Molecular characterization of humanized #APOE mouse models reveals source and #genotype dependent differences Na Wang, Gefei Yu, Zhen Wang, Alla Alnobani...Takahisa Kanekiyo & Chia-Chen Liu & Guojun Bu #AlzheimersDisease #lipids link.springer.com/article/10.1...

🚨 Registration is NOW OPEN for ISMND 2026! Join us in Hong Kong (or virtually) from October 20-23, 2026 for invited talks from leading experts, selected short talks & posters, and plenty of networking! 🔗 Register now: ismnd2026.org/how-register

Inflammatory signaling differentially changes #chromatin accessibility and #gene expression of the PD-associated kinase #LRRK2 between human and mice Alexandra Beilina, Jae-Hyeon Park, Natalie Landeck...Mark R. Cookson @markrcookson.bsky.social #Parkinsons link.springer.com/article/10.1...

PU.1: the conductor of #Alzheimers symphony Chunli Sun & Qianjin Liu #microglia link.springer.com/article/10.1...

Altered trafficking of Kv1-Kvβ2 leads to neuronal hyperexcitability and memory deficits in #amyloid -β pathology Young-Sin Cho, Seo-Hyun Kim...Yong-Keun Jung #AlzheimersDisease link.springer.com/article/10.1...

Systems biology of #AlzheimersDisease: a scoping review of key pathways and mechanisms Paula J. Bice, Kwangsik Nho, Nilüfer Ertekin-Taner, Andrew J. Saykin link.springer.com/article/10.1...

Impaired nucleocytoplasmic transport in #SOD1 -mediated #ALS Shirel Argueti-Ostrovsky, Su Min Lim...Clotilde Lagier-Tourenne @harvardmed.bsky.social @broadinstitute.org & Adrian Israelson @bengurionuniv.bsky.social #amyotrophiclateralsclerosis link.springer.com/article/10.1...

The functional role of #glial cells in the pathologic brain as reviewed by Alois #Alzheimer in 1910 Helmut Kettenmann, Hans Lassmann, Bilge Ugursu, Xianyuan Xiang #microglia #neuroinflammation link.springer.com/article/10.1...

Why some people with #geneticRisk factors develop #ParkinsonsDisease while others never do? M Gu, H Bellen et al have found an explanation. @bcmhouston.bsky.social @bcmgenetics.bsky.social #TexasChildrens @molneurodegen.bsky.social #BCMPostDoc blogs.bcm.edu/2026/02/12/f...

Targeting tau in #AlzheimersDisease: rationale, approach and challenges Aram Aslanyan, Martha S. Foiani, Tatiana A. Giovannucci...Ross W. Paterson @ukdri.ac.uk #biomarkers #therapeutics link.springer.com/article/10.1...

Genetic Duo: #ATP13A2 and #GBA1 Interactions Fuel #Neurodegeneration. M. Gu and H Bellen explain their findings. @bcmhouston.bsky.social #TexasChildrens @molneurodegen.bsky.social @bcmgenetics.bsky.social #BCMPostDoc bioengineer.org/genetic-duo-...

#Lipid alterations in hereditary #peripheralneuropathies: common mechanisms in disease heterogeneity? Koen Kuipers, Sam Vanherle, Kirsten Poelmans, Esther Wolfs, Jeroen Bogie & Tim Vangansewinkel #neurodegeneration #schwanncells #demyelination link.springer.com/article/10.1...

How do two altered genes, #ATP13A2 and #GBA1, in two different cell types lead to neurodegeneration? M. Gu and H Bellen explain their findings. @bcmhouston.bsky.social #TexasChildrens @molneurodegen.bsky.social @bcmgenetics.bsky.social #BCMPostDoc medicalxpress.com/news/2026-02...

It takes two: #genes ATP13A2 and GBA1 interact to drive #neurodegeneration eurekalert.org/news-release... Mingxue Gu, Jinghan Zhao, Mingxi Deng, J. Shulman, H. Bellen et al @bcmhouston.bsky.social @#TexasChildrens #Parkinsons @molneurodegen.bsky.social @bcmgenetics.bsky.social #BCMPostdoc

Two #lysosomal genes ATP13A2 and #GBA1 interact to drive #neurodegeneration Mingxue Gu, Jinghan Zhao, Mingxi Deng...Joshua M. Shulman & Hugo J. Bellen @bcmhouston.bsky.social #Parkinsons link.springer.com/article/10.1...

Multi-omics insights into #GBA1 -associated #Parkinsons disease: interplay of #genomics, #transcriptomics, #proteomics, and #lipidomics Yang Ni, Huaibin Cai, Yaping Shao, Weidong Le link.springer.com/article/10.1...

New mechanism for how synapses deteriorate in #Alzheimers, with new tool that maps dynamic postsynaptic changes after acute tau oligomer exposure. Study in @molneurodegen.bsky.social @taratracylab.bsky.social www.buckinstitute.org/news/discove...

Synaptic control of #RetinalGanglionCell survival and #axon regeneration Yuxuan Qiu, Qi Zhang, Jiahui Tang...Yangjiani Li, Zhe Liu, Fang Chai, Yehong Zhuo, Yiqing Li link.springer.com/article/10.1...

Tau #oligomers modulate synapse fate by eliciting progressive bipartite #synapse dysregulation and synapse loss Kristeen A. Pareja-Navarro, Christina D. King, Grant Kauwe...Tara E. Tracy @buckinstitute.org #AlzheimersDisease #iPSCs link.springer.com/article/10.1...

#Plasma platelet-derived growth factor receptor-β decrease correlates with #bloodbrainbarrier damage in #AlzheimersDisease Jieyin Li, Anqi Li...Xuhui Chen, Dai Shi, Tengfei Guo link.springer.com/article/10.1...

Systemic #complement factors in aging, #AlzheimersDisease and other dementias: a #longitudinal study over 10 years Xiaofeng Fu, Huimin Cai, Shuiyue Quan...Longfei Jia link.springer.com/article/10.1...

The molecular fidelity of Aβ pathology in 5xFAD and AppNL−FPsen1P117L mice revealed by #cryoEM Meinai Song...Deng-Feng Zhang & Qin Cao #amyloid #AlzheimersDisease link.springer.com/article/10.1...

Great study on @molneurodegen.bsky.social showcasing the differences of Aβ generated from glutamatergic and GABAergic neurons with distinct implications for plaque compaction, reactive gliosis, and axonal dystrophy! link.springer.com/article/10.1...

Neuronal subtype governs #amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models Gabriella A. Perez, Zoe Lai...Joanna L. Jankowsky @bcmhouston.bsky.social @washumedicine.bsky.social #AlzheimersDisease #GABAergic link.springer.com/article/10.1...

OMG! A proteomic determinant of #neurodegenerative resiliency Michael R. Duggan, Hamilton Se-Hwee Oh, Philipp Frank...Keenan A. Walker #proteomics #AlzheimersDisease link.springer.com/article/10.1...

Developmental #dopamine loss rewires striatal circuits to promote locomotion Jie Dong...Weidong Le, Jun Jia, Huaibin Cai @NIHAging @NIH #Parkinsons #optogenetics link.springer.com/article/10.1...

#Organelle stress in NLRP3 #inflammasome: a central mediator of #neurodegenerative diseases Huachao Jia, Lianghua Ma...Wanwei Jiang, Minjie Wei, Xin Zhong link.springer.com/article/10.1...

Disrupting α-#Synuclein–ClpP interaction restores #mitochondrial function and attenuates #neuropathology in #Parkinsons disease models Di Hu, Xiaoyan Sun, Xin Qi link.springer.com/article/10.1...

The #complement cascade in #AlzheimersDisease: modern implications of an ancient #immune protagonist Maria-Tzousi Papavergi, Praveen Bathini, Brijendra Singh & Cynthia A. Lemere @harvardmed.bsky.social link.springer.com/article/10.1...

Targeted deletion of EMMPRIN in #microglia /macrophages mitigates neuronal death in intracerebral #hemorrhage Zhe Li, Xiangyu Zhang, Maryam Mobarakabadi...V. Wee Yong & Mengzhou Xue #neuroprotection link.springer.com/article/10.1...

"The #pesticide chlorpyrifos increases the risk of #Parkinsons disease" Kazi Md. Mahmudul Hasan, Lisa M. Barnhill, Kimberly C. Paul...Jeff M. Bronstein @dgsomucla.bsky.social link.springer.com/article/10.1...

Our new study in @molneurodegen.bsky.social shows that microglial DAP12 controls tau buildup and drives myelin loss by mediating a harmful tau-induced SLIT2 signal from neurons to oligodendrocytes link.springer.com/article/10.1...

Diagnostic #biomarkers for α- #synucleinopathies- state of the art and future developments: a systematic review V. Donadio, M. Ingelsson...S. Pritzkow @unibo.it link.springer.com/article/10.1...

DAP12 deletion reduces neuronal SLIT2 and #demyelination and enhances brain resilience in female #tauopathy mice Hao Chen, Li Fan, Qi Guo...Li Gan & Wenjie Luo @liganlab.bsky.social @weillcornell.bsky.social #AlzheimersDisease link.springer.com/article/10.1...

#Pioglitazone modulates #metabolic adaptation and peripheral nerve #regeneration after injury Antonia Seitz, Taylan Özöncü, Daniela Sinske...Sofia Meyer zu Reckendorf @uniulm.bsky.social #PeripheralNerveInjury #schwanncells link.springer.com/article/10.1...

Domain mapping of disease #mutations reveals pathogenic #SORL1 variants in #AlzheimersDisease Olav M. Andersen, Matthijs W. J. de Waal...Henne Holstege @amsterdamumc.bsky.social #genetics link.springer.com/article/10.1...

#Multidomain therapy for #AlzheimersDisease: a scoping review of #cognitive decline trials Jared C. Roach, Gwênlyn Glusman, Molly K. Rapozo... Leroy Hood @isbscience.org link.springer.com/article/10.1...

Death-associated protein kinase 1-dependent SENP1 degradation increases tau #SUMOylation and leads to cognitive dysfunction in a mouse model for #tauopathy Xindong Shui...Dongmei Chen, Tao Zhang, Tae Ho Lee #AlzheimersDisease molecularneurodegeneration.biomedcentral.com/articles/10....

High-sensitivity #plasma #proteomics reveals disease-specific signatures and predictive #biomarkers of #AlzheimersDisease phenotypes in a large mixed-dementia cohort Katherine Gong...Laura Ibanez & Carlos Cruchaga @washumedicine.bsky.social @washumedadrc.bsky.social bit.ly/4r7LxD0

#Plasma TDP-43 is a potential #biomarker for advanced limbic-predominant age-related #TDP43 encephalopathy neuropathologic change Jijing Wang, Julie A. Schneider, David A. Bennett...& Hyun-Sik Yang @harvardmed.bsky.social molecularneurodegeneration.biomedcentral.com/articles/10....

'M102 activates both NRF2 and HSF1 transcription factor pathways and is #neuroprotective in cell and animal models of #AmyotrophicLateralSclerosis' Amy Keerie, Raquel Rua Martins, Chloe Allen...Pamela J. Shaw, Laura Ferraiuolo, Richard J. Mead #ALS bit.ly/4hEAdd6

#Neuropathology of #LewyBodyDementia: Lewy-related pathology, α- #synuclein oligomers, and comorbid pathologies Hiroaki Sekiya, Tomoyasu Matsubara, Michael A. DeTure, Dennis W. Dickson @mayoclinic.org #LewyBodies molecularneurodegeneration.biomedcentral.com/articles/10....

'C-terminus-dependent detection of #lysosomal alpha- #synuclein in nigral #Parkinsons disease human brain neurons' Martino L. Morella, Bana Al Khayrat, Tim E. Moors...Wilma D. J. van de Berg @amsterdamumc.bsky.social molecularneurodegeneration.biomedcentral.com/articles/10....

'Interplay between #astrocyte reactivity and #APOE ε4 status is associated with accelerated #pTau-related tau pathology in #AlzheimersDisease' Xiaoxie Mao, Yan Wang, Ying Luan, Ying Wang...Binyin Li, Zijing Li, Qihao Guo, Fang Xie molecularneurodegeneration.biomedcentral.com/articles/10....

#Microglia sensing of #peripheral signals that bridge the brain and body Claire E. Young & Melanie A. Samuel @bcmhouston.bsky.social #neurodegeneration molecularneurodegeneration.biomedcentral.com/articles/10....

'Modulation of O-GlcNAc cycling influences α-#synuclein amplification, degradation, and associated #neuroinflammatory pathology' Yongzhen Miao...Chun-Feng Liu & Hongrui Meng #proteolysis #alphasynuclein molecularneurodegeneration.biomedcentral.com/articles/10....

'Effect of #antidiabetic drugs in #AlzheimersDisease: a systematic review of preclinical and #clinical studies' Miriam Corraliza-Gomez, Maria Vargas-Soria, Monica Garcia-Alloza @univcadiz.bsky.social #diabetes molecularneurodegeneration.biomedcentral.com/articles/10....

'Entering the era of precision medicine to treat #AmyotrophicLateralSclerosis' Frances Theunissen, Loren Flynn, Alfredo Iacoangeli...Masha Strømme & P. Anthony Akkari @murdoch.edu.au @kingscollegelondon.bsky.social #ALS #oligonucleotide molecularneurodegeneration.biomedcentral.com/articles/10....

'Neurotherapeutic effects of Vutiglabridin as a Paraoxonase-2 modulator in preclinical models of #Parkinsons disease' Heeyoung An, Sora Kang, Jaejin Shin...C. Justin Lee & Youngmi Kim Pak #mitochondria #therapeutics molecularneurodegeneration.biomedcentral.com/articles/10....