1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...

A real triumph for #glycotime and basic research, thanks to the work of Steve Withers and others.🧪

Happy to have this collaborative work out on Biorxiv on how Akkermansia muciniphila deploys it’s carbohydrate sulfatases to metabolise colonic mucin, and that processed glycopeptides/proteins of colonic mucin are a favoured carbon source #glycotime. www.biorxiv.org/content/10.1...

A cool use of DALI/FoldSeek building on new human HG-SNAT protein enabled Bethan Kinniment-Williams & co., to structural unify the TmAT superfamily of membrane-bound acyltransferases first proposed by Milton Saier Jnr in TCDB. @jnb-lab.bsky.social www.jbc.org/article/S002...

Our latest work on rhamnogalacturonan ii degradation (RGII): Functional and structural characterisation of GH139 that removes O2 methylated fucose from RGII #glycotime doi.org/10.1016/j.jb...

Happy to have this work on the effectiveness of sulfamate based inhibitors on carbohydrate sulfatases out in @pnas.org www.pnas.org/doi/10.1073/pnas. #glycotime The summary is: Current sulfatase inhibitor technology is not effective on S1 carbohydrate sulfatases of the human colonic microbiota.

By deep characterisation of 186 N-glycan standards, we @thencfg.bsky.social have made the most comprehensive targeted LC-MS glycomic assay to date. Non-reduced native glycan analysis is key. We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.

PhD available with me & Paul James looking for exciting new enzymes - www.findaphd.com/phds/project...

Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy! www.nature.com/articles/s41...

Our new paper in print describes a new approach: release and analysis of N-glycans in less than 24 hours. A perfect approach for those that are glycan-curious as it does not require changing any of your proteomics buffers! 1/5 #glycotime #teammassspec pubs.acs.org/doi/10.1021/...

Happy to have this deep dive into polysaccharide lyase family 33 out: www.pnas.org/doi/suppl/10... We define features driving substrate specificity, catalytic mechanism, and evolutionary links with multiple lyases and epimerises #glycotime @PNASNews

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS🍬🍬🍬 For the first time, we are able to image the molecular architecture of the glycocalyx at Ångström resolution. A dream come true! Read the preprint: biorxiv.org/content/10.110… And find our tweetorial below#glycotimeme

I have a PhD on how human gut bacteria feed off host glycans and produce metabolites that alter host cell behaviour #glycotime findaphd.com