Two-photon volumetric study of cleared, invasive ductal carcinoma breast tissue samples and associated axillary lymph nodes https://www.biorxiv.org/content/10.1101/2025.11.07.687157v1

TriLeukeVax: A CD80/IL-15/IL-15Rα Expressing Autologous AML Cell Vaccine Elicits Robust Anti-Leukemic Cytolytic Activity https://www.biorxiv.org/content/10.1101/2025.11.07.687000v1

Efficacy of Minnelide in a Next-Generation Dual-Recombinase Regulated Genetically Engineered Mouse Model of CIC::DUX4 Sarcoma https://www.biorxiv.org/content/10.1101/2025.11.06.687065v1

A Sequential Triple-Drug Strategy for Selective Targeting of p53-Mutant Cancers https://www.biorxiv.org/content/10.1101/2025.11.06.687028v1

Hybrid Ornstein-Uhlenbeck-Branching Modeling of Pediatric Leukemia Evolution: A Computational Extension and Cohort-Level Application https://www.biorxiv.org/content/10.1101/2025.11.07.686044v1

Integrative single-cell and spatial mapping of oxidative stress response uncovers GCLC+ mesenchymal tumor cell state linked with favorable outcomes in triple negative breast cancer https://www.biorxiv.org/content/10.1101/2025.11.06.686771v1

Taxonomy-free fecal microbiome profiles enable robust prediction of immunotherapy response and toxicity in melanoma https://www.biorxiv.org/content/10.1101/2025.11.06.686285v1

BAP1 modulates endoplasmic reticulum stress signaling and balances liver homeostasis and malignant progression https://www.biorxiv.org/content/10.1101/2025.11.06.686752v1

Explainable Machine Learning for Preoperative Relapse Prediction in Molecularly Stratified Endometrial Cancer: A Single-Center Finnish Cohort Study https://www.biorxiv.org/content/10.1101/2025.11.06.686680v1

High-Concordance Validation of Droplet Digital PCR and Next-Generation Sequencing for EGFR Mutation Detection Across Diverse Biospecimens in a Large-scale NSCLC Cohort Study https://www.biorxiv.org/content/10.1101/2025.11.05.686693v1

MEX3A control of mitochondrial fitness is essential for ovarian clear cell carcinoma tumorigenesis and liver metastasis https://www.biorxiv.org/content/10.1101/2025.11.05.686880v1

Machine Learning-Driven Discovery of Synergistic Protein Interactions Identifies ATL3 as a Putative Biomarker for Cancer Drug Response https://www.biorxiv.org/content/10.1101/2025.11.05.686871v1

Ambient mass spectrometry imaging enables spatial metabolomics of optimal cutting temperature compound (OCT)-embedded tumors https://www.biorxiv.org/content/10.1101/2025.11.05.686836v1

Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death https://www.biorxiv.org/content/10.1101/2025.11.05.686813v1

Integrated Proteomic and Epigenomic Analysis Reveals IGF2 as a Vulnerability in PRC2-Deficient Malignant Peripheral Nerve Sheath Tumors https://www.biorxiv.org/content/10.1101/2025.11.05.686792v1

NOVEL SMALL-MOLECULE INHIBITORS OF THE PROTEIN KINASE DYRK: POTENTIAL THERAPEUTIC CANDIDATES IN CANCER https://www.biorxiv.org/content/10.1101/2025.11.05.686653v1

A Minimal Plasma Proteome-Based Biomarker Panel for Accurate Prostate Cancer Diagnosis https://www.biorxiv.org/content/10.1101/2025.11.05.686712v1

Synthesis and Preclinical Development of a Novel 68Ga/89Zr-Labelled α{nu}β6-Integrin Targeting Trimer https://www.biorxiv.org/content/10.1101/2025.11.05.686720v1

Spatial Conformation of Pancreatic Cancer Is Associated with Disease Recurrence after Curative-Intent Total Neoadjuvant Therapy https://www.biorxiv.org/content/10.1101/2025.11.03.686383v1

Phospho 394Y LCK flow-cytometry readout predicts dasatinib sensitivity in paediatric T-cell acute lymphoblastic leukaemia https://www.biorxiv.org/content/10.1101/2025.11.04.684929v1

Cascade-Targeting Nanoparticles for Reversing Chemoresistance in Osteosarcoma https://www.biorxiv.org/content/10.1101/2025.11.04.686585v1

A switch from histone methyltransferase-EZH2 to demethylase KDM6A activity marks reinitiation of proliferation of drug treated colorectal cancer cells https://www.biorxiv.org/content/10.1101/2025.11.04.686665v1

Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants https://www.biorxiv.org/content/10.1101/2025.11.04.686643v1

Cell-line specific role of Cathepsin B in triple-negative breast cancer growth, invasion and response to chemotherapy https://www.biorxiv.org/content/10.1101/2025.11.04.686610v1

Differential Wnt/β-Catenin Signaling via TCF7L2/LEF1 Binding Specificity Shapes Cellular and Tumor Phenotypes https://www.biorxiv.org/content/10.1101/2025.11.04.686471v1

Longitudinal investigation of prostate tumor spheroid proliferation with dynamic line-field optical coherence tomography https://www.biorxiv.org/content/10.1101/2025.11.04.686594v1

Identification and validation of liquid biopsy-based methylation biomarkers: a germ cell tumor subtype-specific study https://www.biorxiv.org/content/10.1101/2025.11.04.686501v1

Immune infiltration is linked to increased transcriptional activity and distinct metabolic profiles in chordomas https://www.biorxiv.org/content/10.1101/2025.11.04.686078v1

Therapeutic Eradication of Cancer-associated Fibroblasts Inhibits in vivo progression of Pancreatic Cancer https://www.biorxiv.org/content/10.1101/2025.11.04.686484v1

TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma https://www.biorxiv.org/content/10.1101/2025.11.03.686399v1

Integrative transcriptomic analysis identifies miR-642a-5p as a regulator of POFUT1 expression in colon cancer https://www.biorxiv.org/content/10.1101/2025.11.03.686298v1

Mineralocorticoid and glucocorticoid receptor interaction drives TGFB1-induced triple-negative breast cancer progression to metastasis https://www.biorxiv.org/content/10.1101/2025.11.03.686330v1

Agent-based simulations of lung tumour evolution suggest that ongoing cell competition drives realistic clonal expansions https://www.biorxiv.org/content/10.1101/2025.11.04.686578v1

Design and Development of DNA Damage Chemical Inducers of Proximity (DD-CIP) for Targeted Cancer Therapy https://www.biorxiv.org/content/10.1101/2025.11.03.686423v1

AXL mediates mast cell survival and resistance to tyrosine kinase inhibitors in mastocytosis https://www.biorxiv.org/content/10.1101/2025.11.03.686205v1

Cytoskeleton remodeling caused by keratin dysregulation triggers tumor aggressiveness via promoting genomic instability and cellular adaption https://www.biorxiv.org/content/10.1101/2025.11.03.686269v1

Suppression of Glucosylceramide Synthase Reverses Drug Resistance in Cancer Cells Harbor Homozygous p53 Mutants https://www.biorxiv.org/content/10.1101/2025.11.02.686136v1

IMMUNIA: A Multi-LLM Reasoning Agent for Immunoregulatory Surfaceome Discovery https://www.biorxiv.org/content/10.1101/2025.11.02.686138v1

The transcriptional regulatory circuit as a driver and therapeutic target in CML blast crisis https://www.biorxiv.org/content/10.1101/2025.11.02.686161v1

Lamin B1 Safeguards the B Cell Genome and Shapes Lymphoma Outcome https://www.biorxiv.org/content/10.1101/2025.11.03.686246v1

Longitudinal Imaging of the Premalignant Tumor Microenvironment Reveals Transient Myeloid States Predictive of Tumor Fate https://www.biorxiv.org/content/10.1101/2025.11.02.686127v1

Comprehensive Atlas of Cancer-Type-Specific Molecular Features from Comparative Analysis of TCGA Data https://www.biorxiv.org/content/10.1101/2025.10.26.684620v1

CD38hiCD19dim cells in lymph nodes predict favorable prognosis in patients with stage III melanoma receiving adjuvant PD-1-blockade https://www.biorxiv.org/content/10.1101/2025.11.03.685725v1

A functional map of CDK-drug interactions at single amino acid resolution https://www.biorxiv.org/content/10.1101/2025.11.02.685764v1

Macrophage-secreted Pyrimidine Metabolites Confer Chemotherapy Resistance in Acute Myeloid Leukemia (AML) https://www.biorxiv.org/content/10.1101/2025.11.01.686055v1

A novel 18F-labeled brain penetrant PET ligand for imaging poly(ADP-ribose) polymerase-1 https://www.biorxiv.org/content/10.1101/2025.11.01.686021v1

Single recipient cell tracking of tellurium-labeled extracellular vesicle proteomes (TeLEV) identifies EV-driven immunomodulation https://www.biorxiv.org/content/10.1101/2025.11.01.685872v1

Contribution of Mesenchymal-like and Epithelial Cellular Subsets to Chemotherapy Resistance in Triple-Negative Breast Cancer https://www.biorxiv.org/content/10.1101/2025.11.01.685128v1

Scaffold-free 3D-Cell Co-Culture Model System for the Study of Metastatic Cancer Cell Behavior in the Brain TME https://www.biorxiv.org/content/10.1101/2025.10.31.685975v1

Empirical Evaluation of Single-Cell Foundation Models for Predicting Cancer Outcomes https://www.biorxiv.org/content/10.1101/2025.10.31.685892v1