Excited to share this work out as a preprint! We found that E. faecalis biofilms suppress neutrophil effector functions through two complementary mechanisms: extracellular acidification that dampens ATP and NADPH production and a bacterial density-dependent inhibitory effect.

#Microbiology Loss of Fsr quorum sensing *promotes* biofilm formation and worsens outcomes in enterococcal infective endocarditis @kimingeneva.bsky.social @harisantypas.bsky.social @scelse.bsky.social#Microbiology #biofilms #bacteria

SCELSE-NTU’s Dr Haris Antypas and Prof Kimberly Kline (UNIGE) show that silencing bacterial communication may worsen infectious endocarditis. Published in Nature Communications, the study finds that when Enterococcus faecalis loses quorum sensing, it forms larger biofilms linked to poorer outcomes.

What if quorum sensing doesn’t promote biofilms - but restrains it? 🤔 New work from @harisantypas.bsky.social shows that the Fsr QS system in Enterococcus faecalis acts as a brake on biofilm formation and pathogenesis during infective endocarditis (IE). www.nature.com/articles/s41...

Lactic acid lover? Check out @ronni.bsky.social 's new work in @cp-cellhostmicrobe.bsky.social showing how Enterococcus faecalis-derived LA suppresses macrophage activation, in turn promoting bacterial persistence and polymicrobial wound infection in vivo. www.sciencedirect.com/science/arti...

Just 20 days to SCELSE Open House! Meet our scientists & explore breakthroughs in sustainability, health & industry—from protecting ecosystems to tackling antimicrobial resistance. Join us 28 Aug @ NTU. Register: bit.ly/SCELSEOPENHOUSE25

As Chair of this year’s SCELSE Open House, I’m excited to invite students, researchers, and curious minds to join us on a journey into the microbial world! A perfect opportunity to find your next internship, phd position or your next collaborator!

Today is International Day of Women & Girls in Science. Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM

Check out how 💪🏼Enterococci💪🏼 use lactic acid to suppress the inflammatory response and promote virulence. Project started by Brenda Tien during her PhD and brought home by the always excellent @ronni.bsky.social! 🥳

How does Enterococcal QS activation impact infection outcomes across different host microenvironments? To answer this as fluid dynamics change over the course of infection, @harisantypas.bsky.social led our first foray into enterococcal infective endocarditis w/ some surprisingly results. #microsky

And last preprint of 2023! Postdoc Ronni da Silva's latest in a project aimed at repurposing drugs to reprogram macrophages to treat ESKAPE pathogen infections. Bosutinib stimulates macrophage survival, phagocytosis and intracellular killing of bacteria www.biorxiv.org/content/10.1...