Human neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins pubmed.ncbi.nlm.nih.gov/42102820/ #cryoem

Read about our story in the Washington Post!

Measles is coming back. Until now, we didn't know how human antibodies actually recognize and neutralize the virus. No structure of either measles surface protein bound to a human antibody had ever been reported. We set out to change that.

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Our fourth installment on prefusion herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... Working with Ivelin Georgiev's group, we isolated and characterized prefusion-specific HSV gB antibodies from humans!

I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look! #virology #teamtomo www.nature.com/articles/s41...

I never imagined I'd be writing this, but I am happy to share that, starting this June, I will be joining @cuanschutz.bsky.social @cu-bmg.bsky.social as an Assistant Professor.

CryoEM folks, If you want to handle huge STAR file efficiently in Python, please try starfile-rs! github.com/hanjinliu/star… Reading a motion data of a particle from a 15 MB file is just like this ↓🤩

The US #measles count for this year has topped 2,000 cases for the first time since 1992. These are confirmed cases only, ie there have been more. 3 reported deaths. The vast majority of the cases are in unvaccinated kids & adults. 11% needed hospitalization. www.cdc.gov/measles/data...

Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In Vivo pubmed.ncbi.nlm.nih.gov/41278811/ #cryoem

It’s been a while since I put together the Structural Virology starter pack, and I’m sure some new folks have joined Bluesky since then. There’s still plenty of space to fill, so if you’d like to be added to the list just let me know. #virology #cryoEM go.bsky.app/Qxv95BL

Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.

#NZ measles 🦠 - Now 14 cases - Needs a week-plus to know if there will be a surge in cases (owing to the non-symptomatic phase), and how widespread - vaccination is free RNZ: Extent of measles outbreak will be confirmed over coming days, an epidemiologist says ⬇️

Interesting side-quest. Has #measles immunity in children declined in Austria due to the #COVID19 pandemic, driving measles outbreaks? (It also tangentially addresses a group's assumption that SARS-CoV-2 "destroys our immune system" and is "airborne AIDS" or whatever). Answer: no, it did not. 1/2

Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In Vivo https://www.biorxiv.org/content/10.1101/2025.10.07.681039v1

Huntingtin binds and bundles F-actin! Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery. We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead! #TeamTomo #CryoET #HTT #actin doi.org/10.1126/scia...

New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬 Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social www.embopress.org/doi/full/10....

Our second paper explores the mechanism by which fusion-targeting antibodies neutralize the measles virus. It was exciting to integrate structural biology, virology, and biophysics to demonstrate that these F-targeting antibodies can provide complete protection against measles infection.

One of our new manuscripts is now available on bioRxiv! Stay tuned!

"Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET" www.nature.com/articles/s41...

Hi everyone! I’m a #NewPI just starting my lab and would love to hear your advice on lab management and building the lab culture. Any tips, lessons learned, or resources you’ve found helpful are very welcome! Feel free to reply, message me, or email me at rcastellsg(at)cnio.es thanks a lot!! 🤗

My colleagues @phaips.vd.st and @florentwaltz.bsky.social have put together this wonderful website with step-by-step tutorials for in situ subtomogram averaging using different software packages 🤩 Check it out, especially if you are a newcomer to the field! #CryoET #TeamTomo #ChlamyDataset

“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩‍💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Non-model Bioeng Custom Lab Hardware Turn Key Genetic Design Please repost for reach 💚

1/5: Over the last few months, I have been working on an update for the #FollowRelionGracefully dashboard, which offers improved real-time job previews for #cryoEM #Relion jobs.

Check out our new study revealing how ATP-independent activator Bpa binds asymmetrically to the Mtb #proteasome — and pinpointing key Bpa residues involved in substrate interaction. 👏 Tatjana v. Rosen, Rafal Zdanowicz & @yasser-elhadeg.bsky.social 🔗 www.nature.com/articles/s41...

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

Check out our new story led by @aesully98.bsky.social describing how bacteria turn immune evasion against phage! In collaboration with @benmorehouse.bsky.social lab, we discover that bacteria guard their nucleotide second messenger pool using a nucleotidyltransferase related to Cas10/CRISPR enzymes

✨✨ It's #glycotime for #HIV Env ✨✨ N-linked glycans modulate flexibility & MPER epitope exposure #glycotime Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪 Would love feedback! www.biorxiv.org/content/10.1...

Happy to share that our manuscript on the anti-measles antibody is mentioned in this article: Measles can ravage the immune system and brain, causing long-term damage – a virologist explains theconversation.com/measles-can-...

Herpes viruses are among the most widespread human viruses. Scientists have shown how HSV-1, known for oral and genital sores, assembles in cells thanks to advanced imaging techniques.

Press release from @unibas.ch and @biozentrum.unibas.ch about our new #cryoET study on mitochondrial respirasomes. Led by the unstoppable @florentwaltz.bsky.social 🙌 🧪🧶🧬 #TeamTomo

I'm super happy that our story is now published! 📖 www.science.org/doi/10.1126/... But what changed compared to the original preprint? Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.

New in @elife.bsky.social: LJI Instructor Dawid Zyla (@dzyla.bsky.social) highlights recent research into how herpes simplex virus type 1 assembles within infected cells — revealing the roles of essential viral proteins in viral assembly and exit. elifesciences.org/articles/106... #virology

New Curebound grants may lead to new approaches to fight breast cancer, lung tumors and more! bit.ly/4ixZGVd #Cancer #Oncology #BreastCancer #SanDiego

I am pleased to share my eLife Insight related to an outstanding manuscript by Nahas et al. This manuscript discusses the assembly of the Herpes simplex virus through a combination of light microscopy and X-ray tomography. You can find my Insight here: elifesciences.org/articles/106....

Risk is often hard to understand. @beebrookshire.bsky.social takes a look at how parents assess the risks of MMR vaccine against the risk of measles #scicomm

Another update for [MSS]! Along with some graphical improvements and a faster search, it now supports date filtering! You can specify a date range for your search results. Plus, [MSS] now indicates whether a full, free publication text is available on PubMed Central. mssearch.xyz

LJI recently unveiled a new "pocket" art gallery to showcase breathtaking images of immune cells at work! www.lji.org/blog/new-lji... #SanDiego #STEM #Science #Microscopy #Immunology #ImmuneSystem #SciArt

Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?

"Kennedy has since emphasized that HHS is aiding Texas health officials with their measles response, but declined so far to explicitly call for people to get vaccinated." Politico underrated as carrying water for monsters. Name the measles outbreak RFK Jr exacerbated in American Samoa you cowards!

I updated the metadata extraction from PubMed files, improving the abstracts in the [MSS]. However, only 70% of PubMed entries include abstracts, limiting their contribution to semantic search. To test the new database, check here: mssearch.xyz

High-quality search is now available. Previously, [MSS] returned many empty abstracts or titles; now, you can ensure that only quality entries are displayed. This does not solve the root problem but makes the manuscript search better.

JCI Insight - Frequency of dengue virus–specific T cells is related to infection outcome in endemic settings insight.jci.org/articles/vie...

#Measles cases continue to rise. CBS Health now reporting more than 100 cases of the disease. 16 patients are reported to be currently hospitalized. #vaccination #MMR

This is entirely preventable. Science solved this problem more than 60 years ago.

Search in peace 🔍 arXiv was added to Manuscript Semantic Search [MSS] (database updated 250216)! Check it here: mssearch.xyz

Inverse folding models fine-tuned on ddG data are SOTA on stability/thermostability prediction, & can be further improved by including features from PLMs; additionally, these help identify conserved AAs whose functional importance isn't obvious from structure alone www.biorxiv.org/content/10.1...

In @justinditrani.bsky.social final postdoc paper (with contributions from many others) we show that forming/purifying vesicles (here from M. smegmatis) allows structure det'n of *endogenous* membrane proteins in their *native lipid bilayer* 🧵 on methods & TB biology... www.pnas.org/doi/full/10....

I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz