Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

🚨New paper! 🚨 @jasminealqassar.bsky.social led this work on the silk glands of the pantry moth. These two long tubes inside the caterpillar continuously make a ton of silk How does this special organ work? www.cell.com/iscience/ful... @cp-iscience.bsky.social 🧵THREAD🧵

Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪

Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42... To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.

Now published. Thank you very much to our collaborative team, and very supportive editors and reviewers!!! www.pnas.org/doi/10.1073/...

The latest from RNA-designer extraordinaire @monari-luca.bsky.social is out in @natcomms.nature.com. We introduce PyFuRNAce.de, a design tool for RNA origami. It simplifies design with a rich motif library and automatic 2d/3d modeling and routing optimization 🧬 www.nature.com/articles/s41...

Is it possible to engineer new cellular life from the bottom up? The Göpfrich group @kgoepfrich.bsky.social @mpi-mr.bsky.social have designed an RNA origami nanotube 🟡 to mimic the cytoskeleton: www.nature.com/articles/s41... It was a fun challenge to animate T7 RNA polymerase 🔵 #blender #b3d

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...

I watched the Alien Prometheus movie recently and the opening scene had some pretty funky DNA ✅ Left-handed double helix ✅ Extreme 🔥 grooves ✅ ~15 bases per turn ✅ Super-glued base ladder ✅ Subatomic black goo What are some of your favourite funny molecule structures from TV/movies?

How do trypanosomes evolve resistance to sleeping sickness drugs? Mutations in TbAQP2 🔵 can block melarsoprol and pentamidine 🟠 from entering the cell. It was a pleasure to create this animation for Simone Weyand. Read more here: elifesciences.org/reviewed-pre... #blender #b3d #animation #science

Missed the 2025 Next Generation Biophysics Symposium? Great news – you can now watch the fantastic talks on our YouTube channel! www.youtube.com/playlist?lis... Don't miss these great discussions on how new and emerging technologies may be able to address challenging biological questions.

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

The centriole is crucial for cilia formation, but its molecular architecture is not known. Research from the @Wieczorek Group at ETH Zurich reports structures of the centriole’s A-C linker, revealing how it crosslinks neighboring microtubule triplets. More: biol.ethz.ch/en/news-and-...

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

Are you studying synapses in electron microscopy? Tired of annotating vesicles? We have the tool for you! SynapseNet implements automatic segmentation and analysis of vesicles and other synaptic structures and has now been published: www.molbiolcell.org/doi/full/10....

Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia. Open access link below: www.nature.com/articles/s41... Here's a cool animated summary

New online: Molecular basis for the activation of outer dynein arms in cilia

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM

We are excited to share our latest work, where we unravel the structural and functional secrets of the once-mysterious protein Pex8 revealing how it controls the peroxisomal cargo import receptor Pex5. Read more here: www.biorxiv.org/content/10.1101/2025.08.30.673231v1

Stunning cryo-ET from Peijun Zhang lab: Direct visualization of HIV-1 nuclear import! Hundreds of viral cores captured entering the nucleus. The NPC dilates to let the capsid through. A masterclass in correlative microscopy that makes it quantitative. A leap for structural virology! @emboreports.org

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you! embl.wd103.myworkdayjobs.com/en-US/EMBL/j... With @dudinlab.bsky.social @embl.org @biology-unige.bsky.social @moorefound.bsky.social

🕒 NEW VIDEO 🕒 How can a cell know the time? Let's explore the beautiful 24-hour cycle produced by #KaiC proteins in the cyanobacteria S. Elongatus. Rendered in #blender3d with @bradyajohnston.bsky.social's brilliant Molecular Nodes add-on. #biology

We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!! www.biorxiv.org/content/10.1...

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

The Dunn School is a really great environment for taking up a Career Development Fellowship, and we are looking for candidates! Please spread the word.

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!! Make my day and check it out! www.biorxiv.org/content/10.1... #Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️ ➡️ www.nature.com/articles/s41... Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

Less than two weeks left to apply! Postdoc positions in my lab to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists & structural biologists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

Delighted to share the final version of Richard Zhou's study on how the CD163 scavenger receptor cleans up after toxic haemoglobin spills out from our blood cells. An amazing grabber mechanism! rdcu.be/ewPA2

🎉 Excited to share my first paper as 2nd author! From the Barr & Gruneberg labs, this work explores the structure of the Chromosome Passenger Complex (CPC) and suggests a ‘pivot–tether’ model for how it binds H3pT3-phosphorylated nucleosomes @oxfordbiochemistry.bsky.social @dunnschool.bsky.social

IFT trains are really cool - and what better way to communicate their structure than baking a cake? Created for my 1st year PhD project with Anthony Roberts and @kattoropova.bsky.social IFT-A 🟡 IFT-B 🟢 Dynein-2 🔵

Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors! www.biorxiv.org/content/10.1...

Big news! 📢CCeMMP is holding the 2nd 'Bench to Art' Exhibition to showcase the artistic flair of structural biology. Share your creations to be displayed in a virtual gallery during National Science Week & for a chance to win cash prizes 💰! More info: ccemmp.org/events/arc-c... #CryoEM #Membranes

NEW pub: The role of metabolism in shaping #enzyme structures over 400 million years. Now out in @nature.com Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus! www.nature.com/articles/s41... #alphafold #evolution #genomics

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social. www.science.org/doi/10.1126/...

Excited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing. Glad to be featured in the Editors’ Highlights! www.nature.com/articles/s41... #splicing #cryoEM

New Independent Fellowship position in Microbiology to launch your lab in our department @johninnescentre.bsky.social (UK). We are conducting a broad search in the area of plant-associated microbial interactions. Message me if you have any questions. Apply here: www.jic.ac.uk/vacancies/in...

🦠 NEW VIDEO 🦠 The molecular biology of how Mycobacterium Tuberculosis evades the immune system so well. Starting with this simulation of a full outer envelope of m.TB--let's explore how the deadliest & most persistent human pathogen completely hacks our immune response. #molecularbiology

Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...

Finally published! Many thanks to the reviewers and editor whose comments & suggestions improved this work significantly more than the first preprint version!!! www.pnas.org/doi/10.1073/...

We have a postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability and/or immunity. Expertise in cell biology is required. my.corehr.com/pls/uoxrecru...

Extremely happy to share the first paper of my postdoc work with @parasitematt. It is the product of a great collaboration with Akihito Sakoguchi, Hisashi Arase and Shiroh Iwanaga at Osaka University as well as Marcus Widdess and Mike Dustin here in Oxford. rdcu.be/eqx2J 🧵 1/6

Check it out! I'm proud to unveil CellWalk 2 for Apple Vision Pro. Bring beautiful and immersive biology learning into your space. @cellwalk.bsky.social 🧬🦠🍎 #science #applevisionpro #visionos #apple #wwdc25

A little spoiler of a forthcoming explainer in which @sykhalid.bsky.social explains why its so hard to kill bacteria. If this appeals - please do consider subscribing to our podcast via YouTube: youtube.com/@scienceofth...

Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...