Cell-type Specific Alteration of Dicer1 Accelerates Tumor Progression in Mouse Models of KRAS-driven Lung Adenocarcinoma https://www.biorxiv.org/content/10.64898/2026.05.29.728740v1

Palmitoylated importin α recruits PKCε to the plasma membrane to drive breast cancer cell motility https://www.biorxiv.org/content/10.64898/2026.05.28.728515v1

Tumour architecture shapes polarized epithelial states that predict survival in high-grade serous ovarian cancer https://www.biorxiv.org/content/10.64898/2026.05.27.727977v1

Matched pancreatic cancer liver metastatic model system reveals cancer cell-dependent organotropism and site-specific tumor microenvironment reflective of human disease https://www.biorxiv.org/content/10.64898/2026.05.27.728281v1

Auranofin potentiates cisplatin response through context-dependent NOTCH-associated signaling states in endometrial cancer https://www.biorxiv.org/content/10.64898/2026.05.27.728338v1

Functional Characterization of Myeloid Neoplasm-associated DDX41 Variants Reveals Pathogenic Interaction with Acquired Hotspot Mutation https://www.biorxiv.org/content/10.64898/2026.05.27.727893v1

Differential Transcript Usage Reveals Isoform-Level Remodeling of Tumor Biology in Clear Cell Renal Cell Carcinoma https://www.biorxiv.org/content/10.64898/2026.05.27.728189v1

Candida albicans reprograms host inosine metabolism to drive immunosuppressive macrophage polarization and gastric cancer carcinogenesis https://www.biorxiv.org/content/10.64898/2026.05.27.728170v1

Differential Induction of Cancer Cell Death by Root, Leaf, and Flower Extracts derived from Kalanchoe pinnata https://www.biorxiv.org/content/10.64898/2026.05.27.728130v1

Design-space requirements for abundance-amplified drug-like targeting of RHSVV/PAb240-like p53 exposure in TP53-mutant cancer https://www.biorxiv.org/content/10.64898/2026.05.27.728141v1

TIAR-dependent coordination of alternative splicing and lipid peroxidation is required for CML cell resistance to imatinib in the bone marrow stroma https://www.biorxiv.org/content/10.64898/2026.05.29.728710v1

A functional genomics screen identifies novel drivers of FR900359 resistance in uveal melanoma cells https://www.biorxiv.org/content/10.64898/2026.05.29.728309v1

Conformational drugging pockets at the surface of c-MYC proto-oncongenes https://www.biorxiv.org/content/10.64898/2026.05.28.728384v1

Fibroblast-derived thrombospondin-1 shapes macrophage polarization in advanced human co-culture models https://www.biorxiv.org/content/10.64898/2026.05.28.728363v1

Epigenetic silencing of MAFG is a potential prognosis biomarker in lung adenocarcinomas https://www.biorxiv.org/content/10.64898/2026.05.26.724922v1

Spatial Neuroimmune Crosstalk Driving Perineural Invasion in Head and Neck Squamous Cell Carcinoma https://www.biorxiv.org/content/10.64898/2026.05.26.727931v1

Targeting CD73-A2aR-Mediated Adenosine Signaling at the Tumor-Immune Interface Overcomes Radioresistance https://www.biorxiv.org/content/10.64898/2026.05.26.727904v1

A Novel Drug Candidate that Selectively Targets the Critical Androgen Receptor-ELK1 Growth Axis in Advanced and Drug-Resistant Prostate Cancer https://www.biorxiv.org/content/10.64898/2026.05.26.727474v1

Cutaneous inflammation accelerates the premalignant expansion of melanocytes bearing oncogenic mutations https://www.biorxiv.org/content/10.64898/2026.05.27.728115v1

Integrative prioritization of clinically and biologically relevant long noncoding RNAs across gastrointestinal cancers https://www.biorxiv.org/content/10.64898/2026.05.26.728026v1

Protein arginine-methyltransferase 1 (PRMT1): a new pharmacological target in cholangiocarcinoma https://www.biorxiv.org/content/10.64898/2026.05.29.728163v1

Evaluation of Alcohol, Tobacco, and HPVs Synergistic regulation of Head and Neck Squamous Cell Carcinoma Treatment Response to PD-L1 Checkpoint Inhibitor Treatment https://www.biorxiv.org/content/10.64898/2026.05.26.728017v1

Globular domain histone H3R131C mutation remodels chromatin accessibility to promote oncogenic transcriptional programs https://www.biorxiv.org/content/10.64898/2026.05.27.728333v1

Dual-acting Estrogen Receptor Modulator-Histone Lysine Demethylase Inhibitors https://www.biorxiv.org/content/10.64898/2026.05.26.728021v1

Multiomic dissection of HR+/HER2- invasive lobular breast carcinoma reveals mobilized yet dysfunctional anti-tumor immunity shaped by tumor-stroma crosstalk and impaired antigen presentation https://www.biorxiv.org/content/10.64898/2026.05.28.728418v1

Leveraging epigenetic vulnerabilities of the stem cell-related HOX-signature in glioblastoma https://www.biorxiv.org/content/10.64898/2026.05.26.727851v1

IL-1-activated cancer-associated fibroblasts promote STAT1-driven transcriptional reprogramming of pancreatic tumour cells https://www.biorxiv.org/content/10.64898/2026.05.26.726819v1

PCSK9 Exhibits Novel Nuclear Localization in LSEC and Its Targeting with Bioinspired Nanoparticles Reduces Colorectal Liver Metastasis https://www.biorxiv.org/content/10.64898/2026.05.26.727886v1

Circadian misalignment underlies immune escape in breast cancer https://www.biorxiv.org/content/10.64898/2026.05.26.726543v1

Rapid reduction in global chromatin loop size after acute STAG2 reconstitution in human cancer cells https://www.biorxiv.org/content/10.64898/2026.05.26.727913v1

High Drug-Loading Rucaparib-FdUMP Nanocarriers for Colorectal Cancer Combination Therapy https://www.biorxiv.org/content/10.64898/2026.05.25.727099v1

Benchmarking five extracellular vesicle proteomics workflows, including low-input Exo-insert and Exo-SP3, for deep mass spectrometry profiling https://www.biorxiv.org/content/10.64898/2026.05.28.728409v1

FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia https://www.biorxiv.org/content/10.64898/2026.05.25.727748v1

Transient ATR inhibition following ionizing radiation enhances immune-mediated antitumor response and survival https://www.biorxiv.org/content/10.64898/2026.05.25.727700v1

Distinct and shared synergistic effects of high-fat and high-iron diets on liver tumorigenesis and transcriptomic remodeling in mice https://www.biorxiv.org/content/10.64898/2026.05.24.727480v1

Discovery 4.0: An Escape-Aware Computational Platform for Resistance-Proofed Chimeric Antigen Receptor Design https://www.biorxiv.org/content/10.64898/2026.05.24.727464v1

The DNAJB1-PRKACA Oncogenic Fusion Drives Stepwise Biliary and Pancreatic Carcinogenesis from Intraductal Precursor Lesions https://www.biorxiv.org/content/10.64898/2026.05.23.727425v1

TUMOR HETEROGENEITY AND STEMNESS CAN BE SHAPED BY MECHANO-STRUCTURAL PARAMETERS IN OSTEOSARCOMA https://www.biorxiv.org/content/10.64898/2026.05.22.727299v1

Cross-Cancer Profiling of Cadherin-1 Reveals Context-Dependent Epithelial-Mesenchymal Transition Decoupling, Immune Heterogeneity, and Prognostic Variability in Epithelial Cancers https://www.biorxiv.org/content/10.64898/2026.05.22.727338v1

dbGIST: An LLM-Assisted Multi-Omics Resource for Target Exploration and Cross-Dataset Validation in Gastrointestinal Stromal Tumors https://www.biorxiv.org/content/10.64898/2026.05.22.727292v1

A Rare Nestin-Expressing Granule Cell Precursor Subpopulation Underlies SHH Medulloblastoma Formation https://www.biorxiv.org/content/10.64898/2026.05.26.727818v1

CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma https://www.biorxiv.org/content/10.64898/2026.05.22.727290v1

An oncolytic adenovirus armed with anticancer prodrug-activating enzyme offers enhanced tumor killing and antitumor immunity. https://www.biorxiv.org/content/10.64898/2026.05.26.727470v1

GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions https://www.biorxiv.org/content/10.64898/2026.05.22.724502v1

Occurrence of Biased mTOR Signaling in Hepatocellular Carcinoma https://www.biorxiv.org/content/10.64898/2026.05.22.727188v1

Long-chain Polyunsaturated Fatty Acids Mitigate In Vitro Skeletal Muscle Wasting Induced by Colorectal Carcinoma Cells via a 15-LOX-dependent Pathway https://www.biorxiv.org/content/10.64898/2026.05.22.726995v1

Sexually dimorphic effects of mutations in ccRCC driver genes in renal proximal tubule cells https://www.biorxiv.org/content/10.64898/2026.05.22.727114v1

Oncofetal RNA-binding proteins of IGF2BP family suppress IRF-3 and NF-kB dependent transcription downstream of cytosolic RNA sensors https://www.biorxiv.org/content/10.64898/2026.05.22.726816v1

Transcriptomic profile of MTUS1-low TNBC reveals candidate therapeutic strategies. https://www.biorxiv.org/content/10.64898/2026.05.22.727134v1

Spatially-Resolved Multiomic Atlas of Leiomyosarcoma Identifies Two Clinically Relevant Epigenetically-Driven Cell States https://www.biorxiv.org/content/10.64898/2026.05.22.726988v1