We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)! GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging. Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations. 👉 www.unige.ch/genexm/

🥳 Our new paper on C2CD3 is out in @plosbiology.org With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET. Big congrats to @ebertiaux.bsky.social and all involved.

Congrats to Michal Wieczorek (wieczorekgroup.ethz.ch/research.html, IMBB) on being selected as an @embo.org Young Investigator. The 2024 cohort highlights excellence across the life sciences, and this recognition reflects Michal’s outstanding scientific contributions.

Mike has been selected as EMBO YIP! Huge congrats to Mike and his team! 🥳 @mike-wieczorek.bsky.social

Thank you @embo.org for the honour of joining the EMBO YIP community! This would not have been possible without the efforts of our talented team at ETH Zurich and all our colleagues

The centriole is crucial for cilia formation, but its molecular architecture is not known. Research from the @Wieczorek Group at ETH Zurich reports structures of the centriole’s A-C linker, revealing how it crosslinks neighboring microtubule triplets. More: biol.ethz.ch/en/news-and-...

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are. erc.europa.eu/news-events/...

Our latest collaborative effort - with Eva Gluenz and @zephyris-science.bsky.social - to understand how the various proteins and complexes of the axoneme contribute to ciliary motility:

Scientific Reports meanwhile on course to publish 40K papers = >$100M pubmed.ncbi.nlm.nih.gov?term=%22Scie...

Nature Communications will publish ~10K papers in 2025 pubmed.ncbi.nlm.nih.gov?term=%22Natu... That's ~$70M in revenue, while many of the non-profit journals that used to occupy that slot in the journal hierarchy have seen a precipitous decline in submissions in the 15 years it's existed.

@science.org 🧬🔬🐛🔭🌊🌳🧫🐳

I’m sure this guy is great, not the point, but to think the solution to Canadian scoence is to attract a few dozen scientists from abroad is complete nonsense. There are just as good scientists here. The problem is chronic underfunding. But this does not make headlines www.ctvnews.ca/health/artic...

New video 📹 ! Changes to #eligibility #rules for ERC Starting & Consolidator Grant applicants, as explained by ERC President Maria Leptin. Watch the full 🆕 interview bit.ly/4otIva9 👀 Read the explanatory text (from 15/9/25) 📑 link.europa.eu/hP3WWF #Research #Grant #Funding #AcademicSky 🧪

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

Incredible story - congratulations @klanglab.bsky.social‬ !

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo www.science.org/doi/10.1126/...

🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬 www.biorxiv.org/content/10.1...

Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Today, @rcsbpdb.bsky.social introduces Q-score in EM validation reports. Q-score assesses model-map fit. A new percentile slider will compare an entry’s average Q-score to the full archive and a resolution-matched subset. This would help judge whether the fit is typical for the reported resolution.

Huge congratulations to Girish and team on this beautiful study!

Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu @univie.ac.at @meduniwien.ac.at

Feeling excited & grateful 🌟 Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging. Thanks to Tabea Lilian Marx, Christopher Thomas & our lab! www.mpinat.mpg.de/5118437/pr_2... #FallingWalls #ScienceSummit25 #ScienceBreakthroughs

Exciting new study from new-PI Mohinder Pal on the role of CCDC103 and it's links to PCD as the most recent dynein assembly factor (DNAAF19). Congratulations to the entire team. @Mohinder Pal (currently not on Bluesky) @mike-wieczorek.bsky.social @laurencepearl.bsky.social

New pre-print on the role of CCDC103/DNAAF19 in dynein assembly highlighting it's link to PCD. www.biorxiv.org/content/10.1...

CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia https://www.biorxiv.org/content/10.1101/2025.09.11.675549v1

Asgard archaea were first found in mud at the bottom of the North Sea. Today, cellular biologists Martin Pilhofer and Christa Schleper are exploring one of their more elusive structural elements: a totally tubular system that looks a lot like our own. www.quantamagazine.org/tiny-tubes-r...

Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

Excited to see this work published online at @cp-cell.bsky.social today! www.cell.com/cell/fulltex...

🚨 New Preprint! Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons. ▶️ www.biorxiv.org/content/10.1...

Cells can form patterns within themselves just like embryos do. How? Connie Yan's new preprint shows how the anterior-posterior cytoskeleton pattern in Stentor is dictated by regionalized scaffolding proteins www.biorxiv.org/content/10.1...

Check out 🧐 our new preprint 📜: www.biorxiv.org/content/10.1... Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠 #microsky #teamtomo #Chloroflexota

Check out our latest work now out on biorxiv www.biorxiv.org/content/10.1...

Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization www.biorxiv.org/content/10.1101/2025.08.02.668268v1 #cryoem

Great talk by @sami-c.bsky.social about the proper use and caveats of AlphaFold2/3 predictions, highly recommended to watch www.youtube.com/watch?v=z7vy...

Exciting Aug 1️⃣ for two incredible people- Gregor Weiss and Jingwei Xu! Both are starting their independent labs 🔬🧪 TODAY 🥳 I am incredibly thankful 🙏 for their contributions to the lab and that I could be part of their journey -Martin @xujwet.bsky.social @weiss-lab.bsky.social It was a wild ride👇

A conserved mechanism of membrane fusion in nuclear pore complex assembly https://www.biorxiv.org/content/10.1101/2025.07.21.665908v1

Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors! www.biorxiv.org/content/10.1...

Paumier, Sauvanet, Gigant @mikicalab.bsky.social highlight work from Muñoz-Hernández, Xu et al @mike-wieczorek.bsky.social (rupress.org/jcb/article/...) which describes new insight into the means by which NEDD1 protein recruits the γ-TuRC to microtubule-organizing centers rupress.org/jcb/article/...

Thanks to the Gigant lab for writing this insightful spotlight that discusses our recent work on how NEDD1 binds to and might recruit the γ-TuRC to MTOCs:

Manolo Rios, Jeffrey Woodruff and colleagues use purified human proteins to define the minimal modules for centrosome scaffold assembly and microtubule aster nucleation. journals.biologists.com/jcs/article/...

Excited and honored to be joining the EMBO Member community 🥳 Congratulations also to all the other newly elected members! -Martin

After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6

I'm very excited that my first postdoc paper is out now at @nature.com! www.nature.com/articles/s41... I developed new single cell CDK sensors to investigate how CDK orchestrates mitosis including investigating bistability/hysteresis, how activity is propagated, and the role of centrosomes.

🚨 New preprint! Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM www.biorxiv.org/content/10.1...

✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social‬ & ALMF @embl.org ✨ 👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8

Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...