Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday www.nature.com/articles/nme...

1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: tinyurl.com/mshwjd77

www.science.org/doi/10.1126/... le 🦠💫💫💫 #ribosome #rnasky

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: www.biorxiv.org/content/10.1... This work is spearheaded by PhD Student Sascha Amann Let me walk you through it 🧵 1/9

Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome https://go.nature.com/4iECjJz

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...

Elise and Tarah's work on engineering leucyl-tRNA synthetase to incorporate numerous ncAAs in mammalian cells now published! A bit of good news amidst these chaotic times onlinelibrary.wiley.com/doi/10.1002/...

📢 The Louis-Jeantet Foundation is happy to announce the 2025 #LouisJeantetPrizes, awarded to VEIT HORNUNG @v-hornung.bsky.social @genecenter-lmu.bsky.social and to GILLES LAURENT @ maxplanck.de CONGRATULATIONS!!! 👉 jeantet.ch/en 👇 follow thread

Overjoyed and honestly relieved to share a Chem Rev magnum opus from Brian Chen & Julia Li titled Synthetic Lipid Biology! In it, we organize efforts across numerous fields to create, manipulate, and analyze lipids and biomembranes. Check it out! doi.org/10.1021/acs.... #lipidtime #chemsky #chembio

A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination www.nature.com/articles/s41...

Exciting paper by the groups of Ronald Micura and Alexandra Lusser in @nchembio.bsky.social. Covalent binders to structured RNA based on alkyl halides and alkyl mesylates show engagement of the preQ1 and Pepper aptamers in vitro and in cells. www.nature.com/articles/s41...

Die Fachgruppe Biochemie der @gdch.bsky.social wünscht ein frohes neues Jahr! Wir hatten ein großartiges 2024 mit einer fantastischen Biochemie-Tagung. Wenn Sie in 2024 eine herausragende Doktorarbeit oder Veröffentlichung in Ihrer Gruppe hatten, nominieren Sie für unseren Förderpreis!

Efficient circular RNA synthesis for potent rolling circle translation. Congratulations to Yifei and the team in Venki's lab at @mrclmb.bsky.social! www.nature.com/articles/s41... #RNA #RNABiology #RNAsky #Translation #mRNA

WOW!!! Beautiful new Nature paper from Burkart Lab UCSD reveals how non-ribosomal peptide natural product synthetases work together. They use tetrazine click chemistry to capture these huge protein complexes mid-reaction. 3 different snapshots show different states. www.nature.com/articles/s41...

Curious what we do in my new lab at D-CHAB @ethzurich.bsky.social 🔬⚗️? Save the date for my inaugural lecture on April 3, 2025 and if you can’t wait to know more check out the news article and the associated video. chab.ethz.ch/en/news-and-...

Happy to see my Medicinal Chemistry and Chemical Biology Highlight out in the current CHIMIA and online. Thank you to @klanglab.bsky.social for the invitation! www.chimia.ch/chimia/artic...

First paper of our lab today @natureportfolio.bsky.social by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping! @embl.org #RNAbiology #RNASky t.co/a24Xxcxdo0

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation! www.science.org/doi/10.1126/...

Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway https://www.biorxiv.org/content/10.1101/2024.11.21.623953v1

Very creative use of a prebiotic-inspired, hybridization-accelerated covalent reaction for capture of charged aminoacyl-tRNAs.

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

Hi Bluesky! New here and a bit surprised not to see a starter pack dedicated to Chemical Biology so.. here we go! go.bsky.app/DDpDuvo

🔈🔥! We have two open full professor positions at our institute (LOC) at ETH Zurich! 1. Synthetic Organic Chemistry 2. (Bio)analytical Chemistry Amazing students, staff, colleagues, infrastructure, location and long-term perspectives. 🫵 Apply and be our colleague!! ethz.ch/en/the-eth-z...

Very much looking forward to having you here Michael and learning about your research! 🧬🤩 Safe travels!