Yale Neuroscience
@yaleneuro.bsky.social
📤 575
📥 100
📝 124
Yale Department of Neuroscience
https://medicine.yale.edu/neuroscience/
pinned post!
Hi Bluesky 🦋, this is the Department of Neuroscience at Yale! 🎉 We’re a vibrant community of researchers👨🔬, students 👩🎓, faculty 👩🏫, and staff dedicated to deciphering the mysteries of the nervous system 🧠 Follow us for updates on cutting-edge
#neuroscience
research, events, and opportunities!
about 1 year ago
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4
In a new study,
@yale.edu
researchers led by
@evgoldfarb.bsky.social
found that the stress hormone cortisol increased coordination🤝between memory and emotion brain networks 🧠, leading to enhanced memory for emotional experiences! 🙂🙁 Read More 👇
news.yale.edu/2025/12/10/s...
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Stress hormones can alter brain networks — and strengthen emotional memories
A new Yale study investigates how cortisol, a stress-related hormone, helps the brain build emotional memories.
https://news.yale.edu/2025/12/10/stress-hormones-can-alter-brain-networks-and-strengthen-emotional-memories
9 days ago
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Opened just last year, the Yale
@apdaparkinsons.bsky.social
Center—led by
@yaleneuro.bsky.social
's Clemens Scherzer, MD—uses an innovative approach to predict & prevent the progression of
#Parkinsons
🧠 and develop personalized therapies for patients 🙌 More👇
www.apdaparkinson.org/article/prec...
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Precision Medicine for Parkinson’s: Inside Yale’s APDA Research
Our new research center at Yale has surged forward on multiple fronts: new drug discovery via AI, powerful biomarker studies, and a thriving clinical program.
https://www.apdaparkinson.org/article/precision-medicine-for-parkinsons-at-yale-research-center/
11 days ago
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1
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A new study led by
@tommaso-volpi.bsky.social
, Dr. Faranak Ebrahimian, & Dr. David Matuskey found that
#Parkinsons
patients show dopamine neuron loss was higher than synaptic loss —offering insight into both the disease & potential biomarkers! More👇
medicine.yale.edu/news-article...
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Brain Markers Could Yield Early Clues into Parkinson’s Disease
Yale scientists used brain imaging to map Parkinson’s disease and identify potential targets for early diagnosis.
https://medicine.yale.edu/news-article/brain-markers-could-yield-early-clues-into-parkinsons-disease/
12 days ago
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In a new
@insight.jci.org
study co-led by
@yaleneuro.bsky.social
's Amy Arnsten,
@yaleschoolofmed.bsky.social
researchers uncover how the brain 🧠 uses GLO1 protein to buffer calcium buildup & protect 🛡️against neurodegenerative diseases like
#Alzheimer's
! More 👇
medicine.yale.edu/news-article...
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How the Brain Protects Itself from Alzheimer’s Disease
Researchers discovered a protective mechanism used by the brain to mitigate calcium dysfunction, a risk factor for neurodegeneration.
https://medicine.yale.edu/news-article/how-the-brain-protects-itself-from-alzheimers-disease/
16 days ago
0
1
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In a new
@npr.org
article,
@yaleneuro.bsky.social
's Rajita Sinha, PhD, comments on emerging research suggesting that cannabinoids 🍃 may—at least in the short term—reduce alcohol consumption🍸🍾. Read More👇
www.npr.org/sections/sho...
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Can weed help you drink less? Scientists study how well 'California sober' works
It's trendy in some circles to replace drinking with consuming cannabis. But can it help people with a drinking problem cut back? Scientists set up a bar in the lab to find out.
https://www.npr.org/sections/shots-health-news/2025/11/19/nx-s1-5604813/marijuana-drinking-california-sober
16 days ago
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Join us Monday (11/24) 🗓️for a seminar with Bradley T. Hyman, MD, PhD 🥼 from Massachusetts General Hospital on "Questioning Assumptions About
#Alzheimer's
Disease" 🧠 Thank you to Amy Arnsten, PhD, for hosting! 🙌 We hope to see you there!
about 1 month ago
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2
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Congratulations 🎉 to
@yaleneuro.bsky.social
Dr. Stephen Waxman🥼 who was recently awarded the Sharpey-Schafer Prize 🏆 for his crucial role in developing the first non-addictive pain medication! 💊 Read More 👇
www.research.va.gov/about/awards...
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Dr. Stephen Waxman awarded Sharpey-Schafer Prize for pain research
Awards & Career Milestones
https://www.research.va.gov/about/awards/awardee.cfm?award=258184
about 1 month ago
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TOMORROW 🙌 kicks off the annual Society for Neuroscience meeting—the world’s largest gathering of neuroscientists—in San Diego, Nov 15–19! 🧠☀️ Keep an eye out for all the members of the
@yaleneuro.bsky.social
community who are presenting their research! 💙
#SfN2025
#SfN25
about 1 month ago
0
6
1
In a new
@natcomms.nature.com
study,
@yale.edu
's
@paulsenlab.bsky.social
uncovers how the protein calmodulin regulates pain signaling! ⚡ This breakthrough could lead to better pain management strategies 💊 Read More 👇
news.yale.edu/2025/09/30/u...
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Unraveling a painful mystery: Protein plays key role in modulating pain response
A new Yale study has uncovered the hidden mechanical move that may regulate pain signaling in the human body — and why it sometimes goes awry.
https://news.yale.edu/2025/09/30/unraveling-painful-mystery-protein-plays-key-role-modulating-pain-response
about 1 month ago
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🎉Congrats to
@yaleneuro.bsky.social
's Tamas Horvath, DVM, PhD, whose groundbreaking work on how the hypothalamus regulates metabolism has earned him a well-deserved spot in the National Academy of Medicine (
@nam.edu
)! 🙌 Read More 👇
medicine.yale.edu/news-article...
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Brueckner, Chen, and Horvath Elected to National Academy of Medicine
Martina Brueckner, MD, Lieping Chen, MD, PhD, and Tamas Horvath, DVM, PhD, have been elected to the National Academy of Medicine.
https://medicine.yale.edu/news-article/brueckner-chen-horvath-elected-to-national-academy-of-medicine/
about 2 months ago
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1
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In a new study,
@yale.edu
researchers led by Katarzyna Chawarska, PhD, &
@dscheinost.bsky.social
, PhD🥼 found robust connectivity in the social perception pathway just weeks after birth👶, highlighting how early brain development may shape later social interactions!👇
medicine.yale.edu/news-article...
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Brain Network Active at Birth is Linked to Social Behavior Later in Life
A brain network linked to social attention is functional in newborns, a Yale study finds. It may underlie some of the social vulnerabilities associated with
https://medicine.yale.edu/news-article/brain-network-active-at-birth-linked-to-social-behavior-later-in-life/
about 2 months ago
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Join us this Monday (11/3) for a seminar by
@stanfordmedicine.bsky.social
's Anne Brunet, PhD on the (
@brunetlab.bsky.social
) "Dynamic and Quantitative Analysis of Aging & Longevity!" Thank you to
@schandralab.bsky.social
and Angeliki Louvi, PhD, for hosting! 🙌 See you there!
about 2 months ago
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Join us tomorrow (10/28) for an ✨#Alzheimer's Disease Research Center Seminar✨ by
@heatherdsnell.bsky.social
, PhD This event is open to the
@yale.edu
community only. 📩 The Zoom link is available via email. We hope to see you there! See flyer for more 👇
2 months ago
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Tomorrow, 10/28,
@yaleschoolofmed.bsky.social
& Korea University College of Medicine are hosting a joint neuroscience forum. Topics include: Alzheimer's, EEG, neurodevelopmental genetics, and rare syndrome models 🧠 Access the online forum here 👇
medicine.yale.edu/news-article...
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2025 Yale-KU Forum: Clinical and Basic Neuroscience
Yale School of Medicine and Korea University will co-host the 2025 Yale-KU Forum, showcasing research on clinical and basic neuroscience.
https://medicine.yale.edu/news-article/2025-yale-ku-forum-clinical-and-basic-neuroscience/
2 months ago
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"TOMORROW
@yaleneuro.bsky.social
@kavliatyale.bsky.social
Yale present
#SYNAPSES
, our senior postdoc symposium! 🙌 Hear from four incredible researchers 👩🔬🥼 as they share their latest discoveries and insights! 🗣️ You won't want to miss it! 🗓️"
2 months ago
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reposted by
Yale Neuroscience
Junjie Guo
2 months ago
New article
@natneuro.nature.com
by
@yaleneuro.bsky.social
Suzhou Yang &
@kavliatyale.bsky.social
Postdoc Fellow
@zhenlei.bsky.social
, highlighting studies by
@frattalab.bsky.social
Gitler & La Spada labs on the role of TDP-43 on mRNA 3' end in ALS
@yalerna.bsky.social
www.nature.com/articles/s41...
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TDP-43 loss brings RNA to a twist ending - Nature Neuroscience
In amyotrophic lateral sclerosis (ALS), nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 cause widespread dysregulation of mRNA splicing. Two recent studies have now rev...
https://www.nature.com/articles/s41593-025-02065-3
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Recent
@yale.edu
research led by @adwolfe.bsky.social, Milind Singh &
@dacolon.bsky.social
reveals neurons' ability to store glycogen as a backup fuel ⛽️, keeping the brain running under stress — a process called “glycogen-dependent glycolytic plasticity” (GDGP).
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Neurons use built-in ‘backup batteries’ that fuel the brain under stress
A new Yale study reveals that neurons store their own sugar reserves that kick in to keep the brain functioning during metabolic stress.
https://news.yale.edu/2025/07/15/neurons-use-built-backup-batteries-fuel-brain-under-stress
2 months ago
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Join us next Thursday (10/23) for
#SYNAPSES
, a senior postdoc symposium
@yaleneuro.bsky.social
@kavliatyale.bsky.social
Talks will be given by: -
@annrosebright.bsky.social
, PhD👩🔬 - Peter Hasenhuetl, PhD 🔬 - Minhyeok Chang, PhD 🧑🔬 -
@zhenggang.bsky.social
, PhD 🥼 Register Today! Yale only.
2 months ago
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A new
@natcomms.nature.com
study led by
@yaleneuro.bsky.social
's
@vidyadharadj.bsky.social
🥼 suggests that a mutation in a gene called GBA 🧬 might be behind the observed cognitive decline 🧠📉 in
#Parkinsons
disease. Read More 👇
www.mdlinx.com/news/how-gen...
2 months ago
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reposted by
Yale Neuroscience
Yale Kavli Institute for Neuroscience
3 months ago
Thank you to everyone who joined this year’s
@kavliatyale.bsky.social
Chalk Talk - there were many of you! And a big thank you to our incredible speakers
@schandralab.bsky.social
and
@trevorsorrells.bsky.social
, and all the faculty who gave feedback to postdocs during their mock chalk talks.
0
3
1
New
@nature.com
article from the
@jess-cardin.bsky.social
lab: the team, led by
@q-perrenoud.bsky.social
, identified where gamma activity emerges and how it relates to behavior. "This could lead to an early biomarker for Alzheimer’s disease that is easily accessible in humans."
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Flexible perceptual encoding by discrete gamma events - Nature
Using a new analytical method for tracking gamma band events in mouse visual cortex, flexible encoding of visual information according to behavioural context is shown.
https://doi.org/10.1038/s41586-025-09604-9
3 months ago
1
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reposted by
Yale Neuroscience
Quentin Perrenoud
3 months ago
(1/8) My latest study is out in
@nature.com
! Kudos to coauthors especially
@jess-cardin.bsky.social
and to
@kavliatyale.bsky.social
and
@wutsaiyale.bsky.social
for support. We find that gamma power in mouse visual cortex is caused by brief events of visual processing
www.nature.com/articles/s41...
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Flexible perceptual encoding by discrete gamma events - Nature
Using a new analytical method for tracking gamma band events in mouse visual cortex, flexible encoding of visual information according to behavioural context is shown.
https://www.nature.com/articles/s41586-025-09604-9#Ack1
2
32
7
reposted by
Yale Neuroscience
Junjie Guo
3 months ago
Excited to see this beautiful art, commissioned from the Chinese artist 懒云居画 (@subaiweipainting on Instagram), on this month's cover of Nature Neuroscience!
@natneuro.nature.com
@yaleneuro.bsky.social
@yalerna.bsky.social
@kavliatyale.bsky.social
@wutsaiyale.bsky.social
add a skeleton here at some point
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Join us this Monday (10/6)🗓️ for a seminar with
@harvard.edu
's Jeff Lichtman, MD, PhD, titled "Connectomics: Past, Present & Future" Thank you
@kuanawanda.bsky.social
for hosting. We hope to see you there. See flyer for more info 👇
3 months ago
0
3
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In a new
@natcomms.nature.com
study, Yale's
@schandralab.bsky.social
found that mutations in the GBA gene 🧬 may drive the cognitive decline 🧠 seen in individuals with
#Parkinsons
, as opposed to a buildup of alpha-synuclein as previously thought. Read More 👇
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How Gene Mutations Drive Dementia in Parkinson’s Disease
New findings reveal motor and cognitive deficits arise through separate mechanisms in Parkinson’s disease, challenging previous thinking.
https://medicine.yale.edu/kavli/news-article/how-gene-mutations-drive-dementia-in-parkinsons-disease/
3 months ago
0
3
1
reposted by
Yale Neuroscience
De Camilli Lab
3 months ago
"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology
journals.plos.org/plosbiology/...
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Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C
VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003393
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📢 TOMORROW at NOON Join us as
@chris-dulla.bsky.social
from
@tufts.edu
shares insights from his latest research! Organized by the Yale Neuroscience Postdoc Committee.
3 months ago
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The
@colon-ramos-lab.bsky.social
is hiring a postdoc to study the cell biology of energy metabolism in neurons and in vivo. To apply and for more info, follow the link below.
add a skeleton here at some point
3 months ago
0
1
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In a new
@natcomms.nature.com
study,
@yaleneuro.bsky.social
's Nicola Micali from the Rakic lab, alongside a team of researchers
@prbb.org
, found that many genes 🧬 linked to mental illness 🧠 are turned ON in neural stem cells as early as the first trimester.👶
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Origins of mental illness, fast gas for a black hole
Yale researchers discover a gas guzzling black hole, learn that mental illness may start to develop earlier than once thought, and explore why some brain seizures cause a loss of consciousness.
https://news.yale.edu/2025/09/09/origins-mental-illness-fast-gas-black-hole
3 months ago
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🚨 Only 3 days left to register! 🚨 Yale postdocs, don’t miss the Oct 9th
@kavliatyale.bsky.social
Chalk Talk event, featuring tips by
@schandralab.bsky.social
& a mock talk by
@trevorsorrells.bsky.social
! Register Today!👇
yalesurvey.ca1.qualtrics.com/jfe/form/SV_...
3 months ago
0
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In honor of
#NPAW25
,
@yaleneuro.bsky.social
Postdoc Committee is welcoming
@chris-dulla.bsky.social
from
@tufts.edu
for a✨ special seminar ✨on his cutting-edge research 🔬 and mentoring philosophy 💡 Check out the flyer for more info. We hope to see you there!
3 months ago
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Don't forget to check out this Q&A with
@yaleneuro.bsky.social
's Amy Arnsten on the state of
#Alzheimer's
research, current treatments, & a new blood biomarker that could enable earlier diagnosis—marking a pivotal point in the fight against the disease.
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‘A tipping point’: An update from the frontiers of Alzheimer’s disease research
In a Q&A, Yale neuroscientist Amy Arnsten discusses the state of Alzheimer’s disease research, exciting treatment breakthroughs on the horizon, and the key role of NIH funding in making it all happen.
https://news.yale.edu/2025/08/08/tipping-point-update-frontiers-alzheimers-disease-research
3 months ago
0
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📢 Don't forget to stop by tomorrow for the Yale Neuroscience Postdoc Committee Happy Hour 🥂 celebrating
#NPAW25
! 🎉 Stop by to grab food 😋 or stay for longer and meet some of the other amazing members of the
@yaleneuro.bsky.social
postdoc community!
add a skeleton here at some point
3 months ago
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reposted by
Yale Neuroscience
Michael Hanna
4 months ago
New paper alert! I’m very excited to share our paper published in
@embojournal.org
!
@pdc-lab.bsky.social
@yaleneuro.bsky.social
add a skeleton here at some point
2
24
10
In memory of his mentor, Gordon M. Shepherd,
@yaleschoolofmed.bsky.social
's Alumni, Michael Singer, has generously donated $3 million 💰 to establish a professorship in
#Neuroscience
at
@yale.edu
. 🎓✨ Read More Here 👇
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Yale School of Medicine Alumnus Entrepreneur Gives $3 Million to Establish Professorship in Neuroscience at Yale in Memory of Mentor
Michael Singer, YC ’95, PhD ’00, MD ’02, a biotech entrepreneur, has donated $3 million to Yale School of Medicine to establish an endowed professorship in
https://medicine.yale.edu/neuroscience/news-article/yale-school-of-medicine-alumnus-entrepreneur-gives-dollar3-million-to-establish-professorship-in-neuroscience-at-yale-in-memory-of-mentor/
4 months ago
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Save the date! Join the Yale Neuroscience Postdoc Committee on Sept 18 🗓️, 4–6 PM 🕓 for a Postdoc Happy Hour celebrating
#NPAW25
! 🎉 🍹 Drinks • 🍔 Food • 🎲 Games — what more could you want? We hope to see you there! 👀 Check the flyer to register + get all the details 👇
4 months ago
0
1
1
Just published: the
@pdc-lab.bsky.social
, led by
@anbangdai.bsky.social
, sheds light on the localization and function of BLTP2, a bridge-like lipid transfer protein: BLTP2 is found at contacts between the endoplasmic reticulum (ER) & plasma membrane (PM), and plays a key role in PM dynamics.
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Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics - PubMed
BLTP2/KIAA0100, a bridge-like lipid transfer protein, was reported to localize at contacts of the ER with either the plasma membrane (PM) or recycling tubular endosomes depending on the cell type. Our...
https://pubmed.ncbi.nlm.nih.gov/40899996/
4 months ago
0
2
2
reposted by
Yale Neuroscience
Anirvan Nandy
4 months ago
Super excited about this collaborative project with
@stevewcchang.bsky.social
and Monika Jadi! We show that marmosets possess an arsenal of flexible strategies they use for cooperation.
www.cell.com/current-biol...
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Diverse and flexible strategies enable successful cooperation in marmoset dyads
Meisner and Shi et al. show that common marmosets flexibly coordinate with partners using both gaze-dependent and rhythmic strategies. Cooperation depends on active social monitoring and is shaped by ...
https://www.cell.com/current-biology/fulltext/S0960-9822(25)01036-X
1
1
1
reposted by
Yale Neuroscience
Nature Neuroscience
4 months ago
Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD
@junjieguo.bsky.social
@yalerna.bsky.social
@yaleneuro.bsky.social
www.nature.com/articles/s41...
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Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD - Nature Neuroscience
By selectively isolating and sequencing the rare RNA transcripts containing C9orf72 repeat expansion from ALS–FTD neurons, the authors uncover an alternative splicing mechanism that explains the reten...
https://www.nature.com/articles/s41593-025-02039-5?utm_source=bluesky&utm_medium=social&utm_campaign=neuro
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Less than 2 weeks left to apply to SYNAPSES!
add a skeleton here at some point
4 months ago
0
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Fantastic day of discussions with
@shariwiseman.bsky.social
, Yale INP alum and chief editor at Nature Neuroscience. Thanks for coming, and thank you to the postdocs of the YNPC for organizing!
add a skeleton here at some point
4 months ago
0
4
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The thalamus has been thought to be a relay for information in the brain 🧠. But a new study in Neuron
@cp-neuron.bsky.social
, led by Yue Fei in the lab of Liang Liang @yaleneuro.bsky.social, finds it plays a more important computational role for visual information than previously recognized.
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From Train Station to Control Center—The Thalamus’ Role Gets an Upgrade
The thalamus has been thought to be a relay for information in the brain. But a new study finds it plays a more important computational role for visual
https://medicine.yale.edu/neuroscience/news-article/from-train-station-to-control-centerthe-thalamus-role-gets-an-upgrade/
5 months ago
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Amy Arnsten, PhD, Albert E. Kent Professor of Neuroscience
@yaleneuro.bsky.social
, shares in an interview the current state of Alzheimer's research, where the field is going, and the importance of NIH funding to keep making progress towards treatments.
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‘A tipping point’: An update from the frontiers of Alzheimer’s disease research
In a Q&A, Yale neuroscientist Amy Arnsten discusses the state of Alzheimer’s disease research, exciting treatment breakthroughs on the horizon, and the key role of NIH funding in making it all happen.
https://news.yale.edu/2025/08/08/tipping-point-update-frontiers-alzheimers-disease-research
5 months ago
0
5
2
reposted by
Yale Neuroscience
Sreeganga Chandra Lab at Yale
5 months ago
Postdocs: Apply now for the SYNAPSES series
@kavliatyale.bsky.social
@yaleneuro.bsky.social
! Deadline to apply is September 7th
0
3
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reposted by
Yale Neuroscience
Junjie Guo
5 months ago
Congratulations to Yale INP student in the lab, Denethi Wijegunawardana, and all other 2025
@hhmi.org
Gilliam Fellows!
@yaleschoolofmed.bsky.social
@yaleneuro.bsky.social
@yalerna.bsky.social
www.hhmi.org/programs/gil...
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The 2025 Gilliam Fellows & Advisors | HHMI
The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.
https://www.hhmi.org/programs/gilliam-fellows/2025-fellows
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📢 Calling all senior neuro postdocs: SYNAPSES brings postdocs from around the world to Yale to share their work during an in-person symposium on October 23, 2025. Apply today to present your research, talk with faculty members in 1:1s, & interact with Yale postdocs! 🧠🧪 Deadline Sept 7.
#neuroskyence
5 months ago
0
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In a new study published in
@pnas.org
, the lab of
@dacolon.bsky.social
at
@yaleneuro.bsky.social
shows how brain cells store their own sugar in a "backup battery" that kicks in to keep the brain running in times of high metabolic stress.
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Neurons use built-in ‘backup batteries’ that fuel the brain under stress
A new Yale study reveals that neurons store their own sugar reserves that kick in to keep the brain functioning during metabolic stress.
https://bit.ly/3TTgHi5
5 months ago
0
3
4
New work @currentbiology.bsky.social from the labs of James Jeanne @yaleneuro.bsky.social and Thierry Emonet
@mcdb-yale.bsky.social
show that some fruit fly neurons 🧠 can be multifunctional: the same neuron can tell fruit flies to walk towards the smell of rotting fruit and speed up.
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Two For One: Researchers Find One Neuron Can Send Multiple Messages
In fruit fly brains, one neuron can trigger two different types of behavior in response to an attractive odor.
https://medicine.yale.edu/news-article/two-for-one-researchers-find-one-neuron-can-send-multiple-messages/
5 months ago
0
3
2
reposted by
Yale Neuroscience
Yale Kavli Institute for Neuroscience
6 months ago
This week's
#TraineeTuesday
is Aya Khalaf, PhD! Aya is a postdoc in the Blumenfeld lab in
#Yale
Neurology. She recently published an article in NeuroImage showing how different senses—vision, hearing, touch, and taste—activate the same deep brain regions during transitions in attention [1/5]
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Shared subcortical arousal systems across sensory modalities during transient modulation of attention
Subcortical arousal systems are known to play a key role in controlling sustained changes in attention and conscious awareness. Recent studies indicat…
https://www.sciencedirect.com/science/article/pii/S1053811925002277"
1
3
1
reposted by
Yale Neuroscience
Suel-Kee Kim
6 months ago
Excited to share our latest work, Mato-Blanco et al.,
nature.com/articles/s41...
. Thanks to the incredible collaboration with Nicola Micali, Rakic lab, Sestan lab, Vaccarino lab
@yaleneuro.bsky.social
@santperelab.bsky.social
@carlocolantuoni.bsky.social
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Early developmental origins of cortical disorders modeled in human neural stem cells - Nature Communications
The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem cells, revealing vulnerabi...
https://nature.com/articles/s41467-025-61316-w#citeas
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