Ennio
@amicoennio.bsky.social
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📥 225
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A biochemist. Molecular motors, especially dynein
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Ennio
Verena Cmentowski
10 days ago
Excited to share our new paper! 🎉 The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
www.science.org/doi/10.1126/...
Very thankful to
@andrea-musacchio.bsky.social
for his mentorship and support over the years.
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The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.
https://www.science.org/doi/10.1126/sciadv.ady6890
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reposted by
Ennio
Andrea Musacchio
11 days ago
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances
www.science.org/doi/10.1126/...
Congratulations
@vcmentowski.bsky.social
for solving a remarkably challenging molecular puzzle
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The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.
https://www.science.org/doi/10.1126/sciadv.ady6890
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The power of collaboration (and of in vitro reconstitution)!
add a skeleton here at some point
6 months ago
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reposted by
Ennio
Journal of Cell Biology
8 months ago
New: Colombo et al.
@surreylab.bsky.social
show that NuMA is a mitotic dynein adaptor that binds and caps microtubule minus ends, explaining how dynein, NuMA, dynactin, and Lis1 focus microtubule minus ends at mitotic spindle poles
https://buff.ly/41aj9F9
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Excited to share the first published paper of my postdoc - a collaboration with Yildiz and Dumont groups led by Merve Aslan, on the fascinating dynein adaptor NuMA. Lots of super cool insights on how NuMA can activate dynein during mitosis. Thanks to
@carter-lab.bsky.social
for the support!
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https://www.biorxiv.org/content/10.1101/2024.11.26.625568v2
10 months ago
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reposted by
Ennio
10 months ago
Our
#CryoET
paper on ciliary rootlet ultrastructure from mouse retina is now out in
@elife.bsky.social
! Have a peek with this video or dive deeper at
bit.ly/3ZJzhgc
. Big thanks to
@carter-lab.bsky.social
and
#teamtomo
.
#CryoET
#CryoEM
#Cilia
#Rootlet
#Centriole
#Research
#Science
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Brilliant and supportive mentor, great location, exciting project - what's not to love? Plus a unique opportunity to really learn from the best at figuremaking!
add a skeleton here at some point
10 months ago
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First
#JournalClub
on the blue side: an exciting story about dynein at the kinetochore and its role in biorientation!
www.nature.com/articles/s41...
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Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore - Nature Communications
Mitotic chromosomes recruit multiple microtubule-directed activities to ensure their faithful segregation. Using an approach where only one major activity is present, the authors reveal sufficiency of...
https://www.nature.com/articles/s41467-024-52964-5
10 months ago
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