Tommaso Patriarchi
@tpatriarchi.bsky.social
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📥 383
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Assistant Prof. at UZH 🇨🇭 | protein engineering for pharmacology and neuroscience | opinions my own
Norepinephrine imaging, pushed further. Our latest NE sensors enable highly sensitive monitoring across recording modalities, Have you been using GRABNE2 sensors? the toolkit just got a major upgrade. Interested in trying them in your system? Reach out.
4 days ago
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Tommaso Patriarchi
Nature Methods
17 days ago
Improved red and green indicators for norepinephrine detect norepinephrine release in awake behaving mice.
@tpatriarchi.bsky.social
www.nature.com/articles/s41...
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Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods
Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...
https://www.nature.com/articles/s41592-026-03006-z
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The most sensitive green and red
#norepinephrine
#sensors
engineered to date are out in
#naturemethods
! Deeply grateful to all our funders and contributors who made this work possible. A true team effort.
@erc.europa.eu
@snsf.ch
doi.org/10.1038/s415...
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Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods
Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...
https://doi.org/10.1038/s41592-026-03006-z
21 days ago
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Tommaso Patriarchi
Bence Ölveczky
about 2 months ago
Feels like a pivotal moment. The president is screening a movie about his third wife and crying about a lawsuit challenging his guilded ballroom, while good-hearted Americans looking out for their neighbor are getting murdered by state police. Will Americans finally wake up?
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Tommaso Patriarchi
Peter Rupprecht
about 2 months ago
Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with
@sianduss.bsky.social
@bohaceklab.bsky.social
, and many others:
www.biorxiv.org/content/10.6...
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An engineered nanobody inhibitor for molecular-to-circuit control of opioid receptor function. This was a really fun collaboration with
@miriamstoeber.bsky.social
and
@amanglik.bsky.social
labs, check it out!
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.01.12.698943v1
2 months ago
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Joachim Goedhart
6 months ago
Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains. Is it impressive? Yes Is it new? No Should you use it? Probably not.
www.cell.com/cell/fulltex...
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Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains
A family of rationally designed time-resolved fluorescent proteins with controllable lifetimes across the visible spectrum enables simultaneous multiplexed live imaging, super-resolution microscopy, a...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901027-X
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Congrats Martin, great work!
add a skeleton here at some point
7 months ago
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Amazing work by the Andermann Lab showcasing a perfect use-case for FLIM imaging of dopamine sensors - looking at tonic [DA] changes and adaptations over days! Honored to be part of this effort.
add a skeleton here at some point
10 months ago
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Tommaso Patriarchi
Libby Whittemore
about 1 year ago
#BlueskyResistance
#Voices4Victory
#ProudBlur
Advertisement at a London bus stop. Ya gotta love the British…
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www.nature.com/articles/s41...
This study is absolutely mind-blowing.
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Topological segregation of stress sensors along the gut crypt–villus axis - Nature
Serotonergic enterochromaffin cells of the intestine exhibit distinct sensory, secretory and physiological properties depending on their location within the complex crypt–villus architecture of t...
https://www.nature.com/articles/s41586-024-08581-9
about 1 year ago
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Congratulations Tal!! It's so great to see this out, I am very happy for you and your lab!!
add a skeleton here at some point
about 1 year ago
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Our lab has an open PhD student position in Protein Engineering - Neurotechnology. Apply if interested!
about 1 year ago
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Amazing work by
@massecklab.bsky.social
PinkyCaMP the first mScarlet based Ca2+ indicator! Congrats to all, proud to have contributed to this
add a skeleton here at some point
over 1 year ago
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Extremely proud to see my second PhD student (now Dr.) Xuehan Zhou defending her thesis so brilliantly and successfully! Such happy moments :)
over 1 year ago
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Our lab is looking for a motivated Research Assistant with hands-on experience with molecular cloning techniques, mammalian cell culture and confocal imaging. If you are interested in joining or know anyone who is, please email me your application. Thanks
over 1 year ago
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This is really fascinating work, congrats to the whole team!
add a skeleton here at some point
over 1 year ago
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reposted by
Tommaso Patriarchi
Tim Behrens
over 1 year ago
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)
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