🫴 Processing of reversed replication forks is required for the resolution of replication-transcription conflicts ! 👇 academic.oup.com/nar/article/... #subtiwiki

Very nice work on sugar transport during Proteus UTI

Really lovely work, Marjon & team, puts us closer to being able to decipher #UTI diagnosis based on sequencing - currently difficult in my view, with dozens of strains detected and never being entire sure what the pathogen(s) is/are. We need to understand entire signatures better. #UTISky #IDSky

NAPs anybody? it's H-NS again – @jayhinton.bsky.social you will like it, I assume 😊 #MicroSky #PhageSky

Is colorectal cancer driven by a disruption of anaerobiosis? A recent study by Spiga et al. makes this idea walk and talk like a duck. Read more here: www.sciencedirect.com/science/arti...

Now published in Cell Reports! @cellpress.bsky.social www.cell.com/cell-reports... My postdoc Dr. Maria de la Paz Gutierrez led this work showing that cholera toxin drives epithelial L-lactate production in the small intestine, creating a nutrient that Vibrio cholerae exploits during disease

Also of potential interest to #UTISky followers

Happy to share the last publication of @bobytaillefer.bsky.social, showing that #T6SS heterogeneity is an attenuation strategy to optimizes the trade-off between competitive killing and survival.

Opportunity for someone interested in a full time permanent lectureship in Environmental Microbiology and Biotechnology at @uccmicrobiology.bsky.social www.jobs.ac.uk/job/DRS979/l...

Latest research from the lab out now. We examined the role and expression of fimbriae during UPEC bloodstream infection. A real team effort and brilliant collaboration with Mark Schembri’s lab in Brisbane. Thanks to the MRC and BBSRC for supporting our research @ukri.org

🦠 💫 www.science.org/doi/10.1126/...

One week left to apply for two 3-year postdocs in the lab on molecular mechanisms of Burkholderia pathogenesis. Posts associated with Magdalen College. Our lab is based in the Dunn School of Pathology with amazing collaborators at Oxford and MORU magdalencareers.pinpointhq.com/postings/c90...

Congrats @ainsley-beaton.bsky.social

As an editor at the Biochemical Journal, I'd love to see more papers submitted in the areas of bacterial immune systems / CRISPR / archaeal molecular biology / nucleic acid processing enzymes

Congrats @natalia-los.bsky.social

Now online. Great collaboration with the Tidow lab @seegerlab and the @embl SAXS beamline. Capturing transient states of heterodimeric ABC transporter TM287/288 by time-resolved small-angle X-ray scattering: Biophysical Journal www.cell.com/biophysj/ful...

E. coli ST131 is becoming carbapenem resistant. I suspect as CTX-M moves onto the chromosome and the F plasmid is lost facilitating acquisition of carbapenemase plasmids. No good can come of this

Dear PhD students and postdocs — we want to hear about your science firsthand at our annual Early Career Microbiologists Mini-Symposium @johninnescentre.bsky.social (UK) this September. For more information and to apply: www.jic.ac.uk/event/early-...

Want to work on iron uptake in fungi? Together with Prof Jan Quinn, we have a 4-year funded PhD studentship (UK only) to join us here in Newcastle. Get in touch if you are interested. www.findaphd.com/phds/project...

What are the genetic and molecular determinants underpinning the repair of bidirectional replication fork collapse in bacteria? PhD position open in my lab in collaboration with the brilliant @heathmurraylab.bsky.social. Please share and contact me if interested: www.findaphd.com/phds/project...

We have a PhD studentship open! (UK only sadly) but if you are or know a student keen to work on some *really* weird mycobacterial enzymes then get in touch! #glycotime Advert below www.findaphd.com/phds/project...

Want to research the basis of how drug resistant bacteria interact with human immune cells? Fully funded 4-year PhD position available (UK home students). Come and join our amazing interdisciplinary team at the intersection of microbiology, immunity, metabolism and the clinic! Please spread the word

New paper out in Nature Comms 🎉 Congrats to first author @sekid.bsky.social & thanks team & collaborators We show that B. bifidum & E. coli can cooperate in the breastfed infant gut through nutrient cross-feeding, helping shape early-life microbiome development 🦠👶 www.nature.com/articles/s41...

Finally published. Many thanks to a wonderful collaborative team and scientific platforms!!! And thanks to editors and reviewers for enthusiasm and a great review. www.nature.com/articles/s41...

Each publication in a #Microbio26 journal helps fund 4 student travel grants. Please publish with us if you can!

So my last publication is out! From a clincial trial for a treatment that was argued could not lead to bacterial resistance, uro-associated bacterial isolates were found to be resistant and we show genetically how. Thanks to Chris Harding and Frank Sargent journals.plos.org/plospathogen...

A true labor of love for @calebmallery.bsky.social is out now in PLOS Pathogens: a review article where we highlight current and emerging examples of key protein-protein interactions with LuxR-type receptors that control community behaviors and pathogenesis. journals.plos.org/plospathogen...

This paper started as an idea @albertomarina.bsky.social had many years ago… which of course means he was right all along 😄. Some of us just needed a few years (and a lot of experiments) to catch up. Grateful (and slightly humbled) to be part of this. Thanks Alberto! www.cell.com/cell/fulltex...

Fabulous opportunity

Unbelievably proud of the work that everyone has put into this paper. Really grateful for such fab colleagues! Mycobacteria continue to be (subjectively) the most interesting bacteria 🤭

We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...

Well done team, I know how hard you have all worked on this!!!

All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy? Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation. www.nature.com/articles/s41... (1 out of 3)

Two post-doctoral positions open in our lab. We're looking for people with expertise in molecular microbiology and/or genome-scale tools. Initially 3 yrs, posts could be extended for upto 8 yrs. If you'd like to know more about us take a look at www.graingerlab.com www.jobs.ac.uk/job/DQY475/r...

Now out in its final form, our investigation of how Pseudomonas aeruginosa manages resources to permit ongoing adaptations to environment during starvation: journals.asm.org/doi/10.1128/... Congrats to first author @findunmun1.bsky.social, and co-authors Claudia Hemsley and Elize Ambulte.

Excited to announce our new journal from @isme-microbes.bsky.social ISME Host Microbe is live and now accepting submissions. Look forward to receiving your papers! #Microsky 🧫 🦠

Here we show that buildup of uremic toxins during CKD generates nitrate in the colon. Nitrate supports expansion of Enterobacteriaceae, turning them into a major source of uremic toxins. Inhibiting nitrate production (iNOS inhibition) mitigates disease progression. www.science.org/eprint/YGNMK...

Delighted to share the hard work of undergraduate student Ella Rellis and first publication from my group since relocating to TCD. Here we identify a new stress response regulator induced by D-serine. 🦠🔬🧫 @microbiologysociety.org #publishforthecommunity www.microbiologyresearch.org/content/jour...

Absolutely delighted to see this out! Huge congrats to all involved, especially @pathonick.bsky.social and @drandyjroe.bsky.social for keeping the d-serine saga going!

🚨 A new piece of the preterm gut microbiome puzzle just fell into place! Bifidobacterium metabolise human milk oligosaccharides (HMOs) in early life — shaping immunity, supporting gut development, and protecting against diseases like necrotising enterocolitis (NEC). www.nature.com/articles/s41...

non-correlating mRNA-protein levels during stress 🦠

Great talk from @hobbslabmicro.bsky.social - thank you for visiting @mhd-newcastle.bsky.social and telling us why antibiotic tolerance is so important

Another brilliant opportunity to work the fantastic Andreas in St Andrews!

Like bacteria, phages use sRNAs to regulate gene expression! Out today in @cp-trendsmicrobiol.bsky.social, @mvelascogomariz.bsky.social and I highlight a recent RIL-seq study from the @saharmelamed.bsky.social lab that looked into posttranscriptional regulation of lambda! tinyurl.com/lambda-RIL-seq

Last chance to apply for this exciting PhD with us. Deadline tomorrow the 27th of February!

Superb opportunity to learn from one of the smartest scientists I know. And a lovely place to live so what’s not to like! Apply now!

Early bird registration for VTEC 2026 ends this Friday (February 27th). Please share with your networks and consider registering for this great One-health conference covering all topics VTEC related, taking place in Aberdeen on the 10-13th of May.

What if quorum sensing doesn’t promote biofilms - but restrains it? 🤔 New work from @harisantypas.bsky.social shows that the Fsr QS system in Enterococcus faecalis acts as a brake on biofilm formation and pathogenesis during infective endocarditis (IE). www.nature.com/articles/s41...

Recurrent and chronic UTIs have a huge impact on patient's quality of life and is an area of research which is often overlooked and understudied. There are massive gaps in our understanding which we can fill to... (1/3) See all images in this post and that follow for the top 10! #MicroSky #UTISky