellular signaling networks https://www.biorxiv.org/content/10.64898/2026.02.03.703397v1

TERT drives liver tumorigenesis beyond telomere elongation https://www.biorxiv.org/content/10.64898/2026.02.02.703327v1

Integrative Multi-Omics Analysis Identifies a Functional Enhancer Driving Tumorigenesis in Head and Neck Squamous Cell Carcinoma https://www.biorxiv.org/content/10.64898/2026.02.03.703438v1