bioRxiv Cancer Bio
@biorxiv-cancer.bsky.social
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Cell-type Specific Alteration of Dicer1 Accelerates Tumor Progression in Mouse Models of KRAS-driven Lung Adenocarcinoma
https://www.biorxiv.org/content/10.64898/2026.05.29.728740v1
about 4 hours ago
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Palmitoylated importin α recruits PKCε to the plasma membrane to drive breast cancer cell motility
https://www.biorxiv.org/content/10.64898/2026.05.28.728515v1
about 10 hours ago
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Tumour architecture shapes polarized epithelial states that predict survival in high-grade serous ovarian cancer
https://www.biorxiv.org/content/10.64898/2026.05.27.727977v1
about 15 hours ago
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Matched pancreatic cancer liver metastatic model system reveals cancer cell-dependent organotropism and site-specific tumor microenvironment reflective of human disease
https://www.biorxiv.org/content/10.64898/2026.05.27.728281v1
1 day ago
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Auranofin potentiates cisplatin response through context-dependent NOTCH-associated signaling states in endometrial cancer
https://www.biorxiv.org/content/10.64898/2026.05.27.728338v1
1 day ago
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Functional Characterization of Myeloid Neoplasm-associated DDX41 Variants Reveals Pathogenic Interaction with Acquired Hotspot Mutation
https://www.biorxiv.org/content/10.64898/2026.05.27.727893v1
1 day ago
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Differential Transcript Usage Reveals Isoform-Level Remodeling of Tumor Biology in Clear Cell Renal Cell Carcinoma
https://www.biorxiv.org/content/10.64898/2026.05.27.728189v1
1 day ago
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Candida albicans reprograms host inosine metabolism to drive immunosuppressive macrophage polarization and gastric cancer carcinogenesis
https://www.biorxiv.org/content/10.64898/2026.05.27.728170v1
2 days ago
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Differential Induction of Cancer Cell Death by Root, Leaf, and Flower Extracts derived from Kalanchoe pinnata
https://www.biorxiv.org/content/10.64898/2026.05.27.728130v1
2 days ago
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Design-space requirements for abundance-amplified drug-like targeting of RHSVV/PAb240-like p53 exposure in TP53-mutant cancer
https://www.biorxiv.org/content/10.64898/2026.05.27.728141v1
2 days ago
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TIAR-dependent coordination of alternative splicing and lipid peroxidation is required for CML cell resistance to imatinib in the bone marrow stroma
https://www.biorxiv.org/content/10.64898/2026.05.29.728710v1
3 days ago
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A functional genomics screen identifies novel drivers of FR900359 resistance in uveal melanoma cells
https://www.biorxiv.org/content/10.64898/2026.05.29.728309v1
3 days ago
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Conformational drugging pockets at the surface of c-MYC proto-oncongenes
https://www.biorxiv.org/content/10.64898/2026.05.28.728384v1
3 days ago
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Fibroblast-derived thrombospondin-1 shapes macrophage polarization in advanced human co-culture models
https://www.biorxiv.org/content/10.64898/2026.05.28.728363v1
3 days ago
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Epigenetic silencing of MAFG is a potential prognosis biomarker in lung adenocarcinomas
https://www.biorxiv.org/content/10.64898/2026.05.26.724922v1
3 days ago
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Spatial Neuroimmune Crosstalk Driving Perineural Invasion in Head and Neck Squamous Cell Carcinoma
https://www.biorxiv.org/content/10.64898/2026.05.26.727931v1
3 days ago
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Targeting CD73-A2aR-Mediated Adenosine Signaling at the Tumor-Immune Interface Overcomes Radioresistance
https://www.biorxiv.org/content/10.64898/2026.05.26.727904v1
3 days ago
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A Novel Drug Candidate that Selectively Targets the Critical Androgen Receptor-ELK1 Growth Axis in Advanced and Drug-Resistant Prostate Cancer
https://www.biorxiv.org/content/10.64898/2026.05.26.727474v1
3 days ago
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Cutaneous inflammation accelerates the premalignant expansion of melanocytes bearing oncogenic mutations
https://www.biorxiv.org/content/10.64898/2026.05.27.728115v1
3 days ago
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Integrative prioritization of clinically and biologically relevant long noncoding RNAs across gastrointestinal cancers
https://www.biorxiv.org/content/10.64898/2026.05.26.728026v1
3 days ago
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Protein arginine-methyltransferase 1 (PRMT1): a new pharmacological target in cholangiocarcinoma
https://www.biorxiv.org/content/10.64898/2026.05.29.728163v1
3 days ago
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Evaluation of Alcohol, Tobacco, and HPVs Synergistic regulation of Head and Neck Squamous Cell Carcinoma Treatment Response to PD-L1 Checkpoint Inhibitor Treatment
https://www.biorxiv.org/content/10.64898/2026.05.26.728017v1
3 days ago
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Globular domain histone H3R131C mutation remodels chromatin accessibility to promote oncogenic transcriptional programs
https://www.biorxiv.org/content/10.64898/2026.05.27.728333v1
3 days ago
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Dual-acting Estrogen Receptor Modulator-Histone Lysine Demethylase Inhibitors
https://www.biorxiv.org/content/10.64898/2026.05.26.728021v1
3 days ago
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Multiomic dissection of HR+/HER2- invasive lobular breast carcinoma reveals mobilized yet dysfunctional anti-tumor immunity shaped by tumor-stroma crosstalk and impaired antigen presentation
https://www.biorxiv.org/content/10.64898/2026.05.28.728418v1
3 days ago
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Leveraging epigenetic vulnerabilities of the stem cell-related HOX-signature in glioblastoma
https://www.biorxiv.org/content/10.64898/2026.05.26.727851v1
4 days ago
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IL-1-activated cancer-associated fibroblasts promote STAT1-driven transcriptional reprogramming of pancreatic tumour cells
https://www.biorxiv.org/content/10.64898/2026.05.26.726819v1
4 days ago
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PCSK9 Exhibits Novel Nuclear Localization in LSEC and Its Targeting with Bioinspired Nanoparticles Reduces Colorectal Liver Metastasis
https://www.biorxiv.org/content/10.64898/2026.05.26.727886v1
4 days ago
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Circadian misalignment underlies immune escape in breast cancer
https://www.biorxiv.org/content/10.64898/2026.05.26.726543v1
4 days ago
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Rapid reduction in global chromatin loop size after acute STAG2 reconstitution in human cancer cells
https://www.biorxiv.org/content/10.64898/2026.05.26.727913v1
4 days ago
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High Drug-Loading Rucaparib-FdUMP Nanocarriers for Colorectal Cancer Combination Therapy
https://www.biorxiv.org/content/10.64898/2026.05.25.727099v1
4 days ago
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Benchmarking five extracellular vesicle proteomics workflows, including low-input Exo-insert and Exo-SP3, for deep mass spectrometry profiling
https://www.biorxiv.org/content/10.64898/2026.05.28.728409v1
4 days ago
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FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia
https://www.biorxiv.org/content/10.64898/2026.05.25.727748v1
4 days ago
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Transient ATR inhibition following ionizing radiation enhances immune-mediated antitumor response and survival
https://www.biorxiv.org/content/10.64898/2026.05.25.727700v1
4 days ago
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Distinct and shared synergistic effects of high-fat and high-iron diets on liver tumorigenesis and transcriptomic remodeling in mice
https://www.biorxiv.org/content/10.64898/2026.05.24.727480v1
5 days ago
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Discovery 4.0: An Escape-Aware Computational Platform for Resistance-Proofed Chimeric Antigen Receptor Design
https://www.biorxiv.org/content/10.64898/2026.05.24.727464v1
5 days ago
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The DNAJB1-PRKACA Oncogenic Fusion Drives Stepwise Biliary and Pancreatic Carcinogenesis from Intraductal Precursor Lesions
https://www.biorxiv.org/content/10.64898/2026.05.23.727425v1
5 days ago
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TUMOR HETEROGENEITY AND STEMNESS CAN BE SHAPED BY MECHANO-STRUCTURAL PARAMETERS IN OSTEOSARCOMA
https://www.biorxiv.org/content/10.64898/2026.05.22.727299v1
5 days ago
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Cross-Cancer Profiling of Cadherin-1 Reveals Context-Dependent Epithelial-Mesenchymal Transition Decoupling, Immune Heterogeneity, and Prognostic Variability in Epithelial Cancers
https://www.biorxiv.org/content/10.64898/2026.05.22.727338v1
5 days ago
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dbGIST: An LLM-Assisted Multi-Omics Resource for Target Exploration and Cross-Dataset Validation in Gastrointestinal Stromal Tumors
https://www.biorxiv.org/content/10.64898/2026.05.22.727292v1
6 days ago
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A Rare Nestin-Expressing Granule Cell Precursor Subpopulation Underlies SHH Medulloblastoma Formation
https://www.biorxiv.org/content/10.64898/2026.05.26.727818v1
6 days ago
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CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma
https://www.biorxiv.org/content/10.64898/2026.05.22.727290v1
6 days ago
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An oncolytic adenovirus armed with anticancer prodrug-activating enzyme offers enhanced tumor killing and antitumor immunity.
https://www.biorxiv.org/content/10.64898/2026.05.26.727470v1
6 days ago
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GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions
https://www.biorxiv.org/content/10.64898/2026.05.22.724502v1
6 days ago
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Occurrence of Biased mTOR Signaling in Hepatocellular Carcinoma
https://www.biorxiv.org/content/10.64898/2026.05.22.727188v1
6 days ago
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Long-chain Polyunsaturated Fatty Acids Mitigate In Vitro Skeletal Muscle Wasting Induced by Colorectal Carcinoma Cells via a 15-LOX-dependent Pathway
https://www.biorxiv.org/content/10.64898/2026.05.22.726995v1
6 days ago
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Sexually dimorphic effects of mutations in ccRCC driver genes in renal proximal tubule cells
https://www.biorxiv.org/content/10.64898/2026.05.22.727114v1
6 days ago
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Oncofetal RNA-binding proteins of IGF2BP family suppress IRF-3 and NF-kB dependent transcription downstream of cytosolic RNA sensors
https://www.biorxiv.org/content/10.64898/2026.05.22.726816v1
6 days ago
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Transcriptomic profile of MTUS1-low TNBC reveals candidate therapeutic strategies.
https://www.biorxiv.org/content/10.64898/2026.05.22.727134v1
6 days ago
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Spatially-Resolved Multiomic Atlas of Leiomyosarcoma Identifies Two Clinically Relevant Epigenetically-Driven Cell States
https://www.biorxiv.org/content/10.64898/2026.05.22.726988v1
6 days ago
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