New plasmids from Kai Johnsson now online! 💡 The self-labeling CLIP-tag2 achieves almost 1000-fold faster tagging than the original when combined with a new substrate optimized for live-cell imaging. https://twp.ai/4hrKYy

We are again looking for 3 Flash Talks for the 6th Virtual @chembiotalks.bsky.social. If you are a PhD candidate or postdoc in the field of #ChemBio, I strongly encourage you to apply via our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/... #ChemBio #ChemSky #Competition

Are you a #PhD candidate or #postdoc and do you want to present your #ChemBio research to a large audience? Here is your chance. You can apply through our abstract challenge to present at the 6th Virtual ChemBioTalks on September 29th. chemistry-europe.onlinelibrary.wiley.com/hub/journal/...

In 1915, Gillette began convincing women that leg & armpit hair were embarrassing, masculine & unhygienic--to sell razors. A norm that has no health benefits but incredible compliance. Women are called 'disgusting' when they have the same body hair as men. www.thepersistent.com/tangled-hist...

Still obsessed with histidine (and its mimics)! Our latest work from Benjamin 🎉 uses genetic code expansion—tuning the primary coordination sphere of a dizinc metallohydrolase—lowering the catalytic pKa and boosting activity up to 5x at acidic pH. Check it out! doi.org/10.1021/acs.biochem.5c00768

🚨 Are you in need of a sensitive ratiometric protein kinase A (PKA) biosensor? 🚨 We got you covered: far-red, large changes, rapid response kinetics, selective! Anything you could wish for. Check out these two preprints from the Zhang Lab 🧪 🧑‍🔬 Congrats to everyone involved!

No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition. Which just makes me want to share it again: www.nature.com/articles/d41...

🚨How do we implement synthetic fluorophores into biosensors? Have a look at Elias Dressler’s review article in Chimia. The issue highlights the work of Young Professors and Ambizione Fellows in Switzerland. Glad to be part of this vibrant community. ⚗️ www.chimia.ch/chimia/artic...

A new Review by Agnese Nicoli and Michelle Frei examines the progress in developing synthetic small-molecule fluorophores and how these in combination with innovative labeling strategies can advance chemical biology www.nature.com/articles/s41...

🚨Curious how synthetic fluorophores simplify microscopy? Our review covers applications such as super-resolution microscopy and biosensing. 🎉👩‍🔬Congrats to my first PhD student, Agnese Nicoli, for the fearless deep dive! 🔬 ⚗️ D-CHAB @ethz.ch www.nature.com/articles/s41...

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

#Mifobio2025 Focus on the module 1 : 👉 "Marking strategies at different scales of life" We are delighted to welcome @michellefrei17.bsky.social @ethz.ch Lecture : "Chemigenetic kinase biosensors for multiplexed activity sensing and super-resolution imaging" 👉 imabio-cnrs.fr/mifobio-2025/

The 5th Virtual @chembiotalks.bsky.social on September 30th are one week away. We have an exciting program including our keynotes Sarah O'Connor (@oconnorlab.bsky.social) and @craigmcrews.bsky.social. Make sure to register for free: web.cvent.com/event/... #ChemSky #ChemBio

This is a really, really important story, which is why I provided a gift link. Many people, when they think of higher education, think of elite universities. But most higher education is nonselective (i.e., they admit everyone), and a lot of it is community colleges.

🚨 2 × PhD positions @EPFL! 🚨 Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → [email protected] #PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT

💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭: #nanopores #smFRET #biomolecular #dynamics #singleMolecules We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech. Please share broadly, thank you!🤝 schmid.chemie.unibas.ch

We have multiple PhD and Postdoc positions open in my new group at Masaryk University. Are you an excellent and motivated candidate interested in organic and peptide synthesis and chemical biology? Get in touch! Start in January 2026. www.fialalab.com Appreciate sharing!

Teaching an old bacterial protein new tricks: Fast, bright and reversible rhodamine tags for live-cell imaging: www.biorxiv.org/content/10.1... Congratulations to Julian Kompa and the entire team.

📣Paper alert! Interested in faster and brighter protein labeling than before? 👀 @steffi-k.bsky.social & other colleagues have developed an improved tool for labeling proteins with synthetic fluorophores for bioimaging. Also works in STED microscopy 🤩🔬 Congratulations!🥳 www.nature.com/articles/s41...

We are hiring! Check out our open PhD position for an exciting industry collaboration with Novo Nordisk: jobs.ethz.ch/job/view/JOP...

🔥 We've already received over a third of pre-registrations! #Mifobio2025 is already shaping up to be a highly attractive event... Don't delay in pre-registering! 👉 imabio-cnrs.fr @cnrs.fr @cnrsbiologie.bsky.social @cnrsingenierie.bsky.social @cnrs-inist.bsky.social

Want to be part of the 5th Virtual ChemBio Talks? Submit you abstract until 📅 June 30th. Two amazing keynote speakers @oconnorlab.bsky.social and @craigmcrews.bsky.social are already confirmed. More coming soon. Stay tuned! ⚗️👩‍🔬🦠🧑‍🔬

Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social! www.nature.com/articles/s41...

My lab at @ethzurich.bsky.social is looking for a motivated PhD student. We develop chemical tools for advanced fluorescence microscopy 🔬 and work at the interface of synthetic chemistry ⚗️ and protein engineering 🦠. Sharing with skilled Master students appreciated. More info at tinyurl.com/2dbjk5ty

We are happy to announce the new team that will organize the Virtual ChemBioTalks from this edition onwards Marina Rubini @mlakemeyer.bsky.social @michellefrei17.bsky.social Hana Macíčková Cahová @drglycoben.bsky.social @borisvauzeilles.bsky.social @stephanhacker2.bsky.social (1/4) #ChemBio #ChemSky

🚨 PhD Opportunity! Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student! 🔬 Exciting interdisciplinary research 🤝 Engaging environment 🌱 📄 Does this sound like you, apply now! ⏳🔗 📢 Know someone? Share this! 🔄 jobs.uzh.ch/job-vacancie...

The Frei Research Group is growing! Excited to see how the projects of Mario, Agnese, and Elias will develop in the next months and years. Also grateful for the amazing admin support by Karin. ⚗️🔬👩‍🔬👨‍🔬

Our lab has an open PhD student position in Protein Engineering - Neurotechnology. Apply if interested!

Check out our new fluorescent probe for imaging f-actin dynamics: 𝗦𝗶𝗥-𝗫𝗔𝗰𝘁𝗶𝗻: 𝗔 𝗳𝗹𝘂𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝘁 𝗽𝗿𝗼𝗯𝗲 𝗳𝗼𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗮𝗰𝘁𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝗹𝗶𝘃𝗲 𝗰𝗲𝗹𝗹𝘀 www.biorxiv.org/content/10.1... Thank you @veselin-nasufovic.bsky.social

Hello Bluesky! We're a UC San Diego-based lab that studies cellular signaling, and makes genetically encoded biosensors to study those signals. Talk to us about kinases, fluorescent proteins, GPCRs, and imaging technology!

We made a photoswitchable HaloTag (psHaloTag), which can reversibly turn-on fluorogenic dyes upon illumination 💡. Congrats to Franzi, Bego and all co-authors, check out our preprint below 👇 www.biorxiv.org/content/10.1...

And what better introduction than to share a new publication? Check out this review article I’ve been working on (along with my co-first authors) if you need a biosensor or want a comprehensive overview of the field. Now out as an ASAP article at Chemical Reviews! doi.org/10.1021/acs....

‼️3 postdoc positions open‼️ We are building a quantitative imaging team at Warwick! Join an interdisciplinary endeavor with Mishima, Balasubramanian, and Mayor labs on a @wellcometrust.bsky.social funded project to push probe and microscopy development! warwick-careers.tal.net/vx/lang-en-G...

Curious what we do in my new lab at D-CHAB @ethzurich.bsky.social 🔬⚗️? Save the date for my inaugural lecture on April 3, 2025 and if you can’t wait to know more check out the news article and the associated video. chab.ethz.ch/en/news-and-...

It is official! The fourth edidtion of our winter school on "Fluorescence markers for advanced microscopy" will take place on March 15-20 2026 in Les Houches, in the french Alps. fluorescenceleshouches.wordpress.com Selection of participants will start in 2025. Signup on the website to be informed.

🔈🔥! We have two open full professor positions at our institute (LOC) at ETH Zurich! 1. Synthetic Organic Chemistry 2. (Bio)analytical Chemistry Amazing students, staff, colleagues, infrastructure, location and long-term perspectives. 🫵 Apply and be our colleague!! ethz.ch/en/the-eth-z...

🚨Preprint alert 🚨Do you need a highly sensitive kinase biosensor? Want to multiplex multiple sensors or look at nanoscale activity architecture? Our far-red chemigenetic kinase biosensors are what you are looking for. Thanks to everyone involved! tinyurl.com/d36e2t4m

The Frei Research Group will open its doors this summer @ethzurich.bsky.social! I am therefore looking for motivated PhD students to join me in developing chemistry inspired tools for advanced fluorescence microscopy. Please share with current master students 👩‍🔬🔬⚗️🧪👨‍🔬http://tinyurl.com/437xyu8n