Spontaneous cancer regression as inversion of spontaneous cancer progression: Malignant melanoma remission as a case-study towards clinical applicability https://www.biorxiv.org/content/10.64898/2025.12.27.696663v1

Phenotypic Plasticity and Competition Shape Therapy Sequencing in HER2+/HER2 Breast Cancer: A Mathematical Framework https://www.biorxiv.org/content/10.64898/2025.12.27.696676v1

Pan-cancer tumor classification by a holistic tumor microenvironment atlas https://www.biorxiv.org/content/10.64898/2025.12.27.696641v1

A gastric microbial chromatin remodeler drives gastric cancer progression and immune evasion by reprogramming the host epigenome https://www.biorxiv.org/content/10.64898/2025.12.26.696631v1

STEAP4+ neutrophils: a promising circulating biomarker for lung metastasis https://www.biorxiv.org/content/10.64898/2025.12.27.696660v1

Aging increases ovarian cancer growth, metastasis and immunosuppression that can be alleviated by inhibiting hedgehog signaling https://www.biorxiv.org/content/10.64898/2025.12.23.695206v1

On-target mutations confer resistance to WRN helicase inhibitors in Microsatellite Unstable Cancer Cells. https://www.biorxiv.org/content/10.64898/2025.12.23.695783v1

Decoupling Efficacy from Toxicity: Engineering Spatial Control in AAV-Mediated Gene Therapy https://www.biorxiv.org/content/10.64898/2025.12.26.696588v1

A Mechanistic Model of Oncolytic Virus-CAR T Therapy Identifies Memory-Dependent Control of Solid Tumors https://www.biorxiv.org/content/10.64898/2025.12.24.696207v1

Incomplete developmental silencing of cancer-testis antigen BORIS in humanized mouse model promotes cancer susceptibility https://www.biorxiv.org/content/10.64898/2025.12.24.696438v1

FMAGJ: Fluorescence Microscopic Astrocyte Gap Junction Images Dataset https://www.biorxiv.org/content/10.64898/2025.12.25.695956v1

A MYC Family Switch: L-MYC Drives and Maintains Neuroendocrine Lineage Programs in Prostate Cancer https://www.biorxiv.org/content/10.64898/2025.12.25.696507v1

Bivalent CD47 Immunotoxin for Targeted Therapy of Lung Cancer https://www.biorxiv.org/content/10.64898/2025.12.24.696420v1

Real-time monitoring of pediatric high-grade glioma invasion using organotypic brain cultures reveals a developmentally dependent sensitivity https://www.biorxiv.org/content/10.64898/2025.12.24.696338v1

Orphan Non-Coding RNAs Drive Tumorigenesis and Enable Pre-Diagnostic Detection in HPV-Negative Head and Neck Cancer https://www.biorxiv.org/content/10.64898/2025.12.20.695703v1

An Atlas of Extrachromosomal DNA Structures Illuminates Its Evolution and Biogenesis in Cancer https://www.biorxiv.org/content/10.64898/2025.12.24.696443v1

Adaptive regulation of dNTP homeostasis confers osimertinib resistance in EGFR mutant non-small cell lung carcinoma https://www.biorxiv.org/content/10.64898/2025.12.24.696437v1

Sensitizing the Cell Killing Effects of Doxorubicin as a Possible Therapeutic Strategy Against Glioblastoma Multiforme https://www.biorxiv.org/content/10.64898/2025.12.23.696220v1

A comprehensive bulk and single-cell transcriptional atlas of pediatric leukemias https://www.biorxiv.org/content/10.64898/2025.12.23.696262v1

Mdig shapes 3D chromatin architecture of immune checkpoint genes and limits metastasis of triple negative breast cancer cells https://www.biorxiv.org/content/10.64898/2025.12.23.696275v1

Increased MALAT1 Levels in Thyroid Cancer are Linked to Metabolic Reprogramming and Lymphatic Infiltration in Chilean population https://www.biorxiv.org/content/10.64898/2025.12.23.696116v1

MR-SP2: A Microreactor for Upward Pressure-Catapulting Laser Microdissection for Mass Spectrometry-Based Spatial Proteomics at Single-Cell Resolution https://www.biorxiv.org/content/10.64898/2025.12.23.695936v1

Integrative multi-omics reveals PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma. https://www.biorxiv.org/content/10.64898/2025.12.23.696151v1

Targeting Aberrant FGFR Signaling with Infigratinib Enhances the Efficacy of BTK/PI3K Inhibitors and Bendamustine in Lymphoma Cells https://www.biorxiv.org/content/10.64898/2025.12.23.695986v1

Gene functions determine stochastic or adaptive futile transcription in cancers through deregulated start site deployments https://www.biorxiv.org/content/10.64898/2025.12.22.696121v1

PDK1 and YAP1/TEAD signaling drive acquired KRAS inhibitor resistance in KRAS-mutant non-small cell lung cancer. https://www.biorxiv.org/content/10.64898/2025.12.22.696060v1

PTEN-loss confers dependence on the guanylate synthesis enzyme IMPDH in T-cell acute lymphoblastic leukemia https://www.biorxiv.org/content/10.64898/2025.12.22.696045v1

Iron-Associated Mesenchymal Plasticity and Tumor Invasion in Glioblastoma https://www.biorxiv.org/content/10.64898/2025.12.22.695920v1

Cigarette Smoke and E-Cigarette Aerosol Extracts Induce Myelopoiesis and Suppress Inflammatory Cytokine Production https://www.biorxiv.org/content/10.64898/2025.12.21.693601v1

Revealing the Drivers Underlying Distinct Evolutionary Trajectories in Lung Adenocarcinoma https://www.biorxiv.org/content/10.64898/2025.12.19.695410v1

A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL https://www.biorxiv.org/content/10.64898/2025.12.21.694897v1

Redefining the topology of the human bone marrow using augmented spatial transcriptomic analysis https://www.biorxiv.org/content/10.64898/2025.12.22.694222v1

Engineering cathepsin S selective chemical probes and antibody-drug conjugates through substrate profiling with unnatural amino acids https://www.biorxiv.org/content/10.64898/2025.12.20.695745v1

Identification of senescence-associated drivers of tumour growth and progression using a novel microarray platform https://www.biorxiv.org/content/10.64898/2025.12.20.695739v1

The ratio of RUNX1-ETO oncoprotein to normal RUNX1 expression determines the balance between endothelial reprogramming and hematopoietic cell growth https://www.biorxiv.org/content/10.64898/2025.12.19.695648v1

Deciphering a common code: Unitary gene profile factor enabling Spontaneous Tumor Regression https://www.biorxiv.org/content/10.64898/2025.12.20.695084v1

Breast cancer through the lens of whole transcriptome spatial imaging https://www.biorxiv.org/content/10.64898/2025.12.19.695622v1

Leukemic fusion genes repress viral gene expression and expel adenovirus from persistently infected human B lymphocytes but evidence of the virus lingers behind https://www.biorxiv.org/content/10.64898/2025.12.19.695471v1

PTEN deficiency linked to chromosome 10q loss leads to aggressive NF2mutant meningioma biology https://www.biorxiv.org/content/10.64898/2025.12.21.695820v1

Collagen remodeling promotes a GPCR-mediated mechanosensory immune checkpoint in ADGRG1+ CD8+ T cells and serves as a spatial biomarker of response to immunotherapy https://www.biorxiv.org/content/10.64898/2025.12.19.695209v1

Refined cellular activity expression signatures provide a targeted framework to quantify phenotypic intra-tumor heterogeneity in single-cell data https://www.biorxiv.org/content/10.64898/2025.12.19.695441v1

The Nicotinamide Salvage Pathway is a Metabolic Vulnerability of High-Risk MDS Stem Cells https://www.biorxiv.org/content/10.64898/2025.12.19.695528v1

Hallmarks of adaptive immunity in a metastatic clear cell renal cell carcinoma (ccRCC) long-term elite survivor https://www.biorxiv.org/content/10.64898/2025.12.19.695541v1

HSP90α and KLK6 Co-Regulate Stress-Induced Prostate Cancer Cell Motility https://www.biorxiv.org/content/10.64898/2025.12.19.695259v1

ShapeUpLMD: An Automated Pipeline for Spatially Optimized Laser Microdissection in Multi-omic Tissue Profiling https://www.biorxiv.org/content/10.64898/2025.12.19.695433v1

Robust scoring system to evaluate animal well-being in murine orthotopic breast cancer and ovarian cancer models https://www.biorxiv.org/content/10.64898/2025.12.18.695300v1

Assessment of Imaging Mass Cytometry (IMC) as a Tool to Characterize Circulating Tumor Cells (CTCs) in Preclinical Mouse Models https://www.biorxiv.org/content/10.64898/2025.12.18.695262v1

Single-cell RNA-sequencing of cerebral spinal fluid identifies circulating tumour cells in children with brain cancer https://www.biorxiv.org/content/10.64898/2025.12.18.694991v1

Abnormal bioelectricity during unperturbed cancer growth. Part-I: electrical biopotentials, surface charge density, volumetric charge density, phase-field and Turing approach. https://www.biorxiv.org/content/10.64898/2025.12.19.695347v1

Coevolution of neoplastic and non-neoplastic reactive astrocyte states converges on mesenchymal-like and injury-response programs during murine glioblastoma progression and post-radiotherapy recurrence https://www.biorxiv.org/content/10.64898/2025.12.18.695184v1