Very proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social www.nature.com/articles/s41...

New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion. @coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠

Paying peer reviewers works. Benefits authors, editors & reviewers. Hopefully other journals will try this.

New preprint. In S. sanguinis, a C5a peptidase-like protease (ScpH) polymerizes along eDNA, turning it into a catalytic biofilm scaffold. Great work from @robinanger.bsky.social in our lab, with Pelicic lab @lcbofficiel.bsky.social www.biorxiv.org/content/10.6...

Extension of the deadline for latecomers. Register to the Secretion Days in Marseille !

Finally, @danialv.bsky.social used CG simulations to show that VPS13A can deliver lipids to an acceptor membrane that is bound at the C-terminal of VPS13A, and that XKR1 is proximal, but not continuous, to the delivery site. (6/7)

📢 We are recruiting! I’m looking for a Research Associate in Structural Biology to join my lab at Imperial College London to study horizontal gene transfer using cryo-EM, biochemistry and microbiology. Please share with interested candidates! Apply: shorturl.at/gmJGS

Our new study reveals how bacterial toxins are physically captured through a sequential, concentration-dependent assembly mechanism before secretion via the T6SS. Fantastic collaboration with @fillouxlab.bsky.social. Congrats Patricia & Ambre for leading this work. Paper here: shorturl.at/O31Vn

Open Postdoc Position - Giant E3 ligases: mysterious mechanisms & non‑protein substrates. Interested? Join us to uncover how these molecular giants tag lipids, RNAs, sugars beyond proteins, on organelles and pathogens, to defend the cell. Details & Application here www.imp.ac.at/career/open-...

New preprint! Cell division has to happen at the right place but how Archaea pick that place is unknown. We now identified a three-protein system, Dip, that positions the divisome at midcell in H. volcanii and is broadly conserved across Archaea. A thread 🧵 www.biorxiv.org/content/10.6...

🔬 PhD position at Imperial College London! Uncover how pericytes, mysterious vascular cells, drive asthma inflammation. Use spatial transcriptomics, 3D imaging & transgenic models to unlock new therapies. 3-year funded PhD | Oct 2026 start 👉 www.findaphd.com/phds/project... 📧[email protected]

Big thanks to This Week in Microbiology (TWiM) podcast for featuring our Enhanced Domestication (EDEN) method - designed to cultivate microbial ‘dark matter’ and discover new antibiotics 🦠 💊 Have a listen.. asm.org/podcasts/twi... And here’s the recent paper doi.org/10.1093/isme...

Applications and prospects of cryo-electron tomography in drug discovery and understanding disease Review article by @camilaclemente.bsky.social in our lab www.sciencedirect.com/science/arti...

Wow - this is just amazing. Hui Guo and colleagues from John Briggs’ lab use cryoEM helical reconstruction to discover how filamentous influenza virion assembly is directed by multiple conformations of M1 - explaining how NA is concentrated at the proximal pole. www.biorxiv.org/content/10.6...

Dear PhD students and postdocs — we want to hear about your science firsthand at our annual Early Career Microbiologists Mini-Symposium @johninnescentre.bsky.social (UK) this September. For more information and to apply: www.jic.ac.uk/event/early-...

Time-resolved tmFRET reveals GTP-coupled conformational changes in Mfn1 rupress.org/jcb/article-...

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Come and work with us on #cryoEM of alpha-synuclein amyloid filaments from #Parkinsons disease! 🥳 fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...

We have a PhD studentship open! (UK only sadly) but if you are or know a student keen to work on some *really* weird mycobacterial enzymes then get in touch! #glycotime Advert below www.findaphd.com/phds/project...

Latest paper from the lab - particularly glad that we managed to get this one out, after getting scooped several times over… more spectacular work from PhD students extraordinaire, Kailin and Rosa, in close collaboration with Marc Erhardt’s group.

Don’t miss the 20th Graduate Student Symposium at the LMB in July, organised by students from the LMB and École Polytechnique Fédérale de Lausanne (EPFL) School of Life Sciences. Registration is open now ➡️ www3.mrc-lmb.cam.ac.uk/sites/gsasym... Follow @lmbphdsymposium.bsky.social for updates!

Excited to share our paper about copick, a dataset API and toolkit for collaborative annotation and analysis of #cryoET data! Whether you're picking particles or curating segmentations, copick reduces friction and brings #OME-Zarr to cryoET without breaking pipelines. 🧵👇 doi.org/10.1002/pro.70578

🚨Hear, hear, fellow microbial cell biologists!🚨 🦠 Bacterial and Archaeal Cell Biology will be represented again at this year’s CELL BIO (ASCB-EMBO) meeting! The deadline to be considered for a talk in our Minisymposium is June 9. Help us spread the word! www.ascb.org/cellbio2026/

Most bacteria remain uncultured with vast microbial ‘dark matter’ awaiting discovery.. to address this am excited to share EDEN - an enhanced domestication method to grow uncultured bacteria & new diversity. Using EDEN we isolate a new species active against MDR pathogens.. doi.org/10.1093/isme...

Finally published. Many thanks to a wonderful collaborative team and scientific platforms!!! And thanks to editors and reviewers for enthusiasm and a great review. www.nature.com/articles/s41...

An Asgard archaeon from a modern analog of ancient microbial mats: Current Biology https://www.cell.com/current-biology/fulltext/S0960-9822(26)00330-1?rss=yes

👀 a tad pilus machine feast.. 👏

1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵 🔗 www.nature.com/articles/s41... #CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics

Great times!

We report the Pick fold and 2 variants thereof for tau filaments from individuals with MAPT mutations encoding for D252V, G272V, S320F and Delta_G389-I39, and we use these to reconstitute the Pick fold with recombinant tau in vitro. By @qcxy8886.bsky.social. 🥳 www.biorxiv.org/content/10.6...

👀 mystery solved for the Tad pilus one motor, two directions conundrum.. brilliant story, brilliant work.. 👏

Mapping the ultrastructural topology of septin cage entrapment PhD studentship with @carolynmoores1.bsky.social Direct link here: www.lshtm.ac.uk/study/fees-a...

Come work with Ben Berks FRS in Oxford 2 x PDRA posts: Molecular Analysis of Bacterial Outer Membrane Protein Biogenesis 2 complementary projects investigating bacterial outer membrane protein biogenesis. Building on our recent work (Nature (2015) 647: 479-487) my.corehr.com/pls/uoxrecru...

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...

Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis www.biorxiv.org/content/10.6...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

❗️Highly recommended - please consider applying, 3 weeks to go👇🏻

Extremophile alert! Registration is OPEN for the 2026 EMBO Archaeal workshop in Cambridge. Spaces are limited, so register soon with an abstract if you’d like to give a talk. If you can’t come in person, we are welcoming virtual attendees. So join us online where all talks will be screened!

We are looking for a new RA to join our team working on host-pathogen interactions during Salmonella infection. The appointment is for two years and you will join a diverse team, using cell and protein biochemistry to further our understanding of pathogenesis. my.corehr.com/pls/uoxrecru...

Join our division of Structural Studies at @mrclmb.bsky.social in the wonderful group of @suyangzhang.bsky.social!

E. coli is the leading bacterium causing death from AMR infections worldwide. If you'd like to explore approaches to exploit the DNA damage response as alternative antimicrobial, please apply to the following PhD studentship available in my lab starting October 2026: www.findaphd.com/phds/project...

Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...

‘Why solutions to antimicrobial resistance are urgently needed‘ sergemostowylab.bsky.social & I had the opportunity to write an editorial for @dmmjournal.bsky.social ‘s collection celebrating 100 years of @biologists.bsky.social you can read it here: journals.biologists.com/dmm/article/...

🔬 Just out in @NatureComms! Using cryo-CLEM and cryo-ET, we reveal the unique ultrastructure of dopaminergic varicosities in the striatum. Amazing collaboration with @davip-bdx.bsky.social and Etienne Herzog @iins-bordeaux.bsky.social Congratulations to Paul and Robin for this fantastic work! 🎉

IsoNet2 determines cellular structures at submolecular resolution without averaging https://www.biorxiv.org/content/10.64898/2025.12.09.693325v1

My excellent collaborator, Giulia Zanetti, is advertising for a post-doc to work on our shared MRC grant. Please consider applying to this great lab with a supportive mentor to do some exciting structural biology. www.ucl.ac.uk/work-at-ucl/...

Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42... To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.

Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...

We're advertising for a bacteriology technician and a post-doc to work on AI-guided antibiotic development as part of a large multidisciplinary Fleming Initiative project: www.imperial.ac.uk/jobs/search-... www.imperial.ac.uk/jobs/search-...

Our latest T7SS study is now out in Science Advances! We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery. www.science.org/doi/10.1126/...