Thanks to all of the organisers. It was a great meeting, again. Happy to hear it will be back in Newcastle again next year.

So much exciting structural biology on show 😃

Beautiful work from @augustsilale.bsky.social 🤩 @nusbf.bsky.social

Another exciting day in Newcastle for structural biology! The CCP4 Structural Biology Meeting 2025 is here!

Wow, really impressive work 🤩

Back in the toon to celebrate the launch of the Tundra! Congratulations to everyone involved in making this possible 👏 #NorthernEye #cryoEM @nusbf.bsky.social @thermofishersci.bsky.social

Lots of exciting developments to understand the structure of membrane protein in its native environment

Structural and functional analysis of drug resistance in tuberculosis via a novel MmpL3 binding site. Supervised by @mycobacterium-ncl.bsky.social and @kshbeckham.bsky.social. www.findaphd.com/phds/project...

Welcome to #bluesky 👏🏻

Want to work within a multidisciplinary group to combat antifungal resistance in Candida spp? Fully-funded MRC PhD studentship in collaboration with @nclfungalgroup.bsky.social and Francesco Del Carratore on the mode of action of a new class of antifungal drugs. www.findaphd.com/phds/project...

Interested in a PhD at the intersection of biophysics and microbiology? Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠 Closing 4 Dec! www.findaphd.com/phds/project...

If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.

Want to find ways to combat TB? Check out this PhD position 👇

Prospective PhD Students! The MRC DiMeN Doctoral Training Partnership PhD Projects are now online.. lots of exciting opportunities to join us here in Newcastle. Take a look 👀 www.findaphd.com/phds/mrc-dim...

If you’re interested in metals, microbes and maths 🤘 - please check out this PhD on the impact of metals on microbial communities with @thecopperdoctor.bsky.social @blindmath.bsky.social Denis Patterson and myself, you’d be based in Durham & be part of a vibrant interdisciplinary research group

📣 Open call for life science #interns Our International Summer #Internship 2026 is now open for applications. Three-months fully funded internships at the Max Planck Institute for Infection Biology. 👉 Information on the internship projects and how to apply: www.mpiib-berlin.mpg.de/mpiib-isi

🚀 Introducing fully automated data processing for repeat-target #cryoEM. Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention. Preprint: www.biorxiv.org/content/10.1...

Please join us in the North East on the 5th of November as we celebrate with a one day symposium for the launch of our BBSRC funded 100 keV Tundra TEM aka the Northern Eye: nusbf.ncl.ac.uk/ccpem-tfs-ne... The symposium has been kindly sponsored by @thermofishersci.bsky.social & @ccpem.bsky.social

We’ve kept registrations open till the end of this week so get your last minute applications in for posters and talks!

The CCP4 Northern Structural Biology Meeting is back again in Newcastle 6-7th November 2025. If you are a structural biologist/biochemist in the North of the UK please register and submit abstracts by this Friday 17th. nusbf.ncl.ac.uk/ccp4-norther...

Still time to sign up and submit and abstract for this year’s CCP4 Northern Structural Biology Meeting. This is a really nice meeting and great opportunity for ECRs to present their work ✨ nusbf.ncl.ac.uk/ccp4-norther...

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here: emploi.cnrs.fr/Offres/Docto...

Prof Quinn telling us about her novel findings on bacterial type-VI secretion mediated killing of fungi. @mhd-newcastle.bsky.social @nclfungalgroup.bsky.social #Candida2025

Very cool. Congrats @augustsilale.bsky.social et al :) ✨✨

Now for a final round of PI introductions : Professor John Common investigates the skin microbiome as an ecosystem, studying how its interactions with the host barrier and immune system contribute to diseases such as atopic dermatitis, acne, and ichthyosis www.ncl.ac.uk/medical-scie...

Dr Emma Briggs @emmamariebriggs.bsky.social Studies how trypanosomatid parasites regulate cell cycle arrest and proliferation in response to environmental cues—using CRISPR, microscopy and single-cell transcriptomics to uncover molecular switches and potential drug targets driving transitions

Dr Manuel Banzhaf The Banzhaf group uses high-throughput methods to dissect the life style of bacterial pathogens and how to use this knowledge to optimize antimicrobial treatments. Follow @banzhaflab.bsky.social for more updates

Nice to see our summer student Niamh who did a great job in the lab this year supported by a Vacation Studentship! @proftracypalmer.bsky.social

Next up, Dr Kate Beckham @kshbeckham.bsky.social The Beckham lab is interested mycobacterial membrane transport processes. They focusing on understanding the steps occurring at the mycobacterial outer membrane. www.ncl.ac.uk/cbcb/staff/p...

Next up : Dr Kate Duncan @kateduncan.bsky.social The Duncan group study the chemical language of bacteria (& what influences it) for antibiotic discovery from our oceans. Check out www.medicinesfromthesea.com for more info

The Salgado group focuses on structural and functional characterisation of proteins involved in pathogenicity pathways in C. difficile. They are particularly interested in S-layer and sporulation proteins and their role in infection. Follow @pssalgado.bsky.social salgadolab.org

Day 2 of MHD introductions 😃 Dr Lis Lowe @lislowe.bsky.social The Lowe lab is focussed on microbial glycobiology. They work on bacterial Cazymes from commensals and pathogens, and are particularly interested in enzymes that target microbial glycans such as the cell walls of Mycobacteria.

The @stewartlab.bsky.social use systems biology and cutting-edge human intestinal organoid models to understand diet-microbe-host interaction across the life course, with the ambition to discover novel therapies to improve gut health. www.ncl.ac.uk/medical-scie... www.neonatalresearch.net

The Connolly group focuses on pathogenic Escherichia coli. They study how pathogen gene expression is regulated in response host-cues and determine how these expression changes lead to infection-relevant phenotypes. Follow @ruamicro.bsky.social for more

Dr Alistair Brown’s group is interested in mycobacterial biology, focusing on antimicrobial drug discovery and elucidation of drug mechanisms of action. They aim to understand how existing and novel compounds affect mycobacterial growth, survival, and persistence. @mycobacterium-ncl.bsky.social

Dr Chien-Yi Chang's lab studies how Gram-negative bacteria sense and respond to different environments using molecular and bioimaging approaches. 👉 @davychang.bsky.social chienyichang.wixsite.com/changlab

The Bolam lab uses a range of biochemical, microbiological, genetic and structural techniques to study the molecular mechanisms utilised by our resident gut bacteria to recognise, acquire and degrade complex glycans from both dietary and host sources. Follow @dave-bolam.bsky.social

The Quinn group are interested in stress-sensing and signalling mechanisms in human pathogenic fungi and their importance in virulence. They are also interested anti-fungal mechanisms mediated by the bacterial type-vi secretion system. 👉 @nclfungalgroup.bsky.social www.ncl.ac.uk/medical-scie...

The Palmer group are interested in the mechanisms bacteria use to compete with one another during colonisation. Her group are focused on the type vii secretion system and the toxins it exports. Follow @proftracypalmer.bsky.social for more insights. www.ncl.ac.uk/medical-scie...

Next up, @nickj-dent-res.bsky.social His group is interested in all aspects of oral biofilms and how they contribute to oral health and disease. They look at adhesion and colonisation of surfaces, intermicrobial interactions and the role of the biofilm matrix. blogs.ncl.ac.uk/nickjakubovi...

@jmarlesw.bsky.social is a structural biochemist. His group are interested in how bacteria sense and respond to their environment. Jon is Academic Lead for our Electron Microscopy Facility and is excited for our new Tundra microscope to be up and running. www.marles-wright-lab.org

Next introducing Dr Alessandra Dantas. The Dantas group is interested in stress responses, antifungal resistance and in understanding the molecular mechanisms driving fungal adaptation to environmental stressors. @alesdantas.bsky.social www.ncl.ac.uk/dental/about...

Last introduction for the today.. Dr Kesha Josts @kjosts.bsky.social The Josts lab are working on the mechanisms of iron transport in bacterial pathogens, with a focus on Pseudomonas aeruginosa. www.ncl.ac.uk/cbcb/staff/p...

Keep up to date with all the latest from the MHD theme ✨

The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.

We are now live on Bluesky! Follow us to find out more about the research and activities going on the Microbes in Health and Disease theme @newcastleuni.bsky.social #dreamtheme

Our microbes in health and disease research theme @mhd-newcastle.bsky.social is now on Bluesky! Give us a follow to hear about our exciting science!

We are excited to share our latest work, where we unravel the structural and functional secrets of the once-mysterious protein Pex8 revealing how it controls the peroxisomal cargo import receptor Pex5. Read more here: www.biorxiv.org/content/10.1101/2025.08.30.673231v1

Congrats @lakhanekal.bsky.social et al. Great to see this story out :)

📢 Recruitment for the EMBL International PhD Programme is officially open! At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences! bit.ly/47mmiFF