🔥Proud to share our latest #PKD prognostic model from CRISP IV In ADPKD pts with normal eGFR we can predict probability of kidney failure 15 years later with C-index >0.8 Uses only TKV + data obtained in usual clinical care

Autosomal dominant polycystic kidney disease (ADPKD) is linked to mutations in PKD1 and PKD2 genes, affecting cation channel complexes in kidney cell cilia. This #ASNJASN study explored ways to increase these complexes in cilia to prevent kidney cyst formation: kidney.pub/JASN0942

Cystogenesis and interstitial fibrosis are contributing factors to kidney failure in individuals with ADPKD. This #ASNJASN research examines the role of Integrin Alpha1 Beta1 in a mouse model: kidney.pub/JASN0941#ASNJASN#BasicResearch @rachellennon.bsky.social

Honored to have @juancarlosqvelez.bsky.social visiting KU Nephrology and the Jared Grantham Kidney Institute. Fantastic lecture on #hepatorenal syndrome (of course)👏 Lots of practical recommendations backed up by research conducted by Dr. Velez at @ochsnerhealth.bsky.social

~15 years ago, Dr. Fred Coe put forward the “vas washdown” model for explaining kidney stone formation @alanyuneph.bsky.social & team now report on a new mouse model, showing kidney-specific Cldn-2 KO leads to medullary nephrocalcinosis—supporting the vas washdown model: doi.org/10.1172/JCI1...

Now out @jclinicalinvest led by Christine_Behm with fantastic team of collaborators👇 We discover a corticomedullary gradient for Ca in kidney and show a critical role for claudin-2, with implications for kidney stone disease. @kumedcenter.bsky.social www.jci.org/articles/vie...

Join us in congratulating this winner of the Distinguished Leader Award, an ASN Midcareer Award: Reem A. Mustafa, MD PhD MPH FASN. Read more about her work in #ASNKidneyNews: kidney.pub/KN1710-41#ASNKidneyNews:

New podcast alert! Dr. Priya Vart discusses the results of his study, “Effects of Dapagliflozin on Health-Related Quality of Life in Patients with CKD,” with #ASNJASN Deputy Editor Manjula Kurella Tamura: kidney.pub/JPOD0776

And in the evening - a CAR T in refractory SLE - a PKD trial - increasing PD in Vets - Povetacicept in IgA - TESTING Longterm term data - what do the AHA/ACC BP guidelines mean? #KidneyWk

Starting Soon! Join us for the 2025 Best of ASN Journals session at #KidneyWk. Join us Tomorrow, Thursday, November 6 at 2:00 PM in Grand Ballroom A of the George R. Brown Convention Center for a lively discussion and check out the article collection below. kidney.pub/BestOf2025

The 2025 #ASNJASN #ASNCJASN and #ASNKidney360 Trainees of the Year are Benoit ​Brilland, Thomas Bais, and Yuhei Noda! This prize celebrates the best article submitted to each journal by a trainee as the first author. See more about the contest and this year's winners: kidney.pub/TraineeOf...

New in #ASNJASN: an epigenetic CRISPR Screen was used for the first time to identify critical genes and pathways involved in vascular calcification. kidney.pub/JASN0793

Who says there are no good treatments for AKI? 👇Classic HRS-AKI with dramatic reversal by terlipressin #medsky #nephsky

NEW on the #AJKDBlog: @maximalchange.bsky.social interviews the authors of a recent review of ADPKD, Sara S. Jdiaa and Reem A. Mustafa, and discusses prognosis, goals, and monitoring. bit.ly/Jdiaa25 (FREE)

In a recent #ASNJASN article, authors report that ephrin-B1 at slit diaphragm suppresses cdc42 activity by preventing the interaction of Par6 with cdc42 and functions to keep the specialized phenotype of podocytes. Read more: kidney.pub/JASN0728#ASNJASN#BasicResearch

Genetically modified gut bacteria show promise of combating kidney stones in clinical trial medicalxpress.com/news/2025-07...

NEW on the #AJKDBlog: @maximalchange.bsky.social interviews the authors of a recent review of ADPKD, Sara S. Jdiaa and Reem A. Mustafa, and discusses prognosis, goals, and monitoring. bit.ly/Jdiaa25 (FREE)

⏳ One week left to apply. The Fellows’ Travel Support Scholarship gives nephrology fellows $1,000 to attend the UAB CRRT Academy. Train in person, build practical CRRT skills, and learn through simulation and expert-led sessions. Apply by Monday, July 21 👉 bit.ly/3FGntEx

Guidelines no longer recommend holding typical first-line antihypertensive meds since renin will most often still be suppressed despite being on them in true PA. Growing evidence supports proceeding with screening Hot off the press from the Endo Society: www.endocrine.org/clinical-pra...

Could gene-targeted therapy be coming for autosomal dominant polycystic kidney disease? Farabursen, a new medication acquired by Novartis offers to potentially impact cyst formation and even regression. kidney.pub/KN1707-07 #ASNKidneyNews @nephrosparks.bsky.social

𝗡𝗘𝗪 𝗥𝗘𝗦𝗢𝗨𝗥𝗖𝗘 𝗔𝗟𝗘𝗥𝗧: Download our #ADPKD infographic for a quick overview of diagnosis, delaying progression, complications & more. A handy resource for clinicians and patients alike! ⬇️https://www.theisn.org/wp-content/uploads/2025/07/ADPKD-Infographic.pdf

🔥Submit a Late-Breaking Clinical Trial and have your study considered for contemporaneous publication in JASN, NEJM @nejm.org or Lancet @thelancet.com

Understanding the role of alternative splicing in podocyte biology may lead to theraputic options for patients with glomerular hypertension. Read more in a #BasicResearch article: kidney.pub/JASN0706#BasicResearch#ASNJASN

The 2026 RFAs for grant and fellowship awards from @pkdfoundation.bsky.social are out! Grant: pkdcure.org/research/gra... Fellowship: pkdcure.org/research/fel... LOIs are due August 11. Send us your best ideas!!

The June issue of JASN is now available online! Topics covered include: - Blood Transfusion during Myocardial Infarction in CKD - COL4A5 Variants in an Unselected Health System Population - and more Check out the issue: journals.lww.com/jas... #ASNJASN Cover by @ecorneclegall.bsky.social et al.

Looks like the consolidation of NIDDK, NHLBI and NIAMS into “NI on Body Systems” proposed combined budget cut of 41%. #medsky #maha

New Podcast: Dr. Tobias Hermle & Dominik Spitz discuss a proof-of-concept for whole-animal drug screening using podocyte-like Drosophila nephrocytes. Pilot screen using the novel podocytopathy platform identifies that zacopride restores slit diaphragms despite excess of Rac1. https://bit.ly/JPOD0677

A powerful technique that directly edits proteins in living cells promises to help researchers to study proteins in improved ways. https://go.nature.com/3GyiDJn

Coagulopathy: caused by nephrotic syndrome and worsening nephrotic syndrome! Implications for future studies aiming at risk stratification for pro-thrombotic predisposition and treatment #FSGS #sFSGS #nephroticsyndrome

Study shows plasma prothrombin levels modulated in vivo podocyte health and function in a rat model of glomerular disease. https://bit.ly/JASN0676 #ASNJASN #BasicResearch @drklotter.bsky.social

📣 Don’t miss the review by @bolettalab.bsky.social & S. Clerici on metabolic and mitochondrial alterations in #PolycysticKidneyDisease and other renal #ciliopathies ➡️ doi.org/10.1038/s443... at IRCCS San Raffaele Scientific Institute

Kidney disease is a worldwide killer. Treat it that way www.nature.com/articles/d41...

Vanessa Westerfield and Savanna Moore presenting their poster titled, "Patient-Centered Insights on Treatment Adherence and Social Determinants of Health in Patients with Autosomal Dominant Polycystic Kidney Disease," at @nkf-professionals.bsky.social SCM. Stop by G-498 to learn more!

Check out these posters from Columbia University and University of Kansas Medical Center & Polycystic Kidney Disease Outcomes Consortium (PKDOC) in the Hereditary Kidney Disease/PKD poster aisle at @nkf-professionals.bsky.social SCM25.

The ASN Journal Portfolio seeks early career scientists and junior faculty members interested in participating in the editorial process of peer reviewed journals to join our Junior Associate Editor (JAE) Program. Learn more and apply by May 2. bit.ly/TraineePrograms @rajmehrotra.bsky.social

This is a great opportunity for advanced trainees/junior faculties to get hands-on experience as Editors in the top nephrology portfolio! Join us and have fun with us trying to constructively push authors to publish their best science! #Nephsky #Skyneph @asnkidney.bsky.social @aspnr.bsky.social

Just want to say again I’m grateful for the people doing their best to hold it down at the NIH despite the chaos and uncertainty. I see you 🙌🏾

Also note two large RCTs ongoing - or about to start - in France: bsky.app/profile/dgue...

Great study suggesting exercise slows eGFR decline: Generation 100 Study, 5-yr open-label, randomized clinical trial in Norway. journals.lww.com/jasn/fulltex... Compared with controls, RR 0.93 (95% CI: 0.75, 1.16) for the moderate-intensity and 0.75 (95% CI: 0.59, 0.95) for high-intensity groups

The ASN Journal Portfolio seeks early career scientists and junior faculty members interested in participating in the editorial process of peer reviewed journals to join our Junior Associate Editor (JAE) Program. Learn more and apply by May 2. bit.ly/TraineePrograms @rajmehrotra.bsky.social

Piezo1 plays a key mechanosensory role in podocyte injury during DKD progression by mediating calcium influx and activating the NFATc1/TRPC6 signaling pathway. https://bit.ly/JASN0634 #ASNJASN #BasicResearch

His exceptional scientific work, evidenced by many hundreds of papers and about 50 books as editor or co-editor, has left an unparalleled legacy that will inspire and serve as a guide for future generations of nephrologists. academic.oup.com/ndt/article/... #MedSky #NephSky #RenalSky

☀️📣 Looking for a STATE LEAD and VOLUNTEERS to help us #standupforscience2025 in Kansas! Know someone interested? Fill out this form: airtable.com/app4h5wUssMG... #scienceforall #sciencenotsilence

University of Kansas Nephrology and the Jared Grantham Kidney Institute are ready for Super Bowl LIX🏈 Go Chiefs🔥🔥🔥

BREAKING NEWS: The FDA has approved Ozempic for patients with chronic kidney disease. This means the popular injection can be used to reduce the risk of kidney disease worsening, kidney failure and death from cardiovascular disease in patients with chronic kidney disease and diabetes.

This is really cool: 👉Individualized antisense oligo treatments for patients with nano-rare mutations (i.e., <30 patients worldwide) 👉Drugs are provided for free, for life, for conditions where commercialization is unrealistic Wow!

One year at JASN! While we try to bring excellence to our beloved Journal, some people have left - @alessiafornoni.bsky.social - and some joined: welcome to new Deputy Editor Alan S.L. Yu @alanyuneph.bsky.social ! #Nephsky #Skyneph #Medsky @asnkidney.bsky.social

Join us in congratulating Professor Marie Trudel, winner of the ISN 2025 Lillian Jean Kaplan Prize, who will present "Bridging the Gap: PKD Research and Clinical Care Perspective" during the Kaplan PKD Session at WCN'25 ➡️ ow.ly/bfTR50UoFnx @pkdfoundation.bsky.social #NephSky

As promised, @asnpublications.bsky.social is on the platform. Four publications, one account. Please follow for the best in scientific publishing in nephrology!

Looking for a good liver window to visualize the IVC in my fluid-overloaded ESRD patient and instead I find this👇 @nephropocus.bsky.social