A new study by @thurstonlab.bsky.social reveals how a small virulence protein from Salmonella uses molecular mimicry to reprogramme host kinase specificity. Find out more: www.path.ox.ac.uk/news-article...

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia. Open access link below: www.nature.com/articles/s41... Here's a cool animated summary

We had a fantastic time today showcasing our amazing history and cutting-edge research at #OxfordOpenDoors! Visitors learnt about 100 years of medical research, the development of penicillin and our ongoing work on microbiology and AMR. Thanks to all the volunteers!

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...

The annual Dunn School DPhil studentship competition for 2026 is open for applications. We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested. www.path.ox.ac.uk/project/mech...

Great time showcasing the amazing science we do at the @dunnschool.bsky.social at #OxfordOpenDoors today!

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

Another exciting opportunity @dunnschool.bsky.social ! Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health Please help us find great applicants

The Dunn School PhD programme is live! 🎉 Two projects in our labs: 1) How the motor protein giant dynein-2 works 2) How signalling-essential membrane proteins get into cilia Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more! www.path.ox.ac.uk/study-with-u...

Our PhD studentship programme is officially open; pass it on If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details... Great science and a great environment! www.path.ox.ac.uk/news-article...

Are you a postdoc interested in the mechanisms of disease? Do you have a great record and an exciting vision? Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships. Deadline 30th September...pass it on! www.path.ox.ac.uk/work-with-us...

Very cool!!

Fantastic work by the group of @matteoall.bsky.social : a SUN5:Nesprin3 complex at the head:tail junction of sperm cells. 🤯 #teamtomo www.biorxiv.org/content/10.1...

Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work. www.biorxiv.org/content/10.1...

Cryo-EM and biochemical reconstitution analysis reveal that Nde1 enhances Lis1 binding to autoinhibited dynein, promoting formation of a Phi-like-Lis1 intermediate during dynein activation www.nature.com/articles/s41...

Congratulations team! 🎉🎉

This is a brilliant opportunity. I was sponsored through this scheme, and the support was (and remains) phenomenal. Please share.

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️ ➡️ www.nature.com/articles/s41... Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...

Very impressive cryo-lift out of high-pressure-frozen mouse brain sections by @michaelgrange.bsky.social & co. 🐭🧠❄️🔬 Making it look too easy!! Now all my @biozentrum.unibas.ch colleagues will to want to do #cryoET of their tissue samples, haha 🤷‍♂️ There's no stopping #TeamTomo 🧪🧶🧬

Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...

Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors! www.biorxiv.org/content/10.1...

IFT trains are really cool - and what better way to communicate their structure than baking a cake? Created for my 1st year PhD project with Anthony Roberts and @kattoropova.bsky.social IFT-A 🟡 IFT-B 🟢 Dynein-2 🔵

We are highlighting Pleasantine Mill, 2025 @bsdb.bsky.social Wolpert Medal winner, as an extraordinary biologist this week. Pleasantine is also coordinating a @jcellsci.bsky.social Special Issue and co-organised the 2024 @dmmjournal.bsky.social‬ Journal Meeting. #100biologists @cilialab.bsky.social

Great to see our story on dynein & kinesin co-dependence published www.nature.com/articles/s41..., and absolutely chuffed that it's made the front cover (thanks NSMB!). A brilliant News & Views too by Steven Markus www.nature.com/articles/s41.... Collab between @carter-lab.bsky.social & Straube lab🔬

⏰ Deadline approaching for postdoc position in my lab, Dunn School, University of Oxford. We work on how the cell's antenna receives and transmits essential signals through motor protein driven transport. ❄️ Cryo-EM/ET, smTIRF, cell biology methods 🧪🔬 30/5/25 ➡️ tinyurl.com/KToropovaPDRA

‪ Many congratulations to all our postdocs recently awarded postdoctoral fellowships! 🥳 A special mention to @carokobras.bsky.social for a BBSRC Fellowship, and Emma and Laura for @wellcometrust.bsky.social early career awards! Check the full list here: www.path.ox.ac.uk/news-article...

Postdoc position in my lab: investigating how the microtubule motor protein dynein-2 works in cilia. Here's dynein-2 at work translocating microtubules - how is this activity regulated? How does dynein-2 malfunction in disease? Find out more and apply: my.corehr.com/pls/uoxrecru...

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Amazing instructors and speakers, deadline for applications 25th April 2025.

We are thrilled to announce the 2025 EMBO practical course in cryo-em image processing, Birkbeck College, London, 9-16 Sept 2025. More info & apply: meetings.embo.org/event/25-cry... Organisers Giulia Zanetti & Helen Saibil. Beautiful image from co-organizer @carolynmoores1.bsky.social lab.

Postdoc or PhD working on C. elegans? Interested in applying C. elegans techniques to understand the astonishing world of epigenetics in parasitic nematodes? Apply to our Wellcome Trust funded postdoc position, joint between my lab in Oxford and Mark Viney's in Liverpool: tinyurl.com/5y6cpvcv

I am excited for this opportunity to chair the Department of Biochemistry and Biophysics at Weill Cornell Medicine! news.weill.cornell.edu/news/2025/01...

We just can't stop recruiting! Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly Come and be our colleague Deadline 28 Feb, please spread the word www.path.ox.ac.uk/vacancy/asso...

NEW in @science.org, so happy to contribute to our understanding of the molecular machine, Fidgetin-like 1 (FIGNL1), and elucidating the mechanism of why cells cannot survive when it is lost! #ScienceResearch science.org/doi/10.1126/... (1/7)

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

First last author paper FINALLY out today. Thank you to all the authors for their hard work ☺️

As promised, season's greetings from all of us @dunnschool.bsky.social (and if your building has a rotunda, flaunt it at Christmas)

Congratulations, Teresa!

Andres! @aleschziner.bsky.social My amazing former postdoc advisor is here! #cryo-EM🎉

Please share this PhD opportunity in my new lab in Bristol, using protein design/ engineering to understand and build molecular motors to control intracellular transport. Working with @markdodding.bsky.social and Prof Dek Woolfson. www.findaphd.com/phds/project... www.swbio.ac.uk/biomolecular...

Thanksgiving is definitely when I miss being a postdoc in Boston the most, a special cheers to anyone having a Shipyard Pumpkinhead right now, I am extremely jealous 🦃🎉🍻

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m

This is a brilliant idea, will really help discovery research and can't wait to see the outcome #cryo-ET

Sign of the times, no more bluebird on the biorxiv engagement tab..

We opened our @ukcilianetwork.bsky.social Autumn symposium in Liverpool with a beautiful memorial plenary for David Stephens by long time collaborator Anthony Roberts @dunnschool.bsky.social on his huge influence on shaping cell science, careers & research culture. /1

Our new work! We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination). Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors www.biorxiv.org/content/10.1...

Early snow in Oxford 🌨️❄️ (photos by @isaacsiuwong.bsky.social and Qiaoyu Tian)