The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.

Fantastic team effort. Project led by PDRA Curtis Cottam, with support from recently recruited PDRA Kieran Bowran and collaborators @kjosts.bsky.social and @rhystwhite.bsky.social . Many thanks to the MRC @ukri.org, @acmedsci.bsky.social and @royalsociety.org for funding our research.

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...

New preprint 🚨: with @madejmar.bsky.social we found that the Bacteroidetes beta-barrel assembly machinery is quite different to E. coli. www.biorxiv.org/content/10.1... #cryo-EM

First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group. Deadline end of February. Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239