CDK12/CDK13 inhibition disrupts transcriptional elongation and #ReplicationFork progression in #glioblastoma By S. Lier, M. Lerdrup, D. Pandey & colleagues at University of Copenhagen & University of Oslo 🗞️ doi.org/10.1038/s44321-026-00393-w

New study by L Guenin-Macé, O Join-Lambert, @demangelab.bsky.social & al. @pasteur.fr @univrouen.bsky.social ➡️ P. uenonis colonizes #HidradenitisSuppurativa skin & crosses the epidermis to invade keratinocytes #Infection #ChronicInflammation #Autoimmunity 🗞️ doi.org/10.1038/s44321-026-00407-7

#IGFBP3 repression driven by inflammation links #AirPollution to placental and #DevelopmentalDefects by S. Singh, R. Dhar, S. Karmakar & colleagues at All India Institute of Medical Sciences 🗞️ doi.org/10.1038/s44321-026-00403-x

Blocking microglial reactivity via #purinergic receptors prevents subacute #cognitivedeficits after TIA ➡️ doi.org/10.1038/s44321-026-00397-6 By G. Llovera, @arthurliesz.bsky.social & colleagues @synergy-munich.bsky.social Read related N&V by Kibin Shi & al 🗞️ doi.org/10.1038/s44321-026-00404-w

Online today! Betrixaban activates #cGAS and ERVs to promote dual nucleic-sensing #antiviral #immunity By Y. Zhao, X. Wang, X. Guo, F. You & colleagues at Peking University ➡️ doi.org/10.1038/s44321-025-00356-7

Deadlines are approaching for @keystoneSymposia.bsky.social #TumorMetabolism : Diet, #Microbiome & Beyond, this June in Killarney. @embomolmed.org editor Lise Roth is looking forward to the meeting. See abstract and discount reg dates: hubs.la/Q03TCsnZ0 #KSTumorMetab26

Our March issue is now online! 🗞️ link.springer.com/journal/4432... The cover highlights the article by S. Gan, C. Zhang, W. Yang, Y. Li, H. Huang and colleagues on #HNRNPR mutations and #FertilizationFailure 👉 doi.org/10.1038/s44321-026-00374-z

Metabolically reprogrammed #eosinophils impair T cell immunity and cause chronic #SkinInfection By D. Barinberg, C. Bogdan, U. Schleicher & colleagues @fau.de 🗞️ doi.org/10.1038/s44321-026-00392-x

TDP-43 pathology triggers #neuroinflammation and #CognitiveImpairment by inducing microglial necroptosis, by S. Guo, C. Fu, Y. Yin, W. Cheng & colleagues at Xinhua Hospital, Shanghai 🗞️ doi.org/10.1038/s44321-026-00394-9

Our editor Lise Roth will be attending #CancerImmunotherapy : Mechanisms, Clinical Advances & Combinations, this March in Québec with @keystoneSymposia.bsky.social Reach out to talk about your research! keysym.us/KSCancerImmune26 #KSCancerImmune26

IFN-gene signatures in #Bcells following #influenza A and B virus infection and influenza #vaccination 👉 doi.org/10.1038/s44321-026-00395-8 By W. Zhang, @katherinekedz.bsky.social , T. Nguyen & colleagues @unimelb.edu.au @thedohertyinst.bsky.social

Online now! Cell-free DNA #methylome and #fragmentome analysis for relapse monitoring of #EwingSarcoma By S. Richardson, M. McCabe, @florentmouliere.bsky.social & colleagues @cancerresearchuk.org @manchester.ac.uk ➡️ doi.org/10.1038/s44321-026-00396-7

Thanks so much Arica! It has been a fruitful week of science at #EMBLCardioBiology. I am really honored to receive the prize sponsored by @embomolmed.org. It means a lot to me. I would also like to thank the scientists I met there. The discussions were inspiring! #zebrafishrocks #cardiobiologyrocks

Sign up by 6 March for the EMBO Lab Leadership #training "How to write a scientific paper" delivered by EMBO Press editors at EMBO | EMBL Symposium "#AI and #biology." 🧪 https://www.embl.org/about/info/course-and-conference-office/events/ees26-02/#vf-tabs__section-embo_training#training#AI#biology#vf-tabs__section-embo_training#EESAIBio #EMBOevents

Structure-guided design of a PfCyRPA-based #vaccine against blood-stage #malaria ➡️ doi.org/10.1038/s44321-026-00376-x By N. Alam, @parasitematt.bsky.social and colleagues @ox.ac.uk @kavlioxford.bsky.social

Read this @emboreports.org paper here=> link.springer.com/article/10.1...

KCNA2 variants cause dilated #cardiomyopathy, #obesity and #SleepApnea through RAC-ERK pathway By P. Chimata, P. Dhandapany & colleagues at Institute for Stem Cell Science and Regenerative Medicine 👉 doi.org/10.1038/s44321-026-00391-y

#CITED2 is a druggable #EpigeneticSwitch coupling neuronal maturation to regenerative decline By F. Müller, S. Di Giovanni & colleagues @imperialcollegeldn.bsky.social 🗞️ doi.org/10.1038/s44321-026-00385-w

Online today! ➡️ doi.org/10.1038/s44321-026-00387-8 Sulfated #glycosaminoglycans inhibit #LCMV entry and modulate antiviral immunity and pathology By M. Gorzkiewicz, P. Lang & colleagues @hhu.de

Epigenetic dysregulation of IRF9 drives excessive #interferon signaling in #COPD By M. Llamazares-Prada, R. Jurkowska & colleagues @biomedx.bsky.social & Cardiff University 🗞️ doi.org/10.1038/s44321-026-00386-9

#Encephalopathy linked #UFM1 variants impede neuronal protein translation, development, and function By C. Perdigão, N. Brose, M. Tirard & colleagues @mpi-nat.bsky.social 👉 doi.org/10.1038/s443...

KRAS-dependent glycolytic reprogramming of endothelial cells in #SporadicArteriovenousMalformations By R. Wu, J. Fish and colleagues @utoronto.ca @uhn.ca 🗞️ doi.org/10.1038/s443... Read also related N&V by M. Rudnicki and T. Haas 👉 doi.org/10.1038/s443...

New issue online! ➡️ link.springer.com/journal/4432... This month's cover highlights the article by J. Haas, B. Meder and colleagues at Heidelberg University and German Center for Cardiovascular Research 🗞️ doi.org/10.1038/s443...

I was honored to be profiled by Churchill College regarding our recent @embomolmed.org paper out of the Jackson lab (www.stevejacksonlab.org) on MAEA, DNA repair/replication, and a new diagnosis, DIADEM. (I tried to aim my answers at a general audience.) www.chu.cam.ac.uk/news-and-eve...

A bactericidal #tuberculosis drug regimen driven by inhibition of the terminal oxidases by #pretomanid -> doi.org/10.1038/s44321-026-00378-9 By N. Ab Rahman, K. Pethe & colleagues at Nanyang Technological University, National Centre for Infectious Diseases & @ineosoxford.bsky.social

Dextrorotatory kynurenine suppresses #AcuteRejection through inhibiting M1 macrophage-mediated #inflammation By Y. Zhao, Y. Guo, C. Yang, D. Zhu & colleagues at Fudan University & Chinese Academy of Sciences ➡️ doi.org/10.1038/s44321-026-00377-w

[PUBLICATION] The @goffinlab.bsky.social lab shows a promising therapeutic strategy to mitigate prostate cancer progression towards CRPC — now out in EMBO Molecular Medicine @embomolmed.org 👏🏼 Co-first authors: Manon Baurès & Anne-Sophie Vieira Aleixo 🔗 link.springer.com/article/10.1...

Grateful to @cambiochem.bsky.social for spotlighting my PhD work, recently published in @embomolmed.org. We're really proud of this international collaboration between a wide range of researchers and clinicians. Thanks to everyone involved! www.bioc.cam.ac.uk/news/embo-mo...

Targeting pre-existing club-like cells in #ProstateCancer potentiates #AndrogenDeprivationTherapy by M. Baurès, F. Rambow, @goffinlab.bsky.social & colleagues @inem-necker.bsky.social and Institute for AI in Medicine (IKIM) ➡️ doi.org/10.1038/s443...

Characterization and therapy of #fertilization failure in murine and human models with HNRNPR mutations ➡️ doi.org/10.1038/s443... by S. Gan, C. Zhang, W. Yang, Y. Li, H. Huang and colleagues at Zhejiang University

Our @embojournal.org editor Daniel Klimmeck is looking forward to the #MitoCellFate conference in May. Submit poster abstracts and registration until February 9th => bit.ly/43AaInH @fusionconf.bsky.social

Explore emerging research with field leaders @keystonesymposia.bsky.social #CancerImmunotherapy : Mechanisms, Clinical Advances & Combinations, this March in Québec! hubs.la/Q03TCrxR0 #KSCancerImmune26

TKI-mediated inhibition of NLRP1 #inflammasome restores #erythropoiesis in Diamond-Blackfan anemia syndrome 👉 doi.org/10.1038/s443... By J. Lozano-Gil, A. Martínez-López, S. Tyrkalska, V. Mulero & colleagues @ciberisciii.bsky.social & @um.es

#ExtracellularVesicle -based targeted #ProteinDegradation platform for multiple extracellular proteins By B. Tong, L. Tan, Z. Liao, C. Yang & colleagues at Huazhong University of Science and Technology ➡️ doi.org/10.1038/s443...

Sarcomeric remodelling in human #HeartFailure unraveled by single molecule #LongReadSequencing By J. Haas, B. Meder & colleagues @uniheidelberg.bsky.social

Online today -> A viral glycoprotein targets IgG+ memory #Bcells to mediate humoral #ImmuneEvasion by P. Cramer, M. Rizzi, H. Hengel and colleagues @uni-freiburg.de @univie.ac.at 🗞️ doi.org/10.1038/s443...

Our new issue is online! link.springer.com/journal/44321 The cover illustrates the study by B. Stringer, J. Giacomotto & colleagues that introduces a tool for assessing SMN1 pathogenicity in #SpinalMuscularAtrophy using the zebrafish model ➡️ doi.org/10.1038/s443...

Molecular profile of human ischemic cardiomyopathy in #diabetes reveals reduced mitochondrial complex I and elevated very long chain acylcarnitines @embomolmed.org link.springer.com/article/10.1...

Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with @drjhujh.bsky.social and @profstewartlab.bsky.social alongside @sorenhough.bsky.social and friends in @spjacksongroup.bsky.social.

Mechanisms of resistance to #VHL loss-induced genetic and pharmacological vulnerabilities ➡️ doi.org/10.1038/s443... By J. Ge, D. Muñoz-Espín, @svanharanta.bsky.social & colleagues @cam.ac.uk @helsinki.fi

Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social 🗞️ doi.org/10.1038/s443...

Online today! Mutant #CHCHD10 disrupts cytochrome c oxidation and activates mitochondrial retrograde signaling by M. Campos-Ribeiro, T. Wai & colleagues @pasteur.fr 👉 doi.org/10.1038/s443...

New review by M. Pepin, X. Gong, A. Schulze and J. Backs @uniheidelberg.bsky.social ➡️Metabo-epigenetic circuits of #HeartFailure: chromatin-modifying enzymes as determinants of metabolic plasticity🫀 🗞️ doi.org/10.1038/s443...

Clinical relevance of #zebrafish for gene variants testing. Proof-of-principle with SMN1/SMA 👉 doi.org/10.1038/s443... #SpinalMuscularAtrophy By B. Stringer, J. Giacomotto and colleagues @griffith.edu.au

Microplastics reach human lungs, blood, and brain, yet their biological impact is poorly defined. In our new @embomolmed.org review, we connect environmental exposure to inflammation, stress signalling, epigenetic disruption, and cell identity. link.springer.com/article/10.1...

New Resource Online 👉 Molecular determinants of #CardiacLymphatic dysfunction in a #ChronicPressureOverload model 🗞️ doi.org/10.1038/s443... by C. Heron, H. Dauchel, @hfpef-diva.bsky.social & colleagues @univrouen.bsky.social @inserm.fr

📣 Review on #microplastics as environmental modifiers of #LungDisease 🫁 by E. Epeslidou, @bnmelgert.bsky.social , @stefanprekovic.bsky.social & colleagues @rug.nl & University Medical Center Utrecht ➡️ doi.org/10.1038/s443...

New paper out in EMBO Mol Med! We use machine learning to predict Aβ-PET burden from fluid biomarkers. www.embopress.org/doi/full/10.... Key findings: - Performance R² = 0.79 - CSF Aβ42/Aβ40 most predictive of Aβ plaque presence - Plasma p-tau217 best for tracking increasing amyloid plaque burden

One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org www.embo.org/people/revie...

Loss of #EHMT2 enhances #NKcell -driven #AntiTumorImmunity through #TGFβ1 suppression by S. Chava, R. Gupta, N. Wajapeyee & colleagues @uofalabama.bsky.social doi.org/10.1038/s443...