Cells may work with “Lego®️ bricks” 🧱 at the molecular level. Our new study shows that peroxiredoxins can mix different subunits to form hybrid complexes arranged in donut-like rings 🍩, creating molecular diversity that helps cells fine-tune stress and redox signaling responses. Out in Nat Chem Biol.

Scientists at VIB, Daria Ezeriņa and Joris Messens, with global partners, developed HyPerFLEX🌈 HyPerFLEX tracks cellular stress in real time, glows in multiple colours, works in low-oxygen environments, and could revolutionise research on aging, inflammation & disease!

4/ With the Messens lab, we used negative stain EM to visualise heterooligomers and show that heterooligomerisation strongly affects dimer-decamer equilbrium.

Our first post on Bluesky! 1/ We are excited to share our latest work, showing that heterooligomerisation drives structural plasticity of Prx1-type peroxiredoxins. www.biorxiv.org/content/10.1... Another fantastic collaboration with the Marcel Deponte lab and Joris Messens lab!