A gift of an article from the inimitable Colin Kleanthous as he says a moving farewell to his laboratory. A brave, unrepentant and scientifically brilliant journey is described - please have a read, friends. www.jbc.org/article/S002...

#Microbiology The anti-tuberculosis drug bedaquiline targets the mycobacterial ATP synthase, but how that leads to bacterial death is unclear Here the authors clarify how bedaquiline works @jnblab.bsky.social @morwan.me #TBSky #antibiotics #AMR http://dlvr.it/TQjZ0W

I know what they're getting at with the "could put jobs at risk" but can we focus on the immediate impact? Each suspended round at MRC and BBSRC means about 80 fewer postdoc jobs and the retrospective cuts at MRC add another 30 or so

With much love RIP Catherine O'Hara.

Hudson Freeze #glycotime www.theguardian.com/us-news/vide...

I am completely baffled by the total lack of any action or any evidence of speaking out from our scientific ‘leaders’. We’re in a void of information and the consequences are potentially catastrophic- especially as it looks like BBSRC are following suit.

www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!

Happy New Year – new role! 🎉 We’re looking for a PostDoc to join us in @halllab.bsky.social @unibirmingham.bsky.social. Full-time, fixed-term to March 2028. Note tight closing date: 11 Jan 2026. CV + cover letter (submit via portal). Further details 👇 edzz.fa.em3.oraclecloud.com/hcmUI/Candid...

We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development. www.nature.com/articles/s41... A thread.

Fantastic to have Prof Matthias Wilmanns from EMBL Hamburg hosted by @kshbeckham.bsky.social to give a @mhd-newcastle.bsky.social seminar on mycobacterial infection #dreamtheme

Absolutely blown away by the staging and acting at opening night of my play @taratheatre.com last night. Thanks so @natashakchandra.bsky.social and the entire team for transforming it into something special! Please go see it if you're in London- on until Nov 29th: taratheatre.com/whats-on/i-d...

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

I wrote about my play and where it came from for @qxmagazine.bsky.social : www.qxmagazine.com/2025/11/i-dr...

Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....

Funded PhD opportunity for anyone interested in using cutting-edge chemistry to look at glycan profiles in prostate cancer samples 🙌🏻 The successful student will be based at the University of York with Prof Alison Parkin with the opportunity to carry out a placement at the @nucancer.bsky.social

Excited to share our preprint led by Carlos Voogdt et al We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera. www.biorxiv.org/content/10.1...

Spending some time collecting memories of Harry today 🥺 - this is when he was elected a Fellow of the Royal Society. If anyone in the #glycotime universe has pictures or memories of Harry Gilbert they want to share please send them my way 💚

Next up, Dr Kate Beckham @kshbeckham.bsky.social The Beckham lab is interested mycobacterial membrane transport processes. They focusing on understanding the steps occurring at the mycobacterial outer membrane. www.ncl.ac.uk/cbcb/staff/p...

Day 2 of MHD introductions 😃 Dr Lis Lowe @lislowe.bsky.social The Lowe lab is focussed on microbial glycobiology. They work on bacterial Cazymes from commensals and pathogens, and are particularly interested in enzymes that target microbial glycans such as the cell walls of Mycobacteria.

Absolutely delighted to share the labs latest work. We identify and characterise two pathways for D-ribulose utilisation in pathogenic EHEC and Citrobacter.

*JOB AD*: interested in doing a postdoc in microbial metabolomics? Passionate about natural products mass spec? Come join the group! Informal enquires welcome! Closing Date: 19 August 2025 jobs.ncl.ac.uk/job/Newcastl...

On the way home from a really great CAZyme GRC. Lots of v interesting talks, a poster prize for Jean-Lou, karaoke, lake swims, beers, catching up with friends, and a lot of responsibility in 2029 when I co-Chair the meeting!

Farewell drinks with this guy. @wragbags.bsky.social we will miss you

Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬 📄 www.biorxiv.org/content/10.1... 🌐 search.foldseek.com/folddisco

Learning from bacterial predators on porin-like proteins that trap lipids at rdcu.be/euXWk! Amazing insights by Rebecca J. Parr & Andrew L. Lovering @unibirmingham.bsky.social, and @lalouxlab.bsky.social,‬ as well as all collaborators including Liz Sockett. #MicroSky #predatoryBacteria #porins

Anyway this trans kids book is less than a quid on a place that is definitely not a library but 🤷😑

🦠 NEW VIDEO 🦠 The molecular biology of how Mycobacterium Tuberculosis evades the immune system so well. Starting with this simulation of a full outer envelope of m.TB--let's explore how the deadliest & most persistent human pathogen completely hacks our immune response. #molecularbiology

In about a week we (Biological Sciences @ Monash Uni in Melbourne, Australia) will be opening a search for 3 (!!!) permanent academic positions (40% research, 40% teaching, 20% service) at Lecturer/Senior Lecturer. 1 Genomics, 2 Ecology. Please share, email me, DM, follow, send carrier pigeons…

Jinich et al. present an important new resource for the Mtb community! The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB) is an interactive web resource summarizing 150+ published screens. #MicroSky #Mycobacterium #tuberculosis onlinelibrary.wiley.com/doi/10.1111/...

#profile update - last full week as an employee at an established certain “Higher Education” institution. Then I just get a vacation until the end of July #itsbeenablast

GenerationResearch has two fully funded MRes positions (including stipend!) for UK Home students for projects in Chemistry (including structural biology). Applications are due June 19th, and students from underrepresented backgrounds are encouraged to apply. Please share!

Highly recommend these constructive ‘pitch your grant idea’ sessions open to all. A good way for everyone to hear new ideas and how to develop those aims. Always helped along by a supply of cake!

Too cool to be true? 😎 Nope! GlycoShape ReGlyco runs on PyMol through the GlycoMe interface 🥰😍 check out this fab #glycotime tool from Hiren @glyco.me and Ojas @ojas-singh.bsky.social ⤵️🥳🥳🥳🎉🎉

Holy forking shirtballs this Giro has been 🔥🔥🔥

“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”

Why are prior and concurrent #TB such huge risk factors for M. abscessus infection? #zebrafish preprint lead by our research officer Denise Wee discovers tuberculous granulomas (yellow blob) act as a safe haven for opportunistic mycobacterial pathogens (magenta blobs).

Postdoc position available! This is a 2-year post funded by the Academy of Medical Sciences. You'll be based in the Centre for Bacterial Cell Biology here in Newcastle, using super-resolution microscopy to look at the bacterial cell wall. 🔬🦠 Please re-post 🙏 www.jobs.ac.uk/job/DMY885/r...

Resisting the urge to ask the guy next to me at the bus stop with a phone in one hand and an iPod in the other what he’s listening to.

Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...

This has been a long journey, but it's now out in final form. @kjamali.bsky.social academic.oup.com/bioinformati...

Pretty sure my protein is actually Hestu from Legend of Zelda

Pretty sure my protein is actually Hestu from Legend of Zelda

Gutted that I can’t get to San Diego for my talk at ACS Mycobacterial cell wall session thanks to the Heathrow closure😭 I can justify buying myself a month of Discovery+ so I can watch cycling all day tomorrow instead to deal with the disappointment right? Right?!

Looking for a PhD opportunity in Microbiology? Consider joining one of the strongest clusters of microbiology research in UK at @newcastleuni.bsky.social, Biosciences Institute, and @cbcb-newcastle.bsky.social. See thread for BBSRC DTP PhD studentships currently advertised.

New lysins for medically and environmentally important Mycobacteriales. Supervised by @lislowe.bsky.social and Paul James. www.findaphd.com/phds/project...

An overview of data analysis tools for glycomics and they present an all-in-one solution for glycomic analyses.

AI-based imaging of zebrafish Position with @sergemostowylab.bsky.social @fuchtermatt.bsky.social and @jamesbriscoe.bsky.social jobs.lshtm.ac.uk/Vacancy.aspx...

PhD available with me & Paul James looking for exciting new enzymes - www.findaphd.com/phds/project...

Excited to share that our paper on locus visualisation tool LoVis4u is out! Entirely driven by fantastic PhD student Artyom Egorov @egorov.bsky.social academic.oup.com/nargab/artic...