And now advertised here too if you prefer: www.jobs.ac.uk/job/DPX771/r...

Most common editorial management systems are notoriously bad. So yes, it *is* that hard 😭 So please be aware that many of these things are automated/fixed and are, unfortunately, not under our control.

Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42... To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.

The deadline for the first of our three fully funded PhD studentships is tomorrow! Determining the role of the dual-function VanT in C. diff vancomycin resistance. Collab with @gavinhthomas.bsky.social and Marjan van der Woude

We're advertising for a bacteriology technician and a post-doc to work on AI-guided antibiotic development as part of a large multidisciplinary Fleming Initiative project: www.imperial.ac.uk/jobs/search-... www.imperial.ac.uk/jobs/search-...

Excited to share our latest work with @albertomarina.bsky.social and @avigdoreldar.bsky.social labs, where we decipher the mechanism by which SPβ-like phages sense the SOS response to control the lysis–lysogeny switch. www.biorxiv.org/content/10.1...

Great heroic work by Kevser Bilici demonstrating the import role of biotin for integration of S. aureus into the nasal microbiome.

Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells. See the original preprint-thread for a summary of our findings. www.nature.com/articles/s41... #microsky

rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin

I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.

Or not…

PhD position on bacterial (Staph aureus) transporters and host-adaptation in my group @roslininstitute.bsky.social @edinburgh-uni.bsky.social www.findaphd.com/phds/project...

I may have posted this in haste...

Time to dust this off, again @avishenoy.bsky.social

80 years after the Nobel Prize for penicillin, antimicrobial resistance is one of societies toughest challenges. GSK, the Fleming Initiative, and the @ineosoxford.bsky.social hosted leaders at the Royal Society of Medicine to advance the global response.

Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue. DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.

🆕 We're part of a major new project aiming to understand exactly what makes some bacteria resistant to antibiotics. buff.ly/dpm22l5

In scientific writing, it's the "why" before the "what": "To achieve X, we did Y" "To explore whether A repressed B, we performed C" "To test D, we did E" Starting with the rationale pulls the reader into your logical framework and makes the purpose of every test immediately obvious.

This project is with @jessicamablair.bsky.social and Sara Jabbari at UoB, @webberma.bsky.social at Quadram, @bugsinblood.bsky.social at Imperial and Dong-Hyun Kim at Nottingham - we are kicking off the project right now!

Legit work in progress photo… www.imperial.ac.uk/news/271753/...

Good day for AMR research (part1): www.ukri.org/news/powerin...

📣Applications open for a competition-funded EastBio PhD position in my lab! I will be able to put one exceptional candidate forward and then we cross our fingers we get the funding🤞If you're interested in metabolism, virulence and antibiotic efficacy, please apply by 15th Dec! tinyurl.com/873ycjpr

If I were to do a PhD again, I would not hesitate to apply to Jo's group: timely and exciting science, a great team and excellent supervisor. Plus a lab with a beach view.

Delighted that our review on resistance to last-resort antibiotics in Enterococci has been published in FEMS Microbiology Reviews academic.oup.com/femsre/advan... (accepted manuscript version) TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.

Shout out to people routinely working in their 2nd or 3rd language. Yesterday I gave a 1-hour research seminar in French. Afterwards, my brain was pretty much done for the day. Respect to the loads of scientists who do this daily (and usually a lot more effectively than me!)

I don't understand why journals are so focussed on turnaround time - quality reviews are what matter! A poor review can cost a group months of pointless experiments.

PhD opportunity with me and @kshbeckham.bsky.social www.findaphd.com/phds/project...

If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.

🚨Deadline for our Senior Scientist applications is next week. If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!

Looking for an AMR-themed PhD project? Join us to investigate antibiotic tolerance in Staphylococcus aureus through a fully funded MRC DTP PhD studentship starting in September 2026. This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.

1. Characterising the role of the dual-function VanT in C. difficile vancomycin resistance. A collaboration between our group in @molmicrosheffield.bsky.social and the groups of @gavinhthomas.bsky.social and Marjan van der Woude at the University of York www.findaphd.com/phds/project...

You've got just a few days left to submit your proposal to join us as a new Group Leader 📅 Applications close 2nd November Package includes: 🪙Multi-year funding 🧪Core Facility Access 🥼 #Postdoc & #PhD positions 🤝Mentorship Visit our website to apply: www.cruk.manchester.ac.uk/career/new-g...

🔊 Applications for the tenure-track illuminate global challenge fellowships at Queen’s are now open! Comes with 5 years protected research time, a PhD studentship, & 60k start-up. I had one of these before getting my FLF, happy to chat to anyone interested! www.qub.ac.uk/Research/fel...

Complete nonsense. My advice to post-graduate researchers is to always preprint their work, as it will improve their visibility while the manuscript is going through a (frequently very long) peer review process.

Happy birthday to Antonie van Leeuwenhoek, the "Father of Microbiology" and first person to observe bacteria with a microscope! 🔬 Learn how microscopes made microbiology possible, leading to innumerable insights for biology, medicine & technology. asm.org/articles/202...

Now published in PLOS Biology! We found new retron containing bacteria in the wild, figured out defense mechanisms, and turned them into genome editors. From a cupful of dirt to new parts for genome editing in one story! journals.plos.org/plosbiology/...

Looking for a PhD? 🚀 MIBTP projects are out lots to explore! 🔬 #Bacteria • #AMR • #Interdisciplinary • FUN! My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry. warwick.ac.uk/fac/cross_fa...

Intrinsic resistance pathways & #ResistanceBreaking. Study shows that inhibiting efflux pumps & cell envelope biogenesis sensitizes #bacteria to #antibiotics, but rapid evolutionary recovery may limit long-term effectiveness of resistance-breaking strategies #AMR @plosbiology.org 🧪 plos.io/4huAtvo

I'm delighted to share that I have joined the School of Biological Sciences at @unisouthampton.bsky.social as Professor in Microbial Biofilms. I'm very excited about this next step in my academic journey and the opportunity to work more closely with all the great scientists at Southampton and

✨New paper from @jrpenades.bsky.social and @sanmillan.bsky.social labs. We found that non-conjugative plasmids 🧬 tend to have low mobility to promote functional diversity ⚔️💊 in bacterial communities🦠🦠. Brilliant work by Akshay, @asantoslopez.bsky.social and others. www.cell.com/cell-reports...

Closet friedmanite @marcsdionne.bsky.social on how there's no such thing as a free immune response www.imperial.ac.uk/events/19788...

Join us in Birmingham for the annual BSAC #AntibioticResistance & Mechanisms workshop - excellent talks and it’s designed to make conversation & networking between attendees easy #MicroSky bsac.org.uk/antibiotic-r...

We’ve kept registrations open till the end of this week so get your last minute applications in for posters and talks!

Remarkable increase in vancomycin resistance among clinical Enterococcus faecium isolates in Italy (from 11.5% in 2015 to 32.4% in 2023). aricjournal.biomedcentral.com/articles/10....

Our latest work reveals that arbitrium phages cross-communicate across species! These tiny viruses “listen” to signals from others, coordinating lysis-lysogeny decisions across species. Original idea from @albertomarina.bsky.social and, as usual, he was right. www.biorxiv.org/content/10.1...

New review - thanks to Markus Weingarth for the invitation! www.nature.com/articles/s41...

Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...

Antimicrobial resistance is projected to cause 39 million deaths worldwide over the next 25 years go.nature.com/42x5KHD