Eilika Weber-Ban Lab
@ewb-lab.bsky.social
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We study proteostasis and cellular degradation machines in mycobacteria. weber-ban-lab.ethz.ch
reposted by
Eilika Weber-Ban Lab
Quanta Magazine
26 days ago
Asgard archaea were first found in mud at the bottom of the North Sea. Today, cellular biologists Martin Pilhofer and Christa Schleper are exploring one of their more elusive structural elements: a totally tubular system that looks a lot like our own.
www.quantamagazine.org/tiny-tubes-r...
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We are currently witnessing the complete succumbing to blackmail of the so-called civilized world. The speed of general moral and ethical decline in the name of economic constraints and reasoning is shocking. We must be aware that scientific integrity will not escape untouched.
about 2 months ago
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Proud of my doctoral student Charlotte Schilling who successfully defended her thesis today! Congratulations, Charlotte, on an excellent job! 👏🥂
3 months ago
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reposted by
Eilika Weber-Ban Lab
Ahmad Jomaa
4 months ago
Check out our latest preprint with the Qi lab on the structure and disease physiology of the human ERAD complex. Outstanding work by Leo, a cell physiologist whom we successfully tempted into structural biology! Preprint:
www.biorxiv.org/content/10.1...
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The type 1 pilus in its full glory! 👏
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Structures of the Escherichia coli type 1 pilus during pilus rod assembly and after assembly termination - Nature Communications
Adhesive, filamentous type 1 pili are critical virulence factors in urinary tract infections. Here, the authors describe the cryo-EM structures of the entire type 1 pilus with all its structural compo...
https://www.nature.com/articles/s41467-025-60325-z
4 months ago
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reposted by
Eilika Weber-Ban Lab
Journal of Cell Biology
5 months ago
Muñoz-Hernández, Xu, et al.
@mike-wieczorek.bsky.social
@ethz.ch
report
#cryoEM
structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs
rupress.org/jcb/article/...
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Congratulations to our colleague Jörn Piel and the other awardees!
nachrichten.idw-online.de/2025/05/15/j...
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Jung-Stiftung zeichnet wegweisende Forschungsansätze aus
https://nachrichten.idw-online.de/2025/05/15/jung-stiftung-zeichnet-wegweisende-forschungsansaetze-aus
5 months ago
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reposted by
Eilika Weber-Ban Lab
Department of Biology, ETH Zurich
5 months ago
Breaking news and a great honour for D-BIOL professor Jörn Piel: he wins the very prestigious Jung Prize for Medicine! Our congratulations!
ethz.ch/en/news-and-...
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ETH microbiologist honoured with prestigious European medical award
Chemist and microbiologist Jörn Piel combs through the vast world of bacteria for new natural substances to combat the antibiotic crisis. The ETH professor has now been honoured for his research with ...
https://ethz.ch/en/news-and-events/eth-news/news/2025/05/eth-microbiologist-honoured-with-prestigious-european-medical-award.html
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reposted by
Eilika Weber-Ban Lab
Rafeeque Mavoor
5 months ago
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
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As scientists we must be ready to communicate the importance of vaccination wherever the discussion may come up, with family, friends or at the hair dresser. Be prepared to explain in a fact-based and accessible manner.
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Combating vaccine revisionism - Nature Medicine
The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines.
https://www.nature.com/articles/s41591-025-03682-y
6 months ago
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Coalition Statement on the Impact and Safety of Vaccines - AAI News
Statement on the impact and safety of vaccines led by the American Association of Immunologists and the American College of Physicians.
https://news.aai.org/2025/03/18/coalition-statement-on-the-impact-and-safety-of-vaccines/
6 months ago
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Check out our new study revealing how ATP-independent activator Bpa binds asymmetrically to the Mtb
#proteasome
— and pinpointing key Bpa residues involved in substrate interaction. 👏 Tatjana v. Rosen, Rafal Zdanowicz &
@yasser-elhadeg.bsky.social
🔗
www.nature.com/articles/s41...
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Substrates bind to residues lining the ring of asymmetrically engaged bacterial proteasome activator Bpa - Nature Communications
Mycobacterium tuberculosis has a proteasome similar to eukaryotes. This study reveals how the activator Bpa recruits its substrate HspR, providing structural and mechanistic insights. The authors iden...
https://www.nature.com/articles/s41467-025-58073-1
6 months ago
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reposted by
Eilika Weber-Ban Lab
Pilhofer Lab 🦠❄️🔬
7 months ago
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper
www.cell.com/cell/fulltex...
by
@xujwet.bsky.social
&
@florianwollweber.bsky.social
, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules!
#TeamTomo
#ArchaeaSky
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reposted by
Eilika Weber-Ban Lab
Eric Topol
7 months ago
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until
@science.org
today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
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reposted by
Eilika Weber-Ban Lab
Eric Topol
7 months ago
In case you've forgotten about measles induced immune amnesia
www.nbcnews.com/health/healt...
w/
@michaelmina.bsky.social
@virusesimmunity.bsky.social
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Measles virus targets certain immune cells in the body: What to know about complications
The virus targets certain types of immune cells in the body, destroying them in the process.
https://www.nbcnews.com/health/health-news/measles-immune-system-brain-swelling-long-term-rcna195918?utm_campaign=KHN%3A%20First%20Edition&utm_medium=email&_hsenc=p2ANqtz--hnDuOOFGVj4ExLYnjbX0_xlWxZku2QALabRg-wH6hFCAXc95jHXokckfN6QKqwhi7uCg4_23SM_pcGAYxW-VqZwRVAw&_hsmi=351424356&utm_content=351424356&utm_source=hs_email
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Thank you, Annette, for taking on this important responsibility!
add a skeleton here at some point
7 months ago
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www.nature.com/articles/s41...
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Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
https://www.nature.com/articles/s41586-025-08615-w
7 months ago
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Fully agree! “Peer” review being the important aspect here. And yes, reviewing takes time, as it should.
add a skeleton here at some point
7 months ago
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Babysteps-we’ve all been there… 😂
www.theguardian.com/science/2025...
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Scientists aiming to bring back woolly mammoth create woolly mice
Genetically modified mice have traits geared towards cold tolerance, in step towards modifying elephants
https://www.theguardian.com/science/2025/mar/04/genetically-modified-woolly-mice-mammoth?CMP=Share_iOSApp_Other
7 months ago
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reposted by
Eilika Weber-Ban Lab
Heran Darwin, PhD
7 months ago
Some good news! The final program for the inaugural
#GRCBiologyofMycobacteria
is up! We are also officially oversubscribed but cancellations happen...
www.grc.org/biology-of-m...
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2025 Biology of Mycobacteria Conference GRC
The 2025 Gordon Research Conference on Biology of Mycobacteria will be held in Pomona, California. Apply today to reserve your spot.
https://www.grc.org/biology-of-mycobacteria-conference/2025/
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👏 Another chapter in the midnolin proteasome story from
@xingulab.bsky.social
www.biorxiv.org/content/10.1...
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...
https://www.biorxiv.org/content/10.1101/2025.02.22.639686v1
7 months ago
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reposted by
Eilika Weber-Ban Lab
Department of Biology, ETH Zurich
8 months ago
A new study from the Weber-Ban lab led by Charlotte Schilling @cm_schilling with support from @rafal_Zdanowicz @Glockshuber_lab reveals the signal linking DNA damage to the activation of the mycobacterial DNA damage response. More:
biol.ethz.ch/en/news-and-...
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