🔵 I'm interrupting my social media hiatus to flag this important preprint from the Bruchas lab (is he not on Bluesky!?) together with @davidweinshenker.bsky.social. Very difficult experiments to show that dopamine release from LC terminals is independent of VTA 🔥 www.biorxiv.org/content/10.1...

This preprint has been under review >110 days... I think they can't find reviewers. WOULD YOU BE WILLING TO SERVE AS A REVIEWER? If you're keen, I'd propose your name to the editor... Please re-post

I'd have so much to complain about these days. But given the state of affairs in the world, it feels inappropriate to whine about daily hassles. So let me just say this on behalf of everyone who is struggling but otherwise safe: fucking hell.

🔵 Interesting new work from @davidweinshenker.bsky.social on why locus coeruleus neurons might be vulnerable to degeneration in humans (Alzheimer's) but not in mice. And a new approach on how this could be modelled in mice through human tyrosinase overexpression: www.biorxiv.org/content/10.1...

Impression from the evening panel discussion at #ESC2025. Amazing talks today, wonderfully open and fun atmosphere. After all these years, still my favorite meeting in the conference cycle ❤️

Dopamine and acetylcholine interactions - so hot right now! Tour de force work from Steph Cragg's group out in NN (lead Yan-Feng Zhang). They find Cholinergic Interneurons (ChIs) largely suppress DA release, distinct from what we just reported in songbirds (1/x) www.nature.com/articles/s41...

Stellar women-only (💪) panel on stress and development, loaded with cutting-edge multiomic data kicking off the European Stress Conference #ESC2025 in Innsbruck, Austria

My lab is hiring 2 postdocs on an NIH-funded grant characterizing molecular & cellular changes in the human brain across menopausal transition. Other neuroepigenomics projects are also available. We plan to hire a wet lab scientist and a bioinformatician. Please RT! kundakoviclab.com More info 👇

How much analgesia is needed to manage pain levels in mice after brain surgeries? A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...

I’m trilled to release the largest amount of stress profiling data from our (I think any) lab so far. We asked how the molecular response to acute stress adapts as the stressor becomes chronic. Multiomic profiling in the mouse hippocampus, led by Rebecca Waag and co-last author Pierre-Luc Germain 💪

Uuuhh... DANNCE is back! Now social-DANNCE. Looks very cool, taking multi-animal tracking and analysis of social behavior to a whole new level. Just the green-room multiple-camera setup looks quite complex, I wonder how easy this can be replicated in other labs. Will certainly spark excitement!

SAVE THE DATE: #resilience2025 - the 11th International Symposium on Resilience Research - Mainz, Germany - September 24-26, 2025 Satellite methods workshop: September 23 & many opportunities for early-career researchers Meet the stress resilience research community, get latest insights, spur you

Is this still the place to post scientific updates about papers, preprints and cool new data? Asking for a friend.

Amazing work from our colleagues at ETH/UZH answering many unknowns about arousal during sleep. And congrats to their participants for being able to sleep with their eyes taped open! www.nature.com/articles/s41...

First day of the new semester. 5th time I'm teaching this class. Got tenured along the way. And still, I'm nervous before going in... 😅🤷‍♂️

delighted to share our work revealing a new type of excitatory hippocampal neuron we call the "ovoid cell", which has really exquisite properties relative to adjacent pyramidal cells! superb work of first-author @adriennekinman.bsky.social and many others in the lab www.nature.com/articles/s41...

Check out this cool study by the @markcembrowski.bsky.social lab! They describe a new hippocampus cell population that responds to novel stimuli. But hold on to your seat: they don't if the object is presented again. Even 100 days later! When the behavioral memory has long faded!! 🤯🤯😱🤩

Huh... tumors can have excitable neuron-like cells. And the other tumor cells support them metabolically, akin to the neuron-astrocyte relationship. 🤯

This quote is the reward of agreeing to review a PhD thesis on very short notice. I had exactly the same experience, I just couldn't have phrased it so well. #Psychedelics

It's that time of year, I'm updating my lectures and I have weird questions. BACKGROUND: I've used this graph for many years to joke that sex is more stressful than anything else (and to make the more serious point that CORT levels are a poor readout for stress). ars.els-cdn.com/content/imag...

For LC researchers on BlueSpot Slack but haven't checked it, @mikekelberman.bsky.social and Ellen Rodberg will present their work on LC ephys tomorrow at 11 am EST. Link on General channel. If you are not on BlueSpot and want to attend, email me [email protected]. www.biorxiv.org/content/10.1...

🔵 #LocusCoeruleus alert! Holy cow... I'm supposed to do something else, but this paper looks amazing! I mean the concept, the implications... wow. www.cell.com/cell/fulltex...

Join us on Feb 17 in Bern to celebrate the outstanding contributions of Prof. Jim McGaugh, winner of GSRNet Award 2025! Exciting program: talks by Puder, Adamantidis, Tzanoulinou, Ruff, Andreas Luthi & roundtable with @bohaceklab.bsky.social B Kleim & von Känel www.stressnetwork.ch/events/7th-a...

What a year! #DLC3🔥 is up tested by many of you (👀 watch out for a paper in 2025), we hit 750K downloads, and have over 120 contributors to the code! @deeplabcut.bsky.social ❄️⛷just dropped: new human pose models & high perf. models!

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance! www.biorxiv.org/content/10.1...

All AAVs disproportionally expressed in CA2 of hippocampus!? www.biorxiv.org/content/10.1...

OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list. go.bsky.app/6LWE4dr

New paper from the lab, where we show how the co-chaperone and psychiatric risk factor FKBP5 acts in CRH-expressing neurons to shape stress- sensitive social behavior. Deep phenotyping using #DLC and #DeepOF was key to unravel these effects. www.nature.com/articles/s41...

Although we don’t want this fight now, if we have to have it we will. We have all the funders/unis/institutes on our side. Elife papers will be treated just the same as before. And maybe we can collectively put a dent in Clarivate’s business model.

🔵 blue spot alert: Anita Luethi's team reports a dual role of #locuscoeruleus in #sleep in Nature Neuroscience @natureportfolio.bsky.social 1) high LC activity facilitates cortical microarousals 2) low LC activity is required for NREMS-to-REMS transitions doi.org/10.1038/s415...

Important new work from @heidijacobslab.bsky.social. increased #locuscoeruleus metabolism in #Alzheimers protects against cognitive decline. doi.org/10.1002/alz....

Also, that's why the @thebehaviourforum.bsky.social will become truly useful! When you can finally honestly discuss with other scientists to discover the behind the scene, it will save time and energy. And hopefully improve research 🙏

Intro: we work on the acute stress response, with a focus on the #LocusCoeruleus, #behavior and multiomics. Back on the birdsite we started the tradition of science trailers. This was our first video back in 2020: #Rammstein and #neuroscience ... Volume to 11! 🔊​ www.nature.com/articles/s41...

Neuroscientists! A key message from the ALBA Network Please help us spread the word and share this with your network!!! Nominate (self-n allowed) a mid-career neuroscientist (5+ years post-PhD) for the ALBA-Roche Research Prize for Excellence in Neuroscience! 🔎http://loom.ly/_EvQvm4 🗓️20 January 2025

congrats @stephcragg.bsky.social on the new Nature Communications @natureportfolio.bsky.social paper! Very thorough experimental designs yield interesting insights for a role of #astrocytes as "calcium sponges" to regulate nearby neurons (this is a very crude summary🫣) www.nature.com/articles/s41...

AI-assisted method can reduce number of mice needed for experiments while promoting animal welfare - @bohaceklab.bsky.social et al - better research with keeping #3Rs principles in mind! phys.org/news/2024-11...

"i'm sorry i used your pipette i thought it was mine"

I'm impressed to see so many familiar faces here. Let's see if I can also get help on this platform with a question that someone asks every few months: What reference manager do you recommend for working in google docs? I loved paperpile, but I don't want to pay licenses for everyone in my lab 😖

Hello new world. Can I find all my former tweeps here? @talliezee.bsky.social can you give me a booster? 🙃 In my lab we do stress and noradrenaline, with lots of multiomics and next gen behavior.