Jon Marles-Wright
@jmarlesw.bsky.social
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Scientist, husband to @lislowe, father. Views my own. He/him.
reposted by
Jon Marles-Wright
Microbes in Health and Disease
6 days ago
The Quinn group are interested in stress-sensing and signalling mechanisms in human pathogenic fungi and their importance in virulence. They are also interested anti-fungal mechanisms mediated by the bacterial type-vi secretion system. 👉
@nclfungalgroup.bsky.social
www.ncl.ac.uk/medical-scie...
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reposted by
Jon Marles-Wright
Microbes in Health and Disease
6 days ago
The Palmer group are interested in the mechanisms bacteria use to compete with one another during colonisation. Her group are focused on the type vii secretion system and the toxins it exports. Follow
@proftracypalmer.bsky.social
for more insights.
www.ncl.ac.uk/medical-scie...
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reposted by
Jon Marles-Wright
Microbes in Health and Disease
6 days ago
Next up,
@nickj-dent-res.bsky.social
His group is interested in all aspects of oral biofilms and how they contribute to oral health and disease. They look at adhesion and colonisation of surfaces, intermicrobial interactions and the role of the biofilm matrix.
blogs.ncl.ac.uk/nickjakubovi...
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reposted by
Jon Marles-Wright
Microbes in Health and Disease
6 days ago
Next introducing Dr Alessandra Dantas. The Dantas group is interested in stress responses, antifungal resistance and in understanding the molecular mechanisms driving fungal adaptation to environmental stressors.
@alesdantas.bsky.social
www.ncl.ac.uk/dental/about...
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reposted by
Jon Marles-Wright
Microbes in Health and Disease
6 days ago
Last introduction for the today.. Dr Kesha Josts
@kjosts.bsky.social
The Josts lab are working on the mechanisms of iron transport in bacterial pathogens, with a focus on Pseudomonas aeruginosa.
www.ncl.ac.uk/cbcb/staff/p...
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reposted by
Jon Marles-Wright
Microbes in Health and Disease
6 days ago
@jmarlesw.bsky.social
is a structural biochemist. His group are interested in how bacteria sense and respond to their environment. Jon is Academic Lead for our Electron Microscopy Facility and is excited for our new Tundra microscope to be up and running.
www.marles-wright-lab.org
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Welcome week at the university again. Number 28 for me. Looking forward to welcoming our 7th MRes Biotech and Biodesign cohort this morning.
13 days ago
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reposted by
Jon Marles-Wright
Kevin Waldron
5 months ago
Finally, we're recruiting! If you'd like to do a PhD using NMR structures to study the dynamics of a metalloenzyme, then you're in luck! Come to Warsaw for this project, in collaboration with Simone Ciofi-Baffoni's group at CERM, Florence:
ibb.edu.pl/app/uploads/...
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York Uni campus looking splendid today. Visiting Biology for a viva.
5 months ago
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Happy April 25th to all who observe the perfect date.
5 months ago
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Interested in Engineering Biology and spending a few days in the best city in the world? Designer Biology 2025 is coming to Newcastle: 29-31st July. Abstracts and registration is open:
www.efbiotechnology.org/designerbiol...
6 months ago
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reposted by
Jon Marles-Wright
Kate Beckham
9 months ago
First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group. Deadline end of February. Please spread the word.
www.findaphd.com/phds/projectdetails.aspx?PJID=181239
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PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University on FindAPhD.com
PhD Project - PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University, listed on FindAPhD.com
https://www.findaphd.com/phds/projectdetails.aspx?PJID=181239
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Day trip to Sheffield for a very enjoyable encapsulin viva with
@perbullough.bsky.social
10 months ago
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reposted by
Jon Marles-Wright
RuthLeyMicro
10 months ago
Here we delve deeper into what makes a flagellin “silent” - see Michael Bell’s cryo-EM structure of a silent flagellin from the flagellum of Roseburia hominis- it has a different charge distribution compared to FliC and it dissociates rapidly from TLR5
www.biorxiv.org/content/10.1...
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Kinetic and structure-based comparisons of silent and stimulatory flagellin interactions with TLR5
The bacterial protein flagellin is the sole ligand of the innate immune receptor Toll-like receptor 5 (TLR5). Flagellins with strong agonism bind TLR5 at their D1 and D0 domains, while poor agonist si...
https://www.biorxiv.org/content/10.1101/2024.12.09.627598v1
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A lovely winter graduation ceremony this afternoon. Posing here with some of the fab students I got to work with on the MRes Biotech and Biodesign last year. Always great to hear what they are all up to now.
10 months ago
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reposted by
Jon Marles-Wright
Kevin Waldron
10 months ago
I have a PhD position available in my group, to start in March 2025. If you have a keen interest in biochemistry and would like to study an exciting and novel class of copper proteins (aka weird Cu tubes) from bacteria, I'd love to hear from you. You should apply here:
ibb.edu.pl/app/uploads/...
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reposted by
Jon Marles-Wright
STCmicrobeblog
10 months ago
#ArchaeaSky
www.nature.com/articles/s41...
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Towards a molecular picture of the archaeal cell surface - Nature Communications
The model archaeon Sulfolobus acidocaldarius produces several protein filaments with specialised functions, including flagellum-like archaella, Aap pili, and adhesive threads. Here, the authors descri...
https://www.nature.com/articles/s41467-024-53986-9
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Every year Lis crafts amazing cakes for the kids. This year Rory’s cake really is something else!
add a skeleton here at some point
10 months ago
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reposted by
Jon Marles-Wright
Yu Heng Lau
10 months ago
Long time lurker, first time poster... announcing our latest preprint on encapsulin protein cages! We can now assemble them beautifully in vitro, without the ugly defects you get using acid/base or denaturants. This lets us put any synthetic cargo into these cages.
www.biorxiv.org/content/10.1...
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https://www.biorxiv.org/content/10.1101/2024.11.24.625105v1
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Sunday morning crafts with R.
10 months ago
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reposted by
Jon Marles-Wright
Sebastian S. Cocioba
10 months ago
I am ***absurdly*** excited to announce the launch of a new funding opportunity through Experiment dot com!!! You have one month to pitch something wonderful in the realm of plant biology/biotech research and education. $10,000 max grant. PLEASE RE-POST + SHARE!!! 1/3
experiment.com/programs/pla...
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Plant Biology Exploratory Research Microgrant | Experiment
For Science!
https://experiment.com/programs/plants
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reposted by
Jon Marles-Wright
Jamie Blaza
11 months ago
It’s great to finally share the cryo-EM work I’ve been carrying out with Luke Mackinder over the last few years- 2 papers on how Rubisco is condensed to form CO2 concentrating pyrenoids and how a shell is formed around them
www.nature.com/articles/s41...
www.sciencedirect.com/science/arti...
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#itsgrimupnorth
beers with
@lislowe.bsky.social
at Low Newton by the sea
11 months ago
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reposted by
Jon Marles-Wright
Dr Katherine Duncan
11 months ago
There are two PhD studentships advertised. Both MRC DiMeN DTP, both deadline 13th Dec Project 1: by
@henrikstrahl.bsky.social
with myself & Jessica Buttress
www.findaphd.com/phds/project...
& Project 2: by myself with
@henrikstrahl.bsky.social
& Manuel Banzhaf
www.findaphd.com/phds/project...
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This is why we share our data:
guide.cryosparc.com/processing-d...
a lovely new processing pipeline for some data we published three years ago.
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Case Study: End-to-end processing of encapsulated ferritin (EMPIAR-10716) | CryoSPARC Guide
Processing EMPIAR-10716 with a focus on high-symmetry ab-initio reconstruction, local symmetry, non-point-group symmetry, symmetry expansion, and custom geometry operations.
https://guide.cryosparc.com/processing-data/tutorials-and-case-studies/case-study-end-to-end-processing-of-encapsulated-ferritin-empiar-10716
11 months ago
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Birthday lego with the small person.
over 1 year ago
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It’s grim up north.
almost 2 years ago
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Pumpkins all decorated for Halloween by the kids and
@lislowe.bsky.social
mine not finished yet.
almost 2 years ago
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you reached the end!!
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