Charlie Arber (@celarber.bsky.social)

It's out! More than just making amyloid? What if mutations in PSEN1 also predispose inflammation. We asked if Alzheimer's disease mutations affect cytokine signalling using stem cell derived astrocytes. molecularneurodegeneration.biomedcentral.com/articles/10.....

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Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa... https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-025-00864-7