Our study on Bacteroides iron piracy is now out in @pnas.org. We show how surface-exposed lipoproteins bind xenosiderophores with different iron-chelating chemistries and propose a mechanism for xenosiderophore import across the outer membrane. Lots of structures (mostly X-ray this time)!

We have a PhD studentship open! (UK only sadly) but if you are or know a student keen to work on some *really* weird mycobacterial enzymes then get in touch! #glycotime Advert below www.findaphd.com/phds/project...

What are the genetic and molecular determinants underpinning the repair of bidirectional replication fork collapse in bacteria? PhD position open in my lab in collaboration with the brilliant @heathmurraylab.bsky.social. Please share and contact me if interested: www.findaphd.com/phds/project...

Happy April 25th all who celebrate. Light jacket season is upon us.

We’ve been sciencing! M abscessus makes a arabinanase toxin to chop up the cell wall of competitor mycobacteria! #glycotime 🦠 thanks to @wellcometrust.bsky.social for the funding that makes this collaborative work possible! Also Sam’s structures are 😍 and Jean-Lou did some lovely biochem

www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!

BBSSRC (NEEDL) funded PhD studentship in my lab co-supervised by @thecopperdoctor.bsky.social and @mycobacterium-ncl.bsky.social If you're interested in structural biology and membrane transport processes, check out www.findaphd.com/phds/project... deadline 27th of Feb! Get in touch for more info

Exciting CASE funded PhD opportunity available in the NEEDL PhD programme with me and Thomas Howard: eur03.safelinks.protection.outlook.com?url=https%3A...

We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT

🚨Last chance to apply for two PhD projects in my lab, applying structural biology and single molecule biophysics to investigate gene expression in RNA viruses: www.findaphd.com/phds/?Keywor...

Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

Proud and excited to see my first, first-author paper out on @pnas.org! Huge thank you to Jon @jmarlesw.bsky.social, Luning and my colleagues for their amazing guidance throughout. www.pnas.org/doi/10.1073/...

Assembly, architecture and functional roles of microbial surface layers Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social. S-layers are everywhere! www.nature.com/articles/s41...

Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....

I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...

Afternoon starts with former #Salgadolab student @adamcrawshaw.bsky.social getting the audience engaged on #microcrystals and @diamondlightsource.bsky.social VMXm beamline.

Another exciting day in Newcastle for structural biology! The CCP4 Structural Biology Meeting 2025 is here!

A great overview of #cryoEM in Newcastle from @jmarlesw.bsky.social at #NorthernEye opening @nusbf.bsky.social

Woo. The big day is finally here. @jmarlesw.bsky.social kicking off the Northern Eye Opening Symposium

Please join us in the North East on the 5th of November as we celebrate with a one day symposium for the launch of our BBSRC funded 100 keV Tundra TEM aka the Northern Eye: nusbf.ncl.ac.uk/ccpem-tfs-ne... The symposium has been kindly sponsored by @thermofishersci.bsky.social & @ccpem.bsky.social

Interested in alpha-oxoamine synthases and their use in biotech? Here's a nice methods paper on the production and characterisation of an engineered T. maritima variant from colleagues in the @campopianogroup.bsky.social: www.sciencedirect.com/science/arti...

The Quinn group are interested in stress-sensing and signalling mechanisms in human pathogenic fungi and their importance in virulence. They are also interested anti-fungal mechanisms mediated by the bacterial type-vi secretion system. 👉 @nclfungalgroup.bsky.social www.ncl.ac.uk/medical-scie...

The Palmer group are interested in the mechanisms bacteria use to compete with one another during colonisation. Her group are focused on the type vii secretion system and the toxins it exports. Follow @proftracypalmer.bsky.social for more insights. www.ncl.ac.uk/medical-scie...

Next up, @nickj-dent-res.bsky.social His group is interested in all aspects of oral biofilms and how they contribute to oral health and disease. They look at adhesion and colonisation of surfaces, intermicrobial interactions and the role of the biofilm matrix. blogs.ncl.ac.uk/nickjakubovi...

Next introducing Dr Alessandra Dantas. The Dantas group is interested in stress responses, antifungal resistance and in understanding the molecular mechanisms driving fungal adaptation to environmental stressors. @alesdantas.bsky.social www.ncl.ac.uk/dental/about...

Last introduction for the today.. Dr Kesha Josts @kjosts.bsky.social The Josts lab are working on the mechanisms of iron transport in bacterial pathogens, with a focus on Pseudomonas aeruginosa. www.ncl.ac.uk/cbcb/staff/p...

@jmarlesw.bsky.social is a structural biochemist. His group are interested in how bacteria sense and respond to their environment. Jon is Academic Lead for our Electron Microscopy Facility and is excited for our new Tundra microscope to be up and running. www.marles-wright-lab.org

Welcome week at the university again. Number 28 for me. Looking forward to welcoming our 7th MRes Biotech and Biodesign cohort this morning.

Finally, we're recruiting! If you'd like to do a PhD using NMR structures to study the dynamics of a metalloenzyme, then you're in luck! Come to Warsaw for this project, in collaboration with Simone Ciofi-Baffoni's group at CERM, Florence: ibb.edu.pl/app/uploads/...

York Uni campus looking splendid today. Visiting Biology for a viva.

Happy April 25th to all who observe the perfect date.

Interested in Engineering Biology and spending a few days in the best city in the world? Designer Biology 2025 is coming to Newcastle: 29-31st July. Abstracts and registration is open: www.efbiotechnology.org/designerbiol...

First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group. Deadline end of February. Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239

Day trip to Sheffield for a very enjoyable encapsulin viva with @perbullough.bsky.social

Here we delve deeper into what makes a flagellin “silent” - see Michael Bell’s cryo-EM structure of a silent flagellin from the flagellum of Roseburia hominis- it has a different charge distribution compared to FliC and it dissociates rapidly from TLR5 www.biorxiv.org/content/10.1...

A lovely winter graduation ceremony this afternoon. Posing here with some of the fab students I got to work with on the MRes Biotech and Biodesign last year. Always great to hear what they are all up to now.

I have a PhD position available in my group, to start in March 2025. If you have a keen interest in biochemistry and would like to study an exciting and novel class of copper proteins (aka weird Cu tubes) from bacteria, I'd love to hear from you. You should apply here: ibb.edu.pl/app/uploads/...

#ArchaeaSky www.nature.com/articles/s41...

Every year Lis crafts amazing cakes for the kids. This year Rory’s cake really is something else!

Long time lurker, first time poster... announcing our latest preprint on encapsulin protein cages! We can now assemble them beautifully in vitro, without the ugly defects you get using acid/base or denaturants. This lets us put any synthetic cargo into these cages. www.biorxiv.org/content/10.1...

Sunday morning crafts with R.

I am ***absurdly*** excited to announce the launch of a new funding opportunity through Experiment dot com!!! You have one month to pitch something wonderful in the realm of plant biology/biotech research and education. $10,000 max grant. PLEASE RE-POST + SHARE!!! 1/3 experiment.com/programs/pla...

It’s great to finally share the cryo-EM work I’ve been carrying out with Luke Mackinder over the last few years- 2 papers on how Rubisco is condensed to form CO2 concentrating pyrenoids and how a shell is formed around them www.nature.com/articles/s41... www.sciencedirect.com/science/arti...

#itsgrimupnorth beers with @lislowe.bsky.social at Low Newton by the sea

There are two PhD studentships advertised. Both MRC DiMeN DTP, both deadline 13th Dec Project 1: by @henrikstrahl.bsky.social with myself & Jessica Buttress www.findaphd.com/phds/project... & Project 2: by myself with @henrikstrahl.bsky.social & Manuel Banzhaf www.findaphd.com/phds/project...

This is why we share our data: guide.cryosparc.com/processing-d... a lovely new processing pipeline for some data we published three years ago.

Birthday lego with the small person.

It’s grim up north.