Hi fellow membrane protein #StructuralBiology people! Do you use maltoside detergents / model them in your stuctures? Watch out! ⚠️ Most PDB models of LMNG and GDN are wrong ❌, yet continue to be re-used. Spread the word! See more: doi.org/10.1021/acsc... (w. @sebvidalchem.bsky.social ) #cryoEM

Good news! Erasmus is a great scheme. www.bbc.com/news/article...

Fab afternoon at the MHD festive gathering 🎉 congratulations to the winning quiz team and @johncorrigall.bsky.social for most festive outfit.

Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum | Science www.science.org/doi/10.1126/...

Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42... To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.

Fantastic to have Prof Matthias Wilmanns from EMBL Hamburg hosted by @kshbeckham.bsky.social to give a @mhd-newcastle.bsky.social seminar on mycobacterial infection #dreamtheme

Type VII ABC transporters underpin many core activities in the bacterial cell envelope - including efflux, cell division and lipoprotein trafficking. A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli. dx.plos.org/10.1371/jour...

Excited to share our latest research in @natmicrobiol.nature.com . We uncover hundreds of inhibitory interactions between common chemical pollutants and human gut bacteria. A thread🧵 (1/10) #microbiomesky #microsky @kiranrpatil.bsky.social lab @mrc-tu.bsky.social www.nature.com/articles/s41...

Pleased to share our recent article in PNAS - a collaboration with @jessicaandreani.bsky.social & Pablo Radicella, with important roles played by many members of each team. A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes www.pnas.org/doi/10.1073/...

Happy to see work I contributed to during my MSc at @bioscienceleeds.bsky.social with Jennifer Tomlinson’s lab out in @pnas.org! Everyone Bluesky-less except @antoncalabrese.bsky.social www.pnas.org/doi/10.1073/... #AMR #MRSA #NMR

rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin

Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.

A shared mechanism for Bacteroidota protein transport and gliding motility pubmed.ncbi.nlm.nih.gov/41266322/ #cryoem

Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....

I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

Next up Dr Francesca Mazzotta from Max Plank with some beautiful structures of peptide nanofibrils

Lovely to have 5 “generations” of #Salgadolab PhD students together at #ccp4north! In chronological order: @adamcrawshaw.bsky.social, Paola Lanzoni-Mangutchi, @vic0210.bsky.social, Ellie Rockliff and @pav2601.bsky.social. #proudPI

Dive into our November issue featuring: 🪆nested archaeal symbioses 🌱microbiota driven drought responses in plants 🏗️ BAM complex in Bacteroidota 💨microbial fermentative growth in the gut 🍸hospital-specific phage therapy cocktail and much more..! www.nature.com/nmicrobiol/v...

If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.

Want to find ways to combat TB? Check out this PhD position 👇

Want to work within a multidisciplinary group to combat antifungal resistance in Candida spp? Fully-funded MRC PhD studentship in collaboration with @nclfungalgroup.bsky.social and Francesco Del Carratore on the mode of action of a new class of antifungal drugs. www.findaphd.com/phds/project...

Interested in a PhD at the intersection of biophysics and microbiology? Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠 Closing 4 Dec! www.findaphd.com/phds/project...

Prospective PhD Students! The MRC DiMeN Doctoral Training Partnership PhD Projects are now online.. lots of exciting opportunities to join us here in Newcastle. Take a look 👀 www.findaphd.com/phds/mrc-dim...

Scary orientation bias has arrived for Halloween. 👻🔬 #CryoEM

If you’re interested in metals, microbes and maths 🤘 - please check out this PhD on the impact of metals on microbial communities with @thecopperdoctor.bsky.social @blindmath.bsky.social Denis Patterson and myself, you’d be based in Durham & be part of a vibrant interdisciplinary research group

Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026. Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years. Find out more: www.jic.ac.uk/training-car...

Looking forward to the Grand Opening of the Northern Eye Imaging facility on 5th November at the Frederick Douglass Centre, Newcastle. Register now nusbf.ncl.ac.uk/ccpem-tfs-ne... for the latest #structuralbiology and #cryoem in the region, to see the new Tundra cryo-TEM and lots more!

We’ve kept registrations open till the end of this week so get your last minute applications in for posters and talks!

The CCP4 Northern Structural Biology Meeting is back again in Newcastle 6-7th November 2025. If you are a structural biologist/biochemist in the North of the UK please register and submit abstracts by this Friday 17th. nusbf.ncl.ac.uk/ccp4-norther...

Prof Quinn telling us about her novel findings on bacterial type-VI secretion mediated killing of fungi. @mhd-newcastle.bsky.social @nclfungalgroup.bsky.social #Candida2025

Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social

Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria. doi.org/10.1038/s415...

Spending some time collecting memories of Harry today 🥺 - this is when he was elected a Fellow of the Royal Society. If anyone in the #glycotime universe has pictures or memories of Harry Gilbert they want to share please send them my way 💚

Now we are on Bluesky, over the next couple of days we would like to introduce some of the MHD groups on Bluesky who you can follow for more research updates. Or check out our handy MHD starter pack 😀 go.bsky.app/SoVnvW3

The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.

Exclusion systems, far from slowing down plasmid spread, are in fact essential to preserve host cell viability and thereby ensure the successful dissemination of conjugative plasmids and antibiotic resistance genes. @nfrk92.bsky.social @narjournal.bsky.social academic.oup.com/nar/article/...

Really excited to share my first paper from the Whitney lab, alongside an amazing grad student, Polina. Here we identify a chaperone family required for the folding of a central domain of T7SS toxins, and solve the structure of the chaperone-toxin complex. www.pnas.org/doi/10.1073/...

nusbf.ncl.ac.uk/blog/2025/08... If you want to see the progress of the installation of the Tundra TEM at @nusbf.bsky.social @newcastleuni.bsky.social Johan has been kindly updating the website with pictures as it is being assembled.

🦠 A fan of bacteria? We're hiring a Research Technician to join our team at the @warwicklifesci.bsky.social @uni-of-warwick.bsky.social Positive, organised, skills in molecular biology and protein purification? Apply here 👉 warwick-careers.tal.net/vx/appcentre... Please share! 🔬

Absolutely delighted to share the labs latest work. We identify and characterise two pathways for D-ribulose utilisation in pathogenic EHEC and Citrobacter.

#microsky We challenge the long-standing view that peptidoglycan alone protects cells from bursting. Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria. 📄 www.nature.com/articles/s41...

*JOB AD*: interested in doing a postdoc in microbial metabolomics? Passionate about natural products mass spec? Come join the group! Informal enquires welcome! Closing Date: 19 August 2025 jobs.ncl.ac.uk/job/Newcastl...

My wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor! www.justgiving.com/page/colin-k... (Please repost!)

You thought all OMPs were trimeric? 🧐 Not in our predator B. bacteriovorus! 🦠 Excited to have contributed to this great collab with the Lovering lab on this intriguing protein. @lalouxlab.bsky.social 👉 Paper here! www.nature.com/articles/s41... #BacterialPredation #Bdellovibrio #StructuralBiology

After an unexpectedly long editorial process, our paper describing the structures of the E coli TolAQR and TonB-ExbBD complexes is finally out. The coordinates are to be released on July 9th on the PDB. www.nature.com/articles/s41...

Excited to share some key details on our latest research in @natmicrobiol.nature.com reporting intra-cellular accumulation of #PFAS (aka forever chemicals) by certain human gut bacteria. #microsky #mevosky #microbiomesky www.nature.com/articles/s41...

Happy about our new paper in Nature rdcu.be/eukUB The GluA3 structure provides a framework for understanding this disease-prone glutamate receptor - novel interfaces will provide targets for modulator development