Another fantastic technology development paper by @davidbreslowlab.bsky.social. Being able to perform microscopy-based CRISPR screens on fixed cells is big. And TZMP1 is a fascinating transition zone proteins. We may be missing many more of these #microproteins. Congrats to all authors!

Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase. www.nature.com/articles/s41...

"... the species of trees we choose to nurture may be just as important as the number of trees we plant." Read the blog post behind the paper by Yao et al. regarding the role of #tree species in the #climate impact of European #forests. communities.springernature.com/posts/rethin...

Amazing work by the Breslow lab. Super excited to finally see this published. Unbiased CRISPRa screening reveals a novel and unexpected cilia disassembly pathway associated with neurological disease (focal cortical dysplasia). Must read for both #cilia and screening technology enthusiasts.

It was a lot of fun to write this review on cilia proteimics with Bernhard Schermer @cilib.social.cologne.ap.brid.gy and Ronald Ropeman, and we are excited to see it published in the @jcellsci.bsky.social special issue on Cilia and Flagella: from basic Biology to Disease.

Interesting connection between primary #cilia and energy #metabolism in #mitochondria. www.biorxiv.org/content/10.1...

Very much looking forward to our next focus workshop on #cilia and #centrosomes. We'll have fantastic speakers again.

With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend. mpl.mpg.de/news/article... @fau.de 📸 Stephan Spangenberg

New findings in mice cast light on the pathways behind the growth of painful bone tumors in hereditary multiple osteochondroma and suggest that these mechanisms could be targeted to slow the disease’s progression. Learn more in #ScienceSignaling: https://scim.ag/46VRSIp

We’re renewing our collaboration with Google DeepMind! We'll keep developing the AlphaFold Database to support protein science worldwide 🎉 To mark the moment we’ve synchronised the database with UniProtKB release 2025_03. www.ebi.ac.uk/about/news/t... 🖥️🧬 #AlphaFold @pdbeurope.bsky.social

Today is the #BBSGlobalDay — an opportunity to raise awareness of this rare condition and offer support to everyone living with BBS and their loved ones 🌍 🌎 🌏 www.img.cas.cz/2025/10/8758...

First pizza lunch after a whirlwind week moving into our brand-new research building. Exhausted, but absolutely thrilled by the incredible facilities & lab space. Can’t wait to dive back into science. A few benches are still waiting for curious minds: PhD students and postdocs, come join us! 😉

'This story shows that it is possible to establish a multibillion-dollar industry purely by letting scientists communicate their research, exchange information and share materials.' www.nature.com/articles/d41...

Science doesn’t need to be pretty and go according to plan; it just needs to lead to a discovery. If doesn’t have to be done alone or together with someone else; there just needs to be a discovery. It doesn’t need to happen fast or slow; just as long as there’s a discovery, then everybody is happy.

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️ ➡️ www.nature.com/articles/s41... Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond. embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

SNAP-tag is a widespread tool for labelling protein for bioimaging. An article published in Nature Chemical Biology presents SNAP-tag2 with increased labelling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging. go.nature.com/46fMIZd 🧪

Beautiful work on the development of protein kinase reporters. Congrats all! www.nature.com/articles/s41...

Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia

'Reproductive-associated changes are also known to occur at the organ level, in particular, an increase in intestinal size during pregnancy and lactation has been observed in several mammals such as mice, rats, sheep, and pigs' thenode.biologists.com/re-growing-a...

@sven-m-lange.bsky.social @alanbrownhms.bsky.social epic preprint dropped last night 🔥🔥🔥 #cilia #ift #ubiquitin #compartmentalization #signaling #GPCRs #AnticipationBuilding #SlowRead 🧪 www.biorxiv.org/content/10.1...

Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social Registration is now open www.cfc2025.conferences-pasteur.org

Mark your calendars & repost! Join us for the 2026 FASEB Lipid Droplets Conference! July 26-30, 2026 in beautiful Scottsdale, Arizona. Best of all: The FASEB Lipid Droplet meeting is co-locating with the FASEB Phospholipid meeting. Two wonderful lipid communities brought together!

Fantastic lineup again. Can't wait!

“The Trump administration has canceled funding for an ongoing 30-year, nationwide study tracking patients with prediabetes and diabetes, researchers said, at a time when top officials have emphasized their determination to curb the incidence of such chronic conditions.”

More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention. www.science.org/doi/10.1126/...

A critical role for the ER Membrane Complex (EMC) in lipid droplet homeostasis https://www.biorxiv.org/content/10.1101/2025.03.10.642408v1

Our first post on Bluesky! 1/ We are excited to share our latest work, showing that heterooligomerisation drives structural plasticity of Prx1-type peroxiredoxins. www.biorxiv.org/content/10.1... Another fantastic collaboration with the Marcel Deponte lab and Joris Messens lab!

Happy faces and a lot of sunshine at the start of our Spring School on #cilia dynamics! @jayccblab.bsky.social @nathaliejuya.bsky.social @mick-lab.bsky.social @wachtenlab.bsky.social Looking forward to three days of interactions with early career researchers from our cilia network partners!

The EU foreign policy chief has declared that “the free world needs a new leader”, as European leaders threw their support behind Ukraine’s president, Volodymyr Zelenskyy. www.theguardian.com/world/2025/f...

Nice work on one of my most favorite topics.

A small-molecule agonist of TRPM4 persistently activates the ion channel and induces necrosis characterized by sodium overload www.nature.com/articles/s41...

Chemoproteomic profiling of protein dopamination in the mouse brain reveals a protective role of dopamine in regulating the function of microtubule-associated protein Tau www.nature.com/articles/s41...

Wow. 👀📌

Cool organelle segmentation tool. Time to try it out. Congrats all!

(1/2) On Rare Disease Day, we’re highlighting EMBL's molecular biology research & services in this area. Check out our collection of stories: www.embl.org/news/tag/rar...

HLS, an autosomal recessive #ciliopathy, is associated with a mutation in the centriole protein HYLS1. Curinha, Holland et al. show that HYLS1 mutant mice exhibit developmental abnormalities, with #centriole integrity & #cilia assembly defects https://buff.ly/3XlIry1

Interested in primary #cilia, #microtubules, #protein trafficking, molecular #signaling, #GPCRs, and #ciliopathies? We are looking for a #postdoc and a #PhDstudent to apply advanced #biochemistry and #proteomics methods to study cilia. Check out our website and send your application until March 10.

⌛️9 days left to register for our #WUeBi2025 conference!⌛️ Countdown started: in the next 9 days we will announce our amazing speakers here - so stay tuned! Today starting with our Keynote speakers Brenda Schulman from @mpibiochem.bsky.social and Tom Rapoport from @harvardmed.bsky.social

This week was the 1st publication using our immune cell sequencing to accurately make medical diagnoses. It has enormous implications, as I've reviewed here erictopol.substack.com/p/the-first-... @scottboydlab.bsky.social @science.org @anshulkundaje.bsky.social @maximzaslavsky.bsky.social

NuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends. New study from Sabina Colombo, Thomas Surrey @surreylab.bsky.social and colleagues @crg.eu: https://buff.ly/41aj9F9

The Mn-motif protein MAP6d1 assembles ciliary doublet microtubules https://www.biorxiv.org/content/10.1101/2025.02.17.638590v1

In this fundamental study, scientists uncover a key mechanism in jellyfish embryos that provides new insights into how the body plan of these animals develops along a central axis from their ‘head’ to ‘tail’. https://buff.ly/3QgH4wH

Cool #biochemistry showing microtubule minus end binding by NuMA. It will be interesting to investigate how this binding is regulated on a molecular level.

A Direct Hit, by @holdenthorp.bsky.social @science.org www.science.org/doi/full/10.... "This is a moment to unite."

Today is International Day of Women & Girls in Science. Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM

Danish startup Visibuilt is making a fossil-free bitumen substitute with fungi, and bicycle lanes, car parks and roads could soon sport earth-friendly mushrooms underfoot nature.com/articles/s41... rdcu.be/d8Tko

Our students are scared, confused and disappointed. I started class today by reminding them that 50 years ago, most of the class would not have been eligible to attend UNC, but that they ALL belong here

Can you explain your doctoral research through interpretive dance? The 17th annual #DanceYourPhD competition is open! Submit by 28 March for a chance to win $2000: scim.ag/3BcKi0e

Great mechanistic insight into cilia signaling causing #obesity in the context of #ciliopathies by studying #ubiquitin in GPCR trafficking.