E subunit-enabled ENZYME YOGA. Structures of catalytically active, asymmetric, hybrid acyl-CoA carboxylase, essential in M. tuberculosis @edumullapudi.bsky.social & @matthiaswilmanns.bsky.social & Minh Thai. www.nature.com/articles/s42... see also Liang et al. www.pnas.org/doi/10.1073/...

Architecture of an asymmetric mycobacterial short chain/long chain acyl-CoA carboxylase https://www.biorxiv.org/content/10.1101/2025.11.15.688623v1

Our new preprint is out: www.biorxiv.org/content/10.1... Cryo-EM structure of a multi-substrate mycobacterial ACCase reveals unique stoichiometry, a flexible AccE5-mediated β-barrel, and ~90° BC rotation upon substrate binding-insight into mycolic acid biosynthesis. Huge thanks to my co-authors!

Our new preprint is out: www.biorxiv.org/content/10.1... Cryo-EM structure of a multi-substrate mycobacterial ACCase reveals unique stoichiometry, a flexible AccE5-mediated β-barrel, and ~90° BC rotation upon substrate binding-insight into mycolic acid biosynthesis. Huge thanks to my co-authors!