A new humanized TCR transgenic mouse model to study citrullinated tenascin C reactive T cells relevant to rheumatoid arthritis https://www.biorxiv.org/content/10.64898/2026.02.12.705563v1

Hyperglycemia promotes maladaptive Dectin-1 signaling and impairs skin antifungal host defense. https://www.biorxiv.org/content/10.64898/2026.02.11.705431v1

Elevated ferritin as a companion biomarker of myeloid-driven inflammation in RNP/Sm co-positive, treatment-resistant SLE endotype https://www.biorxiv.org/content/10.64898/2026.02.12.705402v1

Implantation failure linked to altered uterine NK cells in PCOS-like mice https://www.biorxiv.org/content/10.64898/2026.02.12.705498v1

MONOCYTES STRONGLY INDUCE (MYO)FIBROBLAST CONTRACTION IN A NEW 3D SKIN MODEL TO UNDERSTAND THE INFLAMMATION-FIBROSIS AXIS IN SYSTEMIC SCLEROSIS https://www.biorxiv.org/content/10.64898/2026.02.12.705496v1

TCR signal strength determines Treg instability and discrimination of self versus non-self antigens https://www.biorxiv.org/content/10.64898/2026.02.12.705537v1

Prolonged TGF-β locks NK cells in a dysfunctional state through persistent epigenetic remodeling of IRF, T-bet and EOMES binding sites https://www.biorxiv.org/content/10.64898/2026.02.11.705354v1

Glucose-Responsive CD20+ Cytotoxic T Cells: A Novel Pro-inflammatory Mediator in the Immunopathogenesis of Type 2 Diabetes https://www.biorxiv.org/content/10.64898/2026.02.12.705577v1

IFN-driven lipid synthesis shutdown in CD4⁺ T cells during acute SIV infection and persistent OXPHOS with ART initiation https://www.biorxiv.org/content/10.64898/2026.02.12.705596v1

Evolutionary Divergence and Structural Differentiation of Multiple Immunoglobulin M Genes in Gekkota (Squamata: Reptilia) https://www.biorxiv.org/content/10.64898/2026.02.13.705754v1

Deletion of NLRP3 gene blocks traumatic brain injury induced abnormal immune response in 3xTg AD mice https://www.biorxiv.org/content/10.64898/2026.02.11.705384v1

A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn's disease https://www.biorxiv.org/content/10.64898/2026.02.12.705345v1

Generative AI Guided Design of High-Affinity T cell Receptors https://www.biorxiv.org/content/10.64898/2026.02.12.705547v1

Mapping Tissue-Specific Protease Dynamics in the Pig Respiratory Tract During Influenza A Virus Infection https://www.biorxiv.org/content/10.64898/2026.02.11.705325v1

Macrophage renewal in the small intestine governs early-life control of streptococci https://www.biorxiv.org/content/10.64898/2026.02.11.705249v1

Elimination of intramuscular immunoglobulin accumulation alleviates Duchenne Muscular Dystrophy https://www.biorxiv.org/content/10.64898/2026.02.11.703666v1

EBV reprograms autoreactive B cells as antigen presenting cells in multiple sclerosis https://www.biorxiv.org/content/10.64898/2026.02.11.701910v1

Antibody-Dependent Heterotypic Syncytia Drive COVID-19 Inflammation and Disease Progression https://www.biorxiv.org/content/10.64898/2026.02.11.705426v1

Soluble LAG-3 Identifies a Dynamic Early T Cell Activation Window in self-reactivity, Type 1 Diabetes, and Broader Immune Responses. https://www.biorxiv.org/content/10.64898/2026.02.10.705171v1

Divergent disulfide bond architecture defines two IgY subclasses in snakes https://www.biorxiv.org/content/10.64898/2026.02.11.705265v1

Functional Equivalence of Heat-Inactivated (HI) and Live Probiotic RSB11 in Suppressing Inflammation: Expanding Formulation and Application Potential https://www.biorxiv.org/content/10.64898/2026.02.11.705228v1

Tumor-derived Extracellular Vesicles Induce ER Stress to Drive Tolerogenic Dendritic Cell Development in the Tumor Microenvironment https://www.biorxiv.org/content/10.64898/2026.02.10.705213v1

TCR Signal Strength and Eomes Coordinate CD8⁺ T Cell Fate and Antitumor Immunity in Hepatocellular Carcinoma https://www.biorxiv.org/content/10.64898/2026.02.10.705135v1

Spatial immune hubs defined by conserved activated dendritic cells are remodeled by immunotherapy https://www.biorxiv.org/content/10.64898/2026.02.10.703136v1

CD14-deficiency protects against osteoarthritic subchondral bone sclerosis via enhanced osteoclastogenesis following joint injury https://www.biorxiv.org/content/10.64898/2026.02.10.705094v1

RGS10 differently modulates NFκB subunit transcription and inflammatory cytokine profiles in peritoneal macrophages. https://www.biorxiv.org/content/10.64898/2026.02.09.704897v1

Multiplexed high-content imaging uncovers morphological diversity of lymphocyte activation and dysfunction https://www.biorxiv.org/content/10.64898/2026.02.10.704860v1

Base-resolution DNA methylome of human MDS hematopoietic stem cell reveals TET2-GFI1 epigenetic axis repressing MDS https://www.biorxiv.org/content/10.64898/2026.02.10.704995v1

A framework for reparative CAR T engineering in the CNS https://www.biorxiv.org/content/10.64898/2026.02.09.703122v1

Macrophage Phagocytic Impairment is associated with Dysbiosis of the Respiratory Microbiome in Frail older adults https://www.biorxiv.org/content/10.64898/2026.02.09.703495v1

Strength in Unity: a Dual Strategy to Restore NK Cell Cytotoxicity against Pancreatic Ductal Adenocarcinoma https://www.biorxiv.org/content/10.64898/2026.02.09.704789v1

Type I and Type III Interferons Differentially Shape Antiviral Defense and Epithelial Integrity at the Choroid Plexus https://www.biorxiv.org/content/10.64898/2026.02.10.705109v1

Platform-Imprinted Transcriptional and Clonal Remodeling of αβ and γδT Cells After Allogeneic Transplantation https://www.biorxiv.org/content/10.64898/2026.02.09.704768v1

Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function https://www.biorxiv.org/content/10.64898/2026.02.08.704716v1

PDE4 Inhibitor Apremilast Rebalances Inflammatory Responses to Pseudomonas aeruginosa Infection in CF Rats https://www.biorxiv.org/content/10.64898/2026.02.08.704692v1

SERPINA3 and NDRG1 are critical diagnostic immune genes associated with macrophages in preeclampsia https://www.biorxiv.org/content/10.64898/2026.02.09.704892v1

NINJ1 mediates hepatic ischemia-reperfusion injury https://www.biorxiv.org/content/10.64898/2026.02.07.704585v1

EBV Type 1 versus Type 2: A determinant of NK cell anti-tumor activity in Burkitt lymphoma https://www.biorxiv.org/content/10.64898/2026.02.09.704808v1

Serotypic heterogeneity in the response to pneumococcal vaccine https://www.biorxiv.org/content/10.64898/2026.02.06.704301v1

Early developmental placental defects and pregnancy loss in lupus mice expressing human TLR8 https://www.biorxiv.org/content/10.64898/2026.02.07.701591v1

Divergent phenotypic and functional roles of human T follicular helper cells from infancy to adulthood https://www.biorxiv.org/content/10.64898/2026.02.06.704464v1

Innate Immune Function of Neutrophil Cytoplasts Generated Post-Vital NETosis https://www.biorxiv.org/content/10.64898/2026.02.06.704503v1

A KETOGENIC DIET PROMOTES BLOOD-SPINAL CORD BARRIER RESEALING AND PHENOTYPIC SWITCHING OF PRO-INFLAMMATORY MYELOID CELL INFILTRATES IN A PRECLINICAL MODEL OF MULTIPLE SCLEROSIS. https://www.biorxiv.org/content/10.64898/2026.02.06.704406v1

Multimodal Profiling of Repair-associated Immune Dynamics in a Mouse Model of Menstruation https://www.biorxiv.org/content/10.64898/2026.02.06.704418v1

Sheddase Targeting Chimeras (SHEDTACs) catalyze membrane target proteolysis https://www.biorxiv.org/content/10.64898/2026.02.06.703938v1

Extracellular vesicles from antigen-activated B cells stimulate oncogenic herpesvirus lytic gene expression https://www.biorxiv.org/content/10.64898/2026.02.09.704805v1

A Novel Secretome Rewrites the Immune Response in Viral Acute Respiratory Distress Syndrome https://www.biorxiv.org/content/10.64898/2026.02.06.704035v1

IFN gamma-induced IRF1 synergizes with TLR7 signals to tune the IRF4-IRF8 axis and drive pathogenic effector B cell fate https://www.biorxiv.org/content/10.64898/2026.02.06.704376v1

A spatiotemporal immune atlas of subarachnoid hemorrhage from single-cell and spatial transcriptomics https://www.biorxiv.org/content/10.64898/2026.02.02.703421v1

Crosstalk between Stromal cells and Macrophages Shapes Host Immunity to Mycobacteria https://www.biorxiv.org/content/10.64898/2026.02.05.704052v1