Great talk by Beatrix from the group on targeted long-read sequencing of the C9orf72 HRE at the ARUK Thames Valley Network Research Day in Oxford today #ALS #FTD

#ExtracellularVesicles in #TDP43 proteinopathies: pathogenesis and #biomarker potential Elizabeth R. Dellar @lizziedellar.bsky.social Lara Nikel, Stephanie Fowler...Alexander G. Thompson #exosome #ALS #FTD molecularneurodegeneration.biomedcentral.com/articles/10....

Very pleased to share our review in @molneurodegen.bsky.social, assessing evidence for #ExtracellularVesicle associated #TDP43. We highlight knowledge gaps relating to its biomarker usage and possible involvement in seeding of templated aggregation in #ALS, #FTD and #LATE. doi.org/10.1186/s130...

En route for #ISEV2025! If you want to chat EV enrichment from #brain #blood and #CSF for biomarker discovery in neurodegenerative diseases, then come and find me later this week 🫧

“The time to write a fellowship is when it feels right for you.” Great advice from @dryvonnecouch.bsky.social’s new guest blog on writing your first fellowship. www.dementiaresearcher.nihr.ac.uk/blog-writing...

Also contributing were Beatrix with her poster on long-read sequencing of #C9orf72 HRE and @lizziedellar.bsky.social with her poster on #ExtracellularVesicle -based biomarker discovery in CSF.

The @mndoxford.bsky.social team enjoyed the day at the Oxford #MDUK Neuromuscular Centre meeting yesterday. In the #ALS/#MND session Alex spoke on our studies of at-risk pre-symptomatic populations, and Kevin on the path from pre-clinical models to experimental medicine.

Excellent talk by Lizzie @lizziedellar.bsky.social from the group on discovery and validation of early biomarkers in #ALS at the Oxford Neuroscience Symposium this week.

Come and work with me! Research position open to work on isolation of #extracellular #vesicles for biomarker discovery in #ALS #MND. See link for more details, and reach out if you have questions. my.corehr.com/pls/uoxrecru...

Come and join us! Research assistant position open at @mndoxford.bsky.social @ndcnoxford.bsky.social, working on collecting neuroimaging data in #ALS and #FTD. Previous research experience with humans is essential. This post would suit a #Psychology or #Neuroscience graduate. See link below for info

We also have several group members giving platform talks as well as a plenary lecture! We would be delighted to see you there - see below for our presenters and talks #MND #ALS @mndassoc.bsky.social #alsmndsymp

We are excited to be here in Montreal for @mndassoc.bsky.social #alsmndsymp! We would be delighted to see you at our posters - see below for our presenters and poster numbers #MND #ALS

@mndoxford.bsky.social is now also here on Bluesky. Give it a follow to hear research updates from the whole Oxford MND Centre!

Congrats to Steph Fowler and team for their excellent work showing the presence of tau filaments in #extracellularvesicles derived from brain tissue in Alzheimer's disease, out in @NatureNeuro today. www.nature.com/articles/s41... Excited to see more on this!

Here's number 2: (hopefully by now you have figured out where to find them and can head over and browse at your leisure!) www.dementiaresearcher.nihr.ac.uk/guest-blog-i...

This week’s Science Without Anguish post is out: the slippery slope to imposter syndrome in research and how to escape it. Please tell your colleagues on or off social media. 🧪 www.sciencewithoutanguish.com/blog/we-are-...

EV people unite! 😁

PXD051859 🚨 Elevated cerebrospinal fluid ubiquitin carboxyl-terminal hydrolase isozyme L1 levels in asymptomatic C9orf72 hexanucleotide repeat expansion carriers. 🚨 New dataset alert! 🚨

(1/3) Happy to share our new work assessing protein changes in CSF of 48 asymptomatic C9orf72 variant carriers at higher risk of #ALS and #FTD. We find an elevation in levels of UCHL1 protein, even in the absence of elevation in #neurofilament (NFL). onlinelibrary.wiley.com/doi/full/10....