📣 Metabolic #cardiomyopathies: untangling clinical heterogeneity with human #StemCell derived models By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam ➡️ doi.org/10.1038/s443...

Impaired migration and #LungInvasion of human #melanoma by a novel small molecule targeting the transmembrane domain of death receptor #p75NTR by V. Lopes-Rodrigues, C. Ibanez & colleagues doi.org/10.1038/s443...

Bead-based plasma #proteomics workflows boost proteome coverage but are vulnerable to cellular contamination, highlighting the need for contamination-aware quality control in #biomarker discovery. K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social 🗞️ doi.org/10.1038/s443...

Glycans on non-structural protein 1 prevent premature #Tcell mediated #DengueVirus clearance By F. Idris, S. Alonso & colleagues at National Centre for Infectious Diseases Singapore 🗞️ doi.org/10.1038/s443...

Dietary supplementation of #ArachidonicAcid promotes #HumoralImmunity By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University ➡️ doi.org/10.1038/s443...

Bead-based plasma #proteomics workflows boost proteome coverage but are vulnerable to cellular contamination, highlighting the need for contamination-aware quality control in #biomarker discovery. K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social 🗞️ doi.org/10.1038/s443...

Anti-M1R/B6R antibody characterization & bispecific design for enhanced #orthopoxvirus protection. 🗞 doi.org/10.1038/s443... by R. Zhao, L. Wu, Y. Zhang, J. Ma, J. Xue, Q. Wang & colleagues at Chinese Academy of Medical Sciences

CETN3 deficiency induces #microcephaly by disrupting neural stem/progenitor cell fate through impaired #CentrosomeAssembly and #RNAsplicing 👉 doi.org/10.1038/s443... by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University

Our September issue is online! www.embopress.org/toc/17574684... On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443... Scientific image: R. Hahn & K. Avraham, at Tel Aviv University

Identification of #p38 MAPK inhibition as a neuroprotective strategy for combinatorial #SpinalMuscularAtrophy therapy By M. Carlini, L. Pellizzoni & colleagues @columbiauniversity.bsky.social ➡️ doi.org/10.1038/s443...

Novel #Zika vaccine platform designed by disrupting viral #RNATertiaryStructure achieves tissue-specific attenuation & protection, reducing vertical transmission in animal models. X. Chen, ML Cheng, XY Huang, MX Sun, RT Li, CF Qin at Chinese Academy of Medical Sciences doi.org/10.1038/s443...

#TET3 is a regulator and can be targeted for the intervention of #MyocardialFibrosis By C. Zhu, W. Hong, Y. Zhu, D. Jiang, Y. Xu, M. Kong and colleagues at Nanjing Medical University 🗞️ doi.org/10.1038/s443...

New study by K. Avraham & colleagues ➡️ AAV #GeneTherapy rescues #hearing and #balance in a model of CLIC5 deafness 🗞️ doi.org/10.1038/s443...

EMT-ciliary signaling in quasi-mesenchymal-stem-like cells drives #TherapeuticResistance & is a druggable vulnerability in #TNBC By C Tessier, J Derrien, V Guen & al @inserm.fr @cnrs.fr 🗞️ doi.org/10.1038/s443... 👉N&V by AP Morel and @mariaouzounova.bsky.social doi.org/10.1038/s443...

Pyrin #inflammasome -driven #ErosiveArthritis caused by unprenylated RHO GTPase signaling By M. Akula, G. van Loo & colleagues at VIB Ghent 🗞️ doi.org/10.1038/s443...

🎉Congratulations to Yibing Wang at Inst Genet Dev Biol, Beijing, for winning the @embomolmed.org poster award at #OsakaMito2025!

CMG2 (alias the anthrax toxin receptor) on gut cells is vital for replenishing intestinal stem cells – insights into genetic disorder hyaline fibromatosis syndrome 📷 Lucie Bracq et al EPFL (Swiss Federal Technology Institute of Lausanne) in @embomolmed.org ➡️ bpod.org.uk/archive/2025...

🔎 Spotted in @embomolmed.org! Researchers from #KyotoUniversity, among others, used DSHB's anti-PAX7 mAb in a study on miR-33 inhibition in muscular dystrophy, revealing increased satellite cell activity and better muscle recovery. 📄 tinyurl.com/4vv6z783 🧫 dshb.biology.uiowa.edu/PAX7

Don’t miss the article by A. Caplan, F. Pasadyn and N. Mamo published in this issue of @emboreports.org ➡️ "Fool’s-gold science: The ethical and scientific perils of testing most #vaccines using placebo-controlled randomized trials" 🗞️ doi.org/10.1038/s443...

Now published in @embomolmed.org 🥳🎉 Protein-based tools for detection and characterisation of #Oropouche virus infection... See the final paper at doi.org/10.1038/s443... and read the bluetorial 👇

August issue now online! ➡️ www.embopress.org/toc/17574684... The cover highlights the study by X Qiao, J Routila, J Westermarck, S Ventelä & al @westermarcklab.bsky.social showing that LIMA1 detection can be used for #HNSCC patients stratification Scientific image by M. Peltola, Thestra Oy, Turku

A fetal oncogene NUAK2 is an emerging therapeutic target in #glioblastoma By H. Jo, S. Munoz, S. Glasgow & colleagues @ucsandiego.bsky.social 🗞️ doi.org/10.1038/s443...

Online today: Convergent activation of the #IntegratedStressResponse and ER–mitochondria uncoupling in VAPB-associated #AmyotrophicLateralSclerosis By C. Landry, H. Miranda & colleagues at Case Western Reserve University ➡️ doi.org/10.1038/s443...

Check this nice Resource by B. Hunter, J. O’Sullivan, J. Yang, S. Lal & colleagues at University of Sidney 👉 doi.org/10.1038/s443... "Left ventricular myocardial molecular profile of human diabetic #IschaemicCardiomyopathy"

📣Don’t miss this review on the current treatment framework in #ProstateCancer & novel approaches and targets that are set to transform clinical care => doi.org/10.1038/s443... by S. Nouruzi, A. Zoubeidi and colleagues at Vancouver Prostate Centre

Deadlines are approaching for @keystonesymposia.bsky.social Predicting & Responding to Emerging #Virus Infections, this October in Geneva! Our @embomolmed.org editor Zeljko Durdevic will attend. Poster abstract and registration dates => keysym.us/KSEmergingVirus26 #KSEmergingVirus26

Also online today 👉 Perspective by V. Katanaev and G. Solis at University of Geneva on #GaMutations associated with rare diseases 🗞️ doi.org/10.1038/s443...

Read this Perspective by L Martin, G Gabbiani & GRY De Meyer at University of Antwerp on the role of #SMAD7 in cardiac, skeletal muscle, and vascular tissues. 🗞️ doi.org/10.1038/s443...

De novo pyrimidine synthesis is a collateral #MetabolicVulnerability in NF2-deficient #mesothelioma 👉 doi.org/10.1038/s443... By D Xu, Y Gao, RW Peng, Y Shu et al. at University of Bern Read also N&V by J Jia & G Stathopoulos @ucy1.bsky.social @www.helmholtz-munich.de 👉 doi.org/10.1038/s443...

Online today! MicroRNA-33 inhibition ameliorates muscular #Dystrophy by enhancing #SkeletalMuscle regeneration 👉 doi.org/10.1038/s443... By N. Sowa, T. Horie, K. Ono & colleagues at Kyoto University Read also related N&V by M. Lopez & M. Alexander: 🗞️ doi.org/10.1038/s443...

JAK/STAT inhibition protects #GlucocorticoidReceptor knockout mice from lethal #malaria -induced hypoglycemia and hyperinflammation By F. Prenen, L. Vandermosten, P. Van den Stehen & colleagues at Rega Institute for Medical Research KU Leuven ➡️ doi.org/10.1038/s443...

Online today! #PV1: a novel molecular #PrognosticMarker of distant metastases in various #SolidTumors By C. Pozzi, R. Sarti, @mrescigno.bsky.social‬ & colleagues at Humanitas Research Hospital 👉 doi.org/10.1038/s443...

#Peptidomic analysis of #CSF reveals new biomarker candidates for #AmyotrophicLateralSclerosis By B. Muqaku, P. Oeckl & colleagues at University Hospital Ulm & @dzne.science 🗞️ doi.org/10.1038/s443...

New study that identifies a novel immunohistochemical staining-based method for identifying #HNSCC patients who would benefit from surgery alone ➡️ doi.org/10.1038/s443... By X Qiao, J Routila, J Westermarck, S Ventelä & colleagues @utu.fi

Cold exposure promotes the progression of #osteoarthritis through downregulating #APOE in cartilage By Y Zhang, M Fu, C Zhou, S An, X Wang, Z Wang & colleagues ➡️ doi.org/10.1038/s443...

SFX-01 is therapeutic against #MyeloproliferativeDisorders caused by activating mutations in #Shp2 By HJ Cho, J Smith, C Switzer, P. Eaton and colleagues @qmul.bsky.social 🗞️ doi.org/10.1038/s443...

Read this Perspective by S. Schmidt, X. Qiao and M. Bergö @ki.se‬ that highlights the intricate functions of #antioxidants in #cancer progression, and explore their potential clinical implications ➡️ doi.org/10.1038/s443...

Our July issue is online 👉 www.embopress.org/toc/17574684... The cover highlights the article by M Robert, C Swale, MP Brenier-Pinchart, @hakimi.bsky.social‬ & al. that identifies BSM & BCLA as #biomarkers for chronic #ToxoplasmaGondii infection Scientific image by @hakimi.bsky.social @inserm.fr

💡 Publiés récemment dans @embomolmed.org et réalisés @unil.bsky.social ces travaux démontrent qu'un cocktail de seulement deux molécules peut contrer le vieillissement cellulaire, dans des cellules humaines et chez un vers microscopique. 🔗 www.embopress.org/doi/full/10.... @embopress.org @embo.org

🎉Congratulations Judit Jiminez Sainz at Medical University of South Carolina for winning the EMBO Mol. Med. poster award at the #DDRCT25 Fusion conference! #DNArepair #BRCA

A novel modulator of #IL6R prevents inflammation-induced #PretermBirth and improves newborn outcome. By F. Côté, S. Chemtob & colleagues ‪@umontreal-en.bsky.social ➡️ doi.org/10.1038/s443...

New study by L. Schoenfeldt, P. Paine, S. Picó, K. Perez, A. Ocampo & colleagues at University of Lausanne shows that partial chemical reprogramming with small-molecule cocktails rejuvenates aged #HumanCells and extends #lifespan and healthspan in #Celegans ➡️ doi.org/10.1038/s443...

Online today! Loss of p300 in proximal tubular cells reduces #RenalFibrosis and endothelial-mesenchymal transition. By Hyunsik Kim, Beom Seok Kim, Beom Jin Lim, Ho-Geun Yoon & colleagues at Yonsei University College of Medicine Seoul 🗞️ doi.org/10.1038/s443...

Online today! Replicated blood-based #biomarkers for #MyalgicEncephalomyelitis not explicable by inactivity By S.V. Beentjes, @avakhamseh.bsky.social‬, @cgatist.bsky.social‬ & colleagues @edinburgh-uni.bsky.social 🗞️ doi.org/10.1038/s443...

Ki-67 promotes inflammatory signaling governing #neutrophil recruitment during #RespiratoryInfections ➡️ doi.org/10.1038/s443... By M. Yee, M. O’Reilly & colleagues @urochester.bsky.social

Small molecule disruption of RARα/NCoR1 interaction inhibits #ChaperoneMediatedAutophagy in #LungCancer By M. McCabe, A.M. Cuervo, E. Gavathiotis & colleagues @einsteinmededu.bsky.social ➡️ doi.org/10.1038/s443...

In a new study published in embomolmed.org, Evripidis Gavathiotis, Ph.D., and Ana Maria Cuervo, M.D., Ph.D., have identified the NCoR1/RARα protein complex as a regulator of CMA in #lungcancer. The work opens the door for targeted CMA inhibition across a range of cancers. #MedSky #autophagy

#Reelin -LRP8 signaling mediates brain dissemination of breast #CancerCells via abluminal migration. #zebrafish By H. Huang, M. Zhang, E. Huang, G. Ning, J. Zhang & colleagues at Hospital of Guangdong Medical University 🗞️ doi.org/10.1038/s443...

📣Read this new review by M. Shinohara & colleagues @dukemedschool.bsky.social on the interplay between #FungalInfections and #autoimmunity ➡️ doi.org/10.1038/s443...