OUT NOW! The Graduate School of Biomedical Sciences Dean's Report and message from Dean @martafilizola.bsky.social. Learn about the Graduate School at Mount Sinai's growth, innovation and achievement, and how they have excelled in 2025 👉 reports.mountsinai.org/article/grad...

It’s official: ChatGPT can't draw a GPCR, but you’ll master them in the Filizola Lab 😜 Join Us! (send your CV and the names of at least two references to my institutional email) #Postdoc #scientist #research

Our new work with Daniel Wacker’s Lab: not only do structurally different PAMs of the mu #opioid receptor bind at different sites but their modulatory mechanisms also differ as assessed by molecular #dynamics and information theory validated by functional experiments www.biorxiv.org/content/10.1...

For your summer reading, check out the latest from our lab: www.biorxiv.org/content/10.1...

Join an ever-inquisitive community of scholars who make strategic and meaningful connections between science, medicine, education, and health care delivery. We look forward to welcoming new Master’s classes in Biomedical Sciences and Data Science and AI youtu.be/NPNm4KOfwco

It’s time to vote! If you give me your vote, I promise I will work hard and loud for you, the BPS community, and for science. Read my statement. www.biophysics.org/elections/bp...

Twenty case studies showing theoretical predictions in chemistry that were later confirmed experimentally. #CompChem 🧪 doi.org/10.1515/pac-...

The US will not only suffer a brain drain… but will also lose its background brain gain from the rest of the world. econ.trib.al/3hYAuUZ

25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.

New Notice on No Cost Extensions (or lack thereof) grants.nih.gov/grants/guide...

New insights from our group into how frogs resist toxic environments published today! 🎉🐸 Congratulations to Sandra, Samantha @samnscience.bsky.social, Zhou, and our collaborators Tod Leighfield, Filizola lab @martafilizola.bsky.social, and Du Bois lab at Stanford. www.nature.com/articles/s41...

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

Filizola lab - Gmeiner lab finally revealed onlinelibrary.wiley.com/doi/abs/10.1...

"It’s kind of a textbook case of arbitrary and capricious.” A lawsuit alleges that NIH didn't follow proper procedure and was unconstitutionally vague when abruptly terminating >600 grants. My story @science.org www.science.org/content/arti...

Carnage! www.thetransmitter.org/science-and-...

Why AI won’t replace scientists capable of making disruptive conceptual breakthroughs - they pose questions that challenge, rather than align with, the training data set thomwolf.io/blog/scienti...

Are you aiming for leadership roles in pharmaceutical, biotech, high tech, or medical device companies? Consider applying to the revamped MSBS program @GradSchoolSinai @IcahnMountSinai, featuring 1 or 2-year tracks and non-thesis options tailored for industry professionals

At @GradSchoolSinai @IcahnMountSinai, we are excited to train the next generation of #datascience and #AI #professionals for #PrecisionMedicine @MountSinaiNYC and beyond. Apply here: icahn.mssm.edu/education/ad...

You got 5 min to really understand the real costs of scientific research - check out this video www.youtube.com/watch?v=GzNc...

New picture for the Filizola lab on the relentless quest for breakthrough science to build a brighter future. Bring it on!

FRESH OFF THE PRESS @filizolalab1 : Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs | Biochemistry pubs.acs.org/doi/full/10....

Large crowd in New York City at Stand Up for Science.

Francis Collins Retires From N.I.H. www.nytimes.com/2025/03/01/u...

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...

NIH ban on renewing senior scientists adds to assaults on its in-house research | Science | AAAS www.science.org/content/arti...

Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs… “I think they're being short-sighted, because fear does that to you.”

Make sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social Please share widely! www.youtube.com/watch?v=yxTD...

Red-state universities push back against NIH funding cuts

🧵 The Fight Has Come to Them: Science, Institutions & The Indirects Cut I want to take a moment to talk about the perspective behind these slides I put together. I’ve framed them to be as nonpartisan as possible—but in a moment this polarized, there are limits here. 1/

Since there has been a lot of misinformation circulating since last night, I find this AAMC infographic helpful in illustrating which types of expenses are and are not covered by NIH indirect cost reimbursements.

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures. www.washingtonpost.com/health/2025/...

The Howard Hughes Medical Institute, the nation’s largest private funder of biomedical research, yesterday killed a $60 million program aimed at making universities’ STEM education more inclusive. scim.ag/3EtS0US

15%. In 2018, 10% was tried, but it was blocked by Congress. www.nytimes.com/2017/09/11/u... www.science.org/content/arti...

Excellent 🧵 on this evening's NIH announcement of a dramatic reduction in indirect rates for research institutions, which amounts to a generational restructuring of the US research and development ecosystem. These cuts are effective immediately, not just for new grants but for existing ones.

Research universities are often the largest employers in their region. They are often the primary health care providers to communities. This funding shift will not only reduce US research leadership, it will put working people out of work and reduce healthcare access.

Who can blame her?

Freeze rescinded www.nytimes.com/live/2025/01...

States Will Sue Trump to Stop Federal Grant Freeze www.nytimes.com/2025/01/28/u...

All Democrats in Congress and the Senate will fight this—it’s illegal. But Republican lawmakers NEED to hear from their constituents! Priority order: call, then email. Be clear about how this will hurt education, the economy, and health! 🧪 www.nytimes.com/live/2025/01...

OMG! www.cnn.com/2025/01/27/p...

“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO

Charged peptides instead of phospholipids? Another multidisciplinary study - a collaboration led by Neal Devaraj at UCSD. Sims done in my lab by @conradopedebos.bsky.social Out now in Angew Chemie onlinelibrary.wiley.com/doi/10.1002/...

So seems like the group is on a roll this month! Here’s our latest work on parametrising coarse-grained models of sugars (disaccharides) by Astrid Brandner & in collaboration with Iain Smith, @pauloctsouza.bsky.social and @cg-martini.bsky.social pubs.acs.org/doi/10.1021/... #glycotime

Just one month to go until the 2025 GRS/GRC in Molecular Pharmacology! Get ready for an extraordinary program packed with cutting-edge science and inspiring discussions. Full details here: www.grc.org/molecular-ph...