Targeting pre-existing club-like cells in #ProstateCancer potentiates #AndrogenDeprivationTherapy by M. Baurès, F. Rambow, @goffinlab.bsky.social & colleagues @inem-necker.bsky.social and Institute for AI in Medicine (IKIM) ➡️ doi.org/10.1038/s443...

Characterization and therapy of #fertilization failure in murine and human models with HNRNPR mutations ➡️ doi.org/10.1038/s443... by S. Gan, C. Zhang, W. Yang, Y. Li, H. Huang and colleagues at Zhejiang University

Our @embojournal.org editor Daniel Klimmeck is looking forward to the #MitoCellFate conference in May. Submit poster abstracts and registration until February 9th => bit.ly/43AaInH @fusionconf.bsky.social

Explore emerging research with field leaders @keystonesymposia.bsky.social #CancerImmunotherapy : Mechanisms, Clinical Advances & Combinations, this March in Québec! hubs.la/Q03TCrxR0 #KSCancerImmune26

TKI-mediated inhibition of NLRP1 #inflammasome restores #erythropoiesis in Diamond-Blackfan anemia syndrome 👉 doi.org/10.1038/s443... By J. Lozano-Gil, A. Martínez-López, S. Tyrkalska, V. Mulero & colleagues @ciberisciii.bsky.social & @um.es

#ExtracellularVesicle -based targeted #ProteinDegradation platform for multiple extracellular proteins By B. Tong, L. Tan, Z. Liao, C. Yang & colleagues at Huazhong University of Science and Technology ➡️ doi.org/10.1038/s443...

Sarcomeric remodelling in human #HeartFailure unraveled by single molecule #LongReadSequencing By J. Haas, B. Meder & colleagues @uniheidelberg.bsky.social

Online today -> A viral glycoprotein targets IgG+ memory #Bcells to mediate humoral #ImmuneEvasion by P. Cramer, M. Rizzi, H. Hengel and colleagues @uni-freiburg.de @univie.ac.at 🗞️ doi.org/10.1038/s443...

Our new issue is online! link.springer.com/journal/44321 The cover illustrates the study by B. Stringer, J. Giacomotto & colleagues that introduces a tool for assessing SMN1 pathogenicity in #SpinalMuscularAtrophy using the zebrafish model ➡️ doi.org/10.1038/s443...

Molecular profile of human ischemic cardiomyopathy in #diabetes reveals reduced mitochondrial complex I and elevated very long chain acylcarnitines @embomolmed.org link.springer.com/article/10.1...

Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with @drjhujh.bsky.social and @profstewartlab.bsky.social alongside @sorenhough.bsky.social and friends in @spjacksongroup.bsky.social.

Mechanisms of resistance to #VHL loss-induced genetic and pharmacological vulnerabilities ➡️ doi.org/10.1038/s443... By J. Ge, D. Muñoz-Espín, @svanharanta.bsky.social & colleagues @cam.ac.uk @helsinki.fi

Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social 🗞️ doi.org/10.1038/s443...

Online today! Mutant #CHCHD10 disrupts cytochrome c oxidation and activates mitochondrial retrograde signaling by M. Campos-Ribeiro, T. Wai & colleagues @pasteur.fr 👉 doi.org/10.1038/s443...

New review by M. Pepin, X. Gong, A. Schulze and J. Backs @uniheidelberg.bsky.social ➡️Metabo-epigenetic circuits of #HeartFailure: chromatin-modifying enzymes as determinants of metabolic plasticity🫀 🗞️ doi.org/10.1038/s443...

Clinical relevance of #zebrafish for gene variants testing. Proof-of-principle with SMN1/SMA 👉 doi.org/10.1038/s443... #SpinalMuscularAtrophy By B. Stringer, J. Giacomotto and colleagues @griffith.edu.au

Microplastics reach human lungs, blood, and brain, yet their biological impact is poorly defined. In our new @embomolmed.org review, we connect environmental exposure to inflammation, stress signalling, epigenetic disruption, and cell identity. link.springer.com/article/10.1...

New Resource Online 👉 Molecular determinants of #CardiacLymphatic dysfunction in a #ChronicPressureOverload model 🗞️ doi.org/10.1038/s443... by C. Heron, H. Dauchel, @hfpef-diva.bsky.social & colleagues @univrouen.bsky.social @inserm.fr

📣 Review on #microplastics as environmental modifiers of #LungDisease 🫁 by E. Epeslidou, @bnmelgert.bsky.social , @stefanprekovic.bsky.social & colleagues @rug.nl & University Medical Center Utrecht ➡️ doi.org/10.1038/s443...

New paper out in EMBO Mol Med! We use machine learning to predict Aβ-PET burden from fluid biomarkers. www.embopress.org/doi/full/10.... Key findings: - Performance R² = 0.79 - CSF Aβ42/Aβ40 most predictive of Aβ plaque presence - Plasma p-tau217 best for tracking increasing amyloid plaque burden

One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org www.embo.org/people/revie...

Loss of #EHMT2 enhances #NKcell -driven #AntiTumorImmunity through #TGFβ1 suppression by S. Chava, R. Gupta, N. Wajapeyee & colleagues @uofalabama.bsky.social doi.org/10.1038/s443...

Development of blue light activated, kinetically balanced ChR variants optimized for high-frequency #optogenetic stimulation of SGNs at low light intensities #cochlearimplants By L. Roos, T. Moser, T. Mager & colleagues at University Medical Center Göttingen 🗞️ doi.org/10.1038/s44321-025-00350-z

Micrometastasis-derived models enable drug testing for early-stage, high-risk #melanoma patients By K. Weidele, C. A. Klein & colleagues @uniregensburg.bsky.social ➡️ doi.org/10.1038/s44321-025-00339-8

New issue online! ➡️ link.springer.com/journal/4432... The cover highlights the article by S Hirschberger, S Kreth, M Hübner & al 👉 #MitochondrialDamage drives #Tcell immunometabolic paralysis after major surgery: link.springer.com/article/10.1... Scientific illustration by M Hübner; S Hirschberger

Exciting to know that a main finding from our recent publication with @embomolmed.org (link.springer.com/article/10.1...) is taken up in a clinical trial that started a few days ago here in Tübingen and which may revolutionise chemoprophylaxis of malaria: euclinicaltrials.eu/search-for-c....

#TyphoidToxin of Salmonella Typhi elicits host antimicrobial response during acute #TyphoidFever By S. Srour, D. Humphreys & colleagues @sheffielduni.bsky.social 🗞️ doi.org/10.1038/s443...

Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated #tau and #βamyloid 👉 doi.org/10.1038/s443... By N. Mattsson-Carlgren, L. Karlsson, O. Hansson & colleagues @lund-university.bsky.social

📣This timely review by Chin Lin and colleagues discusses advances in #ArtificialIntelligence -enabled #electrocardiography (AI-ECG) including emerging roles in early disease detection, improved risk stratification, and clinical decision-making. #TaipeiMedicalUniversity 👉 doi.org/10.1038/s443...

Isomeranzin activates Gnas-AMPK signaling to drive white #AdiposeBrowning and curb #obesity in mice ➡️ doi.org/10.1038/s443... By M. Shi, Y. Ye, L. Hu, L. Yang, K. Huang, M. Liang & colleagues at Huazhong University of Science and Technology

Online today! 👉 Dynamics of checkpoint receptors in #γδTcell subsets are associated with clinical response during anti-PD-1 #immunotherapies By E. Catafal-Tardos, @vasgdtcells.bsky.social & colleagues at Technical University of Denmark 🗞️ doi.org/10.1038/s443...

Happy to share our article published in @embomolmed.org in which we demonstrate that the repressor Capicua acts as a natural barrier to lung tumor development driven by Kras/Trp53 mutations. You can read it here: www.embopress.org/doi/full/10....

This review by G. Morin, I. Galasso and G. Canaud @inem-necker.bsky.social @upcite.bsky.social presents an overview of the genetic basis of #VascularMalformations (VMs), discussing the ongoing evolution of #PrecisionMedicine for these conditions. ➡️ doi.org/10.1038/s443...

Online today! Activated #GlucocorticoidReceptor is an #EstrogenReceptor silencer in ER+ metastatic #BreastCancer By M. Manivannan, C. Jehanno, @momobentires.bsky.social and colleagues @unibas.ch 👉 doi.org/10.1038/s443...

We are pleased to once again partner with @fusionconf.bsky.social for the 2026 conference season! Looking forward to "Fibroblast Growth Factor Signalling in Development, Health & Disease Conference" in March when @embomolmed.org editor Lise Roth will attend. Registration until 5 Feb: bit.ly/49nSmKj

The canonical #ERstress IRE1α/XBP1 pathway mediates skeletal muscle wasting during #PancreaticCancer #cachexia By A. Joshi, A. Kumar & colleagues @uh.edu 🗞️ doi.org/10.1038/s443...

#Gquadruplexes can form within fungal pathogens and represent new #antifungal targets ➡️ doi.org/10.1038/s443... By G. Middleton, F. Mahamud, I. Storer, Z. Waller, S. Bidula & colleagues at @ucl.ac.uk & @uniofeastanglia.bsky.social

Online today! Inhibiting #cholesterol synthesis halts #rhabdomyosarcoma growth via #ERstress and cell cycle arrest By N.Y. Gisaw, @riikka-k.bsky.social & colleagues @helsinki.fi @wrihelsinki.bsky.social 🗞️ doi.org/10.1038/s443...

The repressor #Capicua is a barrier to #LungTumor development driven by Kras/Trp53 mutations 👉 doi.org/10.1038/s443... By I. Ballesteros-González, @matthiasdrosten.bsky.social & colleagues @ciberisciii.bsky.social @ciccancer.bsky.social

Enhanced #Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in #LoweSyndrome By Y. Sharma, P. Raghu et al @ncbsbangalore.bsky.social 🗞️ doi.org/10.1038/s443...

circ-EGFR is a predictor of response to Cetuximab and a potential target in #ColorectalCancer by S. Sui, A. Goel & al @beckman-foundation.bsky.social @cityofhope.bsky.social 👉 doi.org/10.1038/s443... Related N&V by C. Pilati & P. Laurent-Puig @canceropolegso.bsky.social 👉 doi.org/10.1038/s443...

📣 New issue online with a beautiful cover by B. Angi & F. Caicci! ➡️ www.embopress.org/toc/17574684... It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo" 🗞️ www.embopress.org/doi/full/10....

New paper alert!🚨CMA is selectively impaired in the RPE of AMD patients, leading to the accumulation of undegraded substrate proteins and increased vulnerability. But it can be targeted pharmacologically!💊 @cib-csic.bsky.social @dgsomucla.bsky.social

Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....

New resource online! 🐖 Benchmarking porcine #PancreaticDuctalOrganoids for #DrugScreening applications by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social 🗞️ doi.org/10.1038/s443...

#MitochondrialDamage drives #Tcell immunometabolic paralysis after major surgery By S. Hirschberger, S. Kreth, M. Hübner and colleagues at Ludwig-Maximilian-University 🗞️ doi.org/10.1038/s443...

ENOblock synergizes with colistin to treat #AcinetobacterBaumannii infections By I. Molina Panadero, Y. Smani and colleagues @pablodeolavide.upo.es 🗞️ doi.org/10.1038/s443...

A heterozygous post-zygotic ZNF334 truncation mutation in #monocytes was identified as a cause of late-onset cold-induced #AutoinflammatoryDisease ➡️ doi.org/10.1038/s443... By JL Lan, CA Yang and colleagues at China Medical University Taichung

Defective #ChaperoneMediatedAutophagy in the retinal pigment epithelium of #AgeRelatedMacularDegeneration patients By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA 👉 doi.org/10.1038/s443...

A 6-metabolite plasma panel was developed & validated for #GastricCancer diagnosis, revealing diagnostic potential and a mechanistic role for isovalerylcarnitine 👉 doi.org/10.1038/s443... By Yongjie Xu, Lingbin Du, Xiangdong Cheng & colleagues at Hangzhou Institute of Medicine