1/ New preprint from our lab: “Locus coeruleus activation transforms cortical taste representations” We asked how a major neuromodulatory system reshapes cortical taste coding toward behaviorally meaningful features. www.biorxiv.org/content/10.6...

Exciting progress, lots of new things coming!! Today we tested our new sequential predictive processing task in the new Cima.X scanner with new sequences and our eye-tracker system (now redesigned from 7T to 3T setup)! #locuscoeruleus @mghmartinos.bsky.social

Postdoc opportunity to investigate the role of noradrenaline in Alzheimer's disease. Require: strong fMRI (fMRS) skills and interest in predictive coding. The Martinos Center in Boston is a superb place to work. Reach out for info; I will be in London (AAIC) and NL in July shorturl.at/1HSey

I am recruiting an exceptional postdoc to join my lab at UC Irvine. Must be a productive researcher with experience in functional neuroimaging, network neuroscience, AI/ML, who is interested in aging, neuropsychiatric or neurodegenerative illness. www.linkedin.com/jobs/view/44...

Recent studies have revealed the synchronization of neuromodulators including norepinephrine, serotonin, acetylcholine, dopamine, and histamine during sleep. A new #ScienceReview explores what potential role the synchronization of these oscillations may play in health. https://scim.ag/3PEGdsW

Dual orexin receptor antagonism with lemborexant enhances #microglial clearance of β-#amyloid in mice Ashish Sharma, Emiko Segawa, Xiaoying Chen...Erik S. Musiek @washumedicine.bsky.social #Sleep #AlzheimersDisease link.springer.com/article/10.1...

The locus coeruleus, which provides norepinephrine to the rest of the brain, is even more spatially and functionally diverse than previously thought, new findings suggest. By Holly Barker www.thetransmitter.org/locus-coerul...

🧪 #alzheimer #amyloid Amazing new paper from @sfackley.bsky.social that exposes the statistical alchemy Lilly applied to their donanemab data: jamanetwork.com/journals/jam... There is little to no correlation between amyoid removal and clinical outcomes with donanemab (or lecanemab).

In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests. Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N

Do brain circuits really sit in a 'soup' of neuromodulators? Are neurons like soggy bits of bread soaked in signaling factors? Is the whole brain just squelching around in one big pool of warm modulators?

New paper out: Short review of Rait et al. (2025) on hippocampal drift and memory organisation. doi.org/10.1523/JNEU... #SoloAuthor #JoN #JournalClub

Impressive PhD defense on depression, tau and serotonin by Teodora Markova from @anneberry.bsky.social ‘s lab @brandeisuniversity.bsky.social today!! Congrats Dr.Markova!

Thrilled to share that, supported by @brightfocus.bsky.social we are going to use new MRI-PET methods to examine what happens in the serotonergic system during aging/Alzheimer disease, and what that means for cognition/behavior. #raphenucleus With:@leatgrinberg.bsky.social, @joyitadutta.bsky.social

PhD Position: Computational Affective Neuroscience and Ultrasonic Neuromodulation at @dondersinst.bsky.social >Passionate about ultrasonic modulation? Come and join us! funded by @erc.europa.eu HEART2ADAPT @epanlab.bsky.social in coll. with @lennartverhagen.bsky.social www.ru.nl/en/working-a...

Excited to share our new paper asking a simple question: Why do mental and metabolic health so often go hand in hand? We (@camillanord.bsky.social @hugofleming.bsky.social) tested whether shared neurocognitive signatures play a role in this relationship www.nature.com/articles/s41...

Can you make your life feel “longer” in retrospect? Add a dose of change and novelty in the present to later expand memories of your past. Excited to share our work on how dopamine-related processing bends memory to reflect the passage of distinct events. newsroom.ucla.edu/releases/can...

YouTube ad for #AAIC with of course the best team! Go blue spotters! 🔵 We are looking forward to #AAIC2026 in London @alzassociation.bsky.social

Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

Yesterday saw the first images of our new Panorama PET/CT: incredible spatial resolution showing the smaller nuclei in the brain. This is going to be so exciting!! 🔵

New paper in Imaging Neuroscience by Zhishun Wang, Jack Grinband, et al: MEPrep: A robust pipeline for multi-echo fMRI denoising and preprocessing doi.org/10.1162/IMAG...

This paper has been a long time coming. Instead of reanalyzing the same old resting-state fMRI datasets, we combined nearly all datasets around the world. Note that we didn't exactly find indisputable evidence for "default mode network disintegration." www.nature.com/articles/s41...

Correlating brain maps across datasets is everywhere in neuroimaging. Here we ask: when you contextualize a brain map against genes, metabolism, or connectivity... What can you really conclude? How can we do better? We explore these questions here: tinyurl.com/2dudkevc

Very cool work on locus coeruleus and hypothalamus in narcolepsy: rdcu.be/faNYz

Such a beautiful example demonstrating the importance of developing and using robust biosensors #FluorescenceFriday

Neuroscientists have created a continuous atlas showing how patterns of functional connectivity between brain regions change from birth to old age go.nature.com/47rmMtk

Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...

✨ SHINY NEW PAPER ✨ Evidence of locus coeruleus-noradrenaline (LC-NA) hyperactivity in older adults using behavioral, pupil and EEG data @maramather.bsky.social www.sciencedirect.com/science/arti...

New preprint: our lab’s first Alzheimer’s paper! “Loss of neuronal population organization links pathology to behavior in a model of Alzheimer's disease” www.biorxiv.org/content/10.6... 🧪🧵1/

Very pleased to share that our study “Noradrenaline causes a spread of association in the hippocampal cognitive map” is out in @natcomms.nature.com (my final PhD paper, only 3.5 years post PhD! 🙃) Find the paper here: www.nature.com/articles/s41...

New review on the role of neuromodulatory subcortical system dysfunction in dementia, this time with a specific focus on sex differences. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

📢 New preprint from the lab🧠 ▶️doi.org/10.64898/2026.03.12.710517 What does fMRI connectivity actually reflect at the neural level? The natural intuition is: more neural activity = more connectivity! Using cortical perturbations we show this is not necessarily the case: sometimes less is more! 👇🧵

🔵 for all the locus coeruleus lovers: check out our latest work! www.biorxiv.org/content/10.6... 🧵👇

Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability | doi.org/10.64898/202... Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️

I couldn't find a tool to plot different #neuroimaging data in one consistent style, so I made one! Meet yabplot (yet another brain plot) - a #Python package for (sub)cortex & tracts.🧠 - Simple API - Built-in atlases - Custom atlas support 🔗 github.com/teanijarv/ya... (drop a ⭐️!)

neuromapr 0.2.1 has been accepted and published on CRAN! Very excited to get this out to users in the simplest way possible, and hope the #rstats #neuroimaging community finds it useful! lcbc-uio.github.io/neuromapr/

Lateral hypothalamic input engages a disinhibitory microcircuit in the dorsal raphe to promote behavior activation https://www.biorxiv.org/content/10.64898/2026.02.26.708342v1

🩸 🧠 ⏱️ What if a blood test could predict WHEN an individual would develop symptoms of Alzheimer’s disease? High plasma p-tau217 predicts greater risk for Alzheimer’s symptoms—do the plasma p-tau217 levels provide insights into WHEN symptoms might begin? nature.com/articles/s41...

Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | doi.org/10.1007/s004... How do neuroreceptor distributions vary across people?

Pathogenic tau in the mouse locus coeruleus induces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.01.30.702923v1

New tour de force from @giuliaabaracc.bsky.social. Everything you ever wanted to know about brain signal variability! 🧠 www.nature.com/articles/s41...

The Neuromodulatory Subcortical Systems PIA within @istaart.bsky.social is requesting nominations for the best paper of 2025 on neuromodulatory subcortical systems in Alzheimer's disease!! ISTAART members: promote the work of your colleagues (or yourself) here: alz.surveymonkey.com/r/Publicatio...

The extended version of my thesis procrastination project/subcortex visualization package is out now in both Python and R, now that I’ve graduated 🤠 This figure shows the 9 atlases included (and counting)! Preprint: www.biorxiv.org/content/10.6... Website: anniegbryant.github.io/subcortex_vi...

Adolescent Social Isolation Facilitates Tau Spread in Raphe Nuclei Linking Depression and Hyperalgesia in Alzheimers Disease https://www.biorxiv.org/content/10.64898/2026.01.23.701108v1

The Neuromodulatory Subcortical Systems PIA within @istaart.bsky.social is requesting nominations for the best paper of 2025 on neuromodulatory subcortical systems in Alzheimer's disease!! ISTAART members: promote the work of your colleagues (or yourself) here: alz.surveymonkey.com/r/Publicatio...

Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5

Thrilled this is out, led by former PD Cameron Ogg (now with her own lab at @rhodescollege.bsky.social!). It was a driven by a desire to see, in real-time, how LC activity/NE release influences downstream targets in behaving animals. SO hard to do, but Cameron did it! www.cell.com/cell-reports...