This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition, The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance Iconic imo

Every time people focus on resolution as a competitive number rather than what biochemical detailed is revealed at that resolution is being sent this little guy

Our work on the mechanism of bedaquiline is now published. Nat Comms has open peer review so anyone can see the critical but constructive and supportive peer review we received. Thanks again to @morwan.me on BlueSky, and Suzy, Rowan, Greg, Chen-Li, and Roger who aren't. Original thread below

@poojag96.bsky.social work on the bioenergetics of spore germination is now published- Pooja had a really nice summary that I've put below but essentially we think the role of bioenergetics in spore germination has been completely overlooked! www.pnas.org/doi/10.1073/...

We've got ISSUES. Literally. We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do? arxiv.org/abs/2601.07563 A 🧵 1/n

Atomic resolution cryo-EM at 200 keV www.biorxiv.org/content/10.64898/2026.01.09.698548v1 #cryoem

I am pleased to share our new paper in Molecular Cell: “Capsid restructuring activates semi-conservative dsRNA transcription in cystovirus ɸ6.” We visualized, in structural detail, how a double-stranded RNA virus switches from a quiescent to a transcriptionally active state. Link in the comments

High-Resolution single particle analysis using a scintillator camera XF416 on CRYOARM300II at 300 kV pubmed.ncbi.nlm.nih.gov/41491063/ #cryoem

The @ccpem.bsky.social Spring Symposium is, in my humble opinion, the best #cryoEM methods-oriented meeting 😉

'we have focused on a single class of ligand, and we hope that our findings are not representative of the PDB at large.' Sadly I think they are. Ligands still need a sense-check, often with nothing more than a biochemistry textbook chapter on stereochemistry. This isn't the reviewer's job really

❄️ With all the snow outside, I felt like sharing a cryo tomogram: A neuronal synapse, captured by cryo-ET at the moment a neurotransmitter-filled vesicle fuses at the active zone. Fusion was triggered optogenetically and arrested by plunge freezing. More details: www.nature.com/articles/s41...

"revision requests can expand beyond what is feasible...we've been told reviews are unnecessarily harsh... reviews can seem formidable but usually represent constructive critiques" Interesting reflections and introspection from editors of Development 1/n journals.biologists.com/dev/article/...

I am delighted to announce that in January 2026 I will be starting a new permanent position @uniofgalway.bsky.social as a Lecturer/Assistant Professor in Microbiology! #ZedenLab #Microbiology #AMR #Academia #Tenured #CareerMilestone #NewJob #Galway

Just in time for 2026! 🎆 Presenting a nascent-centric view on the shape of the ribosomal exit tunnel topology, based on MD-derived occupancy maps for 55 distinct ribosomes. 🧶🧬🖥️ 📄 Read the preprint: biorxiv.org/content/10.6... #StructuralBiology #Ribosome #CryoEM #Evolution #Biophysics

The sporulation phosphorelay protein Spo0B is membrane localized in Paenibacillus! The transmembrane domain appears to increase interaction with relay partners. Congrats to former lab undergrad @isabellalin.bsky.social and her grad mentor @cassidyprints.bsky.social journals.asm.org/doi/10.1128/...

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

Atomic resolution structure of spinach rubisco reveals protons and dynamics www.biorxiv.org/content/10.64898/2025.12.22.696010v1 #cryoem

We are looking for a team leader to join the cryo-EM facility work at the new Ernst Ruska-Centre 2.0 at the Forschungszentrum Jülich. We have a series of microscopes used by (@irene-vercellino.bsky.social, Schröder, @sachsegroup.bsky.social) and external users. www.fz-juelich.de/de/karriere/...

Yet more fascinating membrane biochemistry in TB! Brilliant work @luizcarvalholab.bsky.social & co

Professor Ruth: Coming Fall 2026! I'm thrilled to announce that I have officially accepted a tenure-track faculty position in the Biology Department at @macalestercollege.bsky.social! #HeyMac #NewProfessor #WomanInSTEM

Late job posting: My department is hiring a tenure-track faculty member in microbiology! Please share with anyone interested in working at a PUI. We have a preference for someone who can teach Medical Microbiology, but other than that the focus is open-ended. Happy to answer qs.

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

Non-motile microbes are not prisoners of diffusive transport. Just their metabolic activity can be sufficient to stir up the ambient fluid and cause explosive long-range dispersal -- a "metabolic firework". Our latest work -- arxiv.org/abs/2512.16288

The wreath was created using PDB entry 8PDN, with the red bow from EMD-35864. Snowflakes were created using PDB entries 6MQA, 7NI2, 8KG2 and EMDB maps EMD-9861, EMD-15602, EMD-23388, EMD-30158, EMD-32016, EMD-35178, EMD-44639, EMD-50640. Yellow stars were created using PDB entries 6HIF and 8OZL.

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6... Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

Our work on the mechanism of bedaquiline is now published. Nat Comms has open peer review so anyone can see the critical but constructive and supportive peer review we received. Thanks again to @morwan.me on BlueSky, and Suzy, Rowan, Greg, Chen-Li, and Roger who aren't. Original thread below

Love the caption of Fig. 3 in this impressive preprint: "A Goodsell-esque 3D orthogonal rendering of an IsoNet2-processed FIB-milled tomogram of C. reinhardtii" doi.org/10.64898/202... Since I am no expert, what does the cryoET community think of IsoNet? @cellarchlab.com doi.org/10.1038/s414...

🤯

Mycobacterial respiratory chain enzymes and growth are inhibited by decylubiquinone pubmed.ncbi.nlm.nih.gov/41372535/ #cryoem

Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have. mrc.tal.net/vx/mobile-0/...

Full professorship (W3) in Theoretical Chemistry at Potsdam University, hit me up if you are interested. ⚠️ Note that the deadline is over holidays ⚠️

Mycobacterium tuberculosis is an outlier in many ways. One of them is keeping a high degree of functional redundancy despite its obligate pathogen lifestyle. In this review, we reflect on the biological meaning of M. tuberculosis functional redundancies. journals.plos.org/plospathogen...

Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42... To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.

University of Birmingham, UK, are advertising a permanant position (Assistant or Associate Professor) in *Forests under Global Change*. A wide net has been cast - ecology, physiology, modelling, remote sensing, functioning, biodiversity, management... 🌲🌱🌳🌳🦌🌳🛰️🐿️🌲🔬🌳 www.jobs.ac.uk/job/DPS459/a...

We're advertising for a bacteriology technician and a post-doc to work on AI-guided antibiotic development as part of a large multidisciplinary Fleming Initiative project: www.imperial.ac.uk/jobs/search-... www.imperial.ac.uk/jobs/search-...

Ten years of the CCP-EM Spring Symposium pubmed.ncbi.nlm.nih.gov/41324471/ #cryoem

If you or someone you know is looking for a post-doctoral position working on mycobacterial envelope biology, please get in touch. I am recruiting here at the University of Western Ontario in London, Ontario, Canada.

want to see a chemotaxis array (G) and a post-discharge T6SS (I) ? inside 𝘝𝘪𝘣𝘳𝘪𝘰 𝘧𝘪𝘴𝘤𝘩𝘦𝘳𝘪 inside a 𝘌𝘱𝘳𝘺𝘮𝘢 𝘴𝘤𝘰𝘭𝘰𝘱𝘦𝘴 crypt ? go no further... #CryoET #CryoEM #teamtomo #MicroSky

I, @kaytrue.bsky.social, and others on this thread have not made or supported any claims about scaffolds. We have studied 2D phase separation within model membranes and in some cases, such as the yeast vacuole, cell membranes.

I fully agree. The term LLPS is probably not the correct one to describe what happens in cells. However, the formation of dynamic low-order condensates driven by low affinity multivalent proteins (often highly disordered) seems to occur in cells.

Since AI slop is again all over Scientific Reports, a thread on the economics of grey-zone publishing. Why does slop keep getting published? What does it mean for science? How can we stop this? Background readings: Understand the strain: tinyurl.com/2b6wxx5r Stop the drain: tinyurl.com/3jfscscy

Visualizing the translation landscape in human cells at high resolution pubmed.ncbi.nlm.nih.gov/41315256/ #cryoem

Exciting collab with Paul Palme, Peter Imming, & Adrian Richter! Guided by @courbongautier.bsky.social's structure of myco ATP synthase bound to a squaramide, they have made SQAs that are less toxic, more potent, more stable than AstraZeneca's SQ31f #MedChem #TB #NTM pubs.acs.org/doi/full/10....

Required reading for my lab!

Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells. See the original preprint-thread for a summary of our findings. www.nature.com/articles/s41... #microsky

Our latest T7SS study is now out in Science Advances! We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery. www.science.org/doi/10.1126/...

🚨Job claxon 🚨 University College Cork is looking to appoint a lecturer in Medical Microbiology into a permanent, non-clinical post A great opportunity in a microbiology powerhouse For details go to my.corehr.com/pls/uccrecru... and enter reference number 092153