Tunneling nanotubes propagate a BMP-dependent preneoplastic state. https://www.biorxiv.org/content/10.1101/2025.11.11.687852v1

Repurposing Nelfinavir: AIM2 Inflammasome-Driven Anti-tumor Effects in Glioblastoma https://www.biorxiv.org/content/10.1101/2025.11.11.687819v1

Menin inhibition impairs metastatic colonization of Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.11.10.687648v1

Decoding the Circulating Proteome: Matrix and Immune Context Markers Shape Early Multi-Cancer Detection https://www.biorxiv.org/content/10.1101/2025.11.10.687473v1

eIF2B Selectively Anchors and Activates Mutant KRAS https://www.biorxiv.org/content/10.1101/2025.11.10.686860v1

Systems analysis uncovers early temozolomide responses and peptide antigens in glioblastoma https://www.biorxiv.org/content/10.1101/2025.11.10.687735v1

NEUROG3 Is Sufficient to Drive Neuroendocrine Differentiation in Prostate Cancer Cells. https://www.biorxiv.org/content/10.1101/2025.11.10.687642v1

Automation of high-throughput workflow for arrayed CRISPR activation library screening https://www.biorxiv.org/content/10.1101/2025.11.10.687722v1

Cross-Species Transcriptomic Integration Reveals a Conserved, MIRO1-Mediated Macrophage-to-T Cell Signaling Axis Driving Immunosuppression in Glioma https://www.biorxiv.org/content/10.1101/2025.11.10.686781v1

Targeting the IRE1α/XBP1 Signaling Axis Suppresses Rhabdomyosarcoma Growth and Promotes Myogenic Differentiation https://www.biorxiv.org/content/10.1101/2025.11.10.687677v1

Oncogenic mutations convert MET from a pro-apoptotic tumor suppressor to an oncogenic driver https://www.biorxiv.org/content/10.1101/2025.11.10.687614v1

Colibactin-producing E. coli promote carcinogenesis of gastroesophageal adenocarcinoma and simultaneously induce autophagy and differentiation https://www.biorxiv.org/content/10.1101/2025.11.10.687579v1

Deep single-cell immune and signaling profiles predict long term therapy response in chronic myeloid leukemia within hours https://www.biorxiv.org/content/10.1101/2025.11.10.687542v1

TEIP: A Compact, Open-Source Framework for Predicting Tumor Epitope Immunogenicity in Glioblastoma Cancer Using Deep Learning and Multi-Modal Biological Features https://www.biorxiv.org/content/10.1101/2025.11.09.687510v1

Inhibition of bladder cancer cell proliferation by 2-deoxy-D-glucose: A potential therapeutic approach https://www.biorxiv.org/content/10.1101/2025.11.09.687468v1

Combinatorial inhibition of LSD1 and Menin induces therapeutic differentiation in AML https://www.biorxiv.org/content/10.1101/2025.11.09.687496v1

Generation of an in vitro 3D multicellular culture model of ovarian high-grade serous carcinoma https://www.biorxiv.org/content/10.1101/2025.11.07.686515v1

Annotation-Free Prediction of Cancer Cells and Glands and Spatial Analysis of Immune Cells. https://www.biorxiv.org/content/10.1101/2025.11.09.687528v1

BUB1B MITOTIC KINASE DRIVES THERAPY RESISTANT PROSTATE CANCER https://www.biorxiv.org/content/10.1101/2025.11.09.687448v1

Alternate VEGFA isoform expression in fibrosarcoma leads to plasticity in cellular migration and differences in sensitivity to inhibition with anti-VEGFA antibodies https://www.biorxiv.org/content/10.1101/2025.11.09.687017v1

Comparison of volumetric dynamic optical coherence tomography with biological methods for evaluation of radiation effects in prostate tumor spheroids https://www.biorxiv.org/content/10.1101/2025.11.08.687368v1

Star-Motifs: Revealing Single-Cell Spatiotypes from Routine Histology Using Star-Convex Neighborhoods https://www.biorxiv.org/content/10.1101/2025.11.07.687248v1

The impact of patient biology on racial disparities in breast cancer outcome https://www.biorxiv.org/content/10.1101/2025.11.05.685148v1

Two-photon volumetric study of cleared, invasive ductal carcinoma breast tissue samples and associated axillary lymph nodes https://www.biorxiv.org/content/10.1101/2025.11.07.687157v1

TriLeukeVax: A CD80/IL-15/IL-15Rα Expressing Autologous AML Cell Vaccine Elicits Robust Anti-Leukemic Cytolytic Activity https://www.biorxiv.org/content/10.1101/2025.11.07.687000v1

Efficacy of Minnelide in a Next-Generation Dual-Recombinase Regulated Genetically Engineered Mouse Model of CIC::DUX4 Sarcoma https://www.biorxiv.org/content/10.1101/2025.11.06.687065v1

A Sequential Triple-Drug Strategy for Selective Targeting of p53-Mutant Cancers https://www.biorxiv.org/content/10.1101/2025.11.06.687028v1

Hybrid Ornstein-Uhlenbeck-Branching Modeling of Pediatric Leukemia Evolution: A Computational Extension and Cohort-Level Application https://www.biorxiv.org/content/10.1101/2025.11.07.686044v1

Integrative single-cell and spatial mapping of oxidative stress response uncovers GCLC+ mesenchymal tumor cell state linked with favorable outcomes in triple negative breast cancer https://www.biorxiv.org/content/10.1101/2025.11.06.686771v1

Taxonomy-free fecal microbiome profiles enable robust prediction of immunotherapy response and toxicity in melanoma https://www.biorxiv.org/content/10.1101/2025.11.06.686285v1

BAP1 modulates endoplasmic reticulum stress signaling and balances liver homeostasis and malignant progression https://www.biorxiv.org/content/10.1101/2025.11.06.686752v1

Explainable Machine Learning for Preoperative Relapse Prediction in Molecularly Stratified Endometrial Cancer: A Single-Center Finnish Cohort Study https://www.biorxiv.org/content/10.1101/2025.11.06.686680v1

High-Concordance Validation of Droplet Digital PCR and Next-Generation Sequencing for EGFR Mutation Detection Across Diverse Biospecimens in a Large-scale NSCLC Cohort Study https://www.biorxiv.org/content/10.1101/2025.11.05.686693v1

MEX3A control of mitochondrial fitness is essential for ovarian clear cell carcinoma tumorigenesis and liver metastasis https://www.biorxiv.org/content/10.1101/2025.11.05.686880v1

Machine Learning-Driven Discovery of Synergistic Protein Interactions Identifies ATL3 as a Putative Biomarker for Cancer Drug Response https://www.biorxiv.org/content/10.1101/2025.11.05.686871v1

Ambient mass spectrometry imaging enables spatial metabolomics of optimal cutting temperature compound (OCT)-embedded tumors https://www.biorxiv.org/content/10.1101/2025.11.05.686836v1

Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death https://www.biorxiv.org/content/10.1101/2025.11.05.686813v1

Integrated Proteomic and Epigenomic Analysis Reveals IGF2 as a Vulnerability in PRC2-Deficient Malignant Peripheral Nerve Sheath Tumors https://www.biorxiv.org/content/10.1101/2025.11.05.686792v1

NOVEL SMALL-MOLECULE INHIBITORS OF THE PROTEIN KINASE DYRK: POTENTIAL THERAPEUTIC CANDIDATES IN CANCER https://www.biorxiv.org/content/10.1101/2025.11.05.686653v1

A Minimal Plasma Proteome-Based Biomarker Panel for Accurate Prostate Cancer Diagnosis https://www.biorxiv.org/content/10.1101/2025.11.05.686712v1

Synthesis and Preclinical Development of a Novel 68Ga/89Zr-Labelled α{nu}β6-Integrin Targeting Trimer https://www.biorxiv.org/content/10.1101/2025.11.05.686720v1

Spatial Conformation of Pancreatic Cancer Is Associated with Disease Recurrence after Curative-Intent Total Neoadjuvant Therapy https://www.biorxiv.org/content/10.1101/2025.11.03.686383v1

Phospho 394Y LCK flow-cytometry readout predicts dasatinib sensitivity in paediatric T-cell acute lymphoblastic leukaemia https://www.biorxiv.org/content/10.1101/2025.11.04.684929v1

Cascade-Targeting Nanoparticles for Reversing Chemoresistance in Osteosarcoma https://www.biorxiv.org/content/10.1101/2025.11.04.686585v1

A switch from histone methyltransferase-EZH2 to demethylase KDM6A activity marks reinitiation of proliferation of drug treated colorectal cancer cells https://www.biorxiv.org/content/10.1101/2025.11.04.686665v1

Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants https://www.biorxiv.org/content/10.1101/2025.11.04.686643v1

Cell-line specific role of Cathepsin B in triple-negative breast cancer growth, invasion and response to chemotherapy https://www.biorxiv.org/content/10.1101/2025.11.04.686610v1

Differential Wnt/β-Catenin Signaling via TCF7L2/LEF1 Binding Specificity Shapes Cellular and Tumor Phenotypes https://www.biorxiv.org/content/10.1101/2025.11.04.686471v1

Longitudinal investigation of prostate tumor spheroid proliferation with dynamic line-field optical coherence tomography https://www.biorxiv.org/content/10.1101/2025.11.04.686594v1

Identification and validation of liquid biopsy-based methylation biomarkers: a germ cell tumor subtype-specific study https://www.biorxiv.org/content/10.1101/2025.11.04.686501v1