New manuscript from undergrad Alexia and @davidweinshenker.bsky.social on the molecular and behavioral effects of early locus coeruleus lesions in the TgF344-AD rat model alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

New review on the role of neuromodulatory subcortical system dysfunction in dementia, this time with a specific focus on sex differences. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6... 1/3

Pathogenic tau in the mouse locus coeruleus induces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.01.30.702923v1

The Neuromodulatory Subcortical Systems PIA within @istaart.bsky.social is requesting nominations for the best paper of 2025 on neuromodulatory subcortical systems in Alzheimer's disease!! ISTAART members: promote the work of your colleagues (or yourself) here: alz.surveymonkey.com/r/Publicatio...

New paper from @neurozoe.bsky.social www.nature.com/articles/s41.... We uncover a role for nucleus accumbens calcium permeable AMPA receptors (CP-AMPARs) in pair bond formation. Congrats to first author Mostafa and all the other amazing co-authors!

Thrilled this is out, led by former PD Cameron Ogg (now with her own lab at @rhodescollege.bsky.social!). It was a driven by a desire to see, in real-time, how LC activity/NE release influences downstream targets in behaving animals. SO hard to do, but Cameron did it! www.cell.com/cell-reports...

New pre-print led by the talented undergrad Alexia with @davidweinshenker.bsky.social We used chronic DSP-4 treatment to lesion the LC-NE system in young TgF344-AD rats to see whether early degeneration led to accelerated onset of pathology and behavioral deficits. www.biorxiv.org/content/10.1...

At #SFN2025 and interersted in the 🔵? Check out posters from Leslie Hassanein (D52; neuromelanin in the mouse locus coeruleus) and Maggie Tish (C59; human 3D locus coeruleus organoids) today from 1:00-5:00!

With 2 postdocs moving on to faculty positions🥳, we're looking to hire someone new. If you're interested in norepinephrine and neural circuits, please apply! tinyurl.com/42bfe24k

Abstract deadline extended for the Integrative Neuromodulatory Subcortical Systems 2025 meeting! Supported by @ISTAART and hosted by @NSS_PIA & @SleepPIA 🧠💤 Boston, MA USA or online | July 17-18 📅 Abstracts due 4/15 11:30pm EST ✅ Registration & more info: education.martinos.org/inss2025/

Check out the amazing line up of speakers for the Catecholamines GRC! Apply for GRC www.grc.org/catecholamin... & GRS www.grc.org/catecholamin.... In these uncertain times we appreciate any donation to support the participants in the GRC my.grc.org/p/contributi... & GRS my.grc.org/p/contributi...

For anyone studying catecholamines please consider applying for the GRC and GRS (trainees only!) Catecholamines being held in August of this year. I'll be coordinating the GRS portion of the meeting with Darshana, so please reach out with any questions.

For LC researchers on BlueSpot Slack but haven't checked it, @mikekelberman.bsky.social and Ellen Rodberg will present their work on LC ephys tomorrow at 11 am EST. Link on General channel. If you are not on BlueSpot and want to attend, email me [email protected]. www.biorxiv.org/content/10.1...

Introducing myself on here! I'm a Post-Doc in Zoe Donaldson's lab at CU Boulder interested in using prairie voles to understand social deficits in Alzheimer's disease, with a side interest in the coolest brain region, the locus coeruleus 🔵. Check out two of my most recent publications below: