🌍 Cilia2027 | Mar 8–12, 2027 | 📍 Stresa, Lake Maggiore, Italy Join the global cilia community for science, collaboration & discovery (+ fun!!). #Cilia2027 #CiliaBiology

CDKL5 Deficiency Disorder (CDD) leads to seizures & intellectual disability. This study shows that #Chlamydomonas CDKL5 kinase is activated by the LF2/CDK20 kinase; CDKL5 in turn regulates #intraflagellar transport via protein abundance & phosphorylation #cilia @plosbiology.org 🧪 plos.io/45490eP

CiliaQ Editor just received a convenient upgrade allowing to faster inspect and correct segmentations of #cilia in the #CiliaQ workflow (automatic color & BC adjustment, new functions, etc.). If you update FIJI, you automatically update to the new version. All details at github.com/hansenjn/Cil....

📣 Here it is — our overview on ciliary proteomics! Great discussions and writing with @mick-lab.bsky.social and Ronald Roepman 🙏🙏 Hope we didn’t miss anything important - apologies if we did! #cilia #ciliopathies #proteomics @theracilproject.bsky.social @for5547.bsky.social tinyurl.com/yc8ztn5v

Save the date! March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? 🥳 Stay tuned for more info!

We have an open #ERC funded PhD position to work on #cilia #mitochondria #PKD and #matabolism Deadline July 7th. Look forward to welcoming a talented PhD student to our lab in beautiful Milan 👇

Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail https://go.nature.com/45L9NlX

🔬 Excited to share our latest paper! We’ve found how Spd-2 coordinates with Polo and Aurora A to build critical scaffolds in centrosome assembly in Drosophila. 🧬 www.science.org/doi/10.1126/...

Cross-organ metabolite production and consumption in healthy and atherogenic conditions: Cell www.cell.com/cell/fulltex...

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —from decades of NIH funded research www.nejm.org/doi/full/10.... @nejm.org www.nejm.org/doi/full/10.... www.nytimes.com/2025/05/15/h...

Very happy to find our last article in Kidney International Reports online today! #cilia #ciliopathies #kidney

How curvature affects epithelial tissues? Answer in 5 papers! To understand this, one must first gain control over curvature. The most logical way of doing this is through scaffolding in vitro — make a shape and attach cells.

🎉 Huge congratulations to Susan Dutcher @dutcherlab.bsky.social on her election to the National Academy of Sciences! A well-deserved recognition of her outstanding contributions to cell biology and cilia research. 👏🔬 #WomenInSTEM #Cilia

Major congratulations to our fearless leader and team captain Susan Dutcher @dutcherlab.bsky.social for being elected to the National Academy of Sciences! 🙌 Another big win for #cilia biology!!

Congratulations Susan! Super deserved!

📣 Don’t miss the review by @bolettalab.bsky.social & S. Clerici on metabolic and mitochondrial alterations in #PolycysticKidneyDisease and other renal #ciliopathies ➡️ doi.org/10.1038/s443... at IRCCS San Raffaele Scientific Institute

A week until our 51st @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social UK Cilia and Centrosome Network e-symposium: 15/04/2025 15:00-17:15 BST. Still not registered for the series- join us here: www.eventbrite.co.uk/e/bscb-genso... Free and open to all! /1

Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social Registration is now open www.cfc2025.conferences-pasteur.org

I've been doing this for 30 years & I still can't believe that when people ask me what I do for a living I get to tell them "I'm a scientist". It feels like a kid's fantasy career that they dress up as for Halloween, like "astronaut" or "pirate". I feel very lucky I get to do this day in & day out.

Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans www.nature.com/articles/s41...

ICYMI:

Looking for a home for your #cilia submission? Still time to be part of this special issue of the Journal of Cell Science- the journal for the cell biology community, by the cell biology community! ⏰ Reach out to @lottepedersen.bsky.social or I to discuss....

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜: www.biorxiv.org/content/10.1... A short thread🧵👇

Our Guest Editor @lottepedersen.bsky.social is attending our Biologists @ 100 conference. Reach out to Lotte if you have questions about submitting your research to our special issue on cilia and flagella biology: journals.biologists.com/jcs/pages/ci... Submission deadline: 31 March #biologists100

In L.A. heading to Ventura Beach for the #GRC on #mitochondria. Excited to share our long-standing work on mitochondria in #PKD and our more recent discovery of the cross-talk between #cilia and #mitochondria @erc.europa.eu

How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...

1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social www.science.org/doi/10.1126/...

1) We have updated our preprint on #cilia and #extracellular vesicles, which is regulated by #KIF13B: www.biorxiv.org/content/10.1...

More good news: MEP Christian Ehler's ITRE report adopted by the European Parliament: strong support for an expanded and independent ERC. Happy with the proposal of €220 billion for the EU's next research framework programme! Thank you! Press briefing multimedia.europarl.europa.eu/en/webstream...

To be in the same vein with #NephMadness genetics, we will discuss ADPKD @kdigo.org guideline #NephJC pubmed.ncbi.nlm.nih.gov/39848759/

Loved this lab coat that I spotted in Raleigh

Happy #Internationalwomensday to all the strong #ADPKD women’s and to all the women who support #ARPKD or #ADPKD families: you are our rock! 🌷

Thrilled- the @bsdb.bsky.social medal in Wolpert's name marks 'vastly important contributions to research in our field, but also to the communication of its problems to a broader audience'. Communicating the importance of our research has never been more important when science is under such threat!

Michael Caplan and myself have put together a thorough review on #PKD. We worked for over a year with multiple calls, long discussions, writing and re-writing…intense and fun! Hope the outcome is appreciable, final version in prep pubmed.ncbi.nlm.nih.gov/39938884/

Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N

💙 Rare Disease Day 2025 💙 Rare kidney diseases may be individually uncommon, but together they affect thousands of children. 🧬Genomics is changing the game—early diagnosis means better care, targeted treatments, and hope. 🧵 1/4 #RareDiseaseDay #Genetics #KidneyHealth #RareButNotAlone

"Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties" and are made by multiple cell types. This video shows fibroblasts (green arrows) and fibroblast-derived blebbisomes (magenta-arrowhead). Read about blebbisomes here: www.nature.com/articles/s41...

Interested in primary #cilia, #microtubules, #protein trafficking, molecular #signaling, #GPCRs, and #ciliopathies? We are looking for a #postdoc and a #PhDstudent to apply advanced #biochemistry and #proteomics methods to study cilia. Check out our website and send your application until March 10.

Welcome to the PKD Foundation’s Bluesky! We’re proud to be the only organization in the U.S. solely dedicated to finding treatments and a cure for polycystic kidney disease (PKD). Learn more about our organization at pkdcure.org.

Solving 25 years of frustration, Daniel Abbühl managed to tag trypanosome tubulin and to express it in an inducible manner, hence revealing flagellum assembly! A tour-de-force! Preprint here: www.biorxiv.org/content/10.1...

Recent interesting paper on cilia signaling in pancreatic beta-cells. Together with the last one from @nachury.bsky.social lab (see previous post), fascinating examples of complex regulation of GPCR/cAMP signaling in cilia. www.embopress.org/doi/full/10....

Congratulations to Max Liebau 👏 and colleagues for a breakthrough study defining a risk score to predict kidney survival in ARPKD patients 👏 pubmed.ncbi.nlm.nih.gov/39922379/

On the International Day of Women and Girls in Science, we celebrate all female researchers who push the frontiers of knowledge! Introducing @noeliaferruz.bsky.social - a chemist @crg.eu aiming to design a digital mind capable of explaining its reasoning. 👉 aiproteindesign.com

I forgot the all-important 🧪 tag. Please boost, along with the inspiring example of Dr. Levi-Montalcini, whose impediments overcame continue to loom for women scientists around the world even today: www.nobelprize.org/womenwhochan...

👀 🤯

The 2025 ISN Leadership Election results were announced during the ISN General Assembly meeting today at #ISNWCN. Welcome to 2025-27 ISN President-elect, Liz Lightstone @kidneydoc101.bsky.social (UK),

Immagine you could image two cellular structures in the same fluorescent channel and still reliably get them separated afterwards… What would you do with this? Now… what would you do if that also worked with 4 structures at once? 👇 #MicroSplit #preview🧵

A new issue of Cell is out, featuring the 4 winners of the Rising Black Scientists Awards. Their essays bring hope, inspiration and reinforce the importance of equity in science. Do take a moment to check them out: www.cell.com/cell/current @cp-cell.bsky.social