#GutMicrobiota -modulated #GlutamicAcid rejuvenates the quality of #oocytes deteriorated by advanced reproductive age By Feixue Wang, Bo Xiong and colleagues at Nanjing Agricultural University & Zhejiang University 🗞️ doi.org/10.1038/s44321-026-00443-3

Loss of mitochondrial DNA helicase in retinal macroglia drives #neovascular #retinopathy ➡️ doi.org/10.1038/s44321-026-00438-0 by S. Olander, G. Ince-Dunn, @awartiovaara.bsky.social & colleagues @helsinki.fi

New Perspective by @sarah-delliere.bsky.social & @nicolaspaponangers.bsky.social ➡️ Innovation in #antifungal therapy Angers University & @pasteur.fr 🗞️ doi.org/10.1038/s44321-026-00449-x

CCDC174 deficiency impaired human #fertility by affecting the #AlternativeSplicing of maternal mRNAs By Weijie Wang, Lei Wang, Qing Sang & colleagues at Fudan University ➡️ 🗞️ doi.org/10.1038/s44321-026-00448-y

Online today! TMPRSS2-ERG confers resistance of #ProstateCancer to #antiandrogens 👉 doi.org/10.1038/s44321-026-00423-7 by A. Sekar, Y. Yarden & colleagues at Weizmann Institute of Science

Deadlines are approaching for @keystoneSymposia.bsky.social #TumorMetabolism : Diet, #Microbiome & Beyond, this June in Killarney! See scholarship, abstract and discount reg dates: keysym.us/KSTumorMetab26 #KSTumorMetab26

Costimulation loss enhances IL-2-driven #Treg generation by PI3K-STAT3 inhibition in #CNS #autoimmunity ➡️ doi.org/10.1038/s44321-026-00431-7 By Kyung-Ho Nam, Je-Min Choi & colleagues at Hanyang University

Distinct pathophysiological mechanisms of #CEP152 variants in #microcephaly and #BrainAbnormalities By Nanako Hamada, Koh-ichi Nagata & colleagues @en.nagoya-u.ac.jp 🗞️ doi.org/10.1038/s44321-026-00427-3

George Sen & Longlong Luo at University of California, San Diego, propose that RNA-dependent #chromatin architecture influence gene programs in #skin cells and create lasting “structural scars” after #inflammation, influencing future responses 🗞️ doi.org/10.1038/s44321-026-00440-6

A multimodal pipeline combining #snRNAseq, #SpatialTranscriptomics and ex vivo tissue-slice culture maps cell states and drug responses in SMARCB1-deficient #SinonasalCarcinoma -> doi.org/10.1038/s44321-026-00437-1 By P. Jurmeister, S. Flach, F. Klauschen, A. Mock & colleagues @lmu.de

New Resource: Disease-stage-specific immunometabolic remodeling in #PediatricObstructiveSleepApnea: a single-cell #TranscriptomicAtlas of adenoid tissue ➡️ doi.org/10.1038/s44321-026-00419-3 By Q. Yang, H. Pan, S. Qin & colleagues at Hospital Zhejiang University School of Medicine

Interstitial and recruited #macrophages prevent #tuberculosis relapse by limiting immune evasion ➡️ doi.org/10.1038/s44321-026-00432-6 By V. Vinette, @saehrt.bsky.social and colleagues @weillcornell.bsky.social

📣 Read this important perspective by A. Sebe, R. Hernani & J. Müller-Berghaus @pei.de: Regulatory challenges of personalized medicine in the real world: are the right patients being treated with #CD19 -targeting #CARTcells? 🗞️ doi.org/10.1038/s44321-026-00436-2

A role for vitamin D and neutrophils in prostate cancer dissemination 🤔 Our latest work highlights 👉 the protective role of vitamin D signaling in prostatic epithelial cells 👉 the impact of circulating neutrophils in cancer dissemination in the liver.

Our work features the cover of @embomolmed.org ! Check the paper here: link.springer.com/article/10.1...

Our April issue is online! link.springer.com/journal/4432... This month’s cover highlights the article by N. Brose, M. Tirard & colleagues, #Encephalopathy -linked #UFM1 variants impede neuronal protein translation, development, and function ➡️ doi.org/10.1038/s44321-026-00389-6

Impaired #vitaminD signaling reveals #neutrophils as key drivers of #ProstateCancer dissemination 🗞️ doi.org/10.1038/s44321-026-00417-5 by K. Len-Tayon, @gilleslaverny.bsky.social & colleagues @igbmc.bsky.social

New comment by M. Smits, M. van Daal, S. Fuchs, K. Jongsma & colleagues: "Fair priority setting in #GeneEditing research: the accountability for reasonableness framework" 🗞️ doi.org/10.1038/s44321-026-00420-w

Broadly neutralizing #nanobodies target a defined structural pivot site on the #RSV fusion protein 🦠 ➡️ doi.org/10.1038/s44321-026-00412-w By Q. Wang, B. Shu, S. Chiu and colleagues atWuhan Institute of Virology & University of Science and Technology of China

❗Read the new Review on anti-tubercular target validation by Valerie Mizrahi at University of Cape Town, Dirk Schnappinger @weillcornell.bsky.social & colleagues ➡️ doi.org/10.1038/s44321-026-00415-7 #tuberculosis

#Hyperglycemia impairs #CognitiveFunction by inducing mitochondrial damage through #lactylation of LRPPRC at K223 👉 doi.org/10.1038/s44321-026-00422-8 by J. Xu, T. Zheng & colleagues at Guilin Medical University

📣The anti-obesogenic metabolite, Lac-Phe, is elevated by #metformin treatment in #ProstateCancer patients By M. Bilusic, D. Lombard, P. Rai & colleagues at University of Miami Miller School of Medicine 🗞️ doi.org/10.1038/s44321-026-00408-6

If journals shape scientific #careers, shouldn’t we evaluate their quality more rigorously? 🧪 A Science & Society article explores why it may be time to rethink how we assess the quality and impact of journals: https://link.springer.com/article/10.1038/s44319-025-00649-5#careers #LifeSciences #publishing

Online today! #Tomatidine is a #senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice By D. Costa, @dianajurk.bsky.social & colleagues @mayoclinic.org 🗞️ doi.org/10.1038/s44321-026-00400-0

JAK1/2 inhibitor #ruxolitinib reduces aggregates in cardiac #proteinopathy By E. Alizoti, S. R. Singh & colleagues @dzhk.de 🗞️ doi.org/10.1038/s44321-026-00411-x

The lipid transfer protein #STARD7 controls intestinal tumor development in a context-dependent manner 👉 doi.org/10.1038/s44321-026-00409-5 by K. Shostak, A. Chariot & colleagues at University of Liege & WEL Research Institute

#TenascinC orchestrates #radiotherapy -induced head and neck tumor regression #HNSCC by T. Loustau, G. Orend & colleagues @unistra.fr @inserm.fr 🗞️ doi.org/10.1038/s44321-026-00406-8

Bcl-xL blockade targets #neutrophils and synergizes with #chemotherapy in #LungSquamousCellCarcinoma ➡️ doi.org/10.1038/s44321-026-00401-z by A. Mayet, E. Meylan & colleagues @ulbruxelles.bsky.social & University of Lausanne

CDK12/CDK13 inhibition disrupts transcriptional elongation and #ReplicationFork progression in #glioblastoma By S. Lier, M. Lerdrup, D. Pandey & colleagues at University of Copenhagen & University of Oslo 🗞️ doi.org/10.1038/s44321-026-00393-w

New study by L Guenin-Macé, O Join-Lambert, @demangelab.bsky.social & al. @pasteur.fr @univrouen.bsky.social ➡️ P. uenonis colonizes #HidradenitisSuppurativa skin & crosses the epidermis to invade keratinocytes #Infection #ChronicInflammation #Autoimmunity 🗞️ doi.org/10.1038/s44321-026-00407-7

#IGFBP3 repression driven by inflammation links #AirPollution to placental and #DevelopmentalDefects by S. Singh, R. Dhar, S. Karmakar & colleagues at All India Institute of Medical Sciences 🗞️ doi.org/10.1038/s44321-026-00403-x

Blocking microglial reactivity via #purinergic receptors prevents subacute #cognitivedeficits after TIA ➡️ doi.org/10.1038/s44321-026-00397-6 By G. Llovera, @arthurliesz.bsky.social & colleagues @synergy-munich.bsky.social Read related N&V by Kibin Shi & al 🗞️ doi.org/10.1038/s44321-026-00404-w

Online today! Betrixaban activates #cGAS and ERVs to promote dual nucleic-sensing #antiviral #immunity By Y. Zhao, X. Wang, X. Guo, F. You & colleagues at Peking University ➡️ doi.org/10.1038/s44321-025-00356-7

Deadlines are approaching for @keystoneSymposia.bsky.social #TumorMetabolism : Diet, #Microbiome & Beyond, this June in Killarney. @embomolmed.org editor Lise Roth is looking forward to the meeting. See abstract and discount reg dates: hubs.la/Q03TCsnZ0 #KSTumorMetab26

Our March issue is now online! 🗞️ link.springer.com/journal/4432... The cover highlights the article by S. Gan, C. Zhang, W. Yang, Y. Li, H. Huang and colleagues on #HNRNPR mutations and #FertilizationFailure 👉 doi.org/10.1038/s44321-026-00374-z

Metabolically reprogrammed #eosinophils impair T cell immunity and cause chronic #SkinInfection By D. Barinberg, C. Bogdan, U. Schleicher & colleagues @fau.de 🗞️ doi.org/10.1038/s44321-026-00392-x

TDP-43 pathology triggers #neuroinflammation and #CognitiveImpairment by inducing microglial necroptosis, by S. Guo, C. Fu, Y. Yin, W. Cheng & colleagues at Xinhua Hospital, Shanghai 🗞️ doi.org/10.1038/s44321-026-00394-9

Our editor Lise Roth will be attending #CancerImmunotherapy : Mechanisms, Clinical Advances & Combinations, this March in Québec with @keystoneSymposia.bsky.social Reach out to talk about your research! keysym.us/KSCancerImmune26 #KSCancerImmune26

IFN-gene signatures in #Bcells following #influenza A and B virus infection and influenza #vaccination 👉 doi.org/10.1038/s44321-026-00395-8 By W. Zhang, @katherinekedz.bsky.social , T. Nguyen & colleagues @unimelb.edu.au @thedohertyinst.bsky.social

Online now! Cell-free DNA #methylome and #fragmentome analysis for relapse monitoring of #EwingSarcoma By S. Richardson, M. McCabe, @florentmouliere.bsky.social & colleagues @cancerresearchuk.org @manchester.ac.uk ➡️ doi.org/10.1038/s44321-026-00396-7

Thanks so much Arica! It has been a fruitful week of science at #EMBLCardioBiology. I am really honored to receive the prize sponsored by @embomolmed.org. It means a lot to me. I would also like to thank the scientists I met there. The discussions were inspiring! #zebrafishrocks #cardiobiologyrocks

Sign up by 6 March for the EMBO Lab Leadership #training "How to write a scientific paper" delivered by EMBO Press editors at EMBO | EMBL Symposium "#AI and #biology." 🧪 https://www.embl.org/about/info/course-and-conference-office/events/ees26-02/#vf-tabs__section-embo_training#training#AI#biology#vf-tabs__section-embo_training#EESAIBio #EMBOevents

Structure-guided design of a PfCyRPA-based #vaccine against blood-stage #malaria ➡️ doi.org/10.1038/s44321-026-00376-x By N. Alam, @parasitematt.bsky.social and colleagues @ox.ac.uk @kavlioxford.bsky.social

Read this @emboreports.org paper here=> link.springer.com/article/10.1...

KCNA2 variants cause dilated #cardiomyopathy, #obesity and #SleepApnea through RAC-ERK pathway By P. Chimata, P. Dhandapany & colleagues at Institute for Stem Cell Science and Regenerative Medicine 👉 doi.org/10.1038/s44321-026-00391-y

#CITED2 is a druggable #EpigeneticSwitch coupling neuronal maturation to regenerative decline By F. Müller, S. Di Giovanni & colleagues @imperialcollegeldn.bsky.social 🗞️ doi.org/10.1038/s44321-026-00385-w

Online today! ➡️ doi.org/10.1038/s44321-026-00387-8 Sulfated #glycosaminoglycans inhibit #LCMV entry and modulate antiviral immunity and pathology By M. Gorzkiewicz, P. Lang & colleagues @hhu.de

Epigenetic dysregulation of IRF9 drives excessive #interferon signaling in #COPD By M. Llamazares-Prada, R. Jurkowska & colleagues @biomedx.bsky.social & Cardiff University 🗞️ doi.org/10.1038/s44321-026-00386-9

#Encephalopathy linked #UFM1 variants impede neuronal protein translation, development, and function By C. Perdigão, N. Brose, M. Tirard & colleagues @mpi-nat.bsky.social 👉 doi.org/10.1038/s443...

KRAS-dependent glycolytic reprogramming of endothelial cells in #SporadicArteriovenousMalformations By R. Wu, J. Fish and colleagues @utoronto.ca @uhn.ca 🗞️ doi.org/10.1038/s443... Read also related N&V by M. Rudnicki and T. Haas 👉 doi.org/10.1038/s443...