MPI-NAT researchers have decoded how changes in the UFM1 system, a protein modification machinery, disrupt the protein production in neurons, leading to severe developmental disorders. The findings provide a new molecular understanding of childhood encephalopathy ⬇️ www.mpinat.mpg.de/5256523/rn_2...

Our April issue is online! link.springer.com/journal/4432... This month’s cover highlights the article by N. Brose, M. Tirard & colleagues, #Encephalopathy -linked #UFM1 variants impede neuronal protein translation, development, and function ➡️ doi.org/10.1038/s44321-026-00389-6

Our work features the cover of @embomolmed.org ! Check the paper here: link.springer.com/article/10.1...

New #preprint 😍‼️ led by 2 incredible postdocs @ninizhani.bsky.social & Ranj Papareddy: transforming #UFMylation from a local ribosome rescue pathway to systems level regulator of mRNA splicing www.biorxiv.org/content/10.6... A short 🧵

Fantastic new story out in @embo from @catarina and Marilyn Tirard's Lab showcasing the post-translational modifications by ubiquitin-like modifier Ufm1 in the regulation of morphology and translation in neurons. Happy to have contributed! 🤩 Link to the paper 👇🏻 link.springer.com/article/10.1...

New paper from our lab! We studied UFM1, a ubiquitin-like modifier, and found it is essential for neuronal development and synapse function. We also explore the cellular mechanisms that may underlie UFM1-associated encephalopathies. Paper: doi.org/10.1038/s443... A short thread ↓