New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...

@bscb-official.bsky.social Beautiful Cryo-ET talk by Kashish Singh on cytoplasmic lattices in mammalian embryos from @mrclmb.ac.uk at the #DynamicCellVI conference

Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.

Today in #journalclub - An isoform of my favourite mitotic adaptor Spindly is repurposed to regulate lipid droplet localisation in interphase. Worth a look 👇 advanced.onlinelibrary.wiley.com/doi/10.1002/...

Excited to share our new paper! 🎉 The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona www.science.org/doi/10.1126/... Very thankful to @andrea-musacchio.bsky.social for his mentorship and support over the years.

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/... Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle

The power of collaboration (and of in vitro reconstitution)!

New: Colombo et al. @surreylab.bsky.social show that NuMA is a mitotic dynein adaptor that binds and caps microtubule minus ends, explaining how dynein, NuMA, dynactin, and Lis1 focus microtubule minus ends at mitotic spindle poles https://buff.ly/41aj9F9

Excited to share the first published paper of my postdoc - a collaboration with Yildiz and Dumont groups led by Merve Aslan, on the fascinating dynein adaptor NuMA. Lots of super cool insights on how NuMA can activate dynein during mitosis. Thanks to @carter-lab.bsky.social for the support!

Our #CryoET paper on ciliary rootlet ultrastructure from mouse retina is now out in @elife.bsky.social! Have a peek with this video or dive deeper at bit.ly/3ZJzhgc. Big thanks to @carter-lab.bsky.social and #teamtomo. #CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science

Brilliant and supportive mentor, great location, exciting project - what's not to love? Plus a unique opportunity to really learn from the best at figuremaking!

First #JournalClub on the blue side: an exciting story about dynein at the kinetochore and its role in biorientation! www.nature.com/articles/s41...