Sacituzumab Govitecan as an Effective Strategy for Sensitizing Chemoresistant HNSCC Cells to Senolytic Intervention https://www.biorxiv.org/content/10.64898/2026.04.13.718209v1

Progastrin activates colonic fibroblasts and induces a paracrine pro-migratory program in colorectal cancer cells https://www.biorxiv.org/content/10.64898/2026.04.12.718027v1

Tetrahydrocurcumin Suppresses Bladder Carcinogenesis via Reprogramming O-GlcNAcylation-Phosphorylation Crosstalk https://www.biorxiv.org/content/10.64898/2026.04.12.717994v1

Cell fusion reprograms tumor cells and promotes RUNX1-mediated invasion and dissemination in colorectal cancer https://www.biorxiv.org/content/10.64898/2026.04.12.717781v1

Comprehensive profiling reveals Sialyl-Tn upregulation and prognostic value in prostate cancer https://www.biorxiv.org/content/10.64898/2026.04.14.718221v1

Midkine Dependency Defines a Therapeutically Actionable Vulnerability in Medulloblastoma https://www.biorxiv.org/content/10.64898/2026.04.11.717918v1

Protein import-driven mitochondrial hyperactivation dictates angiogenesis independently of HIF-1α https://www.biorxiv.org/content/10.64898/2026.04.11.717880v1

Single-crypt evolutionary trajectories of human sporadic and hereditary colorectal precancers https://www.biorxiv.org/content/10.64898/2026.04.13.718204v1

The UV potentiated mutational signature of clinical stage G-quadruplex binder CX5461. https://www.biorxiv.org/content/10.64898/2026.04.10.717570v1

Increased expression of a subset of genes within reduced copy number regions across multiple cancer types https://www.biorxiv.org/content/10.64898/2026.04.10.717791v1

DNA Demethylation is Dispensable for Venetoclax-HMA Synergy in Acute Myeloid Leukaemia https://www.biorxiv.org/content/10.64898/2026.04.13.718134v1

A PSMA-Targeted Up-conversion Nanoplatform for Deep-Tissue dual activation Photodynamic and Sonodynamic Therapy of Castration Resistant Prostate Cancer. https://www.biorxiv.org/content/10.64898/2026.04.10.717693v1

FUT8 mediated core fucosylation modulates growth related functions of LRP1 in liver cancer cells https://www.biorxiv.org/content/10.64898/2026.04.09.717446v1

Single-cell lineage tracing maps clonal and transcriptional dynamics in melanoma metastasis https://www.biorxiv.org/content/10.64898/2026.04.09.717571v1

SIRT5 acts in the tumor microenvironment via endothelial cell metabolism to support breast cancer growth https://www.biorxiv.org/content/10.64898/2026.04.09.717584v1

Targeting Noncanonical TEAD Axis to Overcome DNA Repair-Driven Chemoresistance https://www.biorxiv.org/content/10.64898/2026.04.09.717588v1

PRMT5 as an Epigenetic Target for Group 3 (MYC-driven) Medulloblastoma https://www.biorxiv.org/content/10.64898/2026.04.09.717536v1

ARID1A deficiency unleashes centromeric RNA transcription to drive chromosomal instability and boosts PKMYT1 inhibitor efficacy via RNA sensing https://www.biorxiv.org/content/10.64898/2026.04.11.717899v1

Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions https://www.biorxiv.org/content/10.64898/2026.04.09.717047v1

Organoids serve as viable in vitro model for functional precision medicine for mesonephric-like adenocarcinoma of the ovary https://www.biorxiv.org/content/10.64898/2026.04.09.717457v1

DNA methylation signatures of mismatch repair-deficient colorectal cancer https://www.biorxiv.org/content/10.64898/2026.04.09.717165v1

CA19-9 promotes liver metastasis of pancreatic cancer through E-selectin mediated extravasation https://www.biorxiv.org/content/10.64898/2026.04.08.717301v1

Brief report on the development of patient-derived lung cancer organoids with keratinizing squamous cell carcinoma morphology https://www.biorxiv.org/content/10.64898/2026.04.08.717166v1

FOXA1 preserves cell polarity and restrains lysosome biogenesis in non-small cell lung adenocarcinoma https://www.biorxiv.org/content/10.64898/2026.04.09.717383v1

Long-read analysis of tetrameric microsatellites with vmwhere supports GGAA repeat length-dependent chromatin state association in Ewing sarcoma https://www.biorxiv.org/content/10.64898/2026.04.08.717017v1

Multi-region biopsies and patient-derived neurosphere cultures reveal spatial divergence in glioblastoma. https://www.biorxiv.org/content/10.64898/2026.04.07.717044v1

Enteroviral epitope mimicry enables NK cell-mediated targeting of ASPH in hepatocellular carcinoma https://www.biorxiv.org/content/10.64898/2026.04.07.717032v1

Intratumoural oncolytic HSV-1 reshapes the local and systemic immune landscape through CD8+ T cell reprogramming https://www.biorxiv.org/content/10.64898/2026.04.07.716986v1

Transcriptomic, Genomic, and Clinical Characterization of Morphological Classes in Localized and Metastatic Pancreatic Cancer https://www.biorxiv.org/content/10.64898/2026.04.07.717011v1

Extracellular signalling regulates gastrin transcription through site-specific phosphorylation and nuclear redistribution of Menin https://www.biorxiv.org/content/10.64898/2026.04.07.717082v1

KRAS inhibition is an effective therapy for appendiceal adenocarcinoma https://www.biorxiv.org/content/10.64898/2026.04.07.717107v1

The HPV E7 oncoprotein promotes LIM and SH3 Domain Protein 1 (LASP1) transcription via the Rb/E2F1 signalling pathway in HPV-positive cervical cancer cells https://www.biorxiv.org/content/10.64898/2026.04.08.717142v1

Sympathoadrenal Lineage Plasticity Drives Intratumoral Heterogeneity in Paraganglioma, Neuroblastoma and Composite Tumors Following KIF1Bb-NF1 Loss https://www.biorxiv.org/content/10.64898/2026.04.07.715303v1

Marker-based CRISPR screens identify POU2F1 as a regulator of DLL3 and neuroendocrine identity in small cell lung cancer https://www.biorxiv.org/content/10.64898/2026.04.08.717069v1

H3 dopaminylation and CaMKII modulate diffuse midline glioma response to CDK9 inhibition https://www.biorxiv.org/content/10.64898/2026.04.07.714507v1

Nanoparticle-delivered resiquimod induces brain tumor regression in medulloblastoma and diffuse midline glioma models by interrupting paracrine growth support and activating myeloid immune signaling and phagocytosis https://www.biorxiv.org/content/10.64898/2026.04.07.714454v1

Myeloma and therapy reshape the bone marrow niche to durably constrain immune reconstitution and vaccine responsiveness https://www.biorxiv.org/content/10.64898/2026.04.08.717307v1

Low-intensity vibration (LIV) cellular mechanotherapy reprograms tumor transcriptomes to suppress cancer-promoting inflammation https://www.biorxiv.org/content/10.64898/2026.04.07.716739v1

Inhibition of miR-1307 Reverses Resistance to Cisplatin in Drug-Resistant Oral Squamous Cell Carcinoma https://www.biorxiv.org/content/10.64898/2026.04.06.709730v1

Expression profile of CASSIOPEIA patients refines prognostic value of MRD negativity in multiple myeloma https://www.biorxiv.org/content/10.64898/2026.04.07.716874v1

RAS-mutant clones drive extramedullary acute myeloid leukemia https://www.biorxiv.org/content/10.64898/2026.04.07.715220v1

A SIRT5-induced metabolic switch underlies chemoresistance and ATR checkpoint dependence in triple-negative breast cancer https://www.biorxiv.org/content/10.64898/2026.04.07.716852v1

REST-AKT-SOX2 axis controls neuronal lineage state and Midkine-mediated communication in SHH-medulloblastoma. https://www.biorxiv.org/content/10.64898/2026.04.06.716597v1

RUNX1-deficiency drives immune-active ER+ mammary tumorigenesis through activation of interferon signaling https://www.biorxiv.org/content/10.64898/2026.04.06.716728v1

Comprehensive drug efficacy data for mucinous ovarian carcinoma using a novel and extensive biobank of patient-derived organoid models https://www.biorxiv.org/content/10.64898/2026.04.06.716848v1

Integrating Fas-mediated apoptosis with IFNγ signaling to drive tumor regression in mRNA cancer therapeutics https://www.biorxiv.org/content/10.64898/2026.04.06.716844v1

A Hierarchical Spatial Graph Neural Network Resolves Immunogenic and Tolerogenic Tertiary Lymphoid Structures in Renal Cell Carcinoma https://www.biorxiv.org/content/10.64898/2026.04.07.717084v1

lncRNA MANCR isoforms selectively mediate multiple levels of epigenomic and P53-responsive transcriptional control in triple negative breast cancer https://www.biorxiv.org/content/10.64898/2026.04.06.716674v1

Antitrypsin surrogate, Alphataxin, increases tumor CD4+ T cells and suppresses murine colon cancer https://www.biorxiv.org/content/10.64898/2026.04.06.716656v1

Early Epigenetic and Metabolic Responses to the Adipocyte Secretome Reveal Stress-Adaptive States in Triple-Negative Breast Cancer https://www.biorxiv.org/content/10.64898/2026.04.06.716548v1