AlphaFold told us where proteins end up. This new work takes a step toward showing how they get there by introducing an atomistic method to get "time-lapse images" of protein folding, e.g. all pathways and their relative frequencies www.biorxiv.org/content/10.6... An exciting glimpse of what's next!

People I can’t recommend this enough! He is one of the most knowledgeable people I know, a great mentor AND a wonderful person

One for the Apicomplexa peeps: ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites. Happy+proud to share and keen to hear thoughts!

The Hanna lab opens this coming January in the Dept of Biochemistry and Molecular Biology at Penn State Uni! Follow us as we uncover the mechanisms that respond to lysosome damage

A very special first post on Bluesky: I’m excited to share that I’ll be starting my lab at Penn State this coming January in the Dept of Biochemistry & Molecular Biology! I’ll be hiring at all levels soon. Check out updates, thoughts, and positions on the lab account: @hanna-lab.bsky.social

Mo and Hans's work here is truly a landmark in dense structural imaging, but the proof of the pudding is in the eating. Do yourself a favor and check out the Neuroglancer links and get an early glimpse at a technique I'm confident we'll see more and more over the next few years.

Earlier this month I had the honor of interviewing Dr. Zoncu @robzonculab.bsky.social during his visit to Yale. It was so inspiring- and also fun! Here is a link: medicine.yale.edu/cellbio/news...

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology rdcu.be/ehbaL

It's been done for a while, accepted almost a year ago, but I'm happy to share that my first analysis of the MICrONs cubic mm dataset is online! nature.com/articles/s41...

When the 1st Muslim ban was about to go into effect, I was toward the end of my PhD. I went to Eric’s office in tears to ask if I could still defend my thesis and get a PhD if my legal status was revoked. I was lucky but I am heartbroken that this is actually happening to some students now

Random small reason to be happy: I have got 777 citations today 😄 my favorite number is 7

Princeton has announced that it is considering selling approximately $320 million of taxable bonds. The bonds are a way for the University to raise short-term funds. The major credit-rating agencies rate University bonds AAA, the highest level of creditworthiness.

Like the cultural revolution, when anyone smarter than the regime was fired and sent to the countryside. Mao-Tse Trump.

Worth following @fly-broadcast.bsky.social for new fly papers on PubMed. They deserve a lot more than 50 followers! @bdsc.bsky.social @flybase.bsky.social @fly-eds.bsky.social @dgrc.bsky.social

Check out our new review on induced proximity modalities (#TPD and a lot more!) aimed cell surface targets @naturebiotech.bsky.social, spearheaded by postdocs Nick Till and "Rahm" Ramanathan www.nature.com/articles/s41...

regarding Columbia University, I just learned about this (anonymous) account of negotiations of the Hitler regime in the 1930s with Frankfurt University -- Germany's most prestigious university at the time:

In this belated, crazy, #EM_Monday I am posting an image I took showing some organellar communications at a neuronal soma: a mitochondria contacting nuclear envelope, and Golgi going all the way from nuclear envelope to plasma membrane.

Honored to be featured this week by @yaleneuro.bsky.social in honor of my Life Sciences Research Foundation @hhmi.org fellowship!

In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n www.nature.com/articles/s41...

Thrilled & honored to be a recipient of a Sloan Fellowship in Chemistry. Thanks for my mentors, colleagues and most importantly my students, for making this possible. #SloanFellow.

So proud of @hajiakbari.bsky.social!! news.yale.edu/2025/02/19/f...

And then comes the firing of scientists…

I feel sick to my stomach… what is happening to US science

Everything you always wanted to know about the Axon Initial Segment might be here: authors.elsevier.com/sd/article/S...

Breaking news: 22 states are suing to block NIH’s cutting of indirect costs. See our updated story on the Friday night news and its aftermath. scim.ag/4hTJQ6v

So how does one become a psychic?! With science down the drains I bet its gonna make a comeback

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

If anyone has the resources to resist, its HHMI. Ending this program with no notice and literally scrubbing evidence it ever existed from the website is shocking and dosappointing

I think this time the gif actually works

This #EM_Monday is a neuron (magenta) dumping its lysosome (blue arrow) into a glia- I think!

This current freeze of research funds in US reminds me of Iran’s cultural revolution en.m.wikipedia.org/wiki/Cultura...

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me. Please amplify. If you are also able to host fly strains, add your name as well.

The so-called Muslim ban is back with a vengeance I feel for students and postdocs on visa in our labs here - note they focus on "identifying... nationals from those countries ...admitted into the United States on or since January 20, 2021"

There's a lot of periodicity going on in these older neurons after 30 days in culture! (3D-SIM stack; orange is actin, green is ß2-spectrin, magenta is adducin, blue is neurofascin, LUTs from @kwolbachia.bsky.social)

Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags! www.biorxiv.org/content/10.1...

Our study on how loss of the adaptor protein complex, AP-4, affects amyloid plaque pathology is now out! www.eneuro.org/content/11/1...

Very proud to share the latest preprint from my lab by Ellie Degen and co. Here Ellie shows that a concentration threshold in the Bcd morphogen gradient is determined by competition with nucleosomes. Great mix of math, imaging, and genomics!

Just work hard and do good science and it will all work out.

US Capitol struck by lightning 12/31/2024 Video: Stephanie Ricker/Twitter

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1...

This #EM_Monday highlights how organelles can shape cells in 🧠! E.g. glia, with their thin processes, often wrap around neurons. But when organelles like lipid droplets (LDs) are present, they can create dents in neighboring neurons—like the one shown here, where a glial LD indents neurons' somas🧵

Delighted to share our new preprint on the cell biology and genome of Stentor pyriformis, a giant ciliate that maintains Chlorella endosymbionts in surface-associated microtubule baskets. www.biorxiv.org/content/10.1...

Interviewer: Can you explain this gap in your resume? Me: I was waiting for the flies to lay eggs… on a rainy day

Such a beautiful work😍

Neurodegenerative Disease bryanwjones.com/2017/12/neur... #SciArt #neurodegeneration

A central question in developmental biology is how different tissues express different subsets of the genes in the genome. This is particularly critical for "master regulators" like the Hox genes that define organ identity. One key is modifying "chromatin"--the histone proteins that bind DNA 1/n 🧪

First post on bsky. We've updated our preprint about the change in the histone H3 variant on chromatin during Zygotic Genome Activation. Thanks to new experiments by Anusha, it seems like our initial, simplistic idea that the embryo "ran out" of H3 was not right. www.biorxiv.org/content/10.1...

If you are a scientist or consumer of scientific knowledge, check out notebooklm.google.com. You can plop PDFs and interact with them via AI, including making an AI generated podcast of the work which summarizes the main findings and implications. It is mind-blowing and surprisingly accurate.

Check out this podcast on our new paper @currentbiology.bsky.social, generated by AI, courtesy of @dacolon.bsky.social! notebooklm.google.com/notebook/a50...