We are extremely happy to share our latest publication on peroxiredoxin heterooligomerisation. A wonderful collaboration with the labs of Marcel Deponte, Joris Messens, Jan Riemer, and many others.

Cells may work with “Lego®️ bricks” 🧱 at the molecular level. Our new study shows that peroxiredoxins can mix different subunits to form hybrid complexes arranged in donut-like rings 🍩, creating molecular diversity that helps cells fine-tune stress and redox signaling responses. Out in Nat Chem Biol.

We are looking for a new colleague in the biology department at Saarland University! We are looking for excellent Cell Biologists / Cell Physiologists for a W2 tenure track W3 professorship in 'Dynamics of Biological Systems'. Please share! jobs.zeit.de/jobs/w2-prof...

8/ 8/ The work now begins to understand the functional implications of peroxiredoxin heterooligomerisation and its implications for our current view of these fascinating proteins.

With Armindo Salvador, we determined that it is possible to form as many as 120 distinct heterodecameric complexes with two monomeric components.

6/ With @riemerlab.bsky.social we could also show the presence of PRDX1-PRDX2 heterooligomers in HEK293T cells.

5/ Heterooligomerisation is inducible in response to oxidative challenge in yeast and stabilises Tsa1 as a Tsa1-Tsa2 heterodecameric complex.

4/ With the Messens lab, we used negative stain EM to visualise heterooligomers and show that heterooligomerisation strongly affects dimer-decamer equilbrium.

3/ Long considered to only form homooligomeric complexes, we find that pairs of peroxiredoxins from human, yeast, plant and parasite readily assemble into heterodimers and heterodecamers.

2/ We also had the pleasure to work with @riemerlab.bsky.social @herrmannlab.bsky.social, Timo Mühlhaus lab, Ana Tomas lab and Armindo Salvador on this exciting project

Our first post on Bluesky! 1/ We are excited to share our latest work, showing that heterooligomerisation drives structural plasticity of Prx1-type peroxiredoxins. www.biorxiv.org/content/10.1... Another fantastic collaboration with the Marcel Deponte lab and Joris Messens lab!