Lots of exciting developments to understand the structure of membrane protein in its native environment

If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.

Want to find ways to combat TB? Check out this PhD position 👇

Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria. doi.org/10.1038/s415...

The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.

Fantastic team effort. Project led by PDRA Curtis Cottam, with support from recently recruited PDRA Kieran Bowran and collaborators @kjosts.bsky.social and @rhystwhite.bsky.social . Many thanks to the MRC @ukri.org, @acmedsci.bsky.social and @royalsociety.org for funding our research.

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...

New preprint 🚨: with @madejmar.bsky.social we found that the Bacteroidetes beta-barrel assembly machinery is quite different to E. coli. www.biorxiv.org/content/10.1... #cryo-EM

First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group. Deadline end of February. Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239