Ehud Isacoff Lab
@isacofflab.bsky.social
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📥 90
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#Neuroscience
#UCBerkeley
https://isacofflab.berkeley.edu
Behavioral resilience via dynamic circuit firing homeostasis | PNAS
www.pnas.org/doi/10.1073/...
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2421386122#supplementary-materials
about 1 year ago
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reposted by
Ehud Isacoff Lab
UC Berkeley
over 1 year ago
East Bay Rep. Lateefah Simon and Los Angeles Rep. Ted Lieu recently paid a visit to the University of California, Berkeley’s Innovative Genomics Institute to hear about the importance of NIH-funded basic research.
news.berkeley.edu/2025/02/24/d...
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During campus visit, U.S. representatives vow to fight freeze on federal research funding - Berkeley News
East Bay Rep. Lateefah Simon and Los Angeles Rep. Ted Lieu visited the Innovative Genomics Institute for a tour and briefing
https://news.berkeley.edu/2025/02/24/during-campus-visit-u-s-representatives-vow-to-fight-freeze-on-federal-research-funding/
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reposted by
Ehud Isacoff Lab
Dan Minor
over 1 year ago
Our THIK study of the THIK K2P is out showing a novel feature that affects function (flow restrictor) and a PUFA modulation site. Congratulations to my team. 🥳 See also work by
@profkalium.bsky.social
in the same issue of NSMB. A growing thicket of THIK structures 😃
www.nature.com/articles/s41...
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Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site - Nature Structural & Molecular Biology
Roy-Chowdhury et al. report structures of the human leak channel K2P13.1 that identify a hydrophilic pore restriction and a polyunsaturated-fatty-acid-binding site corresponding to a small-molecule ag...
https://www.nature.com/articles/s41594-024-01476-3?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=nonoa_20250226&utm_content=10.1038/s41594-024-01476-3
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Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns with
@dirktrauner.bsky.social
, Carmena Lab, and Lammel Lab.
add a skeleton here at some point
over 1 year ago
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reposted by
Ehud Isacoff Lab
Dan Minor
over 1 year ago
Glad to share a new minireview with Zhou Chen summarizing our current thoughts on how cells make electrosomes (aka ion channels).
portlandpress.com/biochemsoctr...
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Electrosome assembly: Structural insights from high voltage-activated calcium channel (CaV)–chaperone interactions
Ion channels are multicomponent complexes (termed here as“electrosomes”) that conduct the bioelectrical signals required for life. It has been appreciated for decades that assembly is critical for pro...
https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20240422/235669/Electrosome-assembly-Structural-insights-from-high
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