A cilium of a fixed RPE-1 cell, expanded and imaged with #3DSTED and #FLEXPOSURE adaptive illumination. CEP164 🟥 (STAR RED), acetylated tubulin+CCDC41 🟦 (STAR ORANGE). Samples courtesy: Dong Kong & Jadranka Loncarek. Cancer Innovation Laboratory, NCI/CCR. #ExM #superresolution #fluorescencefriday

New interview alert! We had a chat with Mike Cianfrocco, Scott Stagg and Jan-Hannes Schäfer about their CryoSift tool – details in the thread. www.youtube.com/watch?v=ROlc...

Bummed to miss #ASCB this year (one of my fav meetings), but the lab is well represented! Stop by poster B169 today and Maneesha will tell you all about her work on basal bodies and cilia homeostasis in multiciliated cells 👇 #CellBio2025

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...

Add our first pre-print to your reading list? Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social! Please share: tinyurl.com/3h8r7f5y

This has now been published in print! Check it out: www.science.org/doi/10.1126/...

Our work accurately measuring the 3D affinity between the OT-I TCR and a large number of foreign and self antigen ligands is now published at EMBO Journal. Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens www.embopress.org/doi/full/10....

We’re excited for the UK Cilia and Centrosome Network e-symposium this afternoon featuring the #JCSciliaSI! To discover more about the research in this issue, check out these JCS snapshots, video highlights from authors about their research: focalplane.biologists.com/2025/11/24/j...

So proud of the lab for its achievements - Thank you to the Pettenkofer foundation for recognising our contributions - here’s to some more bacterial effector related fun in the future! @dunnschool.bsky.social

Thrilled to share our work on the 🔥 single-celled predator Podophrya collini, which rewires its cell morphology to hunt more efficiently. Huge thanks to our amazing team—Amy, Lauren, Omaya, Marine, Mari, and especially Scott—for making this shine! ✨

Key transcripts encoded centrin-like proteins, a frequent component of sensory/contractile structures in protists. We visualized tentacle ultrastructure by U-ExM with @dudinlab.bsky.social lab, discovering stunning tip and collar structures 🤯that add structural complexity to new tentacle formation.

I saw her at the poster session at ASCB 2024! very very impressive work and such a cool model system to study.

Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social www.biorxiv.org/content/10.1...

Thanks for the shoutout! @jcellsci.bsky.social :)

If you’re at #sfn25 you definitely don’t want to miss this nanosymposium on cilia, tomorrow from 1-4pm! Come learn about neuronal cilia, they do some pretty cool stuff!

Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase. www.nature.com/articles/s41...

We're still accepting submissions for our 'Cell Biology of the Nucleus' special issue, which is being guest edited by @abbybuch.bsky.social and Megan King (@luskinglab.bsky.social). Submission deadline: 5 January journals.biologists.com/jcs/pages/nu... #nucleus #notforprofit #freetopublish

Chris is a brilliant structural biologist and mentor. Would highly recommend applying!

Great to see this work out! Congratulations to the team but especially James Stowell and Conny Wu (a real labour of love)

This work is now officially published @natsmb.nature.com with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...

Very excited to share this one! Our comprehensive structure, genetics and biophysics dissection of which flagellar dyneins and other proteins are needed for flagella to beat and drive cells swimming behaviours: www.biorxiv.org/content/10.1...

Wonderful to see this comprehensive study out in pre-print! Congratulations to the whole team.

In an eight-person rowing boat, each rower contributes to movement but also has a unique role: balancing, powering, or setting the rhythm and pace. In our latest collaborative work we asked – do the eight dynein “rowers” in #cilia and #flagella operate in the same way?

Our latest collaborative effort - with Eva Gluenz and @zephyris-science.bsky.social - to understand how the various proteins and complexes of the axoneme contribute to ciliary motility:

The construction industry, where more than a quarter of workers are foreign-born, has long struggled to find enough workers. Now, industry officials say Trump's immigration crackdown is making it worse.

Also in Issue 20: - Editorial from Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social. - 'Cell Scientist to Watch' interviews with Keren Hilgendorf and Girish Ram Mali @dyneinassembly.bsky.social journals.biologists.com/jcs/issue/13... #JCSciliaSI

It was a great pleasure working with @cilialab.bsky.social and @seemagrewal.bsky.social plus others at @jcellsci.bsky.social on this special issue on ‘Cilia and flagella’. Lots of cool stuff on #cilia #flagella in there, enjoy!

We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.

Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together. Happy reading! #cilia #flagella journals.biologists.com/jcs/issue/13...

This was a fun chat. Thanks @jcellsci.bsky.social for featuring me and spotlighting our work. Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13.... We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

Structural dissection of αβ-tubulin heterodimer assembly and disassembly by human tubulin–specific chaperones | Science www.science.org/doi/10.1126/...

Our Special Issue on Cilia and Flagella: from Basic Biology to Disease, guest edited by @cilialab.bsky.social‬ and @lottepedersen.bsky.social, is building. We’ll be highlighting all the articles over the next couple of weeks. Follow along at #JCSciliaSI. journals.biologists.com/jcs/issue/13...

An enormous thanks to @wellcometrust and everyone who’s helped along the way 📢 PhD position open now 🎓– apply here 👉 www.bioch.ox.ac.uk/supervisors-... 🧪 Postdoc adverts coming 2026!

I’m really excited to share that I’ve been awarded a Wellcome Trust Career Development Award to start my own research group at Oxford University Biochemistry Department @BiochemOxford 🧬🎉

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia. Open access link below: www.nature.com/articles/s41... Here's a cool animated summary

Lovely tribute to David's legacy.

Our PhD studentship programme is officially open; pass it on If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details... Great science and a great environment! www.path.ox.ac.uk/news-article...

Another exciting opportunity @dunnschool.bsky.social ! Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health Please help us find great applicants

We've had a very active summer of Cilia and Centrosome science! We had our Annual Network meeting in London this year organised by Prof. Hannah Mitchison and Dr. Dagan Jenkins. Meeting highlights are now available to read on the network website. www.cilianetwork.org.uk/events/annua...

And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4

Exciting new study from new-PI Mohinder Pal on the role of CCDC103 and it's links to PCD as the most recent dynein assembly factor (DNAAF19). Congratulations to the entire team. @Mohinder Pal (currently not on Bluesky) @mike-wieczorek.bsky.social @laurencepearl.bsky.social

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...

The annual Dunn School DPhil studentship competition for 2026 is open for applications. We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested. www.path.ox.ac.uk/project/mech...

The Dunn School PhD programme is live! 🎉 Two projects in our labs: 1) How the motor protein giant dynein-2 works 2) How signalling-essential membrane proteins get into cilia Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more! www.path.ox.ac.uk/study-with-u...

The annual Dunn School DPhil studentship competition for 2026 is open for applications. We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested. www.path.ox.ac.uk/project/mech...

🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia. 📅 Deadline: 29th September 2025. 🙏 Please share with anyone who might be interested.

Are you a postdoc interested in the mechanisms of disease? Do you have a great record and an exciting vision? Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships. Deadline 30th September...pass it on! www.path.ox.ac.uk/work-with-us...

Amazing news! Congratulations Roger