Characterizing cellular subpopulations critical to treatment response in autoimmune diseases https://www.biorxiv.org/content/10.64898/2026.01.05.696211v1

Targeted Lipid Metabolism Screening Uncovers Regulatory Effects on the STING Immune Response in Mevalonate, Eicosanoid and Fatty Acid Pathways https://www.biorxiv.org/content/10.64898/2026.01.05.697750v1

O-GlcNAcylation drives macrophage IL-4 responsiveness and tissue residency through metabolic and cell cycle calibration https://www.biorxiv.org/content/10.64898/2026.01.05.697622v1

Awakening intracellular immunity for functional HIV cure https://www.biorxiv.org/content/10.64898/2026.01.04.697570v1

Molecular and biophysical requirements for B cell receptor dependent enhancement of dengue virus infection https://www.biorxiv.org/content/10.64898/2026.01.05.697627v1

Spatial transcriptomic analysis of myositis muscles reveals novel molecular insights of MDA5+ dermatomyositis https://www.biorxiv.org/content/10.64898/2026.01.04.696800v1

Leveraging TNFR2 for antitumour immunity: T reg depletion and myeloid reprogramming versus T cell costimulation https://www.biorxiv.org/content/10.64898/2026.01.04.697572v1

An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy. https://www.biorxiv.org/content/10.64898/2026.01.03.697515v1

Sub-neutralizing concentrations of Zika virus IgM monoclonal antibodies reduce IgG-mediated antibody-dependent enhancement of infectivity. https://www.biorxiv.org/content/10.64898/2026.01.03.697490v1

Putative target antigens of the stereotyped intrathecal B cell response in multiple sclerosis https://www.biorxiv.org/content/10.64898/2026.01.03.697481v1

ABCC1 protects skin dendritic cells from FITC-induced toxicity by efflux and extracellular glutathione buffering https://www.biorxiv.org/content/10.64898/2026.01.02.697391v1

Interplay between the immune response and the adaptation of metabolic pathways upon infection https://www.biorxiv.org/content/10.64898/2026.01.02.697260v1

Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism https://www.biorxiv.org/content/10.64898/2025.12.31.697156v1

CAR-T-drug conjugate against solid tumor https://www.biorxiv.org/content/10.64898/2026.01.02.696502v1

A Glycosylation-Dependent Checkpoint Restrains Intestinal Intra-Epithelial Lymphocyte Activation https://www.biorxiv.org/content/10.64898/2026.01.02.697332v1

Natural killer cells mediated antibody dependent cellular cytotoxicity response in acute and recovery phases of chikungunya https://www.biorxiv.org/content/10.64898/2026.01.01.697330v1

Tumor-infiltrating natural killer cell profiling for therapeutic stratification in patients with resectable non-small cell lung cancer https://www.biorxiv.org/content/10.64898/2026.01.01.696292v1

Single-cell characterization and machine learning-based classification reveal the transcriptional identity and antigen-experienced features of peripheral CD4+CD8+ double-positive T cells https://www.biorxiv.org/content/10.64898/2026.01.01.697324v1

State-Dependent Regulatory Compression: Chromatin Geometry Gates Information Flow in Hematopoiesis https://www.biorxiv.org/content/10.64898/2025.12.31.697240v1

TMEM33 deletion potentiates anti-tumor CD8+ T cell immunity https://www.biorxiv.org/content/10.64898/2026.01.01.697288v1

Proton-Activated Chloride Channel 1 (PACC1) is essential for innate host defense against bacterial sepsis https://www.biorxiv.org/content/10.64898/2025.12.31.697179v1

Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs https://www.biorxiv.org/content/10.64898/2025.12.31.697220v1

Fezf2 regulates differentiation of Aire-expressing and post-Aire mimetic epithelial populations maintaining thymic homeostasis https://www.biorxiv.org/content/10.64898/2025.12.31.697099v1

State-dependent geometric constraints reveal a regulatory gate in hematopoietic progenitors https://www.biorxiv.org/content/10.64898/2025.12.31.697210v1

Mucosally sourced complement factor B modulates the host response to colitis https://www.biorxiv.org/content/10.64898/2025.12.31.697141v1

Multi-omic analysis reveals nitric oxide dependent remodeling in classically activated macrophages and identifies negative regulation mediated by AKR1A1 https://www.biorxiv.org/content/10.64898/2025.12.31.697202v1

Development and application of nbLIBRA-seq for high-throughput discovery of antigen-specific nanobodies https://www.biorxiv.org/content/10.64898/2025.12.30.697047v1

Discover Potential New Epitopes through Post Translational Modification in Sjogrens Disease https://www.biorxiv.org/content/10.64898/2025.12.30.697079v1

Molecular Mechanisms of Priming Innate Immunity by Small Extracellular Vesicles Released during Infection with Gram-negative Bacteria https://www.biorxiv.org/content/10.64898/2025.12.30.697125v1

Impact of Absent in Melanoma 2 (AIM2) on Antigen-Specific CD4+ T cell Activation and Homeostasis. https://www.biorxiv.org/content/10.64898/2025.12.30.697014v1

Regulation of STING activation by phosphoinositide and cholesterol https://www.biorxiv.org/content/10.64898/2025.12.29.696921v1

SLAMF1-peptide mediated epigenetic priming reprograms innate immune responses in sepsis https://www.biorxiv.org/content/10.64898/2025.12.29.696918v1

Decoy Antibodies Block Extracellular HSP70, Prevent Self Signaling and Inhibit Melanoma Cell Survival https://www.biorxiv.org/content/10.64898/2025.12.29.696857v1

Cross-sectional association study from NHANES between some dietary supplements and anti-HAV antibodies https://www.biorxiv.org/content/10.64898/2025.12.29.696889v1

Myeloid reprogramming by poly(I:C) recruits progenitor-exhausted CD8+ T cells and sensitizes rhabdoid tumors to PD-1 blockade https://www.biorxiv.org/content/10.64898/2025.12.29.696858v1

Ferritin Nanoparticle-Based Indirect ELISA for Immunodominant Region Screening and B-cell Epitope Validation of African Swine Fever Virus https://www.biorxiv.org/content/10.64898/2025.12.28.696791v1

Pre-Human Immunodeficiency Virus (HIV) infection Th17 CD4+ T cells as predictors of early HIV disease progression https://www.biorxiv.org/content/10.64898/2025.12.29.696811v1

Macrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade https://www.biorxiv.org/content/10.64898/2025.12.24.696419v1

A vesicle-based platform for high-efficiency, high-viability CRISPR/Cas9 knockout in primary human myeloid cells https://www.biorxiv.org/content/10.64898/2025.12.28.696771v1

Immune gene co-expression networks are constrained by a non-linear topology spectral relationship https://www.biorxiv.org/content/10.64898/2025.12.25.696503v1

Neutrophil-neuronal crosstalk drives arthritis-induced pain https://www.biorxiv.org/content/10.64898/2025.12.27.696652v1

BCR repertoire analysis and cloning of antibody candidates targeting native and Asp7-isomerized beta-amyloid https://www.biorxiv.org/content/10.64898/2025.12.26.696595v1

Efficacy of immunostimulant feed additive ShrimpGuard, for the preventive management of White Spot Syndrome Virus (WSSV) infection in shrimps https://www.biorxiv.org/content/10.64898/2025.12.26.695863v1

Shared TCRs in peripheral blood offer robust celiac disease classification independent of gluten Intake https://www.biorxiv.org/content/10.64898/2025.12.26.696039v1

Levamisole-Mediated Suppression of B-Cell Proliferation and Antibody Production Reveals Mechanistic Insights into Idiopathic Nephrotic Syndrome Therapy https://www.biorxiv.org/content/10.64898/2025.12.23.695947v1

Differential proteomic and metabolic remodelling of CD4⁺ and CD8⁺ T cells in mesenteric lymph nodes during colitis-associated colorectal cancer https://www.biorxiv.org/content/10.64898/2025.12.26.696593v1

Development and qualification of an enzyme-linked immunosorbent assay to detect human serum immunoglobulin G reactive to multiple lineages of Lassa virus nucleoprotein https://www.biorxiv.org/content/10.64898/2025.12.25.696537v1

Antigen-specific CD8 T cells are generated and reactivated in the bone marrow following viral brain infections and impact the bone marrow niche https://www.biorxiv.org/content/10.64898/2025.12.25.696510v1

Combined antagonism of Oncostatin M (OSM) and Interleukin 6 (IL-6) provides both anti-fibrotic and anti-inflammatory benefit in pulmonary fibrosis https://www.biorxiv.org/content/10.64898/2025.12.25.695625v1

Chronic alcohol exposure drives inflammaging and transposon derepression in hematopoietic stem and progenitor cells https://www.biorxiv.org/content/10.64898/2025.12.25.696246v1