Tommaso Patriarchi
@tpatriarchi.bsky.social
📤 589
📥 402
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Associate Prof. at UZH 🇨🇭 | protein engineering for pharmacology and neuroscience | opinions my own
This is an impressive milestone!
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18 days ago
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The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot
doi.org/10.7554/eLif...
Great work by
@labouessemarie.bsky.social
and her student Alina! Congrats
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The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot
Within the nucleus accumbens shell, a spatially defined rostral subregion selectively modulates hedonic feeding, revealing functional heterogeneity in reward circuitry underlying food consumption.
https://doi.org/10.7554/eLife.108639.3
20 days ago
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Tommaso Patriarchi
Ali Shaib
27 days ago
Hello
#world
, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from
@eboyden3.bsky.social
's lab, in collab with us. Story:
www.biorxiv.org/content/10.6...
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Tommaso Patriarchi
Matteo Carandini
27 days ago
Neuropixels + Optogenetics = Neuropixels Opto Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors. Today in
@natmethods.nature.com
doi.org/10.1038/s415...
Thanks to
@wellcometrust.bsky.social
,
@alleninstitute.org
,
@hhmijanelia.bsky.social
& team.
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Tommaso Patriarchi
about 1 month ago
Out today in
@natneuro.nature.com
What started as a great discussion at an amazing meeting organized by
@joaofoliveira.bsky.social
culminated in our new Perspective on how
#astrocyte
functions operate across multiple spatial scales. Read:
rdcu.be/fk0B7
Full text:
www.nature.com/articles/s41...
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The multiple scales of astrocytic functional units
Nature Neuroscience - Astrocytes modulate complex brain functions. These ubiquitous glial cells constitute a multilayered system of functional units that operate across multiple spatial scales,...
https://rdcu.be/fk0B7
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Absolutely stunning work: de novo designed miniproteins targeting GPCRs as potent agonists and antagonists. This opens countless possibilities for programmable signaling, cleaner therapeutics, and faster drug discovery. Protein design is coming for pharmacology. 🚀
doi.org/10.1038/s415...
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De novo design of miniproteins targeting GPCRs - Nature
Nature - De novo design of miniproteins targeting GPCRs
https://doi.org/10.1038/s41586-026-10656-8
about 1 month ago
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Very cool to see the power of de novo design applied to dye-labeling!
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about 2 months ago
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Tommaso Patriarchi
Talia Lerner
about 2 months ago
🚨Exiting new preprint from Lerner Lab postdoc AJ Miller-Hansen examining the thalamus as a physiological driver of local, acetylcholine-dependent dopamine release! 🚨 DA-ACh interactions have been 🔥but what’s really going on in vivo? We think we have some answers.
#neuroskyence🧪
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Check out the birghtest star in the room: PinkyCaMP - the latest member to the red GECI family! Amazing work led by Olivia Masseck and a wonderful team! Proud to contribute
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2 months ago
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Amazing piece on Locus Coeruleus neurons! Great work
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3 months ago
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This will be a great conference!
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3 months ago
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Wait… localized norepinephrine transients in the awake visual cortex?! Who would have guessed this neuromodulatory signal is that spatially precise, right where visual processing is happening. Brain state control just got a lot more local.
@ruedigersarah.bsky.social
www.nature.com/articles/s41...
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3 months ago
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Wow - this is really amazing work, congrats to the whole team!
add a skeleton here at some point
3 months ago
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Tommaso Patriarchi
Lin Tian, PhD
3 months ago
Nikki Tjahjono’s PhD work is out as a
@cellpress.bsky.social
preview in
@ssrn.bsky.social
! With
@isacofflab.bsky.social
, we introduce iHaloGluSnFR, the first red-shifted chemigenetic glutamate sensors, optimized for simultaneous imaging with neuromodulators.
papers.ssrn.com/sol3/papers....
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Norepinephrine imaging, pushed further. Our latest NE sensors enable highly sensitive monitoring across recording modalities, Have you been using GRABNE2 sensors? the toolkit just got a major upgrade. Interested in trying them in your system? Reach out.
3 months ago
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Tommaso Patriarchi
Nature Methods
4 months ago
Improved red and green indicators for norepinephrine detect norepinephrine release in awake behaving mice.
@tpatriarchi.bsky.social
www.nature.com/articles/s41...
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Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods
Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...
https://www.nature.com/articles/s41592-026-03006-z
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The most sensitive green and red
#norepinephrine
#sensors
engineered to date are out in
#naturemethods
! Deeply grateful to all our funders and contributors who made this work possible. A true team effort.
@erc.europa.eu
@snsf.ch
doi.org/10.1038/s415...
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Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods
Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...
https://doi.org/10.1038/s41592-026-03006-z
4 months ago
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Tommaso Patriarchi
Bence Ölveczky
5 months ago
Feels like a pivotal moment. The president is screening a movie about his third wife and crying about a lawsuit challenging his guilded ballroom, while good-hearted Americans looking out for their neighbor are getting murdered by state police. Will Americans finally wake up?
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Tommaso Patriarchi
Peter Rupprecht
5 months ago
Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with
@sianduss.bsky.social
@bohaceklab.bsky.social
, and many others:
www.biorxiv.org/content/10.6...
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An engineered nanobody inhibitor for molecular-to-circuit control of opioid receptor function. This was a really fun collaboration with
@miriamstoeber.bsky.social
and
@amanglik.bsky.social
labs, check it out!
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.01.12.698943v1
5 months ago
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Joachim Goedhart
9 months ago
Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains. Is it impressive? Yes Is it new? No Should you use it? Probably not.
www.cell.com/cell/fulltex...
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Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains
A family of rationally designed time-resolved fluorescent proteins with controllable lifetimes across the visible spectrum enables simultaneous multiplexed live imaging, super-resolution microscopy, a...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901027-X
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Congrats Martin, great work!
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10 months ago
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Amazing work by the Andermann Lab showcasing a perfect use-case for FLIM imaging of dopamine sensors - looking at tonic [DA] changes and adaptations over days! Honored to be part of this effort.
add a skeleton here at some point
about 1 year ago
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Tommaso Patriarchi
Libby Whittemore
over 1 year ago
#BlueskyResistance
#Voices4Victory
#ProudBlur
Advertisement at a London bus stop. Ya gotta love the British…
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www.nature.com/articles/s41...
This study is absolutely mind-blowing.
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Topological segregation of stress sensors along the gut crypt–villus axis - Nature
Serotonergic enterochromaffin cells of the intestine exhibit distinct sensory, secretory and physiological properties depending on their location within the complex crypt–villus architecture of t...
https://www.nature.com/articles/s41586-024-08581-9
over 1 year ago
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Congratulations Tal!! It's so great to see this out, I am very happy for you and your lab!!
add a skeleton here at some point
over 1 year ago
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Our lab has an open PhD student position in Protein Engineering - Neurotechnology. Apply if interested!
over 1 year ago
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Amazing work by
@massecklab.bsky.social
PinkyCaMP the first mScarlet based Ca2+ indicator! Congrats to all, proud to have contributed to this
add a skeleton here at some point
over 1 year ago
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Extremely proud to see my second PhD student (now Dr.) Xuehan Zhou defending her thesis so brilliantly and successfully! Such happy moments :)
over 1 year ago
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Our lab is looking for a motivated Research Assistant with hands-on experience with molecular cloning techniques, mammalian cell culture and confocal imaging. If you are interested in joining or know anyone who is, please email me your application. Thanks
over 1 year ago
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This is really fascinating work, congrats to the whole team!
add a skeleton here at some point
over 1 year ago
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reposted by
Tommaso Patriarchi
Tim Behrens
over 1 year ago
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)
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