Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria. doi.org/10.1038/s415...

Here I am in 2020 in the flimsiest, most pitful PPE - like so many other NHS staff, some of whom died from the Covid they caught in their hospitals. Tory peer Michelle Mone - who today lost her legal case & must repay the govt £122m - dares to claim she’s been ‘scapegoated’. What, Michelle? 🧵

Today, @rcsbpdb.bsky.social introduces Q-score in EM validation reports. Q-score assesses model-map fit. A new percentile slider will compare an entry’s average Q-score to the full archive and a resolution-matched subset. This would help judge whether the fit is typical for the reported resolution.

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging www.biozentrum.unibas.ch/open-positio... #biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

#cryoEM 🧪⚛️ Lena’s paper on imaging thick biological sections with STEM is finally published! We started this work almost 10 years ago. After Lena passed in 2023, I spent much of my sabbatical working with Yue and Steve to wrap this up. Also learned a lot about TEM vs STEM dose efficiency

SCIENCE IS VERY GOOD!!!! this sparks joy!!!

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM

I feel some responsibility, as we develop the software. But helical reconstruction is prone to getting stuck in local minima, and unfortunately still requires a lot of self-criticism. The most important one: if you don't see expected features in the map, don't trust it!

Carve that last sentence in stone, alongside “if you can’t see your particles they are not there” and “if you can’t see your ligand do not try to just model it anyway”

Structural basis for a filamentous morpheein model of human cystathionine beta-synthase www.biorxiv.org/content/10.1101/2025.09.24.678195v1 #cryoem

Tilt-corrected bright-field scanning transmission electron microscopy (tcBF-STEM) offers enhanced contrast and dose efficiency for cryo-EM in thick biological specimens. www.nature.com/articles/s41...

Wouldn't you say that systematic scientific misconduct (let's say, through neglect or actual fraud) going back decades should also be fully prosecuted? I am also unable to understand the politics here. It's a scientist reading a paper and seeing potential issues. Are we not allowed to talk about it?

The CDC’s newly reconstituted antivax ACIP met last week. The results weren’t as horrific as I’d expected, but not for lack of trying on the part of the antivax members. I’ll focus mainly on one presentation as a lens through which to look at the meeting. sciencebasedmedicine.org/robert-f-ken...

Many studies have shown that there is no relationship between MMR vaccine and the development of autism. Here are two of the best. This one followed every single child born in Denmark from 1991 through 1998 (n=537,303). There was no association.

Keep up to date with all the latest from the MHD theme ✨

Part of something that we have been working on for a while-A 3.1 Å map of a flexibly tethered 38 kDa domain. Hopefully preprinted soon along with a few other structures. #CryoEM

If you’re carrying a chip on your shoulder because you're in the "hard sciences," it's time to let that go. The ongoing pandemic has shown that one discipline alone can’t solve this crisis. We need the social & political sciences, the creativity of the arts. We need to work together

Alien: Earth (N. Hawley and others, 2025)

Peer review is not a "stamp of approval" or a certification of 'truth'; it's a pressure test, and the pressure applied varies by venue. And, ultimately, a paper published in a journal is just a reflection of what an editor thought would be *useful* to their community.

Finally in @nature.com 🎉 We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism. www.nature.com/articles/s41...

Please apply to our tenure-track faculty position at @stanford-chemh.bsky.social! We are searching for a new colleague working at the interface between computation and molecular sciences. See post below and pls forward widely! chemh.stanford.edu/opportunitie...

🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching! Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv! www.biorxiv.org/content/10.1...

Our microbes in health and disease research theme @mhd-newcastle.bsky.social is now on Bluesky! Give us a follow to hear about our exciting science!

Interested in structural biology, membrane proteins, biophysics and working to understand hormone transport in plants?☘️🔬👩‍🔬🧪 We have an open PhD position: - 3 years fully funded. - Details and application link: www.linkedin.com/posts/plant-... Please repost 💚

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

AI can now generate fake microscopy images that are nearly impossible to detect. A serious threat to scientific integrity—and we’re not prepared for it. Commentary in @natnano.nature.com #nanotechnology

Charlie Kirk was a champion of free speech and anyone who says otherwise will be fired

Come and join us in our new home - great colleagues and brand new facilities

FAO the @royalsociety.org which still considers someone who spreads misinformation and encourages violence as worthy of their Fellowship.

Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...

We are looking for a new postdoctoral fellow interested in the further development of our RAPPL technology and studies of translational complexes. Preference will be given to candidates with either structural biology or ribosome profiling backgrounds. www.nature.com/articles/s41...

Watching all these centrist pundits stress the “civility” of Charlie Kirk’s style without addressing the ugliness of his substance is giving me a renewed appreciation of how the civil, polite White Citizens’ Councils conned the same crowd into thinking they were distinct from the cruder Klan.

Esp given assassination of Kirk in US i find Musk's intervention here, calling for dissolution of parliament and a new govt, really scary . Also UK govt bodies should get the fuck off X.

Many news reports are nodding to the fact that Charlie Kirk was “controversial“ but not getting specific about his hateful comments about women, Black people and immigrants. Such rhetoric must be allowed in a free country, and his murder is an outrage. But it Is no reason for whitewashing.

💔 Fred Guttenberg whose daughter died in the 2018 Stoneman Douglas High School shooting

Political violence is bad. It usually begets more political violence. Celebrating political violence is bad. It usually encourages more political violence, against various targets. Campus shootings are bad. They make everyone on campus less safe. It's bad that what I wrote here is controversial.

Dear scientific community, I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford. my.corehr.com/pls/uoxrecru... my.corehr.com/pls/uoxrecru...

nusbf.ncl.ac.uk/blog/2025/08... If you want to see the progress of the installation of the Tundra TEM at @nusbf.bsky.social @newcastleuni.bsky.social Johan has been kindly updating the website with pictures as it is being assembled.

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

This is without any evidence or data to support it. Cancer existed before COVID vaccines. The rise in early onset cancers- going on for decades- is not linked to COVID vaccines. Follow scientists & medical researchers. Not ppl selling snake oil. www.theguardian.com/politics/202...

The Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Please share. Further details: www.vbcphd.at

So #RFKjr appointed a CDC vaccine panel largely comprised of antivaccine cranks, including Joseph Fraiman, whose claim to fame is a terrible paper with half-assed statistics claiming Covid mRNA vaccines were dangerous, which I debunked in same journal.. www.sciencedirect.com/science/arti...

“Prasad’s comments still appeared on anti-vaccine social media accounts, suggesting Prasad was directing his removal demand only at a critic and not anti-vaccine influencers. In the past, Prasad has complained about censorship by social media companies.” Yeah, cause he is an antivaxxer and a fraud.

Come on now. Stand by your past statements or publicly change your mind. But don’t try to pretend.

rich people yoinking stuff and thinking they earned it is a constant of nature. trump thinks he can bully people into giving him a Nobel. people who think prompting AI makes them an artist. losers who cry when people tell them stealing the trophy isn't the same as winning the trophy.

📢 Recruitment for the EMBL International PhD Programme is officially open! At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences! bit.ly/47mmiFF

📢We're #hiring Group Leaders! Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning. 🔹5-year renewable appointment 🔹Pioneer new tools & approaches 🔹Collaborate across disciplines Apply by Nov. 4👉 https://janelia.link/groupleader