'Frog 🐸 protein saves mice 🐭 from deadly toxin ☠️ ' STX is one of the most lethal toxins known. Our new work shows that a single dose of frog saxiphilin neutralizes STX poisoning in mice. Behold the awesome power of frogs 🐸! 🙏🎉 to my fantastic team and collaborators. www.biorxiv.org/content/10.1...

New work from our lab. Structures of K2P6.1 (TWIK2) that yield a new and suprising perspective on how lipids affect K2P channels. Great work from Abishek Mondal and Sangeeta Niranjan in my lab. www.biorxiv.org/content/10.1...

New insights from our group into how frogs resist toxic environments published today! 🎉🐸 Congratulations to Sandra, Samantha @samnscience.bsky.social, Zhou, and our collaborators Tod Leighfield, Filizola lab @martafilizola.bsky.social, and Du Bois lab at Stanford. www.nature.com/articles/s41...

Our THIK study of the THIK K2P is out showing a novel feature that affects function (flow restrictor) and a PUFA modulation site. Congratulations to my team. 🥳 See also work by @profkalium.bsky.social in the same issue of NSMB. A growing thicket of THIK structures 😃 www.nature.com/articles/s41...

Minor lab reunion. A BPS highlight every year 😄🙏

Great talk by Dr Sandra Zakrzewska From our lab about her work on toxin binding proteins from frogs 🐸. Check out her poster tomorrow. / B409 - STRUCTURAL BASIS FOR SAXITOXIN CONGENER BINDING AND NEUTRALIZATION BY ANURAN SAXIPHILINS

Glad to share a new minireview with Zhou Chen summarizing our current thoughts on how cells make electrosomes (aka ion channels). portlandpress.com/biochemsoctr...